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| 1 | Lake eutrophication and its ecosystem response显示文摘China is a country with many lakes,about one-third of which are freshwater mainly distributed in the middle and lower reaches of the Yangtze River.Currently most of the lakes are mesotrophic or eutrophic.Lake eutrophication has become one of the major ecological and environmental problems faced by lakes in China and can lead to a series of abnormal ecosystem responses,including extinction of submerged plants,frequent occurrence of cyanobacterial blooms,increased microbial biomass and productivity,decreased biodiversity,accelerated cycles,and a change in the efficient use of nutrients.With development of eutrophication,the whole lake ecosystem suffers decreased biodiversity,simplification of biotic community structure,instability of the ecosystem,and ultimately the clear-water,macrophyte-dominated ecosystem gradually shifts to a turbid-water,algae-dominated ecosystem.This ecosystem succession mechanism is speculated to be caused by different nutrient utilization efficiencies of macrophytes and phytoplankton.The ultimate ecosystem succession trend of seriously eutrophic lakes is that a phytoplankton-dominated autotrophic lake shifts to a heterotrophic lake dominated by micro-organisms,protozoans. | QIN BoQiang GAO Guang ZHU GuangWei ZHANG YunLin SONG YuZhi TANG XiangMing XU Hai DENG JianMing | 2013 | Chinese Science Bulletin2013，58，9： | 63 |
| 2 | Why Lake Taihu continues to be plagued with cyanobacterial blooms through 10 years(2007–2017) efforts显示文摘With the expansion of urban, industry, and agriculture after World War II, eutrophication firstly emerged as a major water quality threat in small water bodies [1]. As the increasing magnitudes and scales of nutrient pollution and habitat alteration, many of the world's large lakes exhibit symptoms of eutrophication, e.g., toxic cyanobacterial blooms, deoxygenation, and habitat loss. | Boqiang Qin Hans W.Paerl Justin D.Brookes Jianguo Liu Erik Jeppesen Guangwei Zhu Yunlin Zhang Hai Xu Kun Shi Jianming Deng | 2019 | Science Bulletin2019，64，6： | 50 |
| 3 | Seasonal and spatial distributions of euphotic zone and longterm variations in water transparency in a clear oligotrophic Lake Fuxian, China显示文摘To assess the seasonal and spatial variations and long-term trends in water optical properties in Lake Fuxian, investigations based on field work in four seasons and a long-term analysis of data from 1980 to 2014 were conducted. The results show that there was no significant variation in the euphotic depth(Z_(eu)) across the four seasons, and no significant correlations between Z_(eu) and potential influencing factors in seasons other than summer, suggesting that the water itself may be a major factor regulating the Z_(eu)in general. Nevertheless, significant differences in Z_(eu) between the north region(NR) and the south region(SR) were observed in all seasonal tests except spring. This finding relates to a higher abundance of chromophoric dissolved organic matter(CDOM) in the NR due to runoff, especially in the rainy seasons(summer and autumn).CDOM and its terrigenous component had an important impact on Z_(eu)in summer, with the highest precipitation, and impacts from suspended solids and non-algal particles were also found in the NR in summer. The Secchi disk depth in the lake decreased clearly over the years,with significantly negative correlations with the increasing permanganate index and air temperature, implying that organic contaminants(CDOM and/or phytoplankton) are important regulators of water transparency. We estimate that the combined effects of climate warming and changes in land use and land cover are also indirect regulating factors. These findings should be considered in the protection of Lake Fuxian, owing to the importance of light penetration in aquatic ecosystems. | Qichao Zhou Yunlin Zhang Kaidi Li Licheng Huang Fengle Yang Yuanyang Zhou Junjun Chang | 2018 | Journal of Environmental Sciences2018，30，10： | 18 |
