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| 1 | Where Does AlphaGo Go: From Church-Turing Thesis to AlphaGo Thesis and Beyond显示文摘An investigation on the impact and significance of the Alpha Go vs. Lee Sedol Go match is conducted, and concludes with a conjecture of the Alpha Go Thesis and its extension in accordance with the Church-Turing Thesis in the history of computing. It is postulated that the architecture and method utilized by the Alpha Go program provide an engineering solution for tackling issues in complexity and intelligence. Specifically,the Alpha Go Thesis implies that any effective procedure for hard decision problems such as NP-hard can be implemented with Alpha Go-like approach. Deep rule-based networks are proposed in attempt to establish an understandable structure for deep neural networks in deep learning. The success of Alpha Go and corresponding thesis ensure the technical soundness of the parallel intelligence approach for intelligent control and management of complex systems and knowledge automation. | Fei-Yue Wang Jun Jason Zhang Xinhu Zheng Xiao Wang Yong Yuan Xiaoxiao Dai Jie Zhang Liuqing Yang | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 44 |
| 2 | Data mining in Xu Runsan’s Traditional Chinese Medicine practice:treatment of chronic pelvic pain caused by pelvic inflammatory disease显示文摘OBJECTIVE:To research the Traditional Chinese Medicine(TCM)practice of Professor Xu Runsan for treatment of chronic pelvic pain(CPP)caused by sequelae of pelvic inflammatory disease(SPID)by data mining.METHODS:The medical records of inpatients at China-Japan Friendship Hospital confirmed to have CPP caused by SPID were collected(274 visits in total).The data extracted from the medical records were analyzed by frequency statistics,correlation analyses,cluster analyses,and complex network analyses.RESULTS:The most frequently used medicines were warm medicines,bitter medicines,and medicines distributed to the liver meridian.The most common medicinal combinations were Chishao(Radix Paeoniae Rubra)plus Huangqi(Radix Astragali Mongolici)plus Sanqi(Radix Notoginseng)and Ezhu(Rhizoma Curcumae Phaeocoulis);Guizhi(Ramulus Cinnamomi)plus Fuling(Poria)and Chishao(Radix Poeoniae Rubra);and Chaihu(Radix Bupleuri Chinensis)plus Zhishi(Fructus Aurantii Immaturus)and Gancao(Radix Glycyrrhizae).The most frequently used medicines were divided into four groups according to their efficacy;i.e.,medicines that could(a)warm meridians and free collateral vessels,(b)regulate Qi and free collateral vessels,(c)fortify the spleen and nourish blood and Qi,and(d)tonify Qi and activate blood.The most commonly used formulations were Guizhi FulingPill and Sini Powder.The core medicines extracted based on complex network analyses were Chishao(Radix Poeoniae Rubra),Sanqi(Radix Notoginseng),Hua ngqi(Radix Astragali Mongolica),Danshen(Radix Salviae Miltiorrhizae),Ezhu(Rhizoma Curcumae Phaeocaulis), Gancao(Radix Glycyrrhizae),Chaihu(Radix Bupleuri Chinensis),Guizhi(Romulus Cinnomomi),Shuizhi(Hirudo), Fuling(Poria),and Zhishi(Fructus Aurantii Immaturus).CONCLUSION:According to the TCM practice of Professor Xui,treatment of CPP caused by SPID should focus on dissolving stasis and obstructions using medicines that can activate blood,resolve stasis,regulate Qi,and dissipate adhesions.His prescriptions are often based on Guizhi Fuling Pill and Sini Powder.More blood-activating,stasis-resolving,or tonifying medicines could be used according to the accompanying symptoms or symptom patterns identified. | Liu Liuqing Yang Fang Xin Ling Jing Yan | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 20 |
| 3 | SIMO detection schemes for underwater optical wireless communication under turbulence显示文摘In underwater optical wireless communication(UOWC),a channel is characterized by abundant scattering/absorption effects and optical turbulence.Most previous studies on UOWC have been limited to scattering/absorption effects.However,experiments in the literature indicate that underwater optical turbulence(UOT)can cause severe degradation of UOWC performance.In this paper,we characterize an UOWC channel with both scattering/absorption and UOT taken into consideration,and a spatial diversity receiver scheme,say a singleinput–multiple-output(SIMO) scheme,based on a light-emitting-diode(LED) source and multiple detectors is proposed to mitigate deep fading.The Monte Carlo based statistical simulation method is introduced to evaluate the bit-error-rate performance of the system.It is shown that spatial diversity can effectively reduce channel fading and remarkably extend communication range. | Weihao Liu Zhengyuan Xu Liuqing Yang | 2015 | Photonics Research2015，3，3： | 16 |
