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| 1 | The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization显示文摘Objective:Macrophages are a major component of the tumor microenvironment.M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development,whereas tumor-associated macrophages(TAMs)mainly exhibit an M2 phenotype.Our previous studies have shown that the interleukin-33/ST2(IL-33/ST2)axis is essential for activation of the M1 phenotype.This study investigates the role of the IL-33/ST2 axis in TAMs,its effects on tumor growth,and whether it participates in the mutual conversion between the M1 and M2 phenotypes.Methods:Bone marrow-derived macrophages were extracted from wildtype,ST2 knockout(ST2-/-),and Il33-overexpressing mice and differentiated with IL-4.The mitochondrial and lysosomal number and location,and the expression of related proteins were used to analyze mitophagy.Oxygen consumption rates and glucose and lactate levels were measured to reveal metabolic changes.Results:The IL-33/ST2 axis was demonstrated to play an important role in the metabolic conversion of macrophages from OXPHOS to glycolysis by altering mitophagy levels.The IL-33/ST2 axis promoted enhanced cell oxidative phosphorylation,thereby further increasing M2 polarization gene expression and ultimately promoting tumor growth(P<0.05)(Figure 4).This metabolic shift was not due to mitochondrial damage,because the mitochondrial membrane potential was not significantly altered by IL-4 stimulation or ST2 knockout;however,it might be associated with the m TOR activity.Conclusions:These results clarify the interaction between the IL-33/ST2 pathway and macrophage polarization,and may pave the way to the development of new cancer immunotherapies targeting the IL-33/ST2 axis. | Huadan Xu Dong Li Jiaoyan Ma Yuanxin Zhao Long Xu Rui Tian Yanan Liu Liankun Sun Jing Su | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 2 | Primary pulmonary artery chondrosarcoma: the use of different imaging modalities显示文摘Fewer than 300 patients with primary pulmonary artery sarcoma have been reported since 1923,when it was first described by Mandelstamm.1 The diagnosis of pulmonary artery sarcoma is difficult,and misdiagnosis as chronic pulmonary embolism often occurs.Herein,we reported a case of primary pulmonary artery chondrosarcoma.So far as we know,this patient served as the first case ever reported to receive computed tomography pulmonary angiography (CTPA),gadolinium enhanced magnetic resonance imaging (MRI),and positron emission tomography/computed tomography (PET/CT) before surgery.By these means,the utility of different imaging modalities for pulmonary artery sarcoma was well demonstrated. | Wang Fengdan Wang Yining Xue Huadan Zhang Yingqiang Sun Jian Miao Qi Zhang Yan | 2014 | Chinese Medical Journal2014，，15： | 4 |
| 3 | Photonic cavity enhanced high-performance surface plasmon resonance biosensor显示文摘Herein we propose a novel strategy to enhance surface plasmon resonance(SPR)by introducing a photonic cavity into a total-internal-reflection architecture.The photonic cavity,which is comprised of a highly reflective photonic crystal(PC),defect layers,and a gold(Au)film,enables Fabry–Perot(FP)resonances in the defect layers and therefore narrows the SPR resonance width in the metallic surface as well as increases the electric field intensity and penetration depth in the evanescent region.The fabricated sensor exhibits a 5.7-fold increase in the figure of merit and a higher linear coefficient as compared with the conventional Au-SPR sensor.The demonstrated PC/FP cavity/metal structure presents a new design philosophy for SPR performance enhancement. | GUI-SHI LIU XIN XIONG SHIQI HU WEICHENG SHI YAOFEI CHEN WENGUO ZHU HUADAN ZHENG JIANHUI YU NUR HIDAYAH AZEMAN YUNHAN LUO ZHE CHEN | 2020 | Photonics Research2020，8，4： | 4 |
