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| 1 | Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers显示文摘 | Kaichao Feng Yang Liu Yelei Guo Jingdan Qiu Zhiqiang Wu Hanren Dai Qingming Yang Yao Wang Weidong Han1,3 | 2018 | Protein & Cell2018，9，10： | 37 |
| 2 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy显示文摘CD8^+T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1,an interaction acts like brakes to prevent T cell overreaction under normal conditions but is exploited by tumor cells to escape the immune surveillance.Immune checkpoint inhibitors have revolutionized cancer therapeutics by removing such brakes.Unfortunately,only a minority of cancer patients respond to immunotherapies presumably due to inadequate immunity.Antitumor immunity depends on the activation of the cGAS-STING pathway,as STING-deficient mice fail to stimulate tumor-infiltrating dendritic cells(DCs)to activate CD8^+T cells.STING agonists also enhance natural killer(NK)cells to mediate the clearance of CD8^+T cell-resistant tumors.Therefore STING agonists have been intensively sought after.We previously discovered that manganese(Mn)is indispensable for the host defense against cytosolic dsDNA by activating cGAS-STING.Here we report that Mn is also essential in innate immune sensing of tumors and enhances adaptive immune responses against tumors.Mn-insufficient mice had significantly enhanced tumor growth and metastasis,with greatly reduced tumor-infiltrating CD8^+T cells.Mechanically,Mn^2+promoted DC and macrophage maturation and tumor-specific antigen presentation,augmented CD8^+T cell differentiation,activation and NK cell activation,and increased memory CD8^+T cells.Combining Mn^2+with immune checkpoint inhibition synergistically boosted antitumor efficacies and reduced the anti-PD-1 antibody dosage required in mice.Importantly,a completed phase 1 clinical trial with the combined regimen of Mn^2+and anti-PD-1 antibody showed promising efficacy,exhibiting type I IFN induction,manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.We propose that this combination strategy warrants further clinical translation. | Mengze Lv Meixia Chen Rui Zhang Wen Zhang Chenguang Wang Yan Zhang Xiaoming Wei Yukun Guan Jiejie Liu Kaichao Feng Miao Jing Xurui Wang Yun-Cai Liu Qian Mei Weidong Han Zhengfan Jiang | 2020 | Cell Research2020，30，11： | 27 |
| 3 | Flow Characteristics Diagnosis and Optimization for Dust Collectors Inflow Duct in Thermal Power Plants显示文摘火电厂烟风道用于输送烟气、冷风等介质,其设计优化水平不但影响火电厂烟风系统阻力的大小,而且影响与烟风道直接相连的各个设备的运行状态。某600MW机组除尘器前烟道设计不合理,存在磨损严重、进入除尘器烟气分配不均等问题,文中采用标准缸￡模型,利用Fluent求解器对该部分烟道的流场进行数值计算,诊断分析其存在的主要问题,提出的3个改造方案均可使烟道阻力大幅度下降、烟道磨损减轻、进入除尘器烟气分配均匀。同时,研究了缓转半径及烟气流速对该段烟道阻力和烟气分配的影响情况,计算结果表明该段烟道缓转半径宜选在0.875以上,烟气流速对该段烟道的性能基本没有影响。 | LIU Ming MENG Guixiang YAN Junjie CHEN Weixiong LI Weidong CHONG Daotong LIU Jiping | 2013 | 中国电机工程学报2013，33，11： | 22 |
| 4 | Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction. | Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan | 2017 | National Science Review2017，4，1： | 23 |
| 5 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 6 | Impact of urbanization on changes in temperature extremes in Beijing during 1978–2008显示文摘To quantify the impact of urbanization on changes in observed surface air temperature and extremes,a homogenized dataset of daily mean,maximum and minimum temperature(Tm,Tmax and Tmin)observations at 20 stations in Greater Beijing(GBJ)from1978 to 2008 is analyzed.In contrast with previous studies,a cluster analysis is done to objectively classify observing stations into four categories(urbanized,suburban,rural and mountain),which is checked with remote-sensing night-light images since the1990s.At urbanized sites,there is an added warming trend in annual mean Tm representing an average of 10.9%(up to 18.4%or0.12°C/decade at the most strongly influenced site)of overall warming.Corresponding contributions for Tmin are 12.7%(up to20.8%or 0.19°C/decade)and 24%for diurnal temperature range DTR(up to 37.4%or 0.149°C/decade)over the last three decades.Although it has not had a significant impact on daytime records(Tmax),urbanization has enhanced the increasing(decreasing)trend of extremely warm(cold)nights by an average of 12.7%or 2.07 d/decade(29.0%or 5.06 d/decade)at the urbanized sites since the 1970s. | WANG Jun YAN ZhongWei LI Zhen LIU WeiDong WANG YingChun | 2013 | Chinese Science Bulletin2013，58，36： | 18 |
