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| 1 | The implementation of an improved NPML absorbing boundary condition in elastic wave modeling显示文摘在向前当模特儿的有弹性的波浪,吸收边界条件(ABC ) 被用来从模型截断边界减轻不希望得到的思考。完美地匹配的层(PML ) 证明了是最好的可得到的 ABC。然而,传统的切开 PML (SPML ) ABC 有一些严肃的劣势:例如,全球 SPML ABC 要求更多计算记忆,尽管实现是容易的。本地 SPML ABC 的实现也有一些困难,自从边和角落必须被考虑。因为卷绕旋转,传统的非切开的完美地匹配的层(NPML ) ABC 有复杂计算。在这篇论文,基于 ABC 与复杂转移频率的拉长函数(CFS ) 相结合的非切开的完美地匹配的层(NPML ) ,我们为与简单计算方程,小存储器要求,和容易的编程吸收边界条件的 PML 介绍一个新奇数字实现方法。 | Qin Zhen Lu Minghui Zheng Xiaodong Yao Yao Zhang Cai Song Jianyong | 2009 | Applied Geophysics2009，6，2： | 21 |
| 2 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 3 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 4 | Periodic and chaotic dynamics of composite laminated piezoelectric rectangular plate with one-to-two internal resonance显示文摘The bifurcations and chaotic dynamics of a simply supported symmetric cross-ply composite lami- nated piezoelectric rectangular plate are studied for the first time, which are simultaneously forced by the transverse, in-plane excitations and the excitation loaded by piezoelectric layers. Based on the Reddy’s third-order shear deformation plate theory, the nonlinear governing equations of motion for the composite laminated piezoelectric rectangular plate are derived by using the Hamilton’s principle. The Galerkin’s approach is used to discretize partial differential governing equations to a two-degree- of-freedom nonlinear system under combined the parametric and external excitations. The method of multiple scales is employed to obtain the four-dimensional averaged equation. Numerical method is utilized to find the periodic and chaotic responses of the composite laminated piezoelectric rectangular plate. The numerical results indicate the existence of the periodic and chaotic responses in the aver- aged equation. The influence of the transverse, in-plane and piezoelectric excitations on the bifurca- tions and chaotic behaviors of the composite laminated piezoelectric rectangular plate is investigated numerically. | ZHANG Wei YAO ZhiGang YAO MingHui | 2009 | Science China(Technological Sciences)2009，52，3： | 11 |
| 5 | A review of oxygen reduction mechanisms for metal-free carbon-based electrocatalysts显示文摘The sluggish kinetics of Oxygen Reduction Reaction(ORR)at the cathode in proton exchange membrane fuel cells or metal-air batteries requires highly effective and stable electrocatalysts to boost the reaction.The low abundance and high price of Pt-based electrocatalysts hamper the widespread application of proton exchange membrane fuel cells and metal-air batteries.As promising alternatives,metal-free carbon materials,especially upon doping heteroatoms or creating defects demonstrated excellent ORR activity,which is as efficient as or even superior to commercial platinum on carbon.Significant progress on the development of advanced carbon materials as highly stable and durable catalysts has been achieved,but the catalytic mechanisms of these materials still remain undistinguished.In present review,we summarized the up-to-date progress in the studies of carbon materials,and emphasized on the combination of experiment and theory to clarify the underlying mechanisms of these materials.At last,we proposed the perspectives on the proper strategies of elucidating the mechanisms of carbon materials as electrocatalysts towards ORR. | Ruguang Ma Gaoxin Lin Yao Zhou Qian Liu Tao Zhang Guangcun Shan Minghui Yang Jiacheng Wang | 2019 | npj Computational Materials2019，，1： | 9 |
| 6 | Mett13-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells显示文摘 | QiJason Yao Lina Sang Minghui Lin Xiujuan Yin Wenjie Dong Yuping Gong Bo O. Zhou | 2018 | Cell Research2018，28，9： | 8 |
| 7 | Study on power generations and dynamic responses of the bistable straight beam and the bistable L-shaped beam显示文摘In this paper, a simplified model of the bistable piezoelectric cantilever beam with magnets is established, and the potential energy of the bistable system is analyzed. We have proposed the bistable L-shaped beam structure, which has the same geometry dimensions of the bistable straight beam in the first time. The comparative study on power generations and dynamic responses of the bistable straight beam and the bistable L-shaped beam plays an important role in exploring excellent piezoelectric generator.The experiment structure includes the base layer and the piezoelectric layer. The harmonic