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| 1 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 2 | Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy显示文摘An essential concept of cancer immunotherapy is that immunogenic cell death(ICD),characterized by the release of tumor-associated antigens(TAAs)and tumor-specific antigens(TSAs)like neoantigens,danger-associated molecular patterns(DAMPs),and pro-inflammatory cytokines,facilitates the presentation of TAAs and TSAs to adaptive immune cells,eliciting an emerging or reinstating a pre-existing anti-cancer immune response. | Yajie Sun Xiangru Feng Chao Wan Jonathan F.Lovell Honglin Jin Jianxun Ding | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 5 |
| 3 | Photooxidation of arsenic(Ⅲ) to arsenic(Ⅴ) on the surface of kaolinite clay显示文摘As one of the most toxic heavy metals, the oxidation of inorganic arsenic has drawn great attention among environmental scientists. However, little has been reported on the solar photochemical behavior of arsenic species on top-soil. In the present work, the influencing factors(p H, relative humidity(RH), humic acid(HA), trisodium citrate, and additional iron ions) and the contributions of reactive oxygen species(ROS, mainly HOUand HO2U/O2U-) to photooxidation of As(Ⅲ) to As(Ⅴ) on kaolinite surfaces under UV irradiation(λ = 365 nm)were investigated. Results showed that lower p H facilitated photooxidation, and the photooxidation efficiency increased with the increase of RH and trisodium citrate.Promotion or inhibition of As(Ⅲ) photooxidation by HA was observed at low or high dosages, respectively. Additional iron ions greatly promoted the photooxidation, but excessive amounts of Fe2+competed with As(Ⅲ) for oxidation by ROS. Experiments on scavengers indicated that the HOUradical was the predominant oxidant in this system.Experiments on actual soil surfaces proved the occurrence of As(Ⅲ) photooxidation in real topsoil. This work demonstrates that the photooxidation process of As(Ⅲ) on the soil surface should be taken into account when studying the fate of arsenic in natural soil newly polluted with acidic wastewater containing As(Ⅲ). | Wei Ding Yajie Wang Yingtan Yu Xiangzhi Zhang Jinjun Li Feng Wu | 2015 | Journal of Environmental Sciences2015，27，10： | 4 |
| 4 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 5 | Fabrication of flexible AlGaInP LED显示文摘Flexible light-emitting diodes(LEDs)are highly desired for wearable devices,flexible displays,robotics,biomedicine,etc.Traditionally,the transfer process of an ultrathin wafer of about 10–30μm to a flexible substrate is utilized.However,the yield is low,and it is not applicable to thick GaN LED chips with a 100μm sapphire substrate.In this paper,transferable LED chips utilized the mature LED manufacture technique are developed,which possesses the advantage of high yield.The flexible LED array demonstrates good electrical and optical performance. | Qiaoli Liu Yajie Feng Huijun Tian Xiaoying He Anqi Hu Xia Guo | 2020 | Journal of Semiconductors2020，41，3： | 2 |
| 6 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 7 | Photooxidation of arsenite by natural goethite in suspended solution显示文摘 | Yajie Wang Jing Xu Yan Zhao Lin Zhang Mei Xiao Feng Wu | 2013 | Environmental Science and Pollution Research2013，，1： | 1 |
| 8 | Active shim coils design for Halbach magnet based on inverse boundary element method显示文摘With advantages of small volume,high field strength,and compact stray field,the Halbach array magnet is of great potential in desktop NMR applications.However,field inhomogeneity poses a main obstacle to its applications.Active shimming is necessary for improving the field homogeneity.An active shim coil design method for cylindrical Halbach magnet based on inverse boundary element method(iBEM)is introduced in this work.Shim coils targeting 1st~3rd and Z4/Z5/Z6 spherical harmonic(SH)terms were designed with constraints of field accuracy,resistance,inductance,and current density.Wire loops and symmetric property influence were discussed to further improve the performance of high-order shim coils.Finally,with the prototype of the shim coils constructed,field pattern and SH transformation proved that the coils designed could fit the target SH distribution,though contamination from low-order components existed in highorder terms.A practical shimming experiment on the Halbach magnet has improved the homogeneity from 40.3 ppm to 3.8 ppm in radius 2.5 mm,height 5 mm cylindrical sample space,verifying the coils'compensation ability.This work provides a flexible inverse coil design method for cylindrical Halbach magnet and discusses the high-order shim coil design and implementation,which is potential in nuclear magnetic resonance applications based on Halbach magnet arrays. | Yajie Xu Feng Wang Ya Wang Peng Yu Jingzhong Zhang Xiaodong Yang | 2022 | Magnetic Resonance Letters2022，2，3： | 1 |