| 7 | Accuracy of LA-ICPMS zircon U-Pb age determination:An inter-laboratory comparison显示文摘LA-ICPMS zircon U-Pb dating has been greatly advanced and widely applied in the past decade because it is a cheap and fast technique.The internal error of LA-ICPMS zircon U-Pb dating can be better than 1%,but reproducibility(accuracy)is relatively poor.In order to quantitatively assess the accuracy of this technique,zircons from two dioritic rocks,a Mesozoic dioritic microgranular enclave(FS06)and a Neoproterozoic diorite(WC09-32),were dated independently in eight laboratories using SIMS and LA-ICPMS.Results of three SIMS analyses on FS06 and WC09-2 are indistinguishable within error and give a best estimate of the crystallization age of 132.2 and 760.5 Ma(reproducibility is^1%,2RSD),respectively.Zircon U-Pb ages determined by LA-ICPMS in six laboratories vary from 128.3±1.0 to 135.0±0.9 Ma(2SE)for FS06 and from 742.9±3.1 to777.8±4.7 Ma(2SE)for WC09-32,suggesting a reproducibility of^4%(2RSD).Uncertainty produced during LA-ICPMS zircon U-Pb analyses comes from multiple sources,including uncertainty in the isotopic ratio measurements,uncertainty in the fractionation factor calculation using an external standard,uncertainty in the age determination as a result of common lead correction,age uncertainty of the external standards and uncertainty in the data reduction.Result of our study suggests that the uncertainty of LA-ICPMS zircon U-Pb dating is approximately 4%(2RSD).The uncertainty in age determination must be considered in order to interpret LA-ICPMS zircon U-Pb data rationally. | LI XianHua LIU XiaoMing LIU YongSheng SU Li SUN WeiDong HUANG HuiQing YI Keewook | 2015 | Science China Earth Sciences2015，58，10： | 15 |
| 8 | The root microbiome:Community assembly and its contributions to plant fitness显示文摘The root microbiome refers to the community of microbes living in association with a plant's roots,and includes mutualists,pathogens,and commensals.Here we focus on recent advances in the study of root commensal community which is the major research object of microbiomerelated researches.With the rapid development of new technologies,plant-commensal interactions can be explored with unprecedented breadth and depth.Both the soil environment and the host plant drive commensal community assembly.The bulk soil is the seed bank of potential commensals,and plants use root exudates and immune responses to build healthy microbial communities from the available microbes.The plant microbiome extends the functional system of plants by participating in a variety of processes,including nutrient absorption,growth promotion,and resistance to biotic and abiotic stresses.Plants and their microbiomes have evolved adaptation strategies over time.However,there is still a huge gap in our understanding of the regulatory mechanisms of plant-commensal interactions.In this review,we summarize recent research on the assembly of root microbial communities and the effects of these communities on plant growth and development,and look at the prospects for promoting sustainable agricultural development through the study of the root microbiome. | Bo Bai Weidong Liu Xingyu Qiu Jie Zhang Jingying Zhang Yang Bai | 2022 | Journal of Integrative Plant Biology2022，64，2： | 13 |
| 9 | Syntheses and Fungicidal Activities of Thiazole-5-carboxanilides Bearing Thioether Group显示文摘 | XUE Hansong LIU Aiping LIU Weidong LI Jianming REN Yeguo HUANG Lu HE Lian OU Xiaoming YE Jiao HUANG Mingzhi | 2016 | Chemical Research in Chinese Universities2016，32，5： | 13 |
| 10 | Different dietary starch sources alter the carcass traits, meat quality, and the profile of muscle amino acid and fatty acid in finishing pigs显示文摘Background: With increasing health awareness among consumers, the demand for healthier, tastier, higher quality and nutritional value pork is increasing. It has been shown that different dietary starch sources can alter the carcass traits and meat quality. However, research on the effects of different starch sources with clear different amylose/amylopectin ratio on the amino acid and fatty acid composition in Longissimus thoracis(L. thoracis) muscle of pigs is limited. This study aimed to investigate the effects of different dietary starch sources on carcass traits, meat quality, muscle amino acid and fatty acid composition, and the mRNA expression levels of genes involved in lipid metabolism and muscle fiber characteristics in finishing pigs. A total of 72 Duroc × Landrace × Large White barrows were randomly allocated to 3 different dietary treatment groups with 8 replicate pens/group and 3 pigs per pen.Tapioca starch(TS), corn starch(CS), and pea starch(PS), with amylose/amylopectin ratio of 0.11, 0.25, and 0.44,respectively, were used as their dietary starch sources for 40 days.Results: Results showed that the