| 4 | Assessment of Changes in the Cesarean Scar and Uterus Between One and Two Years after Cesarean Section Using 3D T2w SPACE MRI显示文摘Objective Io evaluate changes in morphology of the cesarean scar and uterus between one and two years after cesarean section using high-resolution,three dimensional T2-weighted sampling perfection with application optimized contrast using diflerent flip angle evolutions Magnetic Resonance Imaging(3DT2w SPACE MRI).Methods This prospective study was performed to investigate morphological changes in the cesarean scars and uterus from one to two years after cesarean section using high-resolution,3D T2w SPACE MRI.The healthy volunteers having no childbearing history were recruited as the controls.All data were measured by two experienced radiologists.All data with normal distribution between the one-year and two-year groups were compared using a paired-sample t test or independent t test.Results Finally,46 women took a pelvic MR examination one year after cesarean section,and a subset of 15 completed the same examination again after two years of cesarean section.Both the uterine length and the anterior wall thickness after two years of cesarean section(5.75±0.46 and 1.45±0.35 cm)were significantly greater than those measured at one year(5.33±0.59 and 1.25±0.27 cm)(t=-2.363 and-2.175,P=0.033 and 0.048).No significant difference was shown in myometrial thickness two years after cesarean section(1.45±0.35 cm)with respect to the control group(1.58±0.21 cm,P=0.170).Nine women who underwent MRI twice were considered to have scar diverticula one year after cesarean section,and still had diverticula two years after cesarean section.The thickness,height,and width of the uterine scar showed no significant change from one to two years(all P>0.05).Conclusions 3D T2w SPACE MRI provides overall morphologic details and shows dynamic changes in the scar and the uterus between one and two years after cesarean section.Scar morphology after cesarean section reached relatively stable one year after cesarean section,and uterine morphology was closer to normal two years after cesarean section. | Yafei Qi Yonglan He Ning Ding Liangkun Ma Tianyi Qian Yuan Li Huadan Xue Zhengyu Jin | 2022 | Chinese Medical Sciences Journal2022，37，2： | 3 |
| 5 | High-performance fiber-integrated multifunctional graphene-optoelectronic device with photoelectric detection and optic-phase modulation显示文摘In graphene-based optoelectronic devices,the ultraweak interaction between a light and monolayer graphene leads to low optical absorption and low responsivity for the photodetectors and relative high half-wave voltage for the phase modulator.Here,an integration of the monolayer graphene onto the side-polished optical fiber is demonstrated,which is capable of providing a cost-effective strategy to enhance the light–graphene interaction,allowing us to obtain a highly efficient optical absorption in graphene and achieve multifunctions:photodetection and optical phase modulation.As a photodetector,the device has ultrahigh responsivity(1.5×10^(7) A/W)and high external quantum efficiency(>1.2×10^(9)%).Additionally,the polybutadiene/polymethyl methacrylate(PMMA)film on the graphene can render the device an optical phase modulator through the large thermo-optic effect of the PMMA.As a phase modulator,the device has a relatively low half-wave voltage of 3 V with a 16 dB extinction ratio in Mach–Zehnder interferometer configuration. | LINQING ZHUO PENGPENG FAN SHUANG ZHANG YUANSONG ZHAN YANMEI LINYU ZHANG DONGQUAN LI ZHEN CHE WENGUO ZHU HUADAN ZHENG JIEYUAN TANG JUN ZHANG YONGCHUN ZHONG WENXIAO FANG GUOGUANG LU JIANHUI YU ZHE CHEN | 2020 | Photonics Research2020，8，12： | 3 |
| 6 | The 2-axis stress component decoupling of {100} c-Si by using oblique backscattering micro-Raman spectroscopy显示文摘With the application of strain engineering in microelectronics,complex stress states are introduced into advanced semiconductor devices.However,there is still a lack of effective metrology for the decoupling analysis of the complex stress states in semiconductor materials.This paper presents an investigation on the 2-axis stress component decoupling of{100}monocrystalline silicon(c-Si)by using oblique backscattering micro-Raman spectroscopy.A spectral-mechanical model was established,and two practicable methods for actual stress decoupling analyses were proposed.The verification experiments demonstrated the correctness and applicability of the methods proposed in this paper. | DongHui Fu XiaoYong He LuLu Ma HuaDan Xing Tian Meng Ying Chang Wei Qiu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，9： | 2 |
