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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 3 | Nutrient Release from Weathering of Purplish Rocks in the Sichuan Basin,China显示文摘Purplish soils having high fertility with mineral nutrients inherited from the parent rock are widely distributed in the hills along the Yangtze River,especially in the Sichuan Basin.Pot and field weathering experiments were conducted to mimic rock weathering and nutrient release processes in order to better understand soil fertility and nutrient compensation. Three types of purplish rock formations formed in the Jurassic period,Shaximiao(J_2s),Suining(J_3s),and Penglaizhen (J_3p),as well as one type formed in the Cretaceous period,the Chengqiangyan group(K_1c),were used in this study. Results showed that the soil formation rate was in the range from 11.2 to 19.6 mm every year,and rock weathering was in the order of J_3s>J_3p>J_2s>K_1c.Because more rock surface was exposed to sunlight and rainfall in field conditions,pot weathering was slower than field weathering.Nutrient release rates increased with rock weathering and was in the order similar to that of rock weathering:J_3p>J_3s>J_2s>K_1c.Potassium release was the most important in all rocks;after 2 years of weathering,19.4% to 46.9% of K was released from the initial parent rocks,which suggested that K release from weathering could meet most of the crop K requirement in purplish soils.Thus,rapid release of nutrients from weathering of purplish rocks was key to nutrient replenishment and fertility of purplish soils. | ZHU Bo WANG Tao YOU Xiang GAO Mei-Rong | 2008 | Pedosphere2008，18，2： | 16 |
| 4 | Does Early Postsurgical Temozolomide Plus Concomitant Radiochemotherapy Regimen Have Any Benefit in Newly-diagnosed Glioblastoma Patients? A Multi-center, Randomized, Parallel, Open-label, Phase II Clinical Trial显示文摘 | Ying Mao Yu Yao Li-Wei Zhang Yi-Cheng Lu Zhong-Ping Chen Jian-Min Zhang Song-Tao Qi Chao You Ren-Zhi Wang Shu-Yuan Yang Xiang Zhang Ji-Sheng Wang Ju-Xiang Chen Qun-Ying Yang Hong Shen Zhi-Yong Li Xiang Wang Wen-Bin Ma Xue-Jun Yang Hai-Ning Zhen Liang-Fu Zhou | 2015 | Chinese Medical Journal2015，，20： | 15 |
| 5 | A new type of leak-floor flip bucket显示文摘Flip buckets are commonly used to discharge flow away from a hydraulic structure into the downstream to dissipate energy.A new leak-floor flip bucket is presented,making the ski-jump water jet a typical long-narrow nappe.Based on the model experiments and numerical simulation,the flow pattern,formation process and mechanism of the leak-floor flip bucket are studied.The results show that cross section flow shape develops from the'Y-type'to'|-type',and this is because the natural pressure difference is generated when water flows through the leak-floor area and moves transversely from both sides to the center.Different from the slit-type flip bucket with sidewall contraction,the leak-floor flit bucket makes the water jet narrow and long without high pressure on the side walls of the flip bucket.Under the same jet length condition,the maximum sidewall pressure of the slit-type is 4.67 times that of the leak-floor flip bucket.The effects of flow discharge on the jet length are less significant for the leak-floor bucket than for the slit-type bucket. | DENG Jun YANG ZhengLi TIAN Zhong ZHANG FaXing WEI WangRu YOU Xiang XU WeiLin | 2016 | Science China(Technological Sciences)2016，59，4： | 15 |
| 6 | Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury显示文摘Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography(a EEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with a EEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. a EEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, a EEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury. | Wendong You Qilin Tang Xiang Wu Junfeng Feng Qing Mao Guoyi Gao Jiyao Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 15 |
