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| 1 | Origin of ore-forming fluids of the Dachang Sn-polymetallic ore deposit: Evidence from helium isotopes显示文摘The ore genesis model for the Dachang Sn-polymetallic ore deposit has long been in dispute, and the major debate focuses on whether the stratiform and massive orebodies formed during the Yanshanian magmatic-hydro-thermal event or they were products of Devonian syn-sedi-mentary exhalative-hydrothermal event. This note presents new helium isotope data from fluid inclusions of four pyrites and one fluorite. The pyrites were collected from the stratiform and massive orebodies in the deposit, and their 3He/4He ratios are significantly higher than 1, ranging from 1.7 to 2.5 Ra, which indicates a mantle component in the responsible hydrothermal fluids. It is suggested that the ore-forming fluids were a mixture of deep circulating seawater and a mantle-derived fluid, which are similar to many of those modern submarine hydrothermal fluids. In contrast, the fluorite, collected from a granite-related hydrothermal vein in the deposit, shows a low 3He/4He ratio of 0.7 Ra, which indicates no mantle component | Kuidong Zhao Shaoyong Jiang Hongquan Xiao Pei Ni | 2002 | Chinese Science Bulletin2002，47，12： | 28 |
| 2 | 三段式心土混层犁及其改良白浆土效果的研究显示文摘三段式心土混层犁为改造白浆土土体构型实现了“上翻 2 0 cm,下混 30~ 40 cm”的农艺要求 ,白浆层与淀积层的土壤混拌率 Mx 达到 0 .7,白浆层向淀积层的土壤转移率 TAw→ B达到了 0 .3。 0~ 40 cm土层土壤物理性状明显改善 ,疏松透水 ,硬度下降 ,农田表涝现象得到缓解 ,效果持久稳定 ,连续 4年测定 ,耕翻一次后至第 4年其土壤硬度仍然明显低于常规耕作田块。 1996年~ 1998年大面积示范试验 ,使用该犁耕翻地块作物增产达 10 %~2 7.9%。该犁作业幅宽 5 0 cm,深度 6 0 cm,总牵引阻力 30~ 35 k N。 | 刘峰 张玉龙 贾会彬 Zhang Hongquan 张洪权 张春峰 杨树纯 何宁 新家宪 工藤正义 河部弘道 | 2001 | 农业工程学报2001，17，3： | 15 |
| 3 | Mineralization Styles and Genesis of the Yinkeng Au-Ag-Pb-Zn-Cu-Mn Polymetallic Orefield, Southern Jiangxi Province, SE China: Evidence from Geology, Fluid Inclusions, Isotopes and Chronology显示文摘The Yinkeng orefield in Yudu County, Jiangxi Province, SE China, is a zone of concentrated Au-Ag-Pb-Zn-Cu-Mn polymetallic ores. Based on summing up basic geology and ore geology of the orefield, the polymetallic deposits in the orefield have been divided into seven major substyles according to their occurring positions and control factors. The ore-forming fluid inclusion styles in the orefield include those of two-phase fluid, liquid CO2-bearing three-phase and daughter mineral-bearing multi-phase. The homogenization temperatures range from 382o to 122oC, falling into five clusters of 370o to 390o, 300o to 360o, 230o to 300o, 210o to 290o and 120o to 200o, and the clusters of 300o to 360o, 230o to 300o and 120o to 200o are three major mineralization stages, with fluid salinity peaks from 4.14% to 7.31%, 2.07% to 7.31% and 0.53% to 3.90%, respectively. The ore-forming fluids are mainly type of NaCl-H2O with medium to high density(0.74–1.02 g/cm3), or CO2-bearing NaCl-H2O with medium to low density(0.18–0.79 g/cm3). The fluid salinity and density both show a decline tendency with decreasing temperature. According to the measurement and calculation of Hand O-isotopic compositions in the quartz of the quartz-sulfide veins, δDV-SMOW of the ore-forming fluid is from-84‰ to-54‰, and δ18OV-SMOW of that is from 6.75‰ to 9.21‰, indicating a magmatic fluid. The δ34SV-CDT of sulfides in the ores fall into two groups, one is from-4.4‰ to 2.2‰ with average of-1.42‰, and the other from 18.8‰ to 21.6‰ with average of 19.8‰. The S-isotopic data shows one peak at-4.4‰ to 2.2‰(meaning-1.42‰) suggesting a simple