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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 3 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 4 | Increased serum glycated albumin level is associated with the presence and severity ofcoronary artery disease in type 2 diabetic patients显示文摘 | PU L J LU L SHEN W F | 2007 | Circ J2007，71，7： | 1 |
| 5 | Charge/discharge characteristics of sulfur composite cathode materials in rechargeable lithium batteries显示文摘 | He X Pu W Ren J | 2007 | Electrochim Acta2007，52，25： | 1 |
| 6 | Correction of myopia by implantation of a concave worst iris claw lens into phakic eyes显示文摘 | Fechner PU Strobel J Wichmann W | 1991 | Refract Corneal Surg1991，7，： | 1 |
| 7 | Contrast-enhanced ultra- sound (CEUS)for differentiating between hepatocellular and cholangiocellu|arcarcinoma显示文摘 | Bohle W Clemens PU Heubach T | 2012 | U|trascha|l Med2012，33，7： | 1 |
| 8 | Charge/discharge characteristics of sulfur composite cathode materials in reehargeable lithium batteries显示文摘 | He X M Pu W H Ren J G | 2007 | Electrochim Acta2007，52，25： | 1 |
| 9 | Globally convergent inexact generalized Newton's method for non-smooth equation显示文摘 | Pu D Tian W | 2002 | J Comput and Applied Math2002，138，： | 1 |
| 10 | Electrodeposition of Sn-Cu alloy anodes for lithium batteries显示文摘 | PU W H HE X M REN J G | 2005 | Electrochimica Acta2005，50，20： | 1 |
| 11 | Thermal resistance of VCSEL′s bonded to integrated circuits显示文摘 | PU R WILMSEN C W GEIB K M | 1999 | IEEE Photonics Technology Letters1999，11，12： | 1 |
| 12 | Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer 显示文摘 | Fu M Fan W Pu X | 2013 | IntJClinExpPathol2013，6，10： | 1 |
| 13 | Microrna-1 negatively regulates expression of the hypertrophy-associated calmod- ulin and mef2 a genes 显示文摘 | KANG P M GOLUB T R PU W T | 2009 | Mol Cellular Biol2009，29，： | 1 |
| 14 | Growth and characterization of InGaN blue LED structure on Si (111)by MOCVD显示文摘 | Mo C L Fang W Q Pu Y | 2005 | JCrystGrowth2005，285，： | 1 |
| 15 | 查看详情显示文摘 | H Pu P Maenner W P Zhang H Y Ling | | 0，，05： | 1 |
| 16 | Hydrophilicmodification of poly (ether sulfone) ultrafiltration membranesurface by self-assembly of T1O2 nanoparticles 显示文摘 | Luo M L Zhao J Q Tang W Pu C S | 2005 | Applied Surface Science2005，249，： | 1 |
| 17 | 查看详情显示文摘 | H Y Ling P Maenner W P Zhang H Pu | | 0，，03： | 1 |
| 18 | Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology显示文摘 | ZHOU B WANG J F PU Y W | 2009 | Eur Food Res Technol2009，228，6： | 1 |
| 19 | The impact of group velocity on frequency-hopping optical code division multiple access system显示文摘 | ZUO C MA W H PU H T LIN J T | 2001 | Lightwave Technology2001，19，10： | 1 |
| 20 | 查看详情显示文摘 | Hu QS Vitharana D Liu G Y Jain V Wagaman M W Zhang L Lee T R and Pu L | | 0，，： | 1 |
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