| 4 | Effect of sediment resuspension on underwater light field in shallow lakes in the middle and lower reaches of the Yangtze River:A case study in Longgan Lake and Taihu Lake显示文摘Based on three continuous in situ underwater light field measurement under different wind waves conditions in Longgan Lake, Meiliang Bay of Taihu Lake in July 2003 and littoral zone near TLLER in July 2004, respectively, the effects of sediment resuspension caused by wind waves on PAR diffuse attenuation, absorption coefficients and euphotic depths are analyzed. In Longgan Lake, PAR diffuse attenuation coefficients during small, middle and large wind waves were 1.74, 2.02 and 2.45 m-1, respectively, and the corresponding PAR spectral diffuse attenuations ranged from 0.98 to 2.97, 1.34 to 3.95 and 1.80 to 5.40 m-1, respectively. In Meiliang Bay, PAR diffuse attenuation coefficients were 2.63, 3.72, 4.37 m-1 during small, middle and large wind waves. PAR diffuse attenuation coefficients increased by 41% and 66% from small to middle, large wind waves, respectively.Absorption coefficients integrated over the range of PAR of CDOM, phytoplankton were 0.26, 0.28 m-1;0.76, 0.49 m-1, respectively during middle and large wind waves. Absorption coefficients integrated over the range of PAR of non-algal particulate matter and total suspended particulate matter increased from 0.94 to 1.73 m-1, and from 1.70 to 2.22 m-1, respectively during middle and large wind waves. Relative contributions of absorption coefficients of non-algal particulate matter to total absorption coefficient integrated over the range of PAR were 44.14%, 65.05%, respectively, during middle and large wind waves. PAR euphotic depths decreased by 0.40, 0.19, 0.20 m from middle to large wind waves in Longganhu Lake, Meliang Bay and littoral zone near TLLER. Significant correlations were found between transparency, PAR diffuse attenuation coefficients, euphotic depths and total suspended particulate matter, wind velocity, wave height. Most significant correlations were found between transparency, PAR diffuse attenuation coefficients, euphotic depths and inorganic suspended particulate matter but low correlations for chlorophyll a, dissolved organic carbon. Increase of total suspended particulate matter, especially inorganic suspended particulate matter caused by wind waves was the dominant factor affecting underwater light field in shallow lakes in the middle and lower reaches of the Yangtze River based on observations at three stations. | ZHANG Yunlin, QIN Boqiang, ZHU Guangwei, GAO Guang, LUO Liancong & CHEN Weimin Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2006 | Science China Earth Sciences2006，49，z1： | 14 |
| 5 | Superplastic Solid-Phase Welding of 40 Cr-T10A Steel显示文摘The microstructure of 40Cr and T10A steel sample and its surface to be welded is ultra-fined through salt-bath cyclic quenching and high frequency hardening, then the surface is cleaned. Under non-vacuum and no shielded gas, the welding parameter of isothermal superplastic solidphase welding and the effect of surface microstructure prior to pressure welding on the quality of joint are studied. At the temperature of 730~750°C and at initial strain rate of (2~4) × 10-4 s-1,the strength of the joint is up to or close to that of 40Cr base metal in 3~5 min pressure welding. | Keke ZHANG Yunlin YANG Changsheng WANG Hongke LI Jin XUE | 2001 | Journal of Materials Science & Technology2001，17，1： | 10 |
| 6 | Angiotensin Ⅱ upregulates fibroblastmyofibroblast transition through Cx43- dependent CaMKⅡ and TGF-β1 signaling in neonatal rat cardiac fibroblasts显示文摘 | Li Cao Yunlin Chen Li Lu Yihao Liu Yaowen Wang Jinqi Fan Yuehui Yin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 6 |
| 7 | Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease显示文摘Background:Alzheimer's disease(AD)is an incurable and irreversible neurodegen-erative disease,without a clear pathogenesis.Therefore,identification of candidates before amyloid-βplaque(Aβ)deposition proceeds is of major significance for earlier intervention in AD.Methods:To explore the potential noninvasive earlier biomarkers of AD in a 5XFAD mouse model,microRNAs(miRNAs)from urinary exosomes in 1-month-old pre-Aβaccumulation 5XFAD mice models and their littermate controls were profiled by mi-croarray analysis.The differentially expressed miRNAs were further analyzed via droplet digital PCR(ddPCR).Results:Microarray analysis demonstrated that 48 differentially expressed miRNAs(18 upregulated and 30 downregulated),of which six miRNAs-miR-196b-5p,miR-339-3p,miR-34a-5p,miR-376b-3p,miR-677-5p,and miR-721-were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR.Conclusions:Urinary exosomal miRNAs showing differences in expression prior to Aβ-plaque deposition were identified.These exosomal miRNAs represent potential noninvasive biomarkers that may be used to prevent AD in clinical applications. | Zhiqi Song Yajin Qu Yanfeng Xu Ling Zhang Li Zhou Yunlin Han Wenjie Zhao Pin Yu Yu Zhang Xianglei Li Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，3： | 6 |