excitation is given to the system.Theoretical analysis results show that the potential energy function of the system has two obvious steady potential wells. In addition, the depth of the upper potential well is different from that of the lower potential well when the gravity potential energy is considered. Experimental results demonstrate that the power generation for the straight beam is better than that of the horizontally placed L-shaped beam when the excitation amplitude is 450 m V. There is the existence that the energy harvesting capacity of the bistable L-shaped beam is better than that of the bistable straight beam when the excitation amplitude is 400 m V.Furthermore, the power generation of the bistable L-shaped beam with the upper potential well is obviously better than that of the bistable L-shaped beam with the lower potential well. In addition, comparing with the straight beam, the dynamic response of the bistable L-shaped beam is more complex when the external excitation frequency is changed. It is also observed that the distance between the magnets has the obvious influence on the dynamic response of the bistable system. It is very effective to select the appropriate distance between the magnets to improve the power generation of the bistable energy harvester under the fixed excitation conditions. | YAO MingHui MA Li ZHANG Wei | 2018 | Science China(Technological Sciences)2018，61，9： | 8 |
| 8 | Nonlinear dynamics of angle-ply composite laminated thin plate with third-order shear deformation显示文摘An asymptotic perturbation method is presented based on the Fourier expansion and temporal rescaling to investigate the nonlinear oscillations and chaotic dynamics of a simply supported angle-ply composite laminated rectangular thin plate with parametric and external excitations.According to the Reddy's third-order plate theory,the governing equations of motion for the angle-ply composite laminated rectangular thin plate are derived by using the Hamilton's principle.Then,the Galerkin procedure is applied to the partial differential governing equation to obtain a two-degrees-of-freedom nonlinear system including the quadratic and cubic nonlinear terms.Such equations are utilized to deal with the resonant case of 1:1 internal resonance and primary parametric resonance-1/2 subharmonic resonance.Furthermore,the stability analysis is given for the steady-state solutions of the averaged equation.Based on the averaged equation obtained by the asymptotic perturbation method,the phase portrait and power spectrum are used to analyze the multi-pulse chaotic motions of the angle-ply composite laminated rectangular thin plate.Under certain conditions the various chaotic motions of the angle-ply composite laminated rectangular thin plate are found. | GUO Xiang Ying,ZHANG Wei & YAO MingHui College of Mechanical Engineering,Beijing University of Technology,Beijing 100124,China | 2010 | Science China(Technological Sciences)2010，53，3： | 7 |
| 9 | Free vibration analysis of a pre-twisted sandwich blade with thermal barrier coatings layers显示文摘A rotating cantilever sandwich-plate model with a pre-twisted and pre-set angle has been developed to investigate the vibrational behavior of an aero-engine turbine blade with thermal barrier coating(TBC) layers. The classic von Karman plate theory and the first-order shear deformation theory are applied to derive the energy equations of the rotating TBC blade, in which the geometric shapes, the work ambient temperature, and the TBC material properties are considered. The Chebyshev-Ritz method is used to obtain the nature frequency of the rotating TBC blade. For static frequency and modal analysis, the finite-element method(FEM)is also applied to compare and validate the results from the Chebyshev-Ritz method. A good agreement is found among these kinds of methods. For dynamic frequency, the results are analyzed in detail concerning the influence of system parameters such as the thickness of the TBC layer, the working temperature, and the pre-twisted and pre-set angle. Finally, the Campbell diagram is demonstrated to analyze the resonance property of the cantilever sandwich TBC blade model. | CAO DongXing LIU BingYi YAO MingHui ZHANG Wei | 2017 | Science China(Technological Sciences)2017，60，11： | 7 |