PS diet significantly increased(P < 0.05) the final body weight, average daily gain,loin-eye area, and fat-free lean index compared with the TS diet, but significantly decreased(P < 0.05) the feed to gain ratio and backfat thickness. Compared with the TS diet, PS diet also increased(P < 0.05) the pH45 min, marbling scores, the content of intramuscular fat and inosine monophosphate in the L. thoracis, and decreased(P < 0.05) the drip loss and shear force. In addition, compared with the TS diet, PS diet increased(P < 0.05) the proportions of flavor amino acids, DHA, EPA, and n-3 polyunsaturated fatty acid(PUFA) in the L. thoracis compared with TS diet,but decreased(P < 0.05) the ratio of n-6/n-3 PUFA. Furthermore, compared with the TS diet, PS diet also upregulated(P < 0.05) the lipogenic genes(FAS, LPL, SCD, ACCα) and myosin heavy-chain(MyHC)-IIa mRNA expression levels compared with the TS diet, but downregulated(P < 0.05) the CPT1 B and MyHC-IIb mRNA levels.Conclusions: In conclusion, these results provided compelling evidence that the different dietary starch source altered the carcass traits, meat flavor and quality in finishing pigs, and consumption of a diet with higher amylose/amylopectin ratio results in the production of a healthy, higher quality, and nutritional value pork. | Miao Yu Zhenming Li Ting Rong Gang Wang Zhichang Liu Weidong Chen Jiazhou Li Jianhao Li Xianyong Ma | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 13 |
| 11 | A review on China's constructed wetlands in recent three decades:Application and practice显示文摘Constructed wetlands(CWs)have been introduced to and developed in China for environmental engineering over the most prosperous three decades(1990–2020).To study the origin,development process,and future trend of CWs,this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors.Firstly,the publication number over years,research highlights,and the author contributions with the most published papers in this field were conducted through bibliometric analysis.Secondly,the most principal components of CWs,substrates and macrophytes were summarized and analyzed.Thirdly,the typical application cases from traditional CWs,pond systems to combined pond-wetland systems were presented.In China,CWs were predominately distributed in the east of the so-called'Hu Huanyong Line'.Therefore CWs were limited by the socio-economic level and climatic conditions.It is unquestionable that the overall level of China's CWs has improved significantly,and one of the most prominent features has started towards the plural pattern development.There has been a trend of large-scale or low-cost CW application in the recent years.However,lifecycle research and management are required for better strategies in the future. | Hong Zhang Wenzhong Tang Weidong Wang Wei Yin Honglei Liu Xiaomin Ma Yiqi Zhou Pei Lei Dongyang Wei Litian Zhang Cao Liu Jinmiao Zha | 2021 | Journal of Environmental Sciences2021，33，6： | 13 |
| 12 | Microstructure and Mechanical Properties of Al_2O_3/ZrO_2 Directionally Solidified Eutectic Ceramic Prepared by Laser 3D Printing显示文摘Directionally solidified eutectic ceramics such as(Al)_2O_3/ZrO_2 are promising structural materials for applications in harsh environment with an ultrahigh temperature. In this work, through adopting assistant heating laser 3D printing,(Al)_2O_3/ZrO_2eutectic samples were manufactured with suppressing the formation of cracks. The dependence of the average rod spacing(λav) on the scanning rate(V) follows a relation with λav V0.5= 1 μm1.5s–0.5. Typical eutectic microstructures, so-called complex regular, were analyzed with respect to its evolution with modulating the growth conditions. Formation mechanism of the solidification defect, shrinkage porosity, was discussed and the defect is found to be significantly suppressed by optimizing the solidification parameters. The maximum hardness and fracture toughness are measured to be 16.7 GPa and 4.5 MPa m1/2, respectively. The interplay between the propagation of cracks and the (Al)_2O_3/ZrO_2 interface is discussed. | Zhi Liu Kan Song Bo Gao Tian Tian Haiou Yang Xin Lin Weidong Huang | 2016 | Journal of Materials Science & Technology2016，32，4： | 12 |
| 13 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 14 | The challenge of wide application of information and communication technologies to traditional location theory显示文摘信息和通讯技术(ICT ) 的宽申请被说服了对公司的空间转变批评。在沿着这根线的研究的最近的进展质问了传统的地点理论。然而,存在文学主要集中于 ICT 的影响在位置上的条件和工业空间分发上。在如此的变化后面的动力学被地理学者还没给了足够的注意。给这个背景,这份报纸在传统的地点理论和被新 ICT 启用的工业重定位的动力学上调查新 ICT 的影响,基于从 178 个公司的调查收集的数据。纸主张新 ICT 的申请是在信息时代的一个关键地点因素,并且时间费用对公司的空间组织正在变得批评特别地由于更短的产品生活和集体定制,在另外的动力学之中。 | SONG Zhouying | 2013 | Journal of Geographical Sciences2013，23，2： | 12 |
