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| 1 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 2 | The Main Content,Technical Support and Enforcement Strategy of Digital Agriculture显示文摘This paper deals with the content,purpose and significance of digital agriculture,and gives a brief introduction to digital earth,digital China and digital agriculture abroad.The main content of digital agriculture includes the construction of database,Metadata standard,monitoring system,forecasting and decision_making system,information_releasing system.The main technical supports of digital agriculture are 3S technology,Metadata management technology,fast_handling technology of remote sensing,the technology of computer wide_band network and virtual reality,intelligent agriculture machinery and field real_time information collecting technology.The advantages of implementing digital agriculture in China and the problems worthy of attention are pointed out as well. | Liang Yong Lu Xiushan Zhang Degui Liang Fu | 2002 | Geo-Spatial Information Science2002，5，1： | 6 |
| 3 | Digital zenith telescope prototype of China显示文摘Classical optical astronomy measures the direction of the local plumb line on the stellar background,and is influenced by variations of the earth gravity field.Therefore,classical optical astrometry can be used to measure and study variations of plumb line.This endows classical optical astrometric technologies special significance for the interdisciplinary researches of astronomy and geoscience,and makes them irreplaceable by technologies like very long baseline interferometry,satellite laser ranging.However,classical astrometric instruments have a major drawback of low efficiency,such as the low automaticity,more operating observers,and even operative error which makes it very difficult to reduce the random observation error in some visual instruments.To overcome this drawback,we have successfully developed the digital zenith telescope prototype(DZT-1)with the aperture of200 mm,using charge coupled device and other advanced technologies and new equipments.As proved by test observations,DZT-1 can observe thousands of stars over one night,which significantly reduces the random observation error and increases the observation accuracy.In addition,DZT-1 has a high degree of automation,even allowing unattended observation by remote control.Besides,DZT-1 has a small-size and is easy to move,making it convenient for mobile measurement of the deflection of the vertical.In summary,DZT can be widely used in the geoscience and astronomy fields. | Lili Tian Jinyun Guo Yanben Han Xiushan Lu Weidong Liu Zheng Wang Bo Wang Zhiqiang Yin Hongqi Wang | 2014 | Chinese Science Bulletin2014，59，17： | 4 |
| 4 | An Automatic Cycle-Slip Processing Method and Its Precision Analysis显示文摘On the basis of analyzing and researching the current algorithms of cycle-slip detection and correction, a new method of cycle-slip detection and correction is put forward in this paper, that is, a reasonable cycle-slip detection condition and algorithm with corresponding program COMPRE (COMpass PRE-processing) to detect and correct cycle-slip automatically, compared with GIPSY and GAMIT software, for example, it is proved that this method is effective and credible to cycle-slip detection and correction in GPS data pre-processing. | ZHENG Zuoya LU Xiushan | 2006 | Geo-Spatial Information Science2006，9，2： | 2 |
| 5 | Constructing a Type of New Wavelet Function and its Application in GPS Data Pre-processing显示文摘 | ZHENG Zuoya LU Xiushan DU Zhixing | | AVN0，，： | 1 |
| 6 | Precise positioning of underwater static objects without sound speed profile 显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao etal | 2011 | Marine Geodesy ( S0149- 0419 )2011，34，2： | 1 |
| 7 | Coarse-to-Fine Video Instance Segmentation With Factorized Conditional Appearance Flows显示文摘We introduce a novel method using a new generative model that automatically learns effective representations of the target and background appearance to detect,segment and track each instance in a video sequence.Differently from current discriminative tracking-by-detection solutions,our proposed hierarchical structural embedding learning can predict more highquality masks with accurate boundary details over spatio-temporal space via the normalizing flows.We formulate the instance inference procedure as a hierarchical spatio-temporal embedded learning across time and space.Given the video clip,our method first coarsely locates pixels belonging to a particular instance with Gaussian distribution and then builds a novel mixing distribution to promote the instance boundary by fusing hierarchical appearance embedding information in a coarse-to-fine manner.For the mixing distribution,we utilize a factorization condition normalized flow fashion to estimate the distribution parameters to improve the segmentation performance.Comprehensive qualitative,quantitative,and ablation experiments are performed on three representative video instance segmentation benchmarks(i.e.,YouTube-VIS19,YouTube-VIS21,and OVIS)and the effectiveness of the proposed method is demonstrated.More impressively,the superior performance of our model on an unsupervised video object segmentation dataset(i.e.,DAVIS19)proves its generalizability.Our algorithm implementations are publicly available at http://gffzz188fe103f8f1460askpnqxbwno5uv6xub.ffgz.tsg.suse.edu.cn/zyqin19/HEVis. | Zheyun Qin Xiankai Lu Xiushan Nie Dongfang Liu Yilong Yin Wenguan Wang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 1 |
| 8 | Precise positioning of underwater static objects without sound speed Profile显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao | 2011 | Marine Geodesy(S0149-0419)2011，34，2： | 1 |
| 9 | Global asymptotic stability of a class of nonlinear systems with parametric uncertainty显示文摘Stability of a class of nonlinear systems with parametric uncertainty is dealt with. This kind of systems can be viewed as feedback interconnection systems. By constructing the Lyapunov function for one of the feedback interconnection systems, the Lyapunov function for this kind of systems is obtained. Suffcient conditions of global asymptotic stability for this class of systems are deduced. The simulation shows the effectiveness of the method. | Cai Xiushan Lu Ganyun Zhang Changjiang He Xiuhui | 2009 | Journal of Systems Engineering and Electronics2009，20，1： | 1 |
| 10 | Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation显示文摘 | Shan Li Kefeng Lu Jian Wang Liguo An Guiwen Yang Hui Chen Yu Cui Xiushan Yin Ping Xie Guichun Xing Fuchu He Lingqiang Zhang | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 11 | Learned local similarity prior embedding active contour model for choroidal neovascularization segmentation in optical coherence tomography images显示文摘Dear editor,Choroidal neovascularization(CNV)is characterized by the growth of new blood vessels in the choroid layer.These new blood vessels break beneath the retina and damage the surrounding reti- | Xiaoming XI Xianjing MENG Lu YANG Xiushan NIE Zhilou YU Chunyun ZHANG Haoyu CHEN Yilong YIN Xinjian CHEN | 2018 | Science China(Information Sciences)2018，61，9： | 0 |
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