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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China显示文摘Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese cohort.Methods:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five AIDs.Results:Four hundred and thirty(5.3%)patients developed cancer.Their median agewas 57.5 years and AID durationwas 79.8 months.The estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female vs.male:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix uteri.Patients with SS had a significantly high SIR for developing non-Hodgkin’s lymphoma.Within 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian cancer.RA was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung cancers.SSc patients had increased SIRs for developing cervical uterine,lung,and breast cancers.Conclusion:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection sites and cancer onset time may vary greatly in each AID entity. | Ziyue Zhou Huazhen Liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang | 2022 | Cancer Communications2022，42，5： | 4 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | EXAFS and SR-XRD study on Cu occupation sites in Zn_(1-x)Cu_xO diluted magnetic semiconductors显示文摘ZnO films, doped with 2.9 atom% Cu, were prepared by radio frequency magnetron sputtering on sapphire substrate at different substrate temperatures. No magnetic impurities such as Fe, Co and Ni were found in the PIXE spectra. The ZnO:Cu films possessed the wurtzite ZnO structure. No precipitates such as CuO and Cu2O or Cu cluster, were observed by synchrotron radiation X-ray diffraction in the ZnO:Cu films. Extended X-ray absorption fine structure (EXAFS) analysis showed that Cu atoms were incorporated into ZnO crystal lattice by occupying the sites of Zn atoms. | YANG Chen ZHANG Bin WANG Jianzhong SHI Liqun CHENG Huansheng YANG Tieying WEN Wen HU Fengchun | 2012 | Nuclear Science and Techniques2012，23，2： | 4 |
| 5 | Analysis of the Stability and Mechanical Characteristics of the Jointed Surrounding Rock and Lining Structure of a Deeply Buried Hydraulic Tunnel显示文摘On-site monitoring and numerical simulation have been combined to analyze the stability of the jointed surrounding rock and the stress inside the lining structure of a sample deeply buried hydraulic tunnel.We show that the deformation around the tunnel was mainly concentrated in the range 51.37 mm∼66.73 mm,the tunnel circumference was dominated by shear failure,and the maximum plastic zone was about 3.90 m.When the shotcrete treatment was performed immediately after the excavation,the deformation of the surrounding rock was reduced by 58.94%∼76.31%,and the extension of the plastic zone was relatively limited,thereby leading to improvements in terms of the stability of surrounding rock.When the support was provided at different time points,the stress of the surrounding rock in the shallow part of the tunnel was improved everywhere.In the tunnel section with high ground stress and joint development,when 10 cm steel fiber concrete spray layer and 40 cm C25 concrete secondary lining were used,the maximum tensile stress on the lining structure was 0.89 MPa,i.e.,it was less than the tensile strength of concrete,which indicates that the internal force of the lining can meet the overall requirements. | Changchang Li Zuguo Mo Haibo Jiang Fengchun Yang | 2022 | Fluid Dynamics & Materials Processing2022，18，1： | 2 |
| 6 | Heegaard genera of high distance are additive under annulus sum 显示文摘 | Li Fengling Yang Guoqiu Lei Fengchun | 2010 | Topology and its Application2010，，： | 1 |
| 7 | Re search of fuzzy logic control strategy for engine start/stop in dual-clutch hybrid electric vehicle显示文摘 | YANG Lianghui tie Hongwen SUN Fengchun | 2010 | Seventh International Con{erence on Fuzzy Systems and Knowledge Discovery2010，6，8： | 1 |