| 4 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 5 | MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer显示文摘 | Liuqing Yang Hongwei Liang Yanbo Wang Shanting Gao Kai Yin Zhijian Liu Xi Zheng Ying Lv Lei Wang Chen-Yu Zhang Xi Chen Guifang Xu Weijie Zhang Xiaoping Zou | 2016 | Protein & Cell2016，7，5： | 7 |
| 6 | Energy-saving PPM schemes for WSNs显示文摘Energy conservation is a critical problem in recently-emerging wireless sensor networks (WSNs). Pulse position modulation (PPM), as an exploring-worthy modulation format for energy efficiency, is tailored for WSNs into two schemes, mono-mode PPM and multi-mode PPM, in this paper. Resorting to an idealized system model and a practical system model, which combine the power consumptions in transmission and reception modules of nodes with the idealized and realistic battery characteristics, the battery energy efficiencies of mono-mode PPM and multi-mode PPM are evaluated and compared. To minimize the battery energy consumption (BEC), these schemes are further optimized in terms of constellation size M for a link in path-loss channels. Our analytical and numerical results show that considerable energy can be saved by multi-mode PPM; and the optimization performances of these schemes are noticeable at various communication distances though their optimization properties are different. | TANG QiuLing YANG LiuQing QIN TuanFa ZHANG ShuYi | 2008 | Science in China(Series F)2008，51，5： | 7 |
| 7 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 8 | 5G ENABLED VEHICULAR COMMUNICATIONS AND NETWORKING显示文摘Vehicular communications and networking(VCN)is considered a billion-dollar industry.Its development not only possesses economic value,but also has enormous social potential.The earliest vehicular network started from the dedicated short range networks,such as the IEEE 802.11p standard established at the beginning of this century.In recent years,the public access network based VCN has been rapidly advanced.For example,LTE-V based on 4G LTE is under standardization。 | xiang cheng rongqing zhang shanzhi chen jia li liuqing yang hongwei zhang | 2018 | China Communications2018，15，7： | 5 |
| 9 | A lincRNA switch for embryonic stem cell fate显示文摘 | Liuqing Yang Chunru Lin Michael G Rosenfeld | 2011 | Cell Research2011，21，12： | 4 |
| 10 | Multi-target Collaborative Combat Decision-Making by Improved Particle Swarm Optimizer显示文摘A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat. | Ding Yongfei Yang Liuqing Hou Jianyong Jin Guting Zhen Ziyang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 4 |
| 11 | A Deep Reinforcement Learning Algorithm for the Power Order Optimization Allocation of AGC in Interconnected Power Grids显示文摘The integration of distributed generations(solar power,wind power),energy storage devices,and electric vehicles,causes unpredictable disturbances in power grids.It has become a top priority to coordinate the distributed generations,loads,and energy storages in order to better facilitate the utilization of new energy.Therefore,a novel algorithm based on deep reinforcement learning,namely the deep PDWoLF-PHC(policy dynamics based win or learn fast-policy hill climbing)network(DPDPN),is proposed to allocate power order among the various generators.The proposed algorithm combines the decision mechanism of reinforcement learning with the prediction mechanism of a deep neural network to obtain the optimal coordinated control for the source-grid-load.Consequently it solves the problem brought by stochastic disturbances and improves the utilization rate of new energy.Simulations are conducted with the case of the improved IEEE two-area and a case in the Guangdong power grid.Results show that the adaptability and control performance of the power system are improved using the proposed algorithm as compared with using other existing strategies. | Lei Xi Lipeng Zhou Lang Liu Dongliang Duan Yanchun Xu Liuqing Yang Shouxiang Wang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 4 |