| 8 | Remote sensing of cyanobacterial blooms in inland waters: present knowledge and future challenges显示文摘Timely monitoring, detection and quantification of cyanobacterial blooms are especially important for controlling public health risks and understanding aquatic ecosystem dynamics. Due to the advantages of simultaneous data acquisition over large geographical areas and high temporal coverage, remote sensing strongly facilitates cyanobacterial bloom monitoring in inland waters. We provide a comprehensive review regarding cyanobacterial bloom remote sensing in inland waters including cyanobacterial optical characteristics, operational remote sensing algorithms of chlorophyll, phycocyanin and cyanobacterial bloom areas, and satellite imaging applications. We conclude that there have many significant progresses in the remote sensing algorithm of cyanobacterial pigments over the past 30 years. The band ratio algorithms in the red and near-infrared(NIR) spectral regions have great potential for the remote estimation of chlorophyll a in eutrophic and hypereutrophic inland waters, and the floating algae index(FAI) is the most widely used spectral index for detecting dense cyanobacterial blooms. Landsat, MODIS(Moderate Resolution Imaging Spectroradiometer) and MERIS(MEdium Resolution Imaging Spectrometer) are the most widely used products for monitoring the spatial and temporal dynamics of cyanobacteria in inland waters due to the appropriate temporal, spatial and spectral resolutions. Future work should primarily focus on the development of universal algorithms, remote retrievals of cyanobacterial blooms in oligotrophic waters, and the algorithm applicability to mapping phycocyanin at a large spatial-temporal scale. The applications of satellite images will greatly improve our understanding of the driving mechanism of cyanobacterial blooms by combining numerical and ecosystem dynamics models. | Kun Shi Yunlin Zhang Boqiang Qin Botian Zhou | 2019 | Science Bulletin2019，64，20： | 6 |
| 9 | A bibliometric review of nitrogen research in eutrophic lakes and reservoirs显示文摘The global application of nitrogen is far greater than phosphorus, and it is widely involved in the eutrophication of lakes and reservoirs. We used a bibliometric method to quantitatively and qualitatively evaluate nitrogen research in eutrophic lakes and reservoirs to reveal research developments, current research hotspots, and emerging trends in this area. A total of 2695 articles in the past 25 years from the online database of the Scientific Citation Index Expended(SCI-Expanded) were analyzed. Articles in this area increased exponentially from 1991 to 2015.Although the USA was the most productive country over the past 25 years, China achieved the top position in terms of yearly publications after 2010. The most active keywords related to nitrogen in the past 25 years included phosphorus, nutrients, sediment, chlorophyll-a, carbon,phytoplankton, cyanobacteria, water quality, modeling, and stable isotopes, based on analysis within 5-year intervals from 1991 to 2015 as well as the entire past 25 years. In addition, researchers have drawn increasing attention to denitrification, climate change, and internal loading. Future trends in this area should focus on:(1) nutrient amounts, ratios, and major nitrogen sources leading to eutrophication;(2) nitrogen transformation and the bioavailability of different nitrogen forms;(3)nitrogen budget, mass balance model, control, and management;(4) ecosystem responses to nitrogen enrichment and reduction, as well as the relationships between these responses; and(5)interactions between nitrogen and other stressors(e.g., light intensity, carbon, phosphorus, toxic contaminants, climate change, and hydrological variations) in terms of eutrophication. | Xiaolong Yao Yunlin Zhang Lu Zhang Yongqiang Zhou | 2018 | Journal of Environmental Sciences2018，30，4： | 6 |