| 10 | Control of a Spherical Robot: Path Following Based on Nonholonomic Kinematics and Dynamics显示文摘This paper presents the controller design for the path following of a spherical mobile robot,BHQ-1.Firstly,a desired velocity for the reference path is deduced from the kinematic model,which cannot be transformed into the classic chained form.Secondly,a necessary torque for the desired velocity is obtained based on the dynamic model.As to the kinematics,a one-dimensional function is selected to measure the two-directional tracking error,and the velocity of rolling forward is reasonably assumed to be constant;therefore the multiple-input multiple-output (MIMO) system is transformed into a single-input single-output (SISO) system.As to the dynamics,both exact dynamics and inexact dynamics with modeling error as well as bounded unknown disturbance are taken into account,based on which a proportional-derivative (PD) controller and a sliding mode controller with adaptive parameters are proposed respectively.Finally,convergence analysis and simulation results are provided to validate these controllers. | ZHENG Minghui ZHAN Qiang LIU Jinkun CAI Yao | 2011 | Chinese Journal of Aeronautics2011，24，3： | 6 |
| 11 | Experimental study on broadband bistable energy harvester with L-shaped piezoelectric cantilever beam显示文摘This paper presents an experimental study of the broadband energy harvesting and dynamic responses of an L-shaped piezoelectric cantilever beam.Experimental results show that the L-shaped piezoelectric beam generates two optimal voltage peaks when the horizontal beam size is similar to the vertical beam size.Several optimized L-shaped piezoelectric cantilever beam structures are proposed.Power generation using the inverted bistable L-shaped beam is better.It is observed experimentally that the inverted bistable L-shaped beam structure shows obvious bistable characteristics and hard spring characteristics.Furthermore,the corresponding relationship between the bistable phase portrait and the potential energy curve is found in the experiment.This is the first time that a phase portrait for stiffness hardening of an L-shaped beam has been found experimentally.These results can be applied to analysis of new piezoelectric power generation structures. | Minghui Yao Pengfei Liu Li Ma Hongbo Wang Wei Zhang | 2020 | Acta Mechanica Sinica2020，36，3： | 5 |
| 12 | Higher-dimensional chaotic dynamics of a composite laminated piezoelectric rectangular plate显示文摘The analysis on the chaotic dynamics of a six-dimensional nonlinear system which represents the averaged equation of a composite laminated piezoelectric rectangular plate is given for the first time. The theory of normal form and the energy-phase method are combined to investigate the higher-dimen-sional chaotic dynamics of the composite laminated piezoelectric rectangular plate. Firstly,the theory of normal form is used to reduce the six-dimensional averaged equation to the simpler normal form. Then,the energy-phase method is extended to analyze the global bifurcations and chaotic dynamics of a six-dimensional nonlinear system. The analysis results indicate that there exist the homoclinic bi-furcation and Shilnikov type multi-pulse chaos for the composite laminated piezoelectric rectangular plate. Finally,numerical simulations are also used to investigate the nonlinear dynamic characteristics of the composite laminated piezoelectric rectangular plate. The results of numerical simulations also demonstrate that there exist the chaotic motions and the multi-pulse jumping orbits of the composite laminated piezoelectric rectangular plate. | ZHANG Wei GAO MeiJuan YAO MingHui YAO ZhiGang | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 4 |
| 13 | Vibration of functionally graded sandwich doubly curved shells using improved shear deformation theory显示文摘Nonlinear forced vibrations and natural frequency of sandwich functionally graded material doubly curved shallow shell with a rectangular base are investigated. The sandwich functionally graded material(FGM) doubly curved shell is subjected to a harmonic point load at centre. The sandwich doubly curved shell with homogeneous face sheets and FGM face sheets is considered respectively when the natural frequencies are studied. Reddy's third order shear deformation theory is expanded in which stretching effects in thickness are considered by introducing the secant function. Hamilton's principle and von-Karman type nonlinear geometric equation are applied to obtain partial differential equation of the FGM sandwich doubly curved shell. Comparative studies with other shear deformation theories are carried out to validate the present formulation. Navier method is used to discuss the natural vibration frequencies of the FGM sandwich doubly curved shell. Numerical simulation is applied to demonstrate the nonlinear dynamic responses of the FGM sandwich doubly curved shell. Multiple periods, quasi-period and chaos are detected for the dynamic system for different core thickness. | HAO YuXin LI ZhenNi ZHANG Wei LI ShuangBao YAO MingHui | 2018 | Science China(Technological Sciences)2018，61，6： | 3 |
