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| 1 | The age of the plant fossil assemblage in the Liuqu Conglomerate of southern Tibet and its tectonic significance显示文摘Liuqu 集团企业,位于到 Yarlung Tsangbo 缝术地区(YTSZ ) 的南方,一套糖蜜在在印第安人和 Eurasion 的二个盘子之间的碰撞以后在喜玛拉雅的 orogenic 带的低岬盆被形成。大意义大意义构造进化和西藏高原的高举的历史。然而,这件糖蜜西装的年龄和它到在南部的西藏散布的另外的同步阶层的关联很长时间在大争论。特别在最近的年里,在它的年龄争论与这糖蜜的大沉积构造意义的识别猛烈地正在成长。在最近在这件糖蜜西装上执行的域工作期间,很多计划石块被发现阶层在这的上面的部分处于相当好的条件保存了,它具有在决定的大帮助是它的年龄。由鉴定,植物 fosils 的集合属于一条回归线代替在中间期间在北半球超级大陆的南部的边缘开发到以后的 Eocence 的回归线植物群,它能在它的形成年龄提供好限制。这篇论文是给植物集合和它的年龄的简短介绍,并且讨论他们的构造意义。 | FANG Aimin YAN Zhen LIU Xiaohan PAN Yusheng LI Jiliang YU Liangjun HUANG Feixing TAO Junrong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 9 |
| 2 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 3 | Water-use efficiency in response to simulated increasing precipitation in a temperate desert ecosystem of Xinjiang, China显示文摘Water-use efficiency(WUE) is a key plant functional trait that plays a central role in the global cycles of water and carbon. Although increasing precipitation may cause vegetation changes, few studies have explored the linkage between alteration in vegetation and WUE. Here, we analyzed the responses of leaf WUE, ecosystem carbon and water exchanges, ecosystem WUE, and plant community composition changes under normal conditions and also under extra 15% or 30% increases in annual precipitation in a temperate desert ecosystem of Xinjiang, China. We found that leaf WUE and ecosystem WUE showed inconsistent responses to increasing precipitation. Leaf WUE consistently decreased as precipitation increased. By contrast, the responses of the ecosystem WUE to increasing precipitation are different in different precipitation regimes: increasing by 33.9% in the wet year(i.e., the normal precipitation years)and decreasing by 4.1% in the dry year when the precipitation was about 30% less than that in the wet year.We systematically assessed the herbaceous community dynamics, community composition, and vegetation coverage to explain the responses of ecosystem WUE, and found that the between-year discrepancy in ecosystem WUE was consistent with the extent to which plant biomass was stimulated by the increase in precipitation. Although there was no change in the relative significance of ephemerals in the plant community, its greater overall plant biomass drove an increased ecosystem WUE under the conditions of increasing precipitation in 2011. However, the slight increase in plant biomass exerted no significant effect on ecosystem WUE in 2012. Our findings suggest that an alteration in the dominant species in this plant community can induce a shift in the carbon-and water-based economics of desert ecosystems. | HUANG Gang LI Yan MU Xiaohan ZHAO Hongmei CAO Yanfeng | 2017 | Journal of Arid Land2017，9，6： | 7 |
| 4 | Palynological evidence sheds new light on the age of the Liuqu Conglomerates in Tibet and its geological significance显示文摘The Liuqu Conglomerates consist of a suit of terrestrial molasse deposits formed in a foreland basin of the Himalaya-Tibet orogenic belt before the collision of India and Eurasia.These deposits record considerable geological information regarding the late tectonic evolution of the Neotethyan ocean.The palynological study of interlayers of mudstone and mud-sandstones indicates an Oligocene age.The palynological assemblage consists mainly of deciduous broad-leaved angiosperms,with some coniferous gymnosperms and evergreen broad-leaved angiosperms.The deposits reflect a broad-leaved deciduous forest or mixed with conifer-broad-leaved forest ecotypes,showing a warm-temperate or temperate zone climatic environment.This work provides significant new information about the tectonic evolution,paleogeography,and paleoenvironment of southern Tibet during the Cenozoic. | WEI LiJie LIU XiaoHan YAN FuHua MAI XueShun LI GuangWei LIU XiaoBing ZHOU XueJun | 2011 | Science China Earth Sciences2011，54，6： | 5 |