| 7 | Antiviral therapy for hepatitis B virus-related hepatocellular carcinoma after radical hepatectomy显示文摘Objective:To assess the effect of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)after radical hepatectomy.Methods:A total of 478 HBV-related HCC patients treated by radical hepatectomy were retrospectively collected.Patients in the treatment group(n=141)received postoperative lamivudine treatment(100 mg/d),whereas patients in the control group(n=337)did not.Recurrence-free survival(RFS)rates,overall survival(OS)rates,treatments for recurrent HCC and cause of death were compared between the two groups.Propensity score matching(PSM)analysis was also conducted to reduce confounding bias between the two groups.Results:The 1-,3-,and 5-year RFS rates didn't significantly differ between the two groups(P=0.778);however,the 1-,3-,and 5-year OS rates in the treatment group were significantly higher than those in the control group(P=0.002).Similar results were observed in the matched data.Subgroup analysis showed that antiviral treatment conferred a significant survival benefit for Barcelona Clinical Liver Cancer stage A/B patients.Following HCC recurrence,more people in the treatment group were able to choose curative treatments than those in the control group(P=0.031).For cause of death,fewer people in the treatment group died of liver failure than those in the control group(P=0.041).Conclusion:Postoperative antiviral therapy increases chances of receiving curative treatments for recurrent HCC and prevents death because of liver failure,thereby significantly prolonging OS,especially in early-or intermedian-stage tumors. | Yang Ke Liang Ma Xue-Mei You Sheng-Xin Huang Yong-Rong Liang Bang-De Xiang Le-Qun Li | 2013 | Cancer Biology & Medicine2013，10，3： | 11 |
| 8 | Hierarchical Magnetic Network Constructed by CoFe Nanoparticles Suspended Within “Tubes on Rods” Matrix Toward Enhanced Microwave Absorption显示文摘Hierarchical magnetic-dielectric composites are promising functional materials with prospective applications in microwave absorption(MA)field.Herein,a three-dimension hierarchical“nanotubes on microrods,”core–shell magnetic metal–carbon composite is rationally constructed for the first time via a fast metal–organic frameworksbased ligand exchange strategy followed by a carbonization treatment with melamine.Abundant magnetic CoFe nanoparticles are embedded within one-dimensional graphitized carbon/carbon nanotubes supported on micro-scale Mo2N rod(Mo2N@CoFe@C/CNT),constructing a special multi-dimension hierarchical MA material.Ligand exchange reaction is found to determine the formation of hierarchical magnetic-dielectric composite,which is assembled by dielectric Mo2N as core and spatially dispersed CoFe nanoparticles within C/CNTs as shell.Mo2N@CoFe@C/CNT composites exhibit superior MA performance with maximum reflection loss of−53.5 dB at 2 mm thickness and show a broad effective absorption bandwidth of 5.0 GHz.The Mo2N@CoFe@C/CNT composites hold the following advantages:(1)hierarchical core–shell structure offers plentiful of heterojunction interfaces and triggers interfacial polarization,(2)unique electronic migration/hop paths in the graphitized C/CNTs and Mo2N rod facilitate conductive loss,(3)highly dispersed magnetic CoFe nanoparticles within“tubes on rods”matrix build multi-scale magnetic coupling network and reinforce magnetic response capability,confirmed by the off-axis electron holography. | Chunyang Xu Lei Wang Xiao Li Xiang Qian Zhengchen Wu Wenbin You Ke Pei Gang Qin Qingwen Zeng Ziqi Yang Chen Jin Renchao Che | 2021 | Nano-Micro Letters2021，13，3： | 10 |
| 9 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 10 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 11 | Rainfall and Tillage Impacts on Soil Erosion of Sloping Cropland with Subtropical Monsoon Climate- A Case Study in Hilly Purple Soil area, China显示文摘Under global warming, storm events tend to intensify, particularly in monsoon-affected regions.As an important agricultural area in China, the purple soil region in the Sichuan Basin, where it has a prevailing monsoon climate, is threatened by serious soil erosion. Tillage operations alter runoff and soil erosion processes on croplands by changing the physical