|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 食管鳞状细胞癌基因组改变的确认显示文摘食管癌是最具侵袭性的癌症之一,居全球恶性肿瘤病死率的第六位。全球约70%的食管癌患者在中国,食管鳞状细胞癌是最常见的病理类型(〉90%)。目前,临床上对于食管鳞状细胞癌的早期诊断和治疗非常有限,患者5年生存率仅为10%。然而,直到目前对于导致食管鳞状细胞癌发病的完整基因组事件仍知之甚少。本组对158例食管鳞状细胞癌病例进行一次全面的基因组分析:其中17例食管鳞状细胞癌病例进行全基因组测序,71例进行外显子测序, | Song Y Li L Ou Y 崔淼 许春伟 张博 | 2014 | 临床与实验病理学杂志2014，30，11： | 129 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells显示文摘 | Ma Y Xu Y Xiao Z Yang W Zhang C Song E Du Y Li L | 2006 | 中国生物学文摘2006，20，5： | 58 |
| 4 | 血压变异性与脑小血管病:人群队列的系统回顾和荟萃分析显示文摘脑小血管疾病(cerebral small vessel disease,CSVD)是一种常见的、具有破坏性的亚临床疾病,对卒中和痴呆都有重要影响。血压的变异性可能会增加卒中和痴呆的风险,但血压变异性是否与CSVD有关尚无定论。该研究针对前瞻性队列研究进行了系统回顾和荟萃分析,这些研究考察了血压变异性与CSVD标志物(包括磁共振成像上的白质高信号、腔隙和微出血)的存在或进展之间的关系。该研究搜索了Medline、Embase和Web of Science三大数据库。筛选出10项研究符合综合定性标准,并有7项研究可纳入荟萃分析。这些研究共包括2796例年龄为(74±4)岁的患者,平均随访时间为4.0年。经统计学分析,收缩期血压变异性与白质高信号存在或进展的概率增加相关,约增加1个标准差[优势比1.26(95%CI:1.06~1.50)]。而收缩压血压变异性与腔隙的存在[优势比0.93(95%CI:0.74~1.16)]和微出血的存在[优势比1.13(95%CI:0.89~1.44)]之间的相关性没有统计学意义。结果证明,大的血压变异性与更高的脑白质高信号(WMH)负担相关,这可能为探究卒中和痴呆的早期诱因提供重要的支持。二者的因果关系,则需要未来的纵向研究进行探究。如果观察到因果关系是成立的,则表明通过保持稳定的血压,可以很大程度上预防CSVD,从而预防卒中和痴呆。 | Ma Y Song A Viswanathan A 李铁梅(编译) | 2020 | 中华医学杂志2020，100，43： | 32 |
| 5 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 6 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 7 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 8 | 聚桂醇联合曲安奈德病灶内注射治疗婴幼儿血管瘤的安全性评估显示文摘Chai Y,Zhou Z,Song J,et al.Safety of intralesional injection of lauromacrogol combined with triamcinolone for infantile hemangiomas.J Dermatol,2019 Jul.近年来,聚桂醇注射疗法和病灶内注射曲安奈德治疗婴儿血管瘤(IH)的疗效已得到充分证实,但严重或罕见的不良反应也随之增加。本研究的目的是研究病灶内聚桂醇与曲安奈德联合注射治疗IH的安全性,并研究其对婴儿生长发育的影响。 | 赵泽亮 Chai Y Zhou Z Song J | 2019 | 中国口腔颌面外科杂志2019，17，5： | 13 |
| 9 | 相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析显示文摘【据《Hepatol Int》2020年1月报道】题:相对骨骼肌质量与非酒精性脂肪性肝病的关系:一项系统评价和荟萃分析(作者Cai C等)非酒精性脂肪性肝病(NAFLD)已逐渐成为全世界最常见的慢性肝病之一。越来越多的证据表明,低骨骼肌质量指数(SMI)可能在NAFLD的发展中起作用。该研究目的是探讨量化SMI、肌少症与NAFLD发生和发展之间的关联。作者系统地检索了PubMed、Embase、Web of Science和Cochrane图书馆中相关的英语研究,时间截止至2018年12月20日。 | 蔡昌洲 虞朝辉 CAI C SONG X CHEN Y | 2020 | 临床肝胆病杂志2020，36，3： | 7 |
| 10 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 11 | 癌症患者家庭照顾者照顾负担不容忽视显示文摘韩国延世大学医学院的Sun Young Rha等开展了一项描述性研究,对照顾者负担、健康促进行为及生存质量进行了分析。在2所韩国大学医院的肿瘤住院病房及出院门诊的212名家庭照顾者最终被纳入该研究。家庭照顾者均为患者的家庭成员并且为患者的主要照顾者。研究结果显示:癌症患者家庭照顾者存在中等水平的照顾负担,其中1/4的照顾者照顾负担重。照顾者因素与照顾负担的双变量分析结果显示:照顾者年龄与情绪负担呈弱的负相关; | 陈昌连 焦杰 Rha SY Park Y Song SK | 2017 | 护士进修杂志2017，32，14： | 5 |
| 12 | On generation source sites of internal waves in the Luzon Strait显示文摘This effort aims to determine the generation source sites in the Luzon Strait for energetic,long-crest,transbasin internal waves(IW)observed in the northern South China Sea(NSCS).The roles of islands distributed on eastern side of the strait,Kuroshio,submarine ridges,shoaling thermocline,and strait configuration played in the IW generation are examined using the cruise data analysis,satellite data interpretation,and dynamical analysis.The islands and channels on eastern side of the strait are excluded from a list of possible IW source sites owing to their unmatched horizontal dimensions to the scale of IW crest line length,and the relative low Reynolds number.The Kuroshio has a potential to be a radiator for the long-crest IW disturbances,meanwhile,the Kuroshio west(east)wing absorbs the eastward(westward)propagating IW disturbance.Namely,the Kuroshio blockades the outside west-east propagating IW disturbances.The 3-D