| 5 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 6 | Orthodontic simulation system with force feedback for training complete bracket placement procedures显示文摘Background A virtual system that simulates the complete process of orthodontic bracket placement can be used for pre-clinical skill training to help students gain confidence by performing the required tasks on a virtual patient.Methods The hardware for the virtual simulation system is built using two force feedback devices to support bi-manual force feedback operation.A 3D mouse is used to adjust the position of the virtual patient.A multi-threaded computational methodology is adopted to satisfy the requirements of the frame rate.The computation threads mainly consist of the haptic thread running at a frequency of>1000Hz and the graphic thread at>30Hz.The graphic thread allows the graphics engine to effectively display the visual effects of biofilm removal and acid erosion through texture mapping.Using the haptic thread,the physics engine adopts the hierarchy octree collision-detection algorithm to simulate the multi-point and multi-region interaction between the tools and the virtual environment.Its high efficiency guarantees that the time cost can be controlled within 1 ms.The physics engine also performs collision detection between the tools and particles,making it possible to simulate paint and removal of colloids.The surface-contact constraints are defined in the system;this ensures that the bracket will not divorce from or embed into the tooth during the adjustment of the bracket.Therefore,the simulated adjustment is more realistic and natural.Results A virtual system to simulate the complete process of orthodontic bracket bonding was developed.In addition to bracket bonding and adjustment,the system simulates the necessary auxiliary steps such as smearing,acid etching,and washing.Furthermore,the system supports personalized case training.Conclusions The system provides a new method for students to practice orthodontic skills. | Fan YE Luwei LIU Bin YAN Xiaohan ZHAO Aimin HAO | 2021 | Virtual Reality & Intelligent Hardware2021，3，4： | 2 |
| 7 | Sedimentary environment of the Dajin conglomerate in Tibet, age of foraminiferan assemblages and their tectonic significance显示文摘Dajin 集团企业,它在先是 Xigaze 的最重要的沉积继任之一在西藏的弧盆,中国,由忍受货币石, Assilina, Alveolina 和 Lock-hartia 的深浅的海洋的 tuffaceousturbidites 和棒麴霉素组成。这些石块很类似于有孔虫目动物一在里面在 Gangbaand Dingri 区域的 Jialazi 和 Maila 集团企业,和那些。他们发展了在始新世。由分析西藏高原和有孔虫目动物的 Eocenesedimentary 环境的空间变化一在里面 Dajin 集团企业,我们发现了那始新世沉积应该发生在 Yarlung Tsangpo 缝术的双方上,并且晚始新世的构造高举应该做在先弧盆从海水平暴露并且开始收到非海洋的存款。 | YAN Zhen FANG Aimin PAN Yusheng LI Jiliang LIU Xiaohan YU Liangjun ZHANG Binggao | 2005 | Progress in Natural Science:Materials International2005，15，11： | 2 |
| 8 | Numerical simulation and data assimilation of the water-energy cycle over semiarid northeastern China显示文摘The default fractional vegetation cover and terrain height were replaced by the estimated fractional vegetation cover, which was calculated by the Normalized Difference Vegetation Index(NDVI) of Earth Observing System Moderate-Resolution Imaging Spectroradiometer(EOS-MODIS) and the Digital Elevation Model of the Shuttle Radar Topography Mission(SRTM) system. The near-surface meteorological elements over northeastern China were assimilated into the three-dimensional variational data assimilation system(3DVar) module in the Weather Research and Forecasting(WRF) model. The structure and daily variations of air temperature, humidity, wind and energy fields over northeastern China were simulated using the WRF model. Four groups of numerical experiments were performed, and the simulation results were analyzed of latent heat flux, sensible heat flux, and their relationships with changes in the surface energy flux due to soil moisture and precipitation over different surfaces. The simulations were compared with observations of the stations Tongyu, Naiman, Jinzhou, and Miyun from June to August, 2009. The results showed that the WRF model achieves high-quality simulations of the diurnal characteristics of the surface layer temperature, wind direction, net radiation, sensible heat flux, and latent heat flux over semiarid northeastern China in the summer. The simulated near-surface temperature, relative humidity, and wind speed were improved in the data assimilation case(Case 2) compared with control case(Case 1). The simulated sensible heat fluxes and surface heat fluxes were improved by the land surface parameterization case(Case 3) and the combined case(Case 4). The simulated temporal variations in soil moisture over the northeastern arid areas agree well with observations in Case 4, but the simulated precipitation should be improved in the WRF model. This study could improve the land surface parameters by utilizing remote sensing data and could further improve atmospheric elements with a data assimilation system. This work provides an effective attempt at combining multi-source data with different spatial and temporal scales into numerical simulations. The assimilation datasets generated by this work can be applied to research on climate change and environmental monitoring of arid lands, as well as research on the formation and stability of climate over semiarid areas. | WEN XiaoHang LIAO XiaoHan YUAN WenPing YAN XiaoDong WEI ZhiGang LIU HuiZhi FENG JinMing LU ShiHua DONG WenJie | 2014 | Science China Earth Sciences2014，57，10： | 1 |