magmatic sulfur source. The ore Pbisotopic ratios are 206Pb/204Pb from 17.817 to 17.983, 207Pb/204Pb from 15.470 to 15.620 and 208Pb/204Pb from 38.072 to 38.481, indicating characteristics of mantle-derived lead. The data show that the major ore deposits in the orefield have a magmatic-hydrothermal genesis and that the SHRIMP zircon age of the granodiorite porphyry, closely related to the mineralization, is 151.2±4.2 Ma(MSWD = 1.3), which can represent the formation ages of the ores and intrusion rocks. The study aids understanding of the ore-forming processes of the major metallic ore deposits in the orefield. | FENG Chengyou LI Daxin ZENG Zailin ZHANG Dequan SHE Hongquan | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 14 |
| 4 | Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis显示文摘OBJECTIVE:To investigate the effectiveness of Banxia Xiexin decoction(BXD)in a rat model of chronic atrophic gastritis(CAG).METHODS:Sixty 6-week-old healthy Wistar rats(30 males,30 females)were used in the present study.A rat model of CAG was successfully established using the combined active immunization/ethanol/sodium deoxycholate method.BXD was prepared from a mixture of seven Chinese herbs,and was intragastrically administered to CAG rats at three different doses(6,12,and 24 g·kg^-1·d^-1).Af-ter 24 weeks,the rats were euthanized,and gastric tissue specimens were collected.Gastric mucosal specimens were stained with hematoxylin and eosin for histological examination to evaluate the degree of inflammation and morphological changes.Immunohistochemical staining was performed to examine the mucosal expression of proliferating cell nuclear antigen.Serum gastrin levels were measured using radioimmunoassay.The expression of Notch signaling-associated genes was examined by quantitative polymerase chain reaction and Western blot assay.RESULTS:BXD at all three doses significantly reversed the adverse effects generated by CAG in rats.Compared with control rats,the CAG rats who were administered BXD had an accelerated growth rate,reduced inflammatory cell infiltration,improved gastric mucosal morphology,augmented thickness of the gastric mucosa,increased number of gastric glands,enhanced mucosal expression of proliferating cell nuclear antigen,and elevated serum gastrin levels. | Bai Yu Chen Yongcan Chen Yu Yan Maoxiang Wei Hongquan Wang Hengcang Zeng Guoliang Yang Xiyin | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 14 |
| 5 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 6 | Avoiding the innovation island in infrastructure mega-project显示文摘Infrastructure mega-project(IMP) innovation is a complex process characterized by highly diverse innovators, a dynamic life-cycle, and stickiness of innovation knowledge. The IMP's innovation network can be easily broken due to the fact that the network involves many different innovators across different industries and different projects. Further reasons for the fragility of the IMP's innovation network are the dynamics of the IMP life-cycle, the diversity of the IMP's innovative entities, the uniqueness of each IMP, and the temporary nature of each IMP's organizations. The innovation island formed by the breaking of an IMP's innovation network can stifle and harm innovation performance. Drawing from the knowledge-based view as well as innovation network theory, our research identifies the heterogeneous characteristics of IMP innovation. We propose a framework to analyze the formation mechanism of the IMP innovation island from three dimensions—the horizontal innovation island, the vertical innovation island, and the longitudinal innovation island. We look at the Hong Kong-ZhuhaiMacao Bridge project to elaborate the innovation island concept that negatively impacts IMP innovation. We also offer theoretical implications regarding the broader question of how IMPs can manage their innovation in practice. | Hongquan CHEN Quanke SU Saixing ZENG Daxin SUN Jonathan Jingsheng SHI | 2018 | Frontiers of Engineering Management2018，5，1： | 10 |