| 10 | Topographic species-habitat associations of tree species in a heterogeneous tropical karst seasonal rain forest, China显示文摘Aims Tropical and subtropical karst forests of south China are under increas-ing pressure from over-exploitation causing widespread habitat degra-dation and biodiversity loss.Previous research has demonstrated that topography,as a proxy for resource availability,plays an important role in shaping tree species distributions in tropical forests.However,the association between growth stages and habitats types has not been considered in this analysis.Our aim was to examine the differences among different habitat types to determine whether tree species show similar species-habitat associations at young and mature life stages.Methods We used multivariate regression tree analysis to examined species-habitat associations among eight topographically defined habitats.The results were tested with a torus-translation test and canonical correspondence analysis(CCA)for 74 species in a 15 ha karst tropi-cal seasonal rain forest at the Nonggang National Natural Reserve in south China.We considered two life stages(young and mature)of trees species that showed a positive association with topography.Important Findings We found marked differences in community characteristics and number of associations among the eight habitats.Of the 74 species subjected to torus-translation test,63 had significant positive and 70 had significant negative associations with one or more of the eight habitats.Positive associations were more frequent in higher elevation habitats and negative associations were more frequent in lower eleva-tion habitats.This suggests that edaphic and hydrological variation related to topography play important roles in habitat partitioning in heterogeneous karst forests.For the 63 tree species with significant positive associations to at least one habitat,40 of them had the same positive association at young and mature life stages.The CCA revealed that the six topographic variables considered had consistent relation-ships with species distribution among all individuals and their two life stages.This indicates that most of the karst forest tree species show consistent associations with a single habitat throughout their life.We conclude that niche differentiation plays an important role in main-taining the diversity of this heterogeneous species-rich karst forest. | Yili Guo Bin Wang Azim U.Mallik Fuzhao Huang Wusheng Xiang Tao Ding Shujun Wen Shuhua Lu Dongxing Li Yunlin He Xiankun Li | 2017 | Journal of Plant Ecology2017，10，3： | 6 |
| 11 | Clinical characteristics and changes in living quality of patients with radiation encephalopathy induced by radiation therapy for treating nasopharyngeal carcinoma显示文摘BACKGROUND: Radiation encephalopathy (RE) caused by radiation therapy of nasopharyngeal carcinoma severely influences patients' quality of life (QOL). The factors, which influence such patients' QOL, have not been confirmed. OBJECTIVE: To observe the clinical and imageological characteristics of patients with radiation therapy of nasopharyngeal carcinoma-induced RE and the changes in QOL, and analyze QOL influencing factors. DESIGN: Retrospective case analysis. SETTING: Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS: Eighty-nine inpatients or outpatients with RE induced by radiation therapy of nasopharyngeal carcinoma admitted to Sun Yat-sen University Cancer Center and Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University from March 1994 to August 2004 were involved in this experiment. They all met the diagnosis criteria of RE from MERRITT'S neurology (10th edition). Thirty-three involved patients were randomly chosen as RE group. Another 34 concurrent inpatients or outpatients with nasopharyngeal carcinoma who received radiation therapy but without RE were chosen as control group. Informed consents of detected items were obtained from all the involved subjects. METHODS: ① Patients were evaluated when they were followed up. The World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF) was used for on-the-spot evaluation. High points of WHOQOL-BREF indicated better QOL. The Late Effects on Normal Tissues - Subjective, Objective, Management and Analytic (LENT-SOMA) scale for evaluating radiation injury was used to evaluate headache and neurologic disorder of patients with