| 9 | Spatial-seasonal dynamics of chromophoric dissolved organic matter in Lake Taihu,a large eutrophicshallow lake in China 显示文摘 | ZHANG Yunlin YIN Yan LIU Xiaohan | 2011 | Org Geochem2011，42，5： | 1 |
| 10 | Genomic diversity and post-admixture adaptation in the Uyghurs显示文摘Population admixture results in genome-wide combinations of genetic variants derived from different ancestral populations of distinct ancestry, thus providing a unique opportunity for understanding the genetic determinants of phenotypic variation in humans. Here, we used whole-genome sequencing of 92 individuals with high coverage(30–60×) to systematically investigate genomic diversity in the Uyghurs living in Xinjiang, China(XJU), an admixed population of both European-like and East-Asian-like ancestry.The XJU population shows greater genetic diversity, especially a higher proportion of rare variants,compared with their ancestral source populations, corresponding to greater phenotypic diversity of XJU.Admixture-induced functional variants in EDAR were associated with the diversity of facial morphology in XJU. Interestingly, the interaction of functional variants between SLC24A5 and OCA2 likely influences the diversity of skin pigmentation. Notably, selection has seemingly been relaxed or canceled in several genes with significantly biased ancestry, such as HERC2–OCA2. Moreover, signatures of post-admixture adaptation in XJU were identified, including genes related to metabolism(e.g. CYP2D6), digestion(e.g.COL11A1), olfactory perception(e.g. ANO2) and immunity(e.g. HLA). Our results demonstrated population admixture as a driving force, locally or globally, in shaping human genetic and phenotypic diversity as well as in adaptive evolution. | Yuwen Pan Chao Zhang Yan Lu Zhilin Ning Dongsheng Lu Yang Gao Xiaohan Zhao Yajun Yang Yaqun Guan Dolikun Mamatyusupu Shuhua Xu | 2022 | National Science Review2022，9，3： | 1 |
| 11 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 12 | Characterizing chromophoric dissolved organic matter in Lake Tianmuhu and its catchment basin using excitation-emission matrix fluorescence and parallel factor analysis显示文摘 | Yunlin Zhang Yan Yin Longqing Feng Guangwei Zhu Zhiqiang Shi Xiaohan Liu Yuanzhi Zhang | 2011 | Water Research2011，，16： | 1 |
| 13 | Transport through T-shaped quantum wires under potential modulation:Lattice Green's function approach显示文摘 | Chen Yuanping Yan Xiaohan Xie Yuee | 2005 | Phys Rev B2005，71，24： | 1 |
| 14 | Electron transport of L-shaped graphene nanoribbons显示文摘 | Chen Yuanping Xie Yuee Yan Xiaohan | 2008 | J Appl Phys2008，103，63： | 1 |
| 15 | Research on the Evaporating Crystalization Behavior of the Magnesium Sulfate Subtypes Brine at High Temperature显示文摘Research the evaporating crystalization process of the magnesium sulfate subtypes brine at high temperature from Dalangtan salt lake in Qinghai province.It was revealed that the salt lake is a typical subtype | XIE Shaolei ZHANG Chao WANG Xiaohan JING Yan JIA Yongzhong | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 16 | Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes显示文摘Background:Abnormal lipids are strong predictors of cardiovascular disease in type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM).However,the potential associations of insulin resistance(IR)and beta-cell function(BCF)with abnormal lipids in newly diagnosed T1DM or T2DM patients are not fully understood.Methods:A cross-sectional survey of 15,928 participants was conducted.Homeostasis model assessment and postprandial C-peptide levels were used to estimate IR and BCF.A restricted cubic spline(RCS)nested in binary logistic regression was used to examine the associations of IR and BCF with abnormal lipids.Results:High triglyceride(TG),low high-density lipoprotein cholesterol,and high low-density lipoprotein cholesterol(LDL-C)accounted for 49.7%,47.8%,and 59.2%of the participants,respectively.In multivariable analysis,high IR was associated with an increased risk of high TGs(P for trend<0.001)in T1DM and is associated with an elevated risk of high TG and low HDL-C(all P for trend<0.01)in T2DM.Low BCF was not associated with risks of dyslipidemia in patients with T1DM or T2DM after adjustment for potential confounders.Conclusion:High IR had different associations with the risk of dyslipidemia in newly diagnosed T1DM and T2DM patients,suggesting that early treatment that improves IR may benefit abnormal lipid metabolism. | Xiaohan Tang Xiang Yan Houde Zhou Gan Huang Xiaohong Niu Hongwei Jiang Heng Su Xilin Yang Xia Li Zhiguang Zhou | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 17 | From COX-2 inhibitor nimesulide to potent anti-cancer agent: Synthesis, in vitro, in vivo and pharmacokinetic evaluation显示文摘 | Bo Zhong Xiaohan Cai Snigdha Chennamaneni Xin Yi Lili Liu John J. Pink Afshin Dowlati Yan Xu Aimin Zhou Bin Su | 2011 | European Journal of Medicinal Chemistry2011，，： | 1 |