properties of the soil surface. To clarify the relationship between tillage and soil erosion in the purple soil region, three different tillage practices in this region were investigated at the plot scale over 4 years: bare land with minimum tillage(BL),conventional tillage(CT) and seasonal no-tillage ridges(SNTR) which was initially designed to prevent soil erosion by contoured ridges and no-tillage techniques. The results showed that although there were no significant differences in the surface runoff and soil erosion among the three practices, BL causedrelatively high surface runoff and soil erosion,followed by CT and SNTR. Classification and comparison of the rainfall events based on cluster analysis(CA) verified that the surface runoff was not significantly different between most intensive event and long intensive events but was significantly different between most intensive and short and medium-duration events. Only the rainfall events with the highest rainfall intensity could trigger serious soil erosion, up to 1000 kg ha-1 in the region. Further detailed investigations on the effects of tillage operations on the soil erosion in a subtropical region with a monsoon climate are needed to provide a basis for modeling catchments and designing better management practices. | TANG Jia-liang CHENG Xun-qiang ZHU Bo GAO Mei-rong WANG Tao ZHANG Xi-feng ZHAO Pei YOU Xiang | 2015 | Journal of Mountain Science2015，12，1： | 9 |
| 12 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 13 | Tunable and multichannel terahertz perfect absorber due to Tamm surface plasmons with graphene显示文摘In this paper, we have shown that perfect absorption at terahertz frequencies can be achieved by using a composite structure where graphene is coated on one-dimensional photonic crystal(1 DPC) separated by a dielectric. Due to the excitation of optical Tamm states(OTSs) at the interface between the graphene and 1 DPC, a strong absorption phenomenon occurs induced by the coupling of the incident light and OTSs. Although the perfect absorption produced by a metal–distributed Bragg reflector structure has been researched extensively, it is generally at a fixed frequency and not tunable. Here, we show that the perfect absorption at terahertz frequency not only can be tuned to different frequencies but also exhibits a high absorption over a wide angle range. In addition,the absorption of the proposed structure is insensitive to the polarization, and multichannel absorption can berealized by controlling the thickness of the top layer. | XI WANG XING JIANG QI YOU JUN GUO XIAOYU DAI YUANJIANG XIANG | 2017 | Photonics Research2017，5，6： | 7 |
| 14 | Poly(C)-binding protein 1 (PCBP1) mediates housekeeping :legradation of mitochondrial antiviral signaling (MAVS)显示文摘Mitochondrial (MAVS ) 抗病毒的发信号是在细胞的抗病毒的天生的免疫的一个关键适配器。我们以前 poly 识别了(C) 绑定蛋白质 2 (PCBP2 ) 作为那便于的 MAVS 的一个反馈禁止者,它在病毒的感染以后的降级,而是很少对规章的潜力被知道 poly (C) 绑定蛋白质 1 (PCBP1 ) ,它高度类似于 PCBP2。这里,我们报导 PCBP1 调停用象 PCBP2 的一样的机制的 MAVS 的家务降级采用。PCBP1 的 Overexpression PCBP1 损害调停 MAVS 的抗病毒的回答,当击倒时施加相反的效果。抑制由于导致 PCBP1 的 MAVS 降级。我们观察到在 MAVS 抑制的那个 PCBP1 和 PCBP2 表演协同作用,而是他们的表示模式是不同的:PCBP1 稳定地并且富有地被表示,当 PCBP2 在感染以后与快速的正式就职显示出低基础表示时。击倒的个人和 subcellular 分别分析表明不同于 postinfection 禁止者 PCBP2, PCBP1 连续地消除细胞的 MAVS。我们的调查结果解开在为调整抗病毒的免疫并且阻止发炎调整 MAVS 的 PCBP1 的一个关键角色。 | Xiang Zhou Fuping You Huihui Chen Zhengfan Jiang | 2012 | Cell Research2012，22，4： | 6 |
| 15 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 16 | Recent advances of capillary electrophoresis-mass spectrometry instrumentation and methodology显示文摘Capillary electrophoresis-mass spectrometry(CE-MS) is a powerful separation and analytical technique in the field of analytical chemistry. This review provides an update of instrumentation developments in the methodology of CE-MS systems. A selection of relevant articles covers the literatures published from Jan. 2013 to Feb. 2017. Special attentions were paid to the sample injection and ionization processes.Applications of these CE-MS systems were also introduced through representative examples. General conclusions and perspectives were given at the last. | You Jiang Mu-Yi He Wen-Jing Zhang Pan Luo Dan Guo Xiang Fang Wei Xu | 2017 | Chinese Chemical Letters2017，28，8： | 5 |