| 9 | Morphology and mechanical properties of polypropylene/calcium carbonate nanocomposites 显示文摘 | Yang Kun Yang Qi Li Guangxian Sun Yajie Feng Decai | 2006 | Materials Letters2006，60，6： | 1 |
| 10 | Molecular cloning, functional analysis and localization of a novel gene encoding polygalacturonase-inhibiting protein in Chorispora bungeana显示文摘 | Cuixia Di Ming Li Feng Long Muqun Bai Yajie liu Xiaolin Zheng Shijian Xu Yun Xiang Zhenglong Sun Lizhe An | 2009 | Planta2009，，1： | 1 |
| 11 | Phosphate modified carbon nanotubes for oxidative dehydrogenation of n-butane显示文摘Catalytic performance of phosphate-modified carbon nanotube(PoCNT) catalysts for oxidative dehydrogenation(ODH) of n-butane has been systematically investigated. The Po CNT catalysts are characterized by SEM, TEM, XPS and TG techniques. We set the products selectivity as a function of butane conversion over various phosphate loading, and it is found that the PoCNT catalyst with the 0.8% phosphate weight loading(0.8PoCNT) exhibits the best catalytic performance. When the phosphate loading is higher than 0.8 wt%, the difference of catalytic activity among the PoCNT catalysts is neglectable. Consequently, the ODH of n-butane over the 0.8PoCNT catalyst is particularly discussed via changing the reaction conditions including reaction temperatures, residence time and n-butane/O_2 ratios. The interacting mechanism of phosphate with the oxygen functional groups on the CNT surface is also proposed. | Yajie Zhang Rui Huang Zhenbao Feng Hongyang Liu Chunfeng Shi Junfeng Rong Baoning Zong Dangsheng Su | 2016 | Journal of Energy Chemistry2016，25，3： | 1 |
| 12 | Porous organic polymers: a progress report in China显示文摘Porous organic polymers(POPs) are porous materials composed of light elements such as C, H, N, and O. The benign characters,including large surface area, good physical and chemical stability, well-defined chemical composition, wide ranges of monomer selection, and strong designability, have made POPs one of the frontiers in materials research. In this review, we discussed the design and synthesis of various POP materials that mainly led by Chinese scientists, including conjugated microporous polymers(CMPs), porous aromatic frameworks(PAFs), and hypercrosslinked porous polymers(HCPs), as well as crystalline POPs comprised of covalent organic frameworks(COFs) and a special class of COFs with triazine rings, covalent triazine frameworks(CTFs), and supramolecular organic frameworks(SOFs), and sorted out their main applications in adsorption, separation,catalysis, and electrochemistry fields. | Qing Hao You Tao Xuesong Ding Yajie Yang Jie Feng Rui-Lei Wang Xue-Ming Chen Guan-Le Chen Xiaomeng Li Huang OuYang XunLiang Hu Jia Tian Bao-Hang Han Guangshan Zhu Wei Wang Fan Zhang Bien Tan Zhan-Ting Li Dong Wang Li-Jun Wan | 2023 | Science China Chemistry2023，66，3： | 0 |
| 13 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 14 | Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)显示文摘Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied selectivity.Herein,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards methanation.Theoretical calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher selectivity.Our work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future. | Jiazhi Meng Kaiwen Wang Yang Wang Jiangping Ma Chaogang Ban Yajie Feng Bin Zhang Kai Zhou Liyong Gan Guang Han Danmei Yu Xiaoyuan Zhou | 2024 | Nano Research2024，17，3： | 0 |