| 18 | Rapid and label-free classification of pathogens based on light scattering,reduced power spectral features and support vector machine显示文摘The rapid identification of pathogens is crucial in controlling the food quality and safety.The proposed system for the rapid and label-free identification of pathogens is based on the principle of laser scattering from the bacterial microbes.The clinical prototype consists of three parts:the laser beam,photodetectors,and the data acquisition system.The bacterial testing sample was mixed with 10 mL distilled water and placed inside the machine chamber.When the bacterial microbes pass by the laser beam,the scattering of light occurs due to variation in size,shape,and morphology.Due to this reason,different types of pathogens show their unique light scattering patterns.The photo-detectors were arranged at the surroundings of the sample at different angles to collect the scattered light.The photodetectors convert the scattered light intensity into a voltage waveform.The waveform features were acquired by using the power spectral characteristics,and the dimensionality of extracted features was reduced by applying minimal-redundancy-maximal-relevance criterion(mRMR).A support vector machine(SVM)classifier was developed by training the selected power spectral features for the classification of three different bacterial microbes.The resulting average identification accuracies of E.faecalis,E.coli and S.aureus were 99%,87%,and 94%,respectively.The ove rall experimental results yield a higher accuracy of 93.6%,indicating that the proposed device has the potential for label-free identification of pathogens with simplicity,rapidity,and cost-effectiveness. | Mubashir Hussain Zhen Chen Mu Lv Jingyi Xu Xiaohan Dong Jingzhou Zhao Song Li Yan Deng Nongyue He Zhiyang Li Bin Liu | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 19 | Serrin-Type Overdetermined Problem in H^(n)显示文摘In this paper,we prove the symmetry of the solution to overdetermined problem for the equationσ_(k)(D^(2)u-ul)=C^(k)_(n)in hyperbolic space.Our approach is based on establishing a Rellich-Pohozaev type identity and using a P function.Our result generalizes the overdetermined problem for Hessian equation in Euclidean space. | GAO Zhenghuan JIA Xiaohan YAN Jin | 2023 | Journal of Partial Differential Equations2023，36，1： | 0 |
| 20 | Equilibrium electron beam parameters of the High Energy Photon Source显示文摘Purpose The physics design of the High Energy Photon Source(HEPS)was finished after many times of iteration.Hereby,the typical equilibrium electron beam parameters corresponding to the proposed two baseline operation modes in the baseline design of HEPS are presented.Methods To compute the equilibrium parameters of the electron beam,the lattice parameters,RF parameters,and the parameters of the insertion devices(IDs)were determined first.Furthermore,it is more precise to use the full-current electron beam parameters in the estimations of the performance of the synchrotron light.Therefore,not only the single-particle dynamics but also the current-dependent collective effects need to be considered in the computations of the full-current,equilibrium parameters of the electron beam.Both analytic computations and multi-particle tracking simulations were carried out.Results The full-current,equilibrium parameters of the electron beams in the HEPS storage ring are presented in this paper.Moreover,the main beam parameters in the injector(the booster and the LINAC),corresponding to the two baseline operation modes of the storage ring,are also presented.Conclusion The typical electron beam parameters corresponding to the two baseline operation modes are given in detail in this paper. | Haisheng Xu Cai Meng Yuemei Peng Saike Tian Na Wang Xiaohao Cui Chongchong Du Zhe Duan Yuanyuan Guo Ping He Xiyang Huang Daheng Ji Hongfei Ji Yi Jiao Jingyi Li Nan Li Xiaoyu Li Xiaohan Lu Pengfei Liang Weimin Pan Huamin Qu Bin Wang Jiuqing Wang Yuanyuan Wei Jinyu Wan Gang Xu Fang Yan Chenghui Yu Sen Yue Xiang Zhang Yaliang Zhao | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
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