| 17 | A New Antimicrobial Flavonol Glycoside from Alchornea davidii显示文摘A new flavonol glycoside, isorhamnetin-3-O-b-D-xyloside, was isolated from the extract of leaves and twigs of Alchornea davidii (Euphorbiaceae). Its structure was established on the basis of the spectral analysis and chemical degradation. Antimicrobial assay showed that it moderately inhibited the growth of test bacteria (Staphylococcus aureus, Bacillus subtilis and Pseudomonas fluorescens) and fungi (Candida albicans, Aspergillus niger and Trichophyton rubrum) with MICs at 50 g/mL. | Gui You CUI, Jun Yan LIU, Ren Xiang TAN* Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210093 | 2003 | Chinese Chemical Letters2003，14，2： | 5 |
| 18 | Current progress in metabolomics of gestational diabetes mellitus显示文摘Gestational diabetes mellitus(GDM)is one of the most common metabolic disorders of pregnancy and can cause short-and long-term adverse effects in both pregnant women and their offspring.However,the etiology and pathogenesis of GDM are still unclear.As a metabolic disease,GDM is well suited to metabolomics study,which can monitor the changes in small molecular metabolites induced by maternal stimuli or perturbations in real time.The application of metabolomics in GDM can be used to discover diagnostic biomarkers,evaluate the prognosis of the disease,guide the application of diet or drugs,evaluate the curative effect,and explore the mechanism.This review provides comprehensive documentation of metabolomics research methods and techniques as well as the current progress in GDM research.We anticipate that the review will contribute to identifying gaps in the current knowledge or metabolomics technology,provide evidence-based information,and inform future research directions in GDM. | Qian-Yi Wang Liang-Hui You Lan-Lan Xiang Yi-Tian Zhu Yu Zeng | 2021 | World Journal of Diabetes2021，12，8： | 4 |
| 19 | Optimal subreflector position determination of shaped dual-reflector antennas based on the parameters iteration approach显示文摘A new method based on the parameters iteration technique has been developed to determine the optimal subreflector position for shaped Cassegrain antennas, that are distorted by gravity, to improve their electromagnetic(EM) performance. Both the features of shaped surface and the relationship between optical path difference(OPD) and far field beam pattern are employed. By describing the shaped dualreflector surface as a standard discrete parabola set, we can utilize the optical features of the standard Cassegrain system in the classical OPD relationship. Then, the actual far field beam pattern is expressed as the synthesis of ideal beam and error beam by decomposing subreflector adjustment parameters using a mechanical-electromagnetic-field-coupling-model(MEFCM). Furthermore, a numerical method for determining optimal subreflector position is presented. The proposed method is based on the iteration technique of subreflector adjustment parameters, and the optimal far field pattern is used for the iteration. The numerical solution of optimal adjustment parameters can be obtained rapidly. Results for a 25 m shaped Cassegrain antenna demonstrate that the adjustment of the subreflector to the optimal position as determined by the proposed method can improve the EM performance effectively. | Bin-Bin Xiang Cong-Si Wang Pei-Yuan Lian Na Wang You Ban | 2019 | Research in Astronomy and Astrophysics2019，19，4： | 4 |
| 20 | Two novel gastric cancer-associated genes identified by differential display显示文摘TwonovelgastriccancerassociatedgenesidentifiedbydiferentialdisplayYOUHan,XIAOBing,CUIDaXiang,SHIYongQuanandFANDaiMingSubj... | YOU Han, XIAO Bing, CUI DaXiang, SHI YongQuan and FAN DaiMingKeywords stomach neoplasms gene clone nucleotides sequence analysis in situ hybridization polymerase chain reaction RNA, messenger | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
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