configuration of the Luzon Strait is characterized by a sudden,more than one order widening of the cross-section areas at the outlets on both sides,providing a favorable condition for IW type initial disturbance formation.In the Luzon Strait,the thermocline is featured by a westward shoaling all the year around,providing the dynamical conditions for the amplitude growth(declination)to the westward(eastward)propagating IW type disturbance.Thus,the west slope of western submarine ridge at the western outlet of the Luzon Strait is a high possibility source sites for energetic,long-crest,transbasin IWs in the NSCS.The interpretation results of satellite SAR images during a 13 a period from 1995 to 2007 provide the convincing evidence for the conclusions. | ZHENG Quanan SONG Y Tony LIN Hui HU Xiaomin MENG Junmin WANG Dan | 2008 | Acta Oceanologica Sinica2008，27，3： | 5 |
| 13 | Effect of chiropractic manipulation on disrupted epithelium barrier and its mechanism of specialized pro-resolving mediators in a spleen-deficiency murine model显示文摘OBJECTIVE: To investigate the influence of spleen deficiency on the epithelial barrier of jejunum and lungs in a rat model of spleen-deficiency and the effect and potential specialized pro-resolving mediators (SPMs) mechanism of chiropractic manipulation. METHODS: Three-week-old male Sprague-Dawley rats were divided randomly into normal control group (n = 6), spleen-deficiency group (n = 5) and chiropractic group (n = 6). Spleen-deficiency model was induced in spleen-deficiency group and chiropractic group. Moreover, chiropractic manipulation was performed in chiropractic group. Four weeks later, systemic Th1/Th2 balance was evaluated by the ratio of plasma interferon (IFN)-γ/interleukin (IL)-4 levels by enzyme-linked immunosorbent assay (ELISA). Epithelial barrier integrity were assessed by the observation of morphological changes by hematoxylin-eosin staining and zonula occludens (ZO)-1 gene expressions by quantitative real time polymerase chain reaction in jejunum and lungs. Plasma resolvin D1 (RvD1) and lipoxin A4 (LXA4) levels were measures by ELISA for endogenous SPMs production. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in jejunum and lungs were also measured by HPLC-MS/ MS. RESULTS: Comparing with normal control group, spleen-deficiency group showed disrupted mucosa in jejunum, inflammatory condition in lungs, significantly decreased ratio of plasma IFN-γ/IL-4 levels and lower expressions of ZO-1 mRNA in both jejunum and lung tissues. Comparing with spleen-deficiency group, chiropractic group had less disrupted mucosa in jejunum and inflammatory condition in lungs, significantly increased systemic ratio of IFN-γ/IL-4 and expressions of ZO-1 mRNA in both jejunum and lung tissues. Chiropractic group had significantly enhanced plasma levels of RvD1 and LXA4, but had no significantly higher levels of DHA and AA in jejunum and lungs when comparing with spleen-deficiency group. CONCLUSION: Spleen deficiency caused systemic Th1/Th2 imbalance towards Th2 polarization and epithelial barrier disruption in jejunum and lungs.Chiropractic manipulation helped enhance endogenous SPMs production, which might be one of the action mechanism of chiropractic manipulation on the improvement of epithelial barrier disruption. | Xiong Ying Song Zhixiu Gu Yun Qin Yuhang Wei Jiangfei Lu Jinlu Zhu Y | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 4 |