| 7 | Assessing Liver Function by T1 Maps on Gd-EOB-DTPA- Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help显示文摘Objectives To investigate whether a longer time period of gadolinium ethoxybenzyl diethylenetriaminepen-taacetic add(Gd-EOB-DTPA)-enhanced T1 mapping scanning,as well as dynamic contrast-enhanced(DCE)and multiple hepatobiliary phase magnetic resonance imaging(MRI)have the potential to provide information about liver function in rats with liver fibrosis.Methods Forty rats were divided into the carbon tetrachloride-induced hepatic injury groups[carbon tetrachloride for four(n=14),eight(n=8),or twelve(n=8)weeks]and the control group(n=10).Gd-EOB-DTPA-enhanced MRI was performed including T1-mapping(delayed to 50 min),DCE,and multiple hepatobiliary phases.Indocyanine green retention rate at 15 min(ICG-R15)was determined.Parameters such as T1 reduction rate(△T1),elimination half-life of △T1(T_(△T1 1/2)),relative enhancement(RE),time to maximum RE(T_(max)),and perfusion parameters were calculated.Pearson correlation analysis was used for correlation analysis between ICG-R15 and each MRI indices.Results △T1 at 30,40,and 50 min showed significant positive correlations with ICG-R15(r=0.784,0.653,0.757,P=0.007,0.041,0.030).T_(△T1 1/2) showed a significant positive correlation with ICG-R15(r=0.685,P=0.029).showed a significant positive correlation with ICG-R15(r=0.532,P=0.019).Conclusions △T1 in the late hepatobiliary phase and T_(△T1 1/2) exhibited moderate correlations with liver function.The longer time period of Gd-EOB-DTPA-enhanced Tl mapping scanning,as well as DCE and multiple hepatobiliary phases,may be of some value for estimating liver function in rats with liver fibrosis. | Jia Xu Xuan Wang Zhengyu Jin Qin Wang Yan You Shitian Wang Tianyi Qian Huadan Xue | 2021 | Chinese Medical Sciences Journal2021，36，2： | 2 |
| 8 | Quantitative hepat- ic CT perfusion measurement : comparison of Couinaud' s hepatic segments with dual - source 128 - slice CT 显示文摘 | XUAN Wang XUE Huadan JIN Zhengyu | 2012 | Eur J Radiol2012，82，10： | 1 |
| 9 | Distance-controllable and direction-steerable opto-conveyor for targeting delivery显示文摘Opto-conveyors have attracted widespread interest in various fields because of their non-invasive and non-contact delivery of micro/nanoparticles.However,the flexible control of the delivery distance and the dynamic steering of the delivery direction,although very desirable in all-optical manipulation,have not yet been achieved by optoconveyors.Here,using a simple and cost-effective scheme of an elliptically focused laser beam obliquely irradiated on a substrate,a direction-steerable and distance-controllable opto-conveyor for the targeting delivery of microparticles is implemented.Theoretically,in the proposed scheme of the opto-conveyor,the transverse and longitudinal resultant forces of the optical gradient force and the optical scattering force result in the transverse confinement and the longitudinal transportation of microparticles,respectively.In this study,it is experimentally shown that the proposed opto-conveyor is capable of realizing the targeting delivery for microparticles.Additionally,the delivery distance of microparticles can be flexibly and precisely controlled by simply adjusting the irradiation time.By simply rotating the cylindrical lens,the proposed opto-conveyor is capable of steering the delivery direction flexibly within a large range of azimuthal angles,from-75°to 75°.This study also successfully demonstrated the real-time dynamic steering of the delivery direction from-45°to 45°with the dynamical rotation of the cylindrical lens.Owing to its simplicity,flexibility,and controllability,the proposed method is capable of creating new opportunities in bioassays as well as in drug delivery. | Zhen Che Wenguo Zhu Yaoming Huang Yu Zhang Linqing Zhuo Pengpeng Fan Zhibin Li Huadan Zheng Wenjin Long Wentao Qiu Yunhan Luo Jun Zhang Jinghua Ge Jianhui Yu Zhe Chen | 2020 | Photonics Research2020，8，7： | 1 |
| 10 | Association between TLR2 , MTR , MTRR , XPC , TP73 , TP53 genetic polymorphisms and gastric cancer: A meta-analysis显示文摘 | Chen Cheng Wang Lingyan Huang Yi Zhang Cheng Ye Huadan Xu Xuting Xu Leiting Ye Meng Duan Shiwei | 2014 | Clinics and Research in Hepatology and Gastroenterology2014，，： | 1 |
| 11 | Optimized weak measurement of orbital angular momentum-induced beam shifts in optical reflection显示文摘Tiny but universal beam shifts occur when a polarized light beam is reflected upon a planar interface.Although the beam shifts of Gaussian beams have been measured by the weak measurement technique, the weak measurement for orbital angular momentum(OAM)-induced spatial shifts of vortex beams is still missing.Here, by elaborately choosing the preselection and postselection states, the tiny OAM-induced Goos–H?nchen and Imbert–Fedorov shifts are amplified at an air–prism interface. The maximum shifts along directions both parallel and perpendicular to the incident plane are theoretically predicted and experimentally verified with optimal preselection and postselection states. These maximum shifts can be used to determine the OAM of vortex beams. | Wenjin Long Jintao Pan Xinyi Guo Xiaohe Liu Haolin Lin Huadan Zheng Jianhui Yu Heyuan Guan Huihui Lu Yongchun Zhong Shenhe Fu Li Zhang Wenguo Zhu Zhe Chen | 2019 | Photonics Research2019，7，11： | 1 |