| 12 | Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect显示文摘Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule-intercellular adhesion molecule-1(ICAM-1)on A20 cells and led to enhanced A20 cell apoptosis.LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon(IFN)-c production in vitro.Immunization of BALB/c mice with a LIGHT-modified A20 cell vaccine efficiently elicited protective immunity against challenge with the parental tumor cell line.Adenovirus-mediated gene transfer of LIGHT by intratumoral injection exerted a very potent antitumor effect against pre-existing A20 cell lymphoma in BALB/c mice.This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer(NK)and cytotoxic T lymphocyte(CTL)activity,enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21(CCL21),IFN-inducible protein-10(IP-10)and monokine induced by IFN-c(Mig)from tumor tissues.Thus,adenovirus-mediated LIGHT therapy might have potential utility for the prevention and treatment of B-cell lymphoma. | Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 13 | Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment. | Liu Liuqing Liu Yanfeng Yang Ming Xu Guiqin Li Ruiqi Xu Xiuli Pan Xue Liang Jialing | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 14 | Extraterrestrial artificial photosynthetic materials for in-situ resource utilization显示文摘Aerospace milestones in human history,including returning to the moon and manned Martian missions,have been implemented in recent years.Space exploration has become one of the global common goals,and to ensure the survival and development of human beings in the extraterrestrial extreme environment has been becoming the basic ability and technology of manned space exploration.For the purpose of fulfilling the goal of extraterrestrial survival,researchers in Nanjing University and the China Academy of Space Technology proposed extraterrestrial artificial photosynthesis(EAP)technology.By simulating the natural photosynthesis of green plants on the Earth,EAP converts CO_(2)/H_(2)O into fuel and O_(2)in an in-situ,accelerated and controllable manner by using waste CO_(2)in the confined space of spacecraft,or abundant CO_(2)resources in extraterrestrial celestial environments,e.g.Mars.Thus,the material loading of manned spacecraft can be greatly reduced to support affordable and sustainable deep space exploration.In this paper,EAP technology is compared with existing methods of converting CO_(2)/H_(2)O into fuel and O_(2)in the aerospace field,especially the Sabatier method and Bosch reduction method.The research progress of possible EAP materials for in-situ utilization of extraterrestrial resources are also discussed in depth.Finally,this review lists the challenges that the EAP process may encounter,which need to be focused on for future implementation and application.We expect to deepen the understanding of artificial photosynthetic materials and technologies,and aim to strongly support the development of manned spaceflight. | Liuqing Yang Ce Zhang Xiwen Yu Yingfang Yao Zhaosheng Li Congping Wu Wei Yao Zhigang Zou | 2021 | National Science Review2021，8，8： | 3 |
| 15 | ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs显示文摘 | Liuqing Yang Chunru Lin Wen Liu Jie Zhang Kenneth A. Ohgi Jonathan D. Grinstein Pieter C. Dorrestein Michael G. Rosenfeld | 2011 | Cell2011，，4： | 2 |