| 8 | Hydrolytic dynamics of pesticide N'-(2,4-dimethylphenyl)-N-methylformamidine in aquatic solution显示文摘HydrolyticdynamicsofpesticideN'-(2,4-dimethylphenyl)-N-methylformamidineinaquaticsolution￥MoHanhong;YangKewu;AnFengchun;LiuYe... | Mo Hanhong Yang Kewu An Fengchun Liu Ye (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 9 | A novel intelligent control system for flue-curing barns based on real-time image features显示文摘 | Juan Wu Simon X. Yang Fengchun Tian | 2014 | Biosystems Engineering2014，，： | 1 |
| 10 | Advances in graphene oxide membranes for water treatment显示文摘Graphene oxide(GO),a derivative of graphene,is a novel carbon material that has attracted a lot of attention in the field of membrane materials as its ability to achieve layer-by-layer stacking and the formation of nanochannels between the lamellae makes it excellent for selective separation of substances.In this paper,the separation mechanism of the GO membrane is summarized.According to the different separation substances,the separation mechanism of graphene oxide membrane is reviewed from two aspects of metal ions and organic pollutants.Next,the preparation methods of graphene oxide membranes is introduced,such as spin-coating,vacuum filtration,dip-coating,spraying,and layer-by-layer self-assembly,followed by a review on the structural regulation of GO.Finally,this paper concludes with an overview of the potential development prospects and challenges of GO membranes. | Fengchun Jia Xiao Xiao Ardo Nashalian Sophin Shen Liu Yang Zhenyang Han Huaijiao Qu Tianmei Wang Zhi Ye Zhijun Zhu Linjun Huang Yanxin Wang Jianguo Tang Jun Chen | 2022 | Nano Research2022，15，7： | 1 |
| 11 | An electrochemical biosensor for ascorbic acid based on carbon-supported PdNinanoparticles显示文摘 | Xin Zhang Yang Cao Sha Yu Fengchun Yang Pinxian Xi | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 12 | The inner synergistic effect of bifunctional ionic liquid extractant for solvent extraction显示文摘 | Xiaoqi Sun Yang Ji Fengchun Hu Bo He Ji Chen Deqian Li | 2010 | Talanta2010，，： | 1 |
| 13 | Multiple heavy metals extraction and recovery from hazardous electroplating sludge waste via ultrasonically enhanced two-stage acid leaching显示文摘 | Chuncheng Li Fengchun Xie Yang Ma | 2010 | Journal of Hazardous Materials2010，，82： | 1 |
| 14 | The ultrasonically assisted metals recovery treatment of printed circuit board waste sludge by leaching separation显示文摘 | Fengchun Xie Haiying Li Yang Ma Chuncheng Li Tingting Cai Zhiyuan Huang Gaoqing Yuan | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 15 | Ultra-sharp silicon multimode waveguide bends based on double free-form curves显示文摘Mode-division multiplexing(MDM)can greatly improve the capacity of information transmission.The multimode waveguide bend(MWB)with small size and high performance is of great significance for the on-chip MDM integrated system.In this paper,an MWB with high performance based on double free-form curves(DFFCs)is proposed and realized.The DFFC is a combination of a series of arcs optimized by the inverse design method.The fabrication of this MWB only needs one-step lithography and plasma etching and has a large fabrication tolerance.MWBs with effective radii of 6μm and 10μm are designed to support three modes and four modes,respectively.The proposed method gives the best overall performance considering both the effective bending radius and the transmission efficiency.The fabricated MWB with four mode channels has low excess losses and crosstalks below-21 dB in the wavelength range from 1520 to 1580 nm.It is expected that this design can play an important role in promoting the dense integration of multimode transmission systems. | SHANGSEN SUN ZHIQIANG YANG JUANLI WANG RUNSEN ZHANG FENGCHUN ZHANG NING ZHU LEI WAN ZHAOHUI LI | 2022 | Photonics Research2022，10，6： | 1 |
| 16 | Multiple heavy metals extraction and recovery from hazardous electroplating sludge waste via ultrasonically enhanced twostage acid leaching显示文摘 | Li Chuncheng Xie Fengchun Ma Yang | 2010 | Journal of hazardous materials2010，178，1： | 1 |
| 17 | Fatty acid composition of tilapia显示文摘 | Xie Fengchun Yang Bo Wang Yonghua | 2001 | Journal of South China University of Technology: Natural Science Edition2001，29，10： | 1 |