| 12 | Relation between chemokine(CX-C motif) ligand 12 gene variant(rs1746048) and coronary heart disease=case-control study and meta-analysis显示文摘 | Yi Huang Jianqlng Zhou Huadan Ye | 2013 | qenei2013，521，1： | 1 |
| 13 | Imaging Diagnosis of TypeⅢCholedochal Cyst:A Case Report显示文摘Choledochocele is a congenital abnormality of the biliary system,which characterized by a cystic dilatation of intramural segment of the distal common bile duct.Choledochocele manifests as cystic lesions in the duodenal lumen and resembles duodenal duplication cysts in imaging.We reported a patient with choledochocele.Magnetic resonance cholangiopancreatography showed a thin-walled sac in the duodenal cavity and a fine tubular structure connecting with the end of the common bile duct.Magnetic resonance cholangiopancreatography is a noninvasive and convenient technique in the diagnosis of choledochocele. | Ping Li Liang Zhu Xuan Wang Huadan Xue Xin Wu Zhengyu Jin | 2018 | Chinese Medical Sciences Journal2018，33，3： | 0 |
| 14 | High-sensitivity and fast-response fiber optic temperature sensor using an anti-resonant reflecting optical waveguide mechanism显示文摘Temperature sensing is essential for human health monitoring.High-sensitivity(>1 nm∕℃)fiber sensors always require long interference paths and temperature-sensitive materials,leading to a long sensor and thus slow response(6–14 s).To date,it is still challenging for a fiber optic temperature sensor to have an ultrafast(~ms)response simultaneously with high sensitivity.Here,a side-polished single-mode/hollow/single-mode fiber(SPSHSF)structure is proposed to meet the challenge by using the length-independent sensitivity of an anti-resonant reflecting optical waveguide mechanism.With a polydimethylsiloxane filled sub-nanoliter volume cavity in the SP-SHSF,the SP-SHSF exhibits a high temperature sensitivity of 4.223 nm/℃ with a compact length of 1.6 mm,allowing an ultrafast response(16 ms)and fast recovery time(176 ms).The figure of merit(FOM),defined as the absolute ratio of sensitivity to response time,is proposed to assess the comprehensive performance of the sensor.The FOM of the proposed sensor reaches up to 263.94(nm/℃)∕s,which is more than two to three orders of magnitude higher than those of other temperature fiber optic sensors reported previously.Additionally,a threemonth cycle test shows that the sensor is highly robust,with excellent reversibility and accuracy,allowing it to be incorporated with a wearable face mask for detecting temperature changes during human breathing.The high FOM and high stability of the proposed sensing fiber structure provide an excellent opportunity to develop both ultrafast and highly sensitive fiber optic sensors for wearable respiratory monitoring and contactless in vitro detection. | ZHIBIN LI ZIYE WU ZHUOQI LI LIANGXUN OU WENXIANG ZHANG ZHICONG LAI YU ZHANG MENGYUAN XIE JIEYUAN TANG WENGUO ZHU HUADAN ZHENG YONGCHUN ZHONG XIONG DENG XIHUA ZOU ZHE CHEN JIANHUI YU | 2023 | Photonics Research2023，11，8： | 0 |
| 15 | Side Polished Fiber:A Versatile Platform for Compact Fiber Devices and Sensors显示文摘Side polished fiber(SPF)has a controllable average roughness and length of the side-polishing region,which becomes a versatile platform for integrating multiple materials to interact with the evanescent field to fabricate all-fiber devices and sensors.It has been widely used in couplers,filters,polarizers,optical attenuators,photodetectors,modulators,and sensors for temperature,humidity,strain,biological molecules,chemical gas,and vector magnetic monitoring.In this article,an overview of the development history,fabrication techniques,fiber types,transmission characteristics,and varied recent applications of SPFs are reviewed.Firstly,the fabrication techniques of SPFs are reviewed,including the V-groove assisted polishing technique and wheel polishing technique.Then,the different types of SPFs and their characteristics are discussed.Finally,various applications of SPFs are discussed and concluded theoretically and experimentally,including their principles and structures.When designing the device,the residual thickness and polishing lengths of the SPF need to be appropriately selected in order to obtain the best performance.Developing all-fiber devices and sensors is aimed at practical usability under harsh environments and allows to avoid the high coupling loss between optical fibers and on-chip integrated devices. | Linqing ZHUO Jieyuan TANG Wenguo ZHU Huadan ZHENG Heyuan GUAN Huihui LU Yaofei CHEN Yunhan LUO Jun ZHANG Yongchun ZHONG Jianhui YU Zhe CHEN | 2023 | Photonic Sensors2023，13，1： | 0 |