| 15 | Three-dimensional boron nitride network/polyvinyl alcohol composite hydrogel with solid-liquid interpenetrating heat conduction network for thermal management显示文摘Polyvinyl alcohol hydrogels have been used in wearable devices due to their good flexibility and biocompatibility.However,due to the low thermal conductivity(κ)of pure hydrogel,its further application in high power devices is limited.To solve this problem,melamine sponge(MS)was used as the skeleton to wrap boron nitride nanosheets(BNNS)through repeated layering assembly,successfully preparing a three-dimensional(3D)boron nitride network(BNNS@MS),and PVA hydrogels were formed in the pores of the network.Due to the existence of the continuous phonon conduction network,the BNNS@MS/PVA exhibited an improvedκ.When the content of BNNS is about 6 wt.%,κof the hydrogel was increased to 1.12 W m^(-1)K^(-1),about two times higher than that of pure hydrogel.The solid heat conduction network and liquid convection network cooperate to achieve good thermal management ability.Combined with its high specific heat capacity,the composites have an important application prospect in the field of wearable flexible electronic thermal management. | Mengmeng Qin Yajie Huo Guoying Han Junwei Yue Xueying Zhou Yiyu Feng Wei Feng | 2022 | Journal of Materials Science & Technology2022，，32： | 0 |
| 16 | Pepper variome reveals the history and key loci associated with fruit domestication and diversification显示文摘Pepper(Capsicum spp.)is an important vegetable crop that provides a unique pungent sensation when eaten.Through construction of a pepper variome map,we examined the main groups that emerged during domestication and breeding of C.annuum,their relationships and temporal succession,and the molecular events underlying the main transitions.The results showed that the initial differentiation in fruit shape and pungency,increase in fruit weight,and transition from erect to pendent fruits,as well as the recent appearance of large,blocky,sweet fruits(bell peppers),were accompanied by strong selection/fixation of key alleles and introgressions in two large genomic regions.Furthermore,we identified Up,which encodes a BIG GRAIN protein involved in auxin transport,as a key domestication gene that controls erect vs pendent fruit orientation.The up mutation gained increased expression especially in the fruit pedicel through a 579-bp sequence deletion in its 5′upstream region,resulting in the phenotype of pendent fruit.The function of Up was confirmed by virus-induced gene silencing.Taken together,these findings constitute a cornerstone for understanding the domestication and differentiation of a key horticultural crop. | Yacong Cao Kang Zhang Hailong Yu Shumin Chen Donghui Xu Hong Zhao Zhenghai Zhang Yinqing Yang Xiaozhen Gu Xinyan Liu Haiping Wang Yaxin Jing Yajie Mei Xiang Wang Véronique Lefebvre Weili Zhang Yuan Jin Dongliang An Risheng Wang Paul Bosland Xixiang Li IIan Paran Baoxi Zhang Giovanni Giuliano Lihao Wang Feng Cheng | 2022 | Molecular Plant2022，15，11： | 0 |
| 17 | Efficacy of luteolin on the human gastric cancer cell line MKN45 and underlying mechanism显示文摘OBJECTIVE:To investigate the antitumour efficacy of luteolin on gastric cancer(GC)and study the mechanism underpinning the action.METHODS:Effects of luteolin on cell growth inhibition,apoptosis,and cell cycle arrest in MKN45 cells were investigated using the cell counting kit-8 assay.Changes in the mitochondrial membrane potential after luteolin treatment were assessed using 5,5′,6,6’-tetra-chloro-1,1’,3,3’-tetraethy lbenzimidazolcar bocyanineiodi-de(JC-1)staining.To investigate whether apoptotic effect by luteolin is related to the phosphoinositide 3-kinase/v-akt murine thymoma viral oncogene(PI3K/Akt)pathway,cells were additionally treated with LY294002,a PI3K/Akt pathway inhibitor.Moreover,the expressions of apoptosis-related proteins,namely B-cell lymphoma 2(Bcl-2),Bcl-2 associated X protein(Bax),Akt,p-Akt,caspase-3,and cytochrome C,were detected after luteolin treatment.RESULTS:The study revealed that in MKN45 cells,luteolin could inhibit the cell proliferation in a time-and dose-dependent manner;block the cell cycle in the Sphase;induce apoptosis;reduce the mitochondrial membrane potential;increase the expression of Bax,caspase-3,and cytochrome C;and decrease the expression of Bcl-2 and p-Akt.Luteolin might be involved in the PI3K/Akt signalling pathway,indicating that this pathway could be a therapeutic target for GC treatment.CONCLUSION:Luteolin could inhibit the proliferation of GC cells and block the cell cycle in the S-phase.The mechanism of inducing apoptosis in these cells was related to the PI3K/Akt signalling pathway. | DING Yajie LIU Feng LI Zhaoyan Xu Yan CAO Nida ZHANG Guangao WANG Rui ZHAO Aiguang | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 18 | Computational fluid dynamics-discrete element method simulation of stirred