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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 3 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 4 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 5 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 6 | 显示文摘 | Fu Z P Yang B F Li L | 2003 | J Phys Condens Matter2003，15，： | 1 |
| 7 | Effects of Ginkgo biloba extract and tanshinone on cytochrome P-450 isozymes and glutathione transferase in rats 显示文摘 | Yang X F Wang N P Lu W H | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 8 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 9 | C shaped root canals in mandibular second molars in a Chinese population 显示文摘 | Yang Z P Yang S F Lin Y L | 1988 | Endod Dent Traumatol1988，4，4： | 1 |
| 10 | Color image segmentation using fuzzy C-mean and eigenspace projections显示文摘 | YANG J F HAO S S CHUNG P C | 2002 | Signal Prooeming2002，82，3： | 1 |
| 11 | Multi-Walled Carbon Nanotube-Based Gas Sensors for NH3 Detection显示文摘 | Wang SG Qing Zhang Yang D J Sellin P J Zhong G F | 2004 | Diamond and Related Materials2004，13，： | 1 |
| 12 | Hydrothermal synthesis of lithium iron phosphate 显示文摘 | Yang S F Zavalij P Y Whittingham M S | 2001 | Electrochem Commun2001，3，9： | 1 |
| 13 | Numerical and Experimental Investigation of Two Phase Flow during Boiling in a Coiled Tube 显示文摘 | Yang Z Peng X F Ye P | 2008 | Int J of Heat & Mass Trans2008，51，： | 1 |
| 14 | Naked-eye colorimetric analysis of Hg 2+with bi-color CdTe quantum dots multilayer films显示文摘 | Yang F P Ma Q Yu W | 2011 | Talanta2011，84，2： | 1 |
| 15 | Development of an lateral flow test strip for detection of beta- adrenergic agonist clenbuterol residues显示文摘 | ZHANG G P WANG X N YANG J F | 2006 | Journal of Immunological Methods2006，312，12： | 1 |
| 16 | A new con-stitutive model for blast damage 显示文摘 | Yang R Bawden W F Katsabanis P D | 1996 | InternationalJournal of Rock Mechanics and Mining Sciences1996，33，： | 1 |
| 17 | Apoptosis inducing and differentiation enhancement effect of oridonin on the alltrans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells显示文摘 | Gao F Tang Q Yang P | 2010 | Int J Lab Hematol2010，32，11： | 1 |
| 18 | Exploratory learning and exploitative learning in different organizational structures 显示文摘 | Su Z F Li J Y Yang Z P | 2011 | Asia Pacific Journal of Management2011，28，4： | 1 |
| 19 | Proteomic analysis of the sea-island cotton roots infected by wilt pathogen Verticillium dahliae显示文摘 | WANG F X MAY P YANG C L | | 0，，： | 1 |
| 20 | Warfarin in haemodialysis patients with atrial fibrillation:what benefit显示文摘 | Yang F Chou D Schweitzer P | 2010 | Europace2010，12，： | 1 |
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