| 16 | Pancreatic cancer with ovarian metastasis: cases report and literature review显示文摘Background: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. Patients with ovarian metastases are first diagnosed with ovarian cancer and may miss the opportunity to receive surgical operation. We report 7 rare cases of ovarian metastases secondary to pancreatic adenocarcinoma and review the literature to analyze clinical characteristics, diagnostic methods, and potential therapeutic strategies for the rare malignancy.Cases Summary: We retrospectively analyzed the clinical data of 7 female patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from January 01, 1985, to April 1, 2020. These 7 patients were diagnosed with ovarian metastasis at an average age of 52.28 (38-69) years. The reason for the patient’s visit was generally a mass in the lower abdomen and/or abdominal pain. Six of them had significantly higher serum Carbohydrate antigen19-9 (CA19-9) levels, 6 patients had pancreatic tumors located in the body or tail, and 1 patient had one in the head of the pancreas. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. Five patients had pancreatic ductal adenocarcinoma (PDAC), and 2 had pancreatic cystadenocarcinoma (PCC), all of which were revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, all 7 patients have died (follow-up to January 2, 2021). The median survival time for all patients was 13.7 months (2.9-27 months).Conclusions: For this rare tumor, elevated serum CA19-9 may indicate that the primary lesion is in the pancreas. Enhanced pancreatic Computed Tomography (CT) can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve the quality of life. | Zeru Li Xingtong Zhou Bangbo Zhao Zhibo Zheng Cheng Qin Xudong Liu Huadan Xue Weibin Wang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
| 17 | 一画就是30年——记天祝唐卡画师马才成显示文摘When Ma Caicheng was a boy herding livestock on the grassland in Tianzhu Tibetan Autonomous County,Gansu Province,he was often awed by the different colors of the natural landscape.He also found the colors of Tibetan embroidery and Buddhist paintings rather charming and interesting from the time he was a child,and his special interest in colors led him to follow the path of art creation in his later career. | An Yingquan Huadan Nima | 2023 | China's Tibet2023，34，1： | 0 |
| 18 | Chinese expert consensus on multidisciplinary diagnosis and treatment of pancreatic neuroendocrine liver metastases显示文摘Many management strategies are available for pancreatic neuroendocrine neoplasms with liver metastases.However,a lack of biological,molecular,and genomic information and an absence of data from rigorous trials limit the validity of these strategies.This review presents the viewpoints from an international conference consisting of several expert working groups.The working groups reviewed a series of questions of particular interest to clinicians taking care of patients with pancreatic neuroendocrine neoplasms with liver metastases by reviewing the existing management strategies and literature,evaluating the evidence on which management decisions were based,developing internationally acceptable recommendations for clinical practice,and making recommendations for clinical and research endeavors.The review for each question will be followed by recommendations from the panel. | Yihebali Chi Liming Jiang Susheng Shi Shun He Chunmei Bai Dan Cao Jianqiang Cai Qichen Chen Xiao Chen Yiqiao Deng Shunda Du Zhen Huang Li Huo Yuan Ji Jie Li Wenhui Lou Jie Luo Xueying Shi Lijie Song Bei Sun Huangying Tan Feng Wang Xuan Wang Zhewen Wei Wenming Wu Dianrong Xiu Jianming Xu Huadan Xue Yi Yang Fei Yin Chunhui Yuan Yefan Zhang Weixun Zhou Dongbing Zhao Hong Zhao | 2023 | Journal of Pancreatology2023，6，4： | 0 |
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