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| 1 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 2 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 3 | In vitro degradation and biocompatibility evaluation of typical biodegradable metals (Mg/Zn/Fe) for the application of tracheobronchial stenosis显示文摘Tracheobronchial obstruction in children due to benign stenosis or tracheobronchomalacia still remains a challenging matter of concern.Currently,there is 10%–20%complication rate in clinical treatment.The nonbiodegradable property of silicone stents and nickel-titanium memory alloy stents take the primary responsibility for drawbacks including stimulating local granulation tissue proliferation,displacement,and stent-related infections.Permanent tracheobronchial stent will be a persistent foreign object for a long time,causing excessive secretion of tracheal mucosa,ulceration and even perforation,which is particularly unsuitable for young children with persistent tracheal growth.In this study,the degradation and biocompatibility performance of three typical biodegradable metals were investigated as potential tracheobronchial stent materials.The results exhibited that these materials showed different degradation behaviors in the simulating respiratory fluid environment compared with SBF.Except for pure iron group,high purity magnesium and zinc showed favorable cell adhesion and proliferation in three culture methodologies(direct culture,indirect culture and extraction culture).The proper corrosion rate and good biocompatibility indicated that high purity magnesium and zinc may be good candidates as tracheobronchial stent materials. | Yangyang Li Jianglong Yan Wenhao Zhou Pan Xiong Pei Wang Wei Yuan Yufeng Zheng Yan Cheng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 4 | Typhoon events recorded in coastal lagoon deposits,southeastern Hainan Island显示文摘Coastal lagoon deposits provide evidence for the magnitude and frequency of past tropical cyclones prior to instrumental records and historical documentation.In the present study,we attempt to analyze the sedimentary records containing typhoon information for the northern South China Sea region.For this purpose,sediment cores were collected from two coastal lagoons in the southeastern Hainan Island,and were analyzed in laboratory to derive the data sets about grain size,organic and inorganic carbon contents,and deposition rates.The grain size and organic-inorganic carbon data were used to formulate the proxies of typhoon events.The deposition rates,as calculated using the CRS 210 Pb method,are around 0.5 mm/a for both lagoons,on the basis of which an age model is established.Within the cores,sedimentary layers associated with 35 typhoon events have been identified.On such a basis,a 350 year history of local typhoon activities is reconstructed by incorporating the 210 Pb dating results,typhoon-induced sedimentation patterns and the historical documents.A comparison of the frequency of typhoon occurrence with the regional climate records indicates that the observed changes in tropical cyclone activity patterns,as revealed by the lagoon sedimentary records,may be related to El Ni?o,Pacific Decadal Oscillation(PDO),North Atlantic Oscillation(NAO),sunspot,and other potential climate drivers that affect the tropical cyclone variability.This study demonstrates that the sedimentary record of storms can be analyzed in combination with historical documents,to provide meaningful information on past storm activities and their long-term variability. | ZHOU Liang GAO Shu YANG Yang ZHAO Yangyang HAN Zhuochen LI Gaocong JIA Peihong YIN Yong | 2017 | Acta Oceanologica Sinica2017，36，4： | 6 |
| 5 | A single circular chromosome yeast显示文摘Dear editor,Most of the prokaryotic cells contain a single circular chromosome.In contrast, the eukaryotic cells usually contain multiple linear chromosomes. Recently, we artificially created a single linear chromosome yeast strain SY14 from native 16 chromosomes in a haploid Saccharomyces cerevisiae, which displays minor fitness defects.^1 In this study, we have created a new yeast strain which contains a single circular chromosome and apparently has not been found in nature. | Yangyang Shao Ning Lu Chen Cai Fan Zhou Shanshan Wang Zhihu Zhao Guoping Zhao Jin-Qiu Zhou Xiaoli Xue Zhongjun Qin | 2019 | Cell Research2019，29，1： | 5 |