| 14 | Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191显示文摘抄写因素的 DNA 有约束力的性质上的研究在寻找这些因素调整的下游的基因是重要的。在现在的学习,我们在一个 Cy s2His2 类型抄写因素的 DNA 有约束力的性质上报导,锌手指蛋白质 191 (Zfpl91 ) ,它最新被发现了在老鼠起一个重要作用。由构造包含 Zfpl91 的 DNA 有约束力的域的熔化蛋白质,我们由在锌上决定蛋白质的有约束力的特性和依赖描绘了目标 DNA。数据证明 Zfpl91 的 DNA 有约束力的域能明确地绑在 TCAT 重复主题并且在目标 DNA 的多重有约束力的地点之中有合作效果。而且,有约束力的反应依赖于锌。这个工作在基因规定和开发在 Zfpl91 的角色上为进一步的研究提供一个基础。 | Haoyue Wang Ruilin Sun Guoxiang Liu Minghui Yao Jian Fei Hebai Shen | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 15 | Investigation on Microcrystalline Wax Doped Asphalts by Temperature Control Mode of Atomic Force Microscopy显示文摘Because of its economical and environmentally friendly characteristics, the warm mix asphalt(WMA) is widely used in pavement engineering. However, the lack of microscopic study of WMA brings difficulties in understanding of its mechanical behavior and mechanisms at macroscopic scale which finally hinders the enhancement of WMA's performance. Therefore, this article aims to use atomic force microscopy(AFM), a promising microscopic technique, to investigate the effects of wax-based warm mix agents on asphalt microstructures and micromechanical properties at different temperatures. For simplicity's sake, microcrystalline waxes are selected as an alternative of these wax-based additives. It is shown that the sample preparation method has a vital impact on the morphology of asphalt samples. The effects of microcrystalline wax on asphalt's mechanical properties can be well captured by AFM tests. Results show that the blending of #70, #80 and #90 microcrystalline waxes lowers the modulus(20—60 MPa) of Pen70 asphalt at 25 ℃ while increasing its adhesion force(5—20 n N). The results of this study may shed some light on the comprehension of the effects of wax-based additives on asphalt materials at macroscopic level which can help estimate and predict its actual performance. | Yang Jun Yao Zeheng Gong Minghui Yao Hongmiao | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，4： | 2 |
| 16 | Nonlinear transient responses of rotating twisted FGM cylindrical panels显示文摘This paper develops a new structure dynamic model to investigate nonlinear transient responses of the rotating blade made of functionally graded material(FGM). The rotating blade is simplified as a rotating FGM cylindrical panel with a presetting angle and a twist angle. The geometric nonlinearity effects are taken into account in the strain-displacement relationships, which are derived by Green strain tensor. Based on the first-order piston theory and the first-order shear deformation theory, the equations of motion for the rotating twisted FGM cylindrical panel are acquired by means of Hamilton principle and Galerkin method.Backward Differentiation Formula(BDF) and Runge-Kutta Algorithm are used to solve the nonlinear equations of motion for the system. The effects of four pulse load conditions on the system subjected to the internal pulse load or the external pulse load are fully discussed. A detailed parametric analysis is performed by considering the effects of the rotating speed, volume fraction index and temperature. | NIU Yan YAO MingHui ZHANG Wei | 2021 | Science China(Technological Sciences)2021，64，2： | 2 |
| 17 | Co_(3)Mo_(3)N—An efficient multifunctional electrocatalyst显示文摘Efficient catalysts are required for both oxidative and reductive reactions of hydrogen and oxygen in sustainable energy conversion devices.However,current precious metal-based electrocatalysts do not perform well across the full range of reactions and reported multifunctional catalysts are all complex hybrids.Here,we show that singlephase porous Co3Mo3N prepared via a facile method is an efficient and reliable electrocatalyst for three essential energy conversion reactions;oxygen evolution reaction(OER),oxygen reduction reaction(ORR),and hydrogen evolution reaction(HER)in alkaline solutions.Co3-Mo3N