| 16 | A Novel Forwarding Method for Full-Duplex Two-Way Relay Networks显示文摘An estimate-and-forward(EF) scheme for single-input single-output(SISO) and multiple-input multiple-output(MIMO) full-duplex two-way relay networks is proposed and analyzed. The relay estimates the received signal from two terminal nodes by a minimum mean squared error(MMSE) estimation and forwards a scaled version of the MMSE estimate to the destination. The proposed EF outperforms conventional amplify-and-forward(AF) and decode-and-forward(DF) across all signal-to-noise ratio(SNR) region. Because its computational complexity is high for relays with a large number of antennas(large MIMO) and/or high order constellations, an approximate EF scheme, called list EF, are thus proposed to reduce the computational complexity. The proposed list EF computes a candidate list for the MMSE estimate by using a sphere decoder, and it approaches the performance of the exact EF relay at a negligible performance loss. The proposed forwarding approach also could be used to other relay networks, such as half-duplex, one-way or massive MIMO relay networks. | Shuangshuang Han Xiang Cheng Liuqing Yang | 2017 | China Communications2017，14，4： | 2 |
| 17 | Aqueous two-phase extraction, identification and antioxidant activity of anthocyanins from mulberry ( Morus atropurpurea Roxb.)显示文摘 | Xiangyang Wu Linghong Liang Ye Zou Ting Zhao Jiangli Zhao Fang Li Liuqing Yang | 2011 | Food Chemistry2011，，2： | 2 |
| 18 | Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis显示文摘Hepatocellular carcinoma(HCC),which makes up the majority of liver cancer,is induced by the infection of hepatitis B/C virus.Biomarkers are needed to facilitate the early detection of HCC,which is often diagnosed too late for effective therapy.The tRNA-derived small RNAs(tsRNAs)play vital roles in tumorigenesis and are stable in circulation.However,the diagnostic values and biological functions of circulating tsRNAs,especially for HCC,are still unknown.In this study,we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum.We identified tRF-Gln-TTG-006,which was remarkably upregulated in HCC serum(training cohort:24 HCC patients vs.24 healthy controls).In the validation stage,we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity(80.4%)and specificity(79.4%)even in the early stage(Stage I:sensitivity,79.0%;specificity,74.8%;155 healthy controls vs.153 HCC patients from two cohorts).Moreover,in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells,and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays.In summary,our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC. | Shoubin Zhan Ping Yang Shengkai Zhou Ye Xu Rui Xu Gaoli Liang Chenyu Zhang Xi Chen Liuqing Yang Fangfang Jin Yanbo Wang | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 19 | Structure features of GHIO xylanase from Caldicellulosiruptor bescii: implication for its thermophilic adaption and substrate binding preference显示文摘 | Yong Zhang Jiao An Guangyu Yang Xiaofei Zhang Yuan Xie Liuqing Chen Yan Feng | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 2 |
| 20 | Assessing anxiety,depression,and stress among inpatients with cancer显示文摘Objective This study aimed to assess anxiety,depression,and stress among inpatients with cancer.Methods Two hundred thirty-five hospitalized patients with cancer were surveyed with the Depression Anxiety Stress Scales(simplified Chinese Version).The software program SPSS 25.0 was used for statistical analysis of the survey data.Results The average scores of depression,anxiety,and stress of inpatients with cancer were 12.17,11.84,and 13.98 respectively,which were higher than the normal range.The scores of anxiety and stress of inpatients with different caregivers were statistically different(P=0.024/0.036).The anxiety and stress scores of inpatients with spouses as caregivers were higher than those of inpatients with children as caregivers.There was a statistically significant difference in the incidence of stress between inpatients with cancer with religious beliefs and inpatients with cancer without religious beliefs(P=0.026),and those with religious beliefs had greater incidence of stress.The score of anxiety was significantly higher for inpatients with children than for inpatients without children(P=0.040).Conclusion The anxiety,depression,and stress levels of inpatients with cancer are relatively high.It is necessary to pay special attention to the psychological status of these patients during clinical diagnosis and treatment to improve their quality of life. | Honghong Xu Ruotong Xue Yi Cheng Yujie Zhang Jie Rao Mei Liu Shiying Yu Lingxiang Liu Yiqian Liu Yongqian Shu Liuqing Yang Hanping Shi | 2020 | Oncology and Translational Medicine2020，6，3： | 2 |
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