| 7 | 井筒环空稳态多相流水动力学模型显示文摘基于井筒环空气液两相流流型的分类及特点,建立适合于直井、斜井的井筒环空段塞流、环状流水动力学模型及环空流型过渡准则。基于井筒环空多相流特性,以液膜区域为控制单元,考虑油管膜、套管膜双层液膜的存在及气芯中液滴对质量、动量传递的影响,推导了环空段塞流、环状流质量、动量守恒方程,得到了段塞流与分散泡状流、泡状流及环状流间的流型过渡准则。根据已发表文献中的实验条件,采用本文模型与校正后的圆管模型预测了不同气、液相表观速度下的流型、持液率及压力梯度。结果表明:采用本文模型可以比较准确地预测环空流型、持液率及压降梯度,且预测持液率、压力梯度的准确性优于校正后的圆管模型。 | 尹邦堂 李相方 孙宝江 Zhang Hongquan | 2014 | 石油勘探与开发2014，41，3： | 10 |
| 8 | Comparative study of the mechanical properties,micro-structure,and composition of the cranial and beak bones of the great spotted woodpecker and the lark bird显示文摘Woodpeckers are well able to resist head injury during repeated high speed impacts at 6-7 m s-1 with decelerations up to 1000 g.This study was designed to compare the mechanical properties,microstructures and compositions of cranial bone and beak bone of great spotted woodpecker(Dendrocopos major) and the Mongolian sky lark(Melanocorypha mongolica).Microstructures were observed using micro-computed tomography and scanning electron microscopy and their compositions were characterized by X-ray powder diffraction and Fourier-transform infrared spectroscopy.Under high stress,the cranial bone and the beak of the woodpecker exhibited distinctive mechanical features,which were associated with differences in micro-structure and composition,compared with those of the lark.Evolutionary optimization of bone micro-structure has enabled functional adaptation to the woodpecker's specific lifestyle.Its characteristic micro-structure efficiently avoids head impact injury and may provide potential clues to the prevention of brain injury using bio-inspired designs of shock-absorbing materials. | WANG LiZhen ZHANG HongQuan FAN YuBo | 2011 | Science China(Life Sciences)2011，54，11： | 9 |
| 9 | Complex network theory-based condition recognition of electromechanical system in process industry显示文摘In order to recognize the different operating conditions of a distributed and complex electromechanical system in the process industry,this work proposed a novel method of condition recognition by combining complex network theory with phase space reconstruction.First,a condition-space with complete information was reconstructed based on phase space reconstruction,and each condition in the space was transformed into a node of a complex network.Second,the limited penetrable visibility graph method was applied to establish an undirected and un-weighted complex network for the reconstructed condition-space.Finally,the statistical properties of this network were calculated to recognize the different operating conditions.A case study of a real chemical plant was conducted to illustrate the analysis and application processes of the proposed method.The results showed that the method could effectively recognize the different conditions of electromechanical systems.A complex electromechanical system can be studied from the systematic and cyber perspectives,and the relationship between the network structure property and the system condition can also be analyzed by utilizing the proposed method. | WANG RongXi GAO JianMin GAO ZhiYong GAO Xu JIANG HongQuan | 2016 | Science China(Technological Sciences)2016，59，4： | 9 |
