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| 1 | Mechanisms of hydrocephalus after intraventricular haemorrhage in adults显示文摘Intraventricular haemorrhage(IVH)is defined as the eruption of blood in the cerebroventricular system and occurs mostly secondary to intracerebral haemorrhage(ICH)in adults.Hydrocephalus is a severe complication of IVH that can serve as an independent predictor of increased mortality.In this mini-review,we focus on the mechanisms of hydrocephalus after adult IVH,including blood-clot blockage,barrier impairment,inflammation and blood components,and attempt to reconcile the current research findings into a unified framework.We expect our theoretical framework to help guide future clinical and basic research leading to improved monitoring and intervention for IVH and subsequent hydrocephalus. | Yaoyao Bu Meiyuan Chen Ting Gao Xiao Wang Xuting Li Feng Gao | 2016 | Stroke & Vascular Neurology2016，1，1： | 4 |
| 2 | Ultrafast Synthesis of Metal-Layered Hydroxides in a Dozen Seconds for High-Performance Aqueous Zn(Micro-)Battery显示文摘Efficient synthesis of transition metal hydroxides on conductive substrate is essential for enhancing their merits in industrialization of energy storage field.However,most of the synthetic routes at present mainly rely on traditional bottom-up method,which involves tedious steps,time-consuming treatments,or additional alkaline media,and is unfavorable for high-efficiency production.Herein,we present a facile,ultrafast and general avenue to synthesize transition metal hydroxides on carbon substrate within 13 s by Joule-heating method.With high reaction kinetics caused by the instantaneous high temperature,seven kinds of transition metal-layered hydroxides(TM-LDHs)are formed on carbon cloth.Therein,the fastest synthesis rate reaches~0.46 cm^(2)s^(-1).Density functional theory calculations further demonstrate the nucleation energy barriers and potential mechanism for the formation of metal-based hydroxides on carbon substrates.This efficient approach avoids the use of extra agents,multiple steps,and long production time and endows the LDHs@carbon cloth with outstanding flexibility and machinability,showing practical advantages in both common and micro-zinc ion-based energy storage devices.To prove its utility,as a cathode in rechargeable aqueous alkaline Zn(micro-)battery,the NiCo LDH@carbon cloth exhibits a high energy density,superior to most transition metal LDH materials reported so far. | Xiangyang Li Fangshuai Chen Bo Zhao Shaohua Zhang Xiaoyu Zheng Ying Wang Xuting Jin Chunlong Dai Jiaqi Wang Jing Xie Zhipan Zhang Yang Zhao | 2023 | Nano-Micro Letters2023，15，3： | 2 |
| 3 | immunisation of channel catfish, Ictalurus punctatus,with Ichthyophthirius multifiliis immobilisation antigens elicits serotype-specific protection显示文摘 | Xuting Wang Theodore G Clark J N | 2002 | Fish and Shellfish Immunology2002，13，5： | 1 |
| 4 | Pre-training with asynchronous supervised learning for reinforcement learning based autonomous driving显示文摘Rule-based autonomous driving systems may suffer from increased complexity with large-scale intercoupled rules,so many researchers are exploring learning-based approaches.Reinforcement learning(RL)has been applied in designing autonomous driving systems because of its outstanding performance on a wide variety of sequential control problems.However,poor initial performance is a major challenge to the practical implementation of an RL-based autonomous driving system.RL training requires extensive training data before the model achieves reasonable performance,making an RL-based model inapplicable in a real-world setting,particularly when data are expensive.We propose an asynchronous supervised learning(ASL)method for the RL-based end-to-end autonomous driving model to address the problem of poor initial performance before training this RL-based model in real-world settings.Specifically,prior knowledge is introduced in the ASL pre-training stage by asynchronously executing multiple supervised learning processes in parallel,on multiple driving demonstration data sets.After pre-training,the model is deployed on a real vehicle to be further trained by RL to adapt to the real environment and continuously break the performance limit.The presented pre-training method is evaluated on the race car simulator,TORCS(The Open Racing Car Simulator),to verify that it can be sufficiently reliable in improving the initial performance and convergence speed of an end-to-end autonomous driving model in the RL training stage.In addition,a real-vehicle verification system is built to verify the feasibility of the proposed pre-training method in a real-vehicle deployment.Simulations results show that using some demonstrations during a supervised pre-training stage allows significant improvements in initial performance and convergence speed in the RL training stage. | Yunpeng WANG Kunxian ZHENG Daxin TIAN Xuting DUAN Jianshan ZHOU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，5： | 1 |