| 6 | Synergistic cerium doping and MXene coupling in layered double hydroxides as efficient electrocatalysts for oxygen evolution显示文摘Oxygen evolution reaction(OER) is a bottle-neck process in many sustainable energy conversion systems due to its sluggish kinetics.The development of cost-effective yet efficient electrocatalysts towards OER is highly desirable but still a great challenge at current stage.Herein,a new type of hybrid nanostructure,consisting of two-dimensional(2D) Cerium-doped NiFe-layered double hydroxide nanoflakes directly grown on the 2D Ti3C2Tx MXene surface(denoted as NiFeCe-LDH/MXene),is designed using a facile insitu coprecipitation method.The resultant NiFeCe-LDH/MXene hybrid presents a hierarchical nanoporous structure,high electrical conductivity and strong interfacial junction because of the synergistic effect of Ce doping and MXene coupling.As a result,the hybrid catalyst exhibits an excellent catalytic activity for OER,delivering a low onset overpotential of 197 mV and an overpotential of 260 mV at a current density of 10 mA·cm-2 in the alkaline medium,much lower than its pure LDH counterparts and IrO2 catalyst.Besides,the hybrid catalyst also displays a fast reaction kinetics and a remarkable stable durability.Further theoretic studies using density function theory(DFT) methods reveal that Ce doping could effectively narrow the bandgap of NiFe-LDH and reduce the overpotential in OER process.This work may shed light on the exploration of advanced electrocatalysts for renewable energy conversion and storage systems. | Yangyang Wen Zhiting Wei Jiahao Liu Rui Li Ping Wang Bin Zhou Xiang Zhang Jiang Li Zhenxing Li | 2021 | Journal of Energy Chemistry2021，30，1： | 4 |
| 7 | Distributed Energy Sharing in Energy Internet Through Distributed Averaging显示文摘This paper proposes a distributed averaging iteration algorithm for energy sharing in microgrids of Energy Internet based on common gossip algorithms. This algorithm is completely distributed and only requires communications between neighbors. Through this algorithm, the Energy Internet not only allocates the energy effectively based on the load condition of grids, but also reasonably schedules the energy transmitted between neighboring grids. This study applies theoretical analysis to discuss the condition in which this algorithm can finally reach supply-and-demand balance. Subsequently, the related simulation validates the performance of the algorithm under various conditions. | Yangyang Ming Jie Yang Junwei Cao Ziqiang Zhou Chunxiao Xing | 2018 | Tsinghua Science and Technology2018，23，3： | 3 |
| 8 | An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma显示文摘Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery. | Xingchen Li Yuan Cheng Yangyang Dong Boqiang Shen Xiao Yang Jiaqi Wang Jingyi Zhou Jianliu Wang | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 9 | Branched-chain amino acids regulate plant growth by affecting the homeostasis of mineral elements in rice显示文摘Dear Editor,Branched-chain amino acids(BCAAs)are essential amino acids that must be obtained from the diet for humans and animals.Branched-chain amino acid transaminases(BCATs)catalyze a key step in the BCAA synthesis pathway,however,little is known about their biological roles in planta.In this study,we functionally characterized two BCATs,OsBCAT4 and OsBCAT5,in rice and showed that they regulate the development of rice roots by affecting the levels of mineral elements. | Cheng Jin Yangyang Sun Yuheng Shi Yuanyuan Zhang Kai Chen Yuan Li Guige Liu Fang Yao Deng Cheng Jie Li Junjie Zhou Lianghuan Qu Xianqing Liu Jie Luo | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 10 | Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4-Chlorine Substituted N-Pyridylpyrazole显示文摘To search for potent insecticides targeting at ryanodine receptors(RyRs),a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized.Their insecticidal activities were evaluated and the preliminary struc ture-activity relationships(SARs)were discussed.The insecticidal results showed that some of the compounds(8a-8h,8m,8n)exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L^(-1),and compound 8m possessed 60%insecticidal activityat 0.5 mg·L^(-1).For diamondback moth,8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. | Huangong Li Yangyang Zhao Pengwei Sun Li Gao Yuxin Li Lixia Xiong Na Yang Sha Zhou Zhengming Li | 2021 | Chinese Journal of Chemistry2021，39，1： | 3 |