| 10 | Effect of a Traditional Chinese Medicine combined therapy on adolescent idiopathic scoliosis:a randomized controlled trial显示文摘OBJECTIVE:To evaluate the effectiveness of a combined Traditional Chinese Medicine(TCM) therapy versus conventional treatment on adolescent idiopathic scoliosis.METHODS:One hundred twenty outpatients with mild and moderate adolescent idiopathic scoliosis were randomly divided into a TCM group(TCMG)and a brace group(CG).TCMG patients underwent Daoyin,Tuina,and acupotomology therapies.CG patients were treated with a Milwaukee brace.Each patient's Cobb angle was measured after 12 and 24 months of treatment,and pulmonary function was determined after 12 months of treatment.Average electromyogram(AEMG) ratio of the surface electromyogram was measured after 6 and 12 months of treatment and followed-up after 18 and 24 months.RESULTS:The Cobb angle significantly decreased in both groups after 12 months of treatment compared with before treatment(P< 0.05).The percentages of original Cobb angle in TCMG and CG were51.4%and 47.8%(P > 0.05) after 12 months and62.5%and 34.7%(P < 0.05) after 24 months,respectively.Pulmonary function significantly improved after 12 months in TCMG(P < 0.05) but significantly decreased in CG(P < 0.05).The AEMG ratio was significantly lower(P < 0.01) and tended to remain at1 after stopping treatment in TCMG,but increased in CG(P<0.05).CONCLUSION:TCM combined therapy can prevent the progression of scoliosis.The AEMG ratio is a promising index that could replace radiography in the evaluation of treatment effect and progression in scoliosis. | Wei Hui Xu Jinyuan Jiang Zhong Ye Shuliang Song Hongquan Ning Xitao Huang Huanmin Chen Wei Pei Jianwei Jiang Nengyi Chen Shao Du Honggen | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 9 |
| 11 | The Two Reemergent Confirmed COVID-19 Cases--Manzhouli City,Inner Mongolia Autonomous Region,China,November 20,2020显示文摘On November 20,2020,a 55-year-old male went to the Zhongmeng Hospital of Manzhouli City,Inner Mongolia Autonomous Region for diagnosis and treatment of pain in the waist and lower extremities.His wife,a 55-year-old female,accompanied him to the hospital also feeling unwell.They were first tested for coronavirus disease 2019(COVID-19)in Manzhouli People’s Hospital based on China’s policy of ensuring that“all those in need are tested,isolated,hospitalized,and treated.” | Xiaoling Tian Yang Song Kai Nie Guodong Wang Hongquan Wang Wenbo Xu Wenrui Wang | 2020 | China CDC weekly2020，2，51： | 8 |
| 12 | China's First Independent Cobalt Deposit and its Metallogenic Mechanism:Evidence from Fluid Inclusions and Isotopic Geochemistry显示文摘Tuolugou 钴存款是第一个独立人士大规模共同忍受并且在西北的中国发现的忍受 Au 沉积物。它在 Qinghai 省位于东方 Kunlun orogenic 带,并且在低档一致地发生有开发得好的 Na 富有的热水的沉积岩石和典型热水的沉积矿石织物的变形火山沉积的岩石系列。液体包括和同位素的地球化学研究建议钴使矿物化液体被 NaCl-H2O 系统统治,由为金矿化作用负责的 NaCl-CO2-H2O-N2 系统伴随了。巨大, banded 和传播黄铁矿矿石有类似的作文他和从使矿物化的液体的 Ar 同位素与到 0.31Ra (平均 0.21Ra )的在 0.10 之间的 3He/4He 范围,并且在 302 和 569 之间的 40Ar/36Ar (平均 373 ),它反映使矿物化的液体从深深地传播的大气的水主导地导出的那个公司。零的黄铁矿途径的 34S 价值(34S 从 4.5 到 +1.5,在 -1.8 附近集中到反映它的深来源的 -0.2), 。矿石铅被显然高的 radiogenesis 描绘,与 206Pb/204Pb > 19.279, 207Pb/204Pb > 15.691 并且 208Pb/204Pb > 39.627,并且它的价值从国家岩石显示出一个增加趋势,地区性的古生代的暴烈的岩石到矿石。这可能建议了矿石 Pb 由沥滤主要从国家岩石导出的那高 radiogentic 大气的水主导的热水的液体在它在深度的发行量期间。钴主要在硫化物阶段发生(例如黄铁矿) ,但是钴丰富和矿物质有的共同忍受的增加的内容与变形的度的积极关联。Tuolugou 沉积物和沉积物有在地质的特征和主要的钴的 metallogenic 模式打击类似的另外的典型阶层界限 Co-Cu-Au 所有他们是 syngenetic 在起源的热水的 exhalative 沉积。 | FENG Chengyou QI Feng ZHANG Dequan LI Daxin SHE Hongquan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 8 |