| 5 | Association between TLR2 , MTR , MTRR , XPC , TP73 , TP53 genetic polymorphisms and gastric cancer: A meta-analysis显示文摘 | Chen Cheng Wang Lingyan Huang Yi Zhang Cheng Ye Huadan Xu Xuting Xu Leiting Ye Meng Duan Shiwei | 2014 | Clinics and Research in Hepatology and Gastroenterology2014，，： | 1 |
| 6 | Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence显示文摘Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin resistance.Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and atherosclerosis.However,it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy.Methods:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko mice.Rapamycin was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce hypertrophy.Human vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic studies.Results:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ISO.Conversely,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and senescence.Furthermore,vaspin significantly potentiated the ISO-induced decrease in autophagy.Both rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated cardioprotection.Moreover,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and NRVMs.Our data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination degradation.Conclusion:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hypertrophy. | Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu Jinxin Wang Li Xue | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 7 | Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage显示文摘Background:Phototherapies based on sunlight,infrared,ultraviolet,visible,and laser-based treatments present advantages like high curative effects,small invasion,and negligible adverse reactions in cancer treatment.We aimed to explore the potential therapeutic effects of blue light emitting diode(LED)in human hepatoma cells and decipher the underlying cellular and molecular mechanisms.Methods:Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED.The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer stem cell properties.Immunofluorescence and western blotting were used to detect the changes inγ-H2AX.The Cell Counting Kit-8 assay,5-ethynyl-2′-deoxyuridine staining,and colony formation assay were used to detect the combined effect of blue LED and sorafenib on cell proliferation inhibition.Results:We demonstrated that the irradiation of blue LED light in hepatoma cells could lead to cell proliferation reduction along with the increase of cell apoptosis.Simultaneously,blue LED irradiation also markedly suppressed the migration and invasion ability of human hepatoma cells.Sphere formation analysis further revealed the decreased cancer stemness of hepatoma cells upon blue LED irradiation.Mechanistically,blue LED irradiation significantly promoted the expression of the phosphorylation of the core histone protein H2AX(γ-H2AX),a sensitive molecular marker of DNA damage.In addition,we found that the combined treatment of blue LED irradiation and sorafenib increased cancer cell sensitivity to sorafenib.Conclusion:Collectively,we demonstrated that blue LED irradiation exhibited anti-tumor effects on liver cancer cells by inducing DNA damage and could enhance chemosensitivity of cancer cells,which represents a potential approach for human hepatoma treatment. | TONG WANG JINHUAN HONG JIAJIE XIE QIAN LIU JINRUI YUE XUTING HE SHIYU GE TAO LI GUOXIN LIU BENZHI CAI LINQIANG LI YE YUAN | 2023 | BIOCELL2023，47，8： | 0 |
| 8 | The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract显示文摘Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic activity.Hence,in this study,the quality standard and the hypoglycemic effect of CCAE were investigated.Cinnamaldehyde and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)method.The results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,respectively.The investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)levels.The results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice. | Xuting Hao Ziheng Jin Ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang | 2024 | Journal of Future Foods2024，4，2： | 0 |
| 9 | 新抗氧化因子iASPP通过与Nrf2竞争结合Keap1的方式促进肿瘤细胞生长和耐药显示文摘文章简介人类细胞不可避免地暴露于来自于外界(如UV)以及细胞内有氧代谢所产生的活性氧(reactive oxygen species,ROS)。少量ROS是调控细胞正常生理活动的重要信号分子,高水平ROS则会作用于细胞内包括DNA在内的生物大分子,致其损伤,破坏其功能,成为肿瘤发生的重要推动力。 | 葛文杰 赵坤明 Xingwen Wang Huayi Li Miao Yu Mengmeng He Xuting Xue Yifu Zhu 张诚 程易为 Shijian Jiang 胡颖 | 2018 | 科学新闻2018，0，4： | 0 |
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