| 11 | CHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis显示文摘PICKLE(PKL), a putative CHD3 chromatin remodeling factor, has been suggested to be involved in multiple processes in Arabidopsis. Here, we confirmed the late-flowering phenotype caused by pkl mutation with pkl mutants in two different ecotypes, and investigated the possible mechanisms that account for PKL regulation of flowering time. Quantitative RT-PCR and RNA-seq assays showed that expression of the LEAFY gene(LFY) and a number of LFY-regulated floral homeotic genes were down-regulated in seedlings of the pkl mutants. As predicted, overexpression of LFY restored normal flowering time of pkl mutants. Our results suggest that PKL may be involved in regulating flowering time via LFY expression. To uncover the underlying mechanism, Ch IP-PCR using anti-PKL was performed on materials from three developmental stages of seedlings. Our results showed that PKL associated with the genomic sequences of LFY, particularly at 10-day and 25-day after germination. We also showed that loss of PKL affected H3K27me3 level at the promoter of LFY. Taken together, our data suggest that transcriptional regulation of LFY at the chromatin level by PKL may at least partially account for the late-flowering phenotype of pkl mutants. | Xing Fu Chaonan Li Qing Liang Yangyang Zhou Hang He Liu-Min Fan | 2016 | Science China(Life Sciences)2016，59，5： | 2 |
| 12 | Reconstructing Environmental Changes of a Coastal Lagoon with Coral Reefs in Southeastern Hainan Island显示文摘Coastal lagoons with small catchment basins are highly sensitive to natural processes and anthropogenic activities. To figure out the environmental changes of a coastal lagoon and its contribution to carbon burial, two sediment cores were collected in Xincun Lagoon, southeastern Hainan Island and (210) ~Pb activities, grain size parameters, total organic carbon(TOC), total nitrogen(TN), total inorganic carbon(TIC) and stable carbon isotopes(δ^(13)C) were measured. The results show that in 1770–1815, the decreasing water exchange capacity with outer open water, probably caused by the shifting and narrowing of the tidal inlet, not only diminished the currents and fined the sediments in the lagoon, but also reduced the organic matter of marine sources. From 1815 to 1950, the sedimentary environment of Xincun Lagoon was frequently influenced by storm events. These extreme events resulted in the high fluctuation of sediment grain size and sorting, as well as the great variation in contributions of terrestrial(higher plants, soils) and marine sources(phytoplankton, algae, seagrass). The extremely high content of TIC, compared to TOC before 1950 could be attributed to the large-scale coverage of coral reefs. However, with the boost of seawater aquaculture activities after 1970, the health growth of coral species was severely threatened, and corresponding production and inorganic carbon burial flux reduced. The apparent enhanced inorganic carbon burial rate after 1990 might result from the concomitant carbonate debris produced by seawater aquaculture. This result is important for local government long-term coastal management and environmental planning. | ZHOU Liang GAO Shu GAO Jianhua ZHAO Yangyang HAN Zhuochen YANG Yang JIA Peihong | 2017 | Chinese Geographical Science2017，27，3： | 2 |
| 13 | Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation显示文摘Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells.A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs.Therefore,to achieve a transplantable organ in animals without rejection,creation of vascular endothelial cells derived from humans within the organ is necessary.In this study,to explore whether donor xeno-pluripotent stem cells can compensate for blood vasculature in host animals,we generated rat-mouse chimeras by injection of rat embryonic stem cells(rESCs)into mouse blastocysts with deficiency of Flk-1 protein,which is associated with endothelial and hematopoietic cell development.We found that rESCs could differentiate into vascular endothelial and hematopoietic cells in the rat-mouse chimeras.The whole yolk sac(YS)of Flk-1^EGFP/ECFP rat-mouse chimera was full