RE induced by radiation therapy of nasopharyngeal carcinoma. The evaluation was graded into 5 degrees. High degrees indicted severer clinical symptoms. ② Disease latency (i.e. time interval from symptoms and body signs appearing or radiation therapy ending to onset), initial symptoms, common symptoms, imageological characteristics, QOL and other related factors of patients were recorded. ③ Statistical management was carried out with SPSS 10.0 software. MAIN OUTCOME MEASURES: QOL and clinical characteristics of patients with RE induced by radiation therapy of nasopharyngeal carcinoma as well as QOL influencing factors. RESULTS: All the involved subjects participated in the final analysis. ① Disease latency of patients with RE ranged from 0 to 24 years, and 95% confidence interval was 0 to 15 years. There were significant differences in amount of invaded cases between 6 months after one radiation therapy and 6 months after two or more radiation therapies (χ2=36.76,P < 0.01). ② The common initial symptom of patients with RE was glossopharyngeal paralysis (33 cases, 37%). ③ The first 3 common symptoms of patients with RE were glossopharyngeal paralysis (52 cases, 58%), limb inertia and sensory disorder (25 cases, 28%) and headache (25 cases, 28%).④Imageology of patients with RE was characterized by long T1 and T2 signal shadow on magnetic resonance. ⑤Total scores of health, of daily life and of social relationship, measured with WHOQOL-BREF, of patients in RE group were significantly lower than those in the control group, respectively [(2.06±0.86)points vs. (2.59±0.66)points; (2.45±0.75)points vs. (2.91±0.75)points; (51.67±15.24) points vs. (59.22±13.03)points, P < 0.05]. Patients undergoing two or more radiation therapies were inferior to those undergoing one radiation therapy in total scores of health, and of daily life, scores of physiology, and of psychology (P < 0.05). ⑥Glossopharyngeal paralysis was negatively correlated with scores of psychology, total scores of daily life and of health in WHOQOL-BREF (P < 0.05); Head was negatively correlated with scores of psychology in WHOQOL-BREF (P < 0.05); Neurologic deficit wasnegatively correlated with scores of psychology, and total scores of health in WHOQOL-BREF (P < 0.05). CONCLUSION: ①The latency of RE of patients undergoing two or more radiation therapies is remarkably shortened, and QOL is decreased, but there is no difference in QOL between two genders. ② Brain edema is common in imageology of RE after radiation therapy. The first 3 ones of initial symptoms and common symptoms both are glossopharyngeal paralysis, neurologic deficit and headache, which greatly negatively influence QOL of patients. | Yamei Tang Yi Li Fusheng Zhang Yunlin Liu Haihong Zhou Jianhong Ye Yigang Xing | 2007 | Neural Regeneration Research2007，2，2： | 5 |
| 12 | Enhanced lakebed sediment erosion in Dongting Lake induced by the operation of the Three Gorges Reservoir显示文摘从 1951 ~ 2011 在东廷·莱克分水岭基于地调查水文学系列, lakebed 沉积 siltation/erosion (证券交易所) 的变化在三座峡水库(TGR ) 的操作以后的东廷·莱克的政体被分析。显著地积极的关联从 Zhicheng 和三个插头在流动率之间被发现(r 2=0.859, p < 0.0001 ) ,并且在流动之间,率和沉积交货在三个插头评价(r 2=0.895, p < 0.0001 ) 。这显示在三个插头的流动率和沉积交货率被流动率大部分从在上游的长江决定。在东廷·莱克盆的沉积免职数量从 +4796.4 落下 ?? | ZHOU Yongqiang LI Jingbao ZHANG Yunlin ZHANG Xinping LI Xichun | 2015 | Journal of Geographical Sciences2015，25，8： | 5 |
| 13 | Extraction and characterization of bound extracellular polymeric substances from cultured pure cyanobacterium(Microcystis wesenbergii)显示文摘Preliminary characterization of bound extracellular polymeric substances(bEPS) of cyanobacteria is crucial to obtain a better understanding of the formation mechanism of cyanobacterial bloom. However,the characterization of bEPS can be affected by extraction methods. Five sets(including the control) of bEPS from Microcystis extracted by different methods were characterized using three-dimensional excitation and emission matrix(3DEEM) fluorescence spectroscopy combined chemical spectrophotometry; and the characterization results of bEPS samples were further compared. The agents used for extraction were NaOH,pure water and phosphate buffered saline(PBS) containing cationic exchange resins,and hot water. Extraction methods affected the fluorescence signals and intensities in the bEPS. Five fluorescence peaks were observed in the excitation and emission matrix