| 18 | Multiple heavy metals extraction and recovery from hazardous electroplating sludge waste via ultrasonically enhanced two-stage acid leaching显示文摘 | Chuncheng Li Fengchun Xie Yang Ma Tingting Cai Haiying Li Zhiyuan Huang Gaoqing Yuan | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 19 | Fluid Inclusion and Carbon-Oxygen Isotope Studies of the Hujiayu Cu Deposit,Zhongtiao Mountains,China:Implications for Synmetamorphic Copper Remobilization显示文摘The Hujiayu Cu deposit,representative of the 'HuBi-type' Cu deposits in the Zhongtiao Mountains district in the southern edge of the North China Craton,is primarily hosted in graphitebearing schists and carbonate rocks.The ore minerals comprise mainly chalcopyrite,with minor sphalerite,siegenite[(Co,Ni)_3S_4],and clausthalite[Pb(S,Se)].The gangue minerals are mainly quartz and dolomite,with minor albite.Four fluid inclusion types were recognized in the chalcopyrite-pyrite-dolomite-quartz veins,including CO_2-rich inclusions(type Ⅰ),low-salinity,liquid-dominated,biphase aqueous inclusions(type Ⅱ),solid-bearing aqueous inclusions(type Ⅲ),and solid-bearing aqueous-carbonic inclusions(type Ⅳ).Type I inclusion can be further divided into two sub-types,i.e.,monophase CO_2 inclusions(type Ⅰa) and biphase CO_2-rich inclusions(with a visible aqueous phase),and type Ⅲ inclusion is divided into a subtype with a halite daughter mineral(type Ⅲa) and a subtype with multiple solids(type Ⅲb).Various fluid inclusion assemblages(FIAs) were identified through petrographic observations,and were classified into four groups.The group-1 FIA,consisting of monophase CO_2 inclusions(type Ⅰa),homogenized into the liquid phase in a large range of temperatures from-1 to 28℃,suggesting post-entrapment modification.The group-2 FIA consists of type Ⅰb,Ⅲb and Ⅳ inclusions,and is interpreted to reflect fluid immiscibility.The group-3 FIA comprises type Ⅱ and Ⅲa inclusions,and the group-4FIA consists of type Ⅱ inclusions with consistent phase ratios.The group-1 and group-2 FIAs are interpreted to be entrapped during mineralization,whereas group-3 and group-4 FIAs probably represent the post-mineralization fluids.The solid CO_2 melting temperatures range from-60.6 to56.6℃ and from-66.0 to-63.4℃ for type Ⅰa and type Ⅳ inclusions,respectively.The homogenization temperatures for type Ⅱ inclusions range from 132 to 170℃ for group-3 FIAs and115 to 219℃ for group-4 FIAs.The halite melting temperatures range from 530 to 562℃ for typeⅢ b and Ⅳ inclusions,whereas those for type Ⅲa inclusions range from 198 to 398℃.Laser Raman and SEM-EDS results show that the gas species in fluid inclusions are mainly CO_2 with minor CH_4,and the solids are dominated by calcite and halite.The calcite in the hosting marble and dolomite in the hydrothermal veins have δ^(13)C_(V-pdb) values of-0.2 to 1.2‰ and-1.2 to-6.3‰,and δ^(18)O_(v-smow) values of 14.0 to 20.8 ‰ and 13.2 to 14.3‰,respectively.The fluid inclusion and carbon-oxygen isotope data suggest that the ore-forming fluids were probably derived from metamorphic fluids,which had reacted with organic matter in sedimentary rocks or graphite and undergone phase separation at 1.4-1.8 kbar and 230-240℃,after peak metamorphism.It is proposed that the Hujiayu Cu deposit consists of two mineralization stages.The early stage mineralization,characterized by disseminated and veinlet copper sulfides,probably took place in an environment similar to sediment-hosted stratiform copper mineralization.Ore minerals formed in this precursor mineralization stage were remobilized and enriched in the late metamorphic hydrothermal stage,leading to the formation of thick quartz-dolomite-sulfides veins. | QIU Zhengjie FAN Hongrui LIU Xuan WEN Bojie HU Fangfang YANG Kuifeng GUO Shuanglong ZHAO Fengchun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 1 |
| 20 | Multiple heavy metals extraction and recovery from hazardous electroplating sludge waste via ultrasonically enhanced twostage acid leaching显示文摘 | Chuncheng Li Fengchun Xie Yang Ma | 2010 | Journal of Hazardous Materials2010，，178： | 1 |
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