| 14 | 电力系统经济调度中遗传算法的比较研究显示文摘本文介绍了在电力经济调度中用于改善系统运行性能的遗传算法的某些修改。目的是试图找出供遗传算法使用的最佳运行点。为了改善运行性能,涉及到问题的两个阶段:即首先是选择一种适当的遗传策略,其次是为所选定的遗传策略对各种参数的值进行协调。这两个阶段均已在六机系统中经过试验,并按照在线及离线两种情况对试验结果进行了比较。全部研究工作清楚地表明,采用先进的遗传算子及优化选择参数值能使系统性能显著增强。 | Y.H. Song, University of Bath, UKF. li . R. Morgan , John Moores University, Liverpool, UKD. T. Y Cheng, National Grid Cornpany , UK | 1995 | 电网技术1995，19，3： | 4 |
| 15 | Syntax of first-order lattice valued logic system FM显示文摘PAVELKA in ref. [1] established a propositional logic system whose truth values domain is an enriched residuated lattice and obtained some beautiful results. In order to study more general lattice valued logic systems, we proposed the concept of lattice implication algebra, discussed the corresponding lattice valued propositional logic system, and established a | Xu, Y Qin, KY Song, ZM | 1997 | Chinese Science Bulletin1997，42，16： | 4 |
| 16 | 血浆7-酮胆固醇与冠状动脉疾病患者心血管结局和总死亡率的关系显示文摘7-酮胆固醇(7-ketocholesterol,7-KC)是胆固醇氧化产物的一种形式,在动物动脉粥样硬化模型的形成中起重要作用。该文研究人员试图确定循环7-KC与稳定型冠状动脉疾病(coronary artery disease,CAD)患者的临床心血管结局和总死亡率的关系。 | 刘莉 叶鹏 Song J Wang D Chen H Huang X Zhong Y Jiang N Chen C Xia M | 2017 | 中华高血压杂志2017，25，6： | 4 |
| 17 | Dynamical analysis of mesoscale eddy-induced ocean internal waves using linear theories显示文摘This study aims to explore generation mechanisms of the ocean internal wave using the dynamical analysis methods based on linear theories.Historical cruise measurements and recent synthetic aperture radar(SAR)observations of mesoscale eddies with diameter of several tens of kilometers to hundreds of kilometers show that the internal wave packets with wavelength of hundreds of meters to kilometer exist inside the mesoscale eddies.This coexistence phenomenon and inherent links between the two different scale processes are revealed in the solutions of governing equations and boundary conditions for the internal wave disturbance with a horizontally slowly variable amplitude in a cylindrical coordinate system.The theoretical solutions indicate that the instability of eddy current field provides the dynamical mechanism to internal wave generation.The derived dispersion relation indicates that the internal wave propagation is modified by the eddy current field structure.The energy equation of the internal waves clearly shows the internal wave energy increment comes from the eddy.The theoretical models are used to explain the observation of the mesoscale eddy-induced internal waves off the Norwegian coast.The two-dimensional waveform solution of the anticyclonic eddy-induced internal wave packet appears as ring-shaped curves,which contains the typical features of eddy stream lines.The comparison of theoretical solutions to the structure of the internal wave packets on SAR image shows a good agreement on the major features. | XU Qing ZHENG Quanan LIN Hui LIU Yuguang SONG Y Tony YUAN Yeli | 2008 | Acta Oceanologica Sinica2008，27，3： | 3 |
| 18 | Priming of the Cells: Hypoxic Preconditioning for Stem Cell Therapy显示文摘 | Zheng Z Wei Yan-Bing Zhu James Y Zhang Myles R McCrary Song Wang Yong-Bo Zhang Shan-Ping Yu Ling Wei | 2017 | Chinese Medical Journal2017，，19： | 3 |
| 19 | Cloning and expression of the VP2 gene of an infectious bursal disease virus显示文摘 | Yu L Song K Zhang Y | 2000 | Avian Dis2000，44，1： | 3 |
| 20 | Research and experiments of the dynamical model system for short-term climate prediction显示文摘 | Ding Y H Liu Y .M Song J | | 气候与环境研究0，，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员