| 13 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 14 | Global profiling of crotonylation on non-histone proteins显示文摘 | Weizhi Xu Junhu Wan Jun Zhan Xueying Li Huiying He Zhaomei Shi Hongquan Zhang | 2017 | Cell Research2017，27，7： | 7 |
| 15 | Generation of mouse anti-human urate anion exchanger antibody by genetic immunization and its identification显示文摘Background Human urate anion exchanger (hURAT1) as a major urate transporter expressed on renal tubular epithelial cells regulates blood urate level by reabsorbing uric acid. Antibody is an important tool to study hURAT1. This study aimed, by genetic immunization, to produce mouse anti-hURAT1 polyclonal antibody with high throughput and high specificity and to detect the location of hURAT1 in human kidney.Methods Human renal total RNA was isolated and the entire cDNA of hURAT1 was amplified by RT-PCR. The sequence of intracellular high antigenicity fragment (A280 to R349) was chosen by prediction software of protein antigenicity, and its cDNA was amplified from cDNA of hURAT1, and then cloned into pBQAP-TT vector to construct recombinant plasmid pBQAP-TT-hURAT1-210 for genetic immunization. Mice were inoculated with this recombinant plasmid and two other adjuvant plasmids, pCMVi-GMCSF and pCMVi-Flt3L, which helped to enhance the antibody’s generation. After four weeks, the mice were sacrificed to obtain the anti-hURAT1 antibody from serum. The antibody was identified by western blot analysis and immunohistochemistry. At the same time, rabbit anti-hURAT1 antibody was produced by protein immunization. The specificity and efficiency between the rabbit and mouse anti-hURAT1 antibody were compared by western blot analysis and immunohistochemistry. Results The entire cDNA of hURAT1 and cDNA of its intracellular high immunogenic fragment were amplified successfully. Recombinant plasmid pBQAP-TT-hURAT1-210 for genetic immunization was confirmed by restriction digestion and sequencing. Both!the mouse anti-hURAT1 antibody and rabbit anti-hURAT1 antibody recognized 58kD hURAT1 and 64kD glycosylated hURAT1 protein bands in western blot. Immunohistochemically, hURAT1 was located at the brush border membrane of renal proximal tubular cells. In addition, the throughput and specificity of the mouse anti-hURAT1 antibody were higher than those of the rabbit anti-hURAT1 antibody.Conclusion Genetic immunization can generate anti-hURAT1 polyclonal antibody of high throughput and specificity. | XUGuo-shuang WUDi CHENXiang-mei SHISuo-zhu HONGQuan ZHANGPing LUYang | 2005 | Chinese Medical Journal2005，，8： | 7 |
| 16 | Cloning and bioinformatics analysis of a full-length cDNA of porcine CRl-like gene显示文摘 | Jing Cheng Junbing Jiang Junxing Zhao Zhirui Wang Yaogui Sun Haili Ma Kuohai Fan Wei Yin Na Sun Zhiwei Wang Xin Zhao Hongquan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 7 |