of rat blood vasculature.Rat genes related to vascular endothelial cells,arteries,and veins,blood vessels formation process,as well as hematopoietic cells,were highly expressed in the YS.Our results suggested that rat vascular endothelial cells could undergo proliferation,migration,and self-assembly to form blood vasculature and that hematopoietic cells could differentiate into B cells,T cells,and myeloid cells in rat-mouse chimeras,which was able to rescue early embryonic lethality caused by Flk-1 deficiency in mouse. | Xiaomin Wang Hui Shi Juanjuan Zhou Qingjian Zou Quanjun Zhang Shixue Gou Pengfei Chen Lisha Mou Nana Fan Yangyang Suo Zhen Ouyang Chengdan Lai Quanmei Yan Liangxue Lai | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 14 | Regulating the Function of Nanocomposite Made from Hydroxypropyl Methyl Cellulose with Bacterial Cellulose Nanocrystal显示文摘Hydroxypropyl methyl cellulose(HPMC)-based hybrid nanocomposites reinforced with bacterial cellulose nanocrystals(BCNC) were prepared and characterized.The HPMC nanocomposites exhibited good thermal stability,with a thermogravimetric peak temperature of around 346℃.The addition of BCNC did not significantly affect the thermal degradation temperature or improve the transparency of HPMC nanocomposites.However,the addition of BCNC favorably affected the light scattering properties of the nanocomposites and enhanced mechanical properties such as tensile stress and Young's modulus from 65 MPa and 1.5 GPa up to 139 MPa and 3.2 GPa,respectively.The oxygen permeability of the HPMC nanocomposites also increased with increase in the amount of BCNC added. | AiJing Zhou YangYang Peng ShiYu Fu Hao Liu | 2016 | Paper And Biomaterials2016，1，2： | 2 |
| 15 | Boron carbide boosted Fenton-like oxidation: A novel Fe(Ⅲ)/Fe(Ⅱ) circulation显示文摘The sluggish kinetics of Fe(Ⅱ)recovery in Fenton/Fenton-like reactions significantly limits the oxidation efficiency.In this study,we for the first time use boron carbide(BC)as a green and stable promotor to enhance the reaction of Fe(Ⅲ)/H_(2)O_(2) for degradation of diverse organic pollutants.Electron paramagnetic resonance analysis and chemical quenching/capturing experiments demonstrate that hydroxyl radicals(·OH)are the primary reactive species in the BC/Fe(Ⅲ)/H_(2)O_(2) system.In situ electrochemical analysis indicates that BC remarkably boosts the Fe(Ⅲ)/Fe(Ⅱ)redox cycles,where the adsorbed Fe(Ⅲ)cations were transformed to more active Fe(Ⅲ)species with a higher oxidative potential to react with H_(2)O_(2) to produce Fe(Ⅱ).Thus,the recovery of Fe(Ⅱ)from Fe(Ⅲ)is facilitated over BC surface,which enhancesOH generation via Fenton reactions.Moreover,BC exhibits outstanding reusability and stability in successive cycles and avoids the secondary pollution caused by conventional organic and metalliferous promotors.Therefore,metal-free BC boosting Fe(Ⅲ)/H_(2)O_(2) oxidation of organics provides a green and advanced strategy for water decontamination. | Peng Zhou Feng Cheng Gang Nie Yangyang Yang Kunsheng Hu Xiaoguang Duan Yongli Zhang Shaobin Wang | 2020 | Green Energy & Environment2020，5，4： | 2 |
| 16 | Ultrasmall Ga-ICG nanoparticles based gallium ion/photodynamic synergistic therapy to eradicate biofilms and against drug-resistant bacterial liver abscess显示文摘Pyogenic liver abscess and keratitis are aggressive bacterial infections and the treatment has failed to eradicate bacteria in infectious sites completely owing to the currently severe drug resistance to existing antibiotics.Here,we report a simple and efficient one-step development of ultrasmall non-antibiotic nanoparticles(ICG-Ga NPs)containing clinically approved gallium(Ⅲ)(Ga^(3+))and liver targeting indocyanine green(ICG)molecules to eradicate multi-drug resistant(MDR)bacteria thought the synergetic effect of photodynamic therapy and iron metabolism blocking.The ICG-Ga NPs induced photodynamic effect could destroy the bacterial membrane,further boost the endocytosis of Ga^(3+),then replace iron in bacteria cells to disrupt bacterial iron metabolism,and demonstrate the synergetic bacterial killing and biofilm disrupting effects.The ICG-Ga NPs show an excellent therapeutic effect against extended spectrumβ-lactamases Escherichia coli(ESBL E.coli)and significantly improve treatment outcomes in infected liver abscess and keratitis.Meanwhile,the ultrasmall size of ICG-Ga NPs could be cleared rapid via renal clearance route,guaranteeing the biocompatibility.The protective effect and good biocompatibility of ICG-Ga NPs will facilitate clinical treatment of bacteria infected diseases and enable the development of next-generation non-antibiotic antibacterial agents. | Tingting Xie Yuchen Qi Yangyang Li Feilu Zhang Wanlin Li Danni Zhong Zhe Tang Min Zhou | 2021 | Bioactive Materials2021，6，11： | 2 |