fluorescence spectra of bEPS samples. Two peaks(peaks T1 and T2) present in all extractions were identified as protein-like fluorophores,two(peaks A and C) as humic-like fluorophores,and one(peak E) as a fulvic-like substance.Among these substances,the humic-like and fulvic-like fluorescences were only seen in the bEPS extracted with hot water. Also,NaOH solution extraction could result in strong fluorescence intensities compared to the other extraction methods. It was suggested that NaOH at pH 10.0 was the most appropriate method to extract bEPS from Microcystis. In addition,dialysis could affect the yields and characteristics of extracted bEPS during the determination process. These results will help us to explore the issues of cyanobacterial blooms. | Lizhen Liu Boqiang Qin Yunlin Zhang Guangwei Zhu Guang Gao Qi Huang Xin Yao | 2014 | Journal of Environmental Sciences2014，26，8： | 5 |
| 14 | Research on Superplasticity and Superplastic Extrusion of MB26 Magnesium Alloy显示文摘The superplastic flow characteristics of hot extruded MB26 Mg alloy under the conditions of tension are studied. The effects of deformation temperature and strain rate on superplasticity are analyzed. On the other hand, the superplastic extrusion of MB26 Mg alloy is also studied. | Fuxiao CHEN Juanhua SU Yunlin YANG and Hongtao in Dept. of Material and Engineering, Luoyang institute of Technology, Luoyang 417039, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 5 |
| 15 | Isolation and characterization of glacier VMY22, a novel lytic cold-active bacteriophage of Bacillus cereus显示文摘As a unique ecological system with low temperature and low nutrient levels, glaciers are considered a 'living fossil' for the research of evolution. In this work, a lytic cold-active bacteriophage designated VMY22 against Bacillus cereus MYB41-22 was isolated from Mingyong Glacier in China, and its characteristics were studied. Electron microscopy revealed that VMY22 has an icosahedral head(59.2 nm in length, 31.9 nm in width) and a tail(43.2 nm in length). Bacteriophage VMY22 was classified as a Podoviridae with an approximate genome size of 18 to 20 kb. A one-step growth curve revealed that the latent and the burst periods were 70 and 70 min, respectively, with an average burst size of 78 bacteriophage particles per infected cell. The pH and thermal stability of bacteriophage VMY22 were also investigated. The maximum stability of the bacteriophage was observed to be at pH 8.0 and it was comparatively stable at p H 5.0–9.0. As VMY22 is a cold-active bacteriophage with low production temperature, its characterization and the relationship between MYB41-22 and Bacillus cereus bacteriophage deserve further study. | Xiuling Ji Chunjing Zhang Yuan Fang Qi Zhang Lianbing Lin Bing Tang Yunlin Wei | 2015 | Virologica Sinica2015，30，1： | 5 |
| 16 | Simultaneous Prediction of Wheat Yield and Grain Protein Content Using Multitask Deep Learning from Time-Series Proximal Sensing显示文摘Wheat yield and grain protein content(GPC)are two main optimization targets for breeding and cultivation.Remote sensing provides nondestructive and early predictions of yield and GPC,respectively.However,whether it is possible to simultaneously predict yield and GPC in one model and the accuracy and influencing factors are still unclear.In this study,we made a systematic comparison of different deep learning models in terms of data fusion,time-series feature extraction,and multitask learning.The results showed that time-series data fusion significantly improved yield and GPC prediction accuracy with R 2 values of 0.817 and 0.809. | Zhuangzhuang Sun Qing Li Shichao Jin Yunlin Song Shan Xu Xiao Wang Jian Cai Qin Zhou Yan Ge Ruinan Zhang Jingrong Zang Dong Jiang | 2022 | Plant Phenomics2022，4，1： | 4 |
| 17 | Polluted lake restoration to promote sustainability in the Yangtze River Basin,China显示文摘China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement ^([1]). However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met ^([2]). | Boqiang Qin Yunlin Zhang Jianming Deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji | 2022 | National Science Review2022，9，1： | 4 |