| 17 | Systematic Identification of the Light-quality Responding Anthocyanin Synthesis-related Transcripts in Petunia Petals显示文摘Previous studies have shown that high light intensity can induce anthocyanin synthesis(AS)in petunia plants.To identifywhich kind of light quality plays a role in inducing such metabolic process,and what transcripts participate in controlling it,we carried out whole-transcriptome sequencing and analysis of petunia petals treated with different light-quality conditions.Among the red and white light treatments,a total of 2205 differentially expressed genes and 15,22,and 20 differentially expressed circRNAs,miRNAs,and lncRNAs,were identified respectively.The AS-related genes,including the structural genes CHSj,F3H,F35H,DFR,and ANS,and the regulatory genes AN4,DPL,PHZ and MYBx were found to be downregulated under red light condition compared with their levels under white light condition.Furthermore,the light photoreceptor Cryptochrome 3(CRY3)and a series of light-dependent genes,such as PIF,HY5,andBBXs,were also determined to respond to the light treatments.The anthocyanin contents in early petunia petals under red light were significantly lower than that under white and blue light.The results of qRT-PCR further confirmed the expression pattern of some AS-related and light-response genes in response to different light quality.Yeast two-hybrid results showed that the key elements in the light signal pathway,HY5 can interact with BBX19,BBX24 and BBX25.And PHZ,the important AS regulator can induce anthocyanin synthesis in response to blue light quality fromtransient expression analysis in petunia petals.These findings presented here not only deepen our understanding of how light quality controls anthocyanin synthesis,but also allow us to explore potential target genes for improving pigment production in petunia flower petals. | Zhenzhu Fu Hongquan Shang Hui Jiang Jie Gao Xiaoyu Dong Huijuan Wang Yanmin Li Limin Wang Jing Zhang Qingyan Shu Yacong Chao Menglan Xu Rui Wang Liangsheng Wang Hechen Zhang | 2020 | Horticultural Plant Journal2020，6，6： | 7 |
| 18 | Temporal and spatial evolution of coastline and subaqueous geomorphology in muddy coast of the Yellow River Delta显示文摘基于海岸线和 bathometry 的测量数据,由遨游者和 Mapinfo 的软件处理了,并且与在在 Lijin 估计车站,海岸线的时间、空间的进化和在黄河三角洲的泥泞海岸的水下的地形学被分析的不同阶段的沉积负担结合了。结果证明 68% 沉积被从 1953 ~ 2000 绕河嘴并且在沿岸的区域扔的黄河交付。在不同海岸的海岸线响应河路线的移动有特殊变化。海岸线在 Diaokou 河嘴的西方是稳定的。从到 Gudong 油矿的北方的 Diaokou 河嘴的东方的海岸线与海墙保存经历了 siltation,然后严肃的侵蚀,和最后保留的马厩。通常, Qingshuigou 河功课的熬过的河嘴的海岸线拉长了朝海的方向,而在 Qingshuigou 旧河嘴的沙吐痰的南方方面在 Qing 8 在在位置附近注入的黄河以后被侵蚀。离开熬过的河嘴的水下的地形学从 1976 ~ 1996 展出了 siltation,与扁平的 topset 床和更陡峭的 foreset 床。从 1996 ~ 2005,离开 Qingshuigou 旧河嘴的水下的地形学在 topset 和 foreset 被侵蚀在 bottomset 床上的床,而是 silted。离开新河嘴的水下的地形学顺序与 19761996 的相比与小度执行了 siltation。 | PENG Jun MA Suisui CHEN Hongquan LI Zhiwen | 2013 | Journal of Geographical Sciences2013，23，3： | 6 |
| 19 | Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice显示文摘Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus(MMTV) long terminal repeat(LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway. | Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang | 2019 | Science China(Life Sciences)2019，62，2： | 6 |
| 20 | A Harmful-Intrusion Detection Method Based on Background Reconstruction and Two-Dimensional K-S Test in an Optical Fiber Pre-Warning System显示文摘为光纤维侵入警告前系统(OFIPS ) 的关键技术和主要困难是有害侵入的信号的抽取。在被阶段敏感的光时间域反射计处理以后(-OTDR), 颤动信号能 preliminarily 被提取。通常,这些包括噪音和侵入。这里,侵入能被划分成有害、无害的侵入。关于信号特征的仔细的学习,有害侵入的一个有效抽取方法在纸被建议。在背景重建的部分,第一,所有侵入信号被经常的虚惊率(CFAR ) 首先检测。我们然后重建由提取警报点,时间和振幅的由二部合成的信息的背景。这保证察觉背景由侵入信号组成。在二维的 Kolmogorov-Smirnov (K-S ) 测试的部分,第二提取了侵入以便从所有提取有害的,我们设计一个分离方法。它基于有害侵入的信号特征,它是更短的时间间隔和更高的振幅。在实际 OFIPS,察觉方法在一些典型场面被使用,它包括很多无害的侵入,例如构造地点和忙道路。结果证明我们能有效地提取有害侵入。 | Fukun BI Tong ZHENG Hongquan QU Liping PANG | 2016 | Photonic Sensors2016，6，2： | 5 |
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