| 17 | Study on the optimization of the combined blown converter process in Chongqing Iron and Steel Company显示文摘The effects of lance height and bottom blown flowrate on the mixed time,the splashing amount,the penetrating depth,and the level fluctuation of an 85 t combined blown converter have been studied using a water model.The results show that the maximal stirring energy is provided to the bath at the top lance height of about 50-100 mm.When the top lance height is in the range of 90- 110 mm,the splashing amount caused by the top jet can reach the maximal value.The appropriate operational parameters of Chongqing Iron and Steel Company(CISC)converter have been established that the top lance height is 1600-1760 mm and the bot- tom blowing flowrate is 240-480 Nm^3/h in the primary phase of a heat,1100-1300 mm and 160-200 Nm^3/h in the second phase,and 1040-1120 mm and 200-350 Nm^3/h in the end phase.Also,the trial shows that the metallurgical result of the studied blow pattern is better than that of the former pattern.At the starting 3-4 min of a heat,the strong splashing is eliminated. | Ping Tang Yangyang Yu Guanghua Wen Mingmei Zhu Liang Zhou Yiju Long Qing Liang | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 2 |
| 18 | Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs显示文摘 | Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou Yingli Luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang | 2018 | Nano Research2018，11，10： | 2 |
| 19 | Effect of Morphological Structure of PtSnNa/ZSM-5 on Its Catalytic Performance in Propane Dehydrogenation显示文摘The ZSM-5 zeolite with flower-shaped crystallites(marked as ZFS)was synthesized through the hydrothermal preparation method.The properties of ZFS as a supporting material have been investigated in comparison with the traditional ZSM-5 zeolite.The prepared samples were characterized by XRD,N2 adsorption-desorption,TEM,NH3-TPD,XRF,and XPS techniques.The results showed that the formation of the flower-shaped crystallites directly influenced the physicochemical properties of ZFS material.In ZFS,the pore structure was changed,the acid content was decreased,and the surface properties were promoted.Besides,in the PtSnNa/ZFS catalyst,the amount of oxidized Sn species was remarkably increased and the dispersion of Pt was relatively improved.Meanwhile,due to these modifications,the capacity of the catalyst supported on ZFS to accommodate coke was greatly improved and the coke deposits on PtSnNa/ZFS were migrated from active metals to the support.Furthermore,as expected,the catalytic performance of the PtSnNa/ZFS catalyst for propane dehydrogenation to propylene and the stability of catalyst were significantly improved. | Wang Yongjuan Zhou Yuming Zhou Shijian He Qiang Zhong Yangyang | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，1： | 2 |
| 20 | A CRISPR-Cas9 screen shows the combination efficacy of lenvatinib plus epidermal growth factor receptor inhibitors for treatment of liver cancer显示文摘Recently,in cooperation with the Netherlands Cancer Institute,we demonstrated that epidermal growth factor receptor(EGFR)activation limited the response of liver cancer to lenvatinib.The original article was published in Nature as a cover story,which resulted in considerable attention from major scientific journals.Here,we were invited by Cancer Biology&Medicine to provide comments on preclinical and clinical findings about the combination of lenvatinib plus EGFR inhibitors as a promising strategy for hepatocellular carcinoma(HCC)treatment.Primary liver cancer represents the sixth most common malignancy and the third leading cause of cancer-related mortality worldwide,with an estimated 906,000 new cases and 830,000 deaths in 20201. | Yuchen Guo Yangyang Zhou Wenxin Qin | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
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