tank reactor for graphene production显示文摘Liquid phase exfoliation(LPE)process for graphene production is usually carried out in stirred tank reactor and the interactions between the solvent and the graphite particles are important as to improve the production efficiency.In this paper,these interactions were revealed by computational fluid dynamics–discrete element method(CFD-DEM)method.Based on simulation results,both liquid phase flow hydrodynamics and particle motion behavior have been analyzed,which gave the general information of the multiphase flow behavior inside the stirred tank reactor as to graphene production.By calculating the threshold at the beginning of graphite exfoliation process,the shear force from the slip velocity was determined as the active force.These results can support the optimization of the graphene production process. | Shuaishuai Zhou Jing Li Kaixiang Pang Chunxi Lu Feng Zhu Congzhen Qiao Yajie Tian Jingwei Zhang | 2023 | Chinese Journal of Chemical Engineering2023，64，12： | 0 |
| 19 | The levels of osteopontin in human milk of Chinese mothers and its associations with maternal body composition显示文摘Objective:This study explored the content and change trend of osteopontin(OPN)in breast milk and analyzed the relationship between OPN in breast milk and maternal body composition.Methods:Breast-feeding mothers were recruited in Xinhua Hospital to collect breast milk and provide pertinent information.The content of OPN in breast milk was determined by enzyme-linked immunosorbent assay(ELISA).Determination of protein content in human milk was performed via the BCA method.The maternal body composition was determined by the bioelectrical impedance method.Serum glucocorticoid receptorα,adiponectin,insulin,and leptin were determined by ELISA.SPSS 25 was used for statistical analysis.Results:In the longitudinal cohort,106 mothers provided 318 milk samples at different lactation periods.The results indicate that the OPN showed dynamic changes.OPN levels were(343.2±163.5)mg/L during 1-14 days postpartum,(228.4±121.5)mg/L during 2-4 months postpartum,and(204.8±100.6)mg/L during 5-7 months postpartum.The content of OPN was very high in the first 1-14 days postpartum and then decreased.Compared with early postpartum milk,the OPN content of mature milk showed a significant relationship with maternal weight-related parameters.Additional body composition analysis was performed in 88 women at the mature milk phase.The results show that the OPN in milk is related to the mother’s body composition,especially the content of skeletal muscle mass,but not to relevant humoral factors.Conclusions:The levels of OPN in human milk of Chinese mothers showed dynamic changes with the extension of lactation time.The OPN in human milk was related to the mother’s body composition but not related to related humoral factors. | Huijuan Ruan Qingya Tang Xuan Zhao Yajie Zhang Xuelin Zhao Yi Xiang Wei Geng Yi Feng Wei Cai | 2022 | Food Science and Human Wellness2022，11，5： | 0 |
| 20 | Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo显示文摘Cell transplantation is an effective strategy to improve the repair effect of nerve guide conduits(NGCs).However,problems such as low loading efficiency and cell anoikis undermine the outcomes.Microcarriers are efficient 3D cell culture scaffolds,which can also prevent cell anoikis by providing substrate for adhesion during transplantation.Here,we demonstrate for the first time microcarrier-based cell transplantation in peripheral nerve repair.We first prepared macroporous chitosan microcarriers(CSMCs)by the emulsion-phase separation method,and then decorated the CSMCs with polylysine(pl-CSMCs)to improve cell affinity.We then loaded the pl-CSMCs with adipose-derived stem cells(ADSCs)and injected them into electrospun polycaprolactone/chitosan NGCs to repair rat sciatic nerve defects.The ADSCs-laden pl-CSMCs effectively improved nerve regeneration as demonstrated by evaluation of histology,motor function recovery,electrophysiology,and gastrocnemius recovery.With efficient cell transplantation,convenient operation,and the multiple merits of ADSCs,the ADSCs-laden pl-CSMCs hold good potential in peripheral nerve repair. | Yi Sun Xiaoqi Chi Haoye Meng Mengjiao Ma Jing Wang Zhaoxuan Feng Qi Quan Guodong Liu Yansen Wang Yajie Xie Yudong Zheng Jiang Peng | 2021 | Bioactive Materials2021，6，11： | 0 |
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