| 18 | Selective synthesis of triacetin from glycerol catalyzed by HZSM-5/MCM-41 micro/mesoporous molecular sieve显示文摘HZSM-5/MCM-41 molecular sieve (H-ZM) catalysts with well-defined micro/mesoporous structures were synthesized and showed high performance for selective synthesis of triacetin via the esterification reaction of glycerol with acetic acid. The conversion of glycerol was demonstrated to be 100% and the triacetin selectivity was over 91%, which can be attributed to the synergistic effect regarding suitable acidic property, excellent diffusion efficiency and good stability derived from the combined advantages of microporous molecular sieve HZSM-5 and mesoporous molecular sieve MCM-41. | Jiangyong Liu Zihao Wang Yunlin Sun Ruiqi Jian Panming jian Dan Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 3 |
| 19 | Importance and vulnerability of lakes and reservoirs supporting drinking water in China显示文摘Drinking water is closely related to human health,disease and mortality,and contaminated drinking water causes 485,000 deaths from diarrhea each year worldwide.China has been facing increasingly severe water scarcity due to both water shortages and poor water quality.Ensuring safe and clean drinking water is a great challenge and top priority,especially for China with 1.4 billion people.In China,more than 4000 centralized drinking water sources including rivers,lakes and reservoirs,and groundwater have been established to serve urban residents.However,there is little knowledge on the percentage,serving population and water quality of three centralized drinking water source types.We collected nationwide centralized drinking water sources data and serving population data covering 395 prefecture-level and county-level cities and water quality data in the two most populous provinces(Guangdong and Shandong)to examine their contribution and importance.Geographically,the drinking water source types can be classified into three clear regions exhibiting apparent differences in the respective contributions of rivers,lakes and reservoirs,and groundwater.We further found that overall,lakes and reservoirs account for 40.6%of the centralized drinking water sources vs.river(30.8%)and groundwater(28.6%)in China.Lakes and reservoirs are particularly important in the densely populated eastern region,where they are used as drinking water sources by 51.0%of the population(318 million).Moreover,the contribution to the drinking water supply from lakes and reservoirs is increasing due to their better water quality and many cross-regional water transfer projects.These results will be useful for the government to improve and optimize the establishment of centralized drinking water sources,which provide safe and clean drinking water in China to safeguard people's lives and health and realize sustainable development goals. | Yunlin Zhang Jianming Deng Boqiang Qin Guangwei Zhu Yinjun Zhang Erik Jeppesen Yindong Tong | 2023 | Fundamental Research2023，3，2： | 3 |
| 20 | Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers显示文摘Alternative splicing is a tightly regulated process that contributes to cancer development.CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several cancers.However,whether deregulated expression of CRNDE is common and which isoforms are mainly involved in cancers remain unclear.In this study,we report that CRNDE is aberrantly expressed in the majority of solid and hematopoietic malignancies.The investigation of CRNDE expression in normal samples revealed that CRNDE was expressed in a tissue- and cell-specific manner.Further comparison of CRNDE expression in 2938 patient samples from 15 solid and hematopoietic tumors showed that CRNDE was significantly overexpressed in 11 malignancies,including 3 reported and 8 unreported,and also implicated that the overexpressed isoforms differed in various cancer types.Furthermore,anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and primary samples,and even had different impacts on the expression of CRNDE isoforms.Finally,experimental profiles of 12 alternatively spliced isoforms demonstrated that the spliced variant CRNDE-g was the most highly expressed isoform in multiple cancer types.Collectively,our results emphasize the cancer-associated feature of CRNDE and its spliced isoforms,and may provide promising targets for cancer diagnosis and therapy. | Xuefei Ma Wei Zhang Rong Zhang Jingming Li Shufen Li Yunlin Ma Wen Jin Kankan Wang | 2019 | Frontiers of Medicine2019，13，3： | 3 |
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