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A single circular chromosome yeast

查看全文 作　　者：Yangyang [1,2]Shao;Ning [1,2]Lu;Chen [2,3,4]Cai;Fan [5]Zhou;Shanshan [3]Wang;Zhihu [6]Zhao;Guoping [1,7,8,9]Zhao;Jin-Qiu [3,4]Zhou;Xiaoli [1]Xue;Zhongjun [1]Qin 高影响力作者 机构地区：[1]Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,200032 Shanghai,China;[2]University of Chinese Academy of Sciences,100049 Beijing,China;[3]The State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,200031 Shanghai,China;[4]School of Life Science and Technology,ShanghaiTech University,201210 Shanghai,China;[5]Wuhan Frasergen Bioinformatics Co,430075 Wuhan,China;[6]Beijing Institute of Biotechnology,100071 Beijing,China;[7]Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,201203 Shanghai,China;[8]Department of Microbiology and Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Prince of Wales Hospital,Shatin,New Territories,Hong Kong SAR,China;[9]State Key Laboratory of Genetic Engineering,Department of Microbiology,School of Life Sciences and Institute of Biomedical Sciences,Fudan University,200032 Shanghai,China高影响力机构 出　　处：《Cell Research》索引2019年第29卷第1期,共3页高影响力期刊 基　　金：grants from Chinese Academy of Sciences (XDB19000000);National Natural Science Foundation of China (3183010S, 31770099,31521061);Ministry of Science and Technology (2016YFA0500701). 摘　　要：Dear editor,Most of the prokaryotic cells contain a single circular chromosome.In contrast, the eukaryotic cells usually contain multiple linear chromosomes. Recently, we artificially created a single linear chromosome yeast strain SY14 from native 16 chromosomes in a haploid Saccharomyces cerevisiae, which displays minor fitness defects.^1 In this study, we have created a new yeast strain which contains a single circular chromosome and apparently has not been found in nature. 关 键 词：PROKARYOTIC cells SACCHAROMYCES CEREVISIAE
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