presents outstanding OER,ORR,and HER activity with high durability,comparable with the commercial catalysts RuO2 for OER and Pt/C for ORR and HER.In practical demonstrations,Co3Mo3N gives high specific capacity(850 mA h gZn^(-1) at 10 mA cm^(-2))as the cathode in a zinc-air battery,and a low potential(1.63 V at 10 mA cm^(-2))used in a water-splitting electrolyzer.Availability of Co and Mo d-states appear to result in high ORR and HER performance,while the OER properties result from a cobalt oxide-rich activation surface layer.Our findings will inspire further development of bimetallic nitrides as cost-effective and versatile multifunctional catalysts that will enable scalable usage of electrochemical energy devices. | Yao Yuan Samira Adimi Tiju Thomas Jiacheng Wang Haichuan Guo Jian Chen J.Paul Attfield Francis J.DiSalvo Minghui Yang | 2021 | The Innovation2021，2，2： | 2 |
| 18 | A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans显示文摘Caenorhabditis elegans 的 lifespan 被各种各样的基因、环境的因素决定。在这篇论文, spr-3, C。elegans 哺乳动物的神经限制 silencing 因素(NRSF/REST ) 的相应基因,被报导是调整 C 的 lifespan 的重要基因。elegans。spr-3, spr-3 (ok2525 ) ,或 spr-3 表示的 RNAi 抑制的一个删除变化在 C 导致了短 lifespan 显型。elegans。然而, spr-3 的一个胡说八道变化, spr-3 (by108 ) ,增加了 lifespan 26% 什么时候与野类型的线虫的相比。spr-3 (by108 ) 也显示出增加的抵抗到环境应力。spr-3 (by108 ) 变异基因编码 C 终端有与 REST4 可比较的结构的截断的蛋白质, NRSF/REST 在的 splice 变体哺乳动物。spr-3 (by108 ) 的长 lifespan 显型异种在 daf-16 和 glp-1 的正常功能上作为功能和依赖者的获得被证实。spr-3 (by108 ) 的 lifespan 能被在 daf-2 导致一个变化 synergistically 提高。量的聚合酶链反应结果证明 daf-16 以及它的目标基因 sod-3, mtl-1,和 sip-1 的表示在 spr-3 (by108 ) 是起来调整的变异。这些结果将是有用的进一步理解 NRSF/REST 基因的复杂功能在哺乳动物,特别在变老的过程和长寿决心。 | Ping Yang Ruilin Sun Minghui Yao Weidong Chen Zhugang Wang Jian Fei | 2013 | Acta Biochimica et Biophysica Sinica2013，45，7： | 2 |
| 19 | Bifurcation and dynamic behavior analysis of a rotating cantilever plate in subsonic airflow显示文摘Turbo-machineries,as key components,have wide applications in civil,aerospace,and mechanical engineering.By calculating natural frequencies and dynamical deformations,we have explained the rationality of the series form for the aerodynamic force of the blade under the subsonic flow in our earlier studies.In this paper,the subsonic aerodynamic force obtained numerically is applied to the low pressure compressor blade with a low constant rotating speed.The blade is established as a pre-twist and presetting cantilever plate with a rectangular section under combined excitations,including the centrifugal force and the aerodynamic force.In view of the first-order shear deformation theory and von-K′arm′an nonlinear geometric relationship,the nonlinear partial differential dynamical equations for the warping cantilever blade are derived by Hamilton’s principle.The second-order ordinary differential equations are acquired by the Galerkin approach.With consideration of 1:3 internal resonance and 1/2 sub-harmonic resonance,the averaged equation is derived by the asymptotic perturbation methodology.Bifurcation diagrams,phase portraits,waveforms,and power spectrums are numerically obtained to analyze the effects of the first harmonic of the aerodynamic force on nonlinear dynamical responses of the structure. | Li MA Minghui YAO Wei ZHANG Dongxing CAO | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，12： | 1 |
| 20 | Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy显示文摘Chronic hepatitis B virus(HBV)infection is a global public health problem,which can cause chronic hepatitis,liver cirrhosis,hepatocellular carcinoma(HCC),and other diseases.Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B,prevent or delay cirrhosis,HCC,and other kinds of liver decompensation events.At present,the anti-hepatitis B virus drugs are mainly nucleoside(acid)analogues(NAs)and interferon.Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients(such as HCC).In this paper,we discussed the biological characteristics,natural course and prognosis of HBV infection,the mechanism of HBV-related HCC,the effect of different antiviral drugs on patients’outcome,predictive biomarkers and model for HBV clinical outcome,predictors of sustained response and recurrence after withdrawal of antiviral therapy,consideration of expanding therapeutic indications and antiviral therapy,hoping to give a hand to the clinical diagnosis and treatment of HBV. | Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie | 2021 | Biosafety and Health2021，3，4： | 1 |
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