| 15 | Speciation, distribution, and potential ecological risk assessment of heavy metals in Xiamen Bay surface sediment显示文摘Based on the survey of surface sediment in Xiamen Bay in October 2011, the speciation, distribution, and potential ecological risk assessment of heavy metals(Cu, Pb, Zn, Cd, and Cr) in this area were studied using the sequential extraction method and ecological risk assessment method. The results indicated:(1) the total concentrations of these heavy metals were influenced by runoff, industrial wastewater, and sewage, and were all higher in the coastal area than the offshore area while the highest area of Pb was a little farther away from the coastal water due to atmosphere deposition;(2) sequential extractions suggested that Cu was mainly composed with residual and Fe/Mn-oxide bound fractions, Pb was bound to Fe/Mn-oxide, Zn and Cr were dominated by residual, and Cd bound to exchangeable and carbonate fractions;(3) the order of migration and transformation sequence was Cd>Pb>Cu>Zn>Cr and the degree of pollution was Cd>Pb>Cu>Zn>Cr; and(4) the ratios of the secondary and primary phases showed that Zn and Cr were both clean, Cu may be polluted, Pb was moderately polluted, while Cd was heavily polluted. | LIN Cai LIU Yang LI Wenquan SUN Xiuwu JI Weidong | 2014 | Acta Oceanologica Sinica2014，33，4： | 11 |
| 16 | Chimeric antigen receptor (CAR)-modified natural killer cell-based immunotherapy and immunological synapse formation in cancer and HIV显示文摘 | Dongfang Liu Shuo Tian Kai Zhang Wei Xiong Ndongala Michel Lubaki Zhiying Chen Weidong Han | 2017 | Protein & Cell2017，8，12： | 11 |
| 17 | Plate subduction, oxygen fugacity, and mineralization显示文摘Plate subduction is the largest natural factory that processes elements,which controls recycling and mineralization of a variety of elements.There are three major ore deposit belts in the world:the circumPacific,the centralAsian,and the Tethys belts.All the three belts are closely associated with plate subductions,the mechanism remains obscure.We approached this problem from systematic studies on the behaviours of elements during geologic processes.This contribution summaries the recent progress of our research group.Our results suggest that porphyry Cu deposits form through partial melting of subducted young oceanic crust under oxygen fugacities higher than AFMQ^+1.5,which is promoted after the elevation of atmospheric oxygen at ca.550 Ma.Tin deposits are associated with reducing magmatic rocks formed as a consequence of slab rollback.The Neo-Tethys tectonic regime hosts more than 60%of the world's total Sn reserves.This is due to the reducing environment formed during the subduction of organic rich sediments.For the same reason,porphyry Cu deposits formed in the late stages during the closure of the Neo-Tethys Ocean.Tungsten deposits are also controlled by slab rollback,but is not so sensitive to oxygen fugacity.Subduction related W/Sn deposits are mostly accompanied by abundant accessory fluorites due to the breakdown of phengite and apatite.Decomposition of phengite is also significant for hard rock lithium deposits,whereas orogenic belt resulted from plate subduction promote the formation of Li brine deposits.Cretaceous red bed basins near the Nanling region are favorable for Li brines.Both Mo and Re are enriched in the oxidationreduction cycle during surface processes,and may get further enriched once Mo-,Re-enriched sediments are subducted and involved in magmatism.During plate subduction,Mo and Re fractionate from each other.Molybdenum is mainly hosted in porphyry Mo deposits and to a less extent,porphyry Cu-Mo deposits,whereas Re is predominantly hosted in porphyry Cu-Mo deposits and sedimentary sulfide deposits. | LIU He LIAO Renqiang ZHANG Lipeng LI Congying SUN Weidong | 2020 | Journal of Oceanology and Limnology2020，38，1： | 10 |
| 18 | In-plane corrugated cosine honeycomb for 1D morphing skin and its application on variable camber wing显示文摘A novel 0-Poisson's ratio cosine honeycomb support structure of flexible skin is proposed. Mechanical model of the structure is analyzed with the energy method, finite element method (FEM) and experiments have been performed to validate the theoretical model. The in-plane characteristics of the cosine honeycomb are compared with accordion honeycomb through analytical models and experiments. Finally, the application of the cosine honeycomb on a variable camber wing is studied. Studies show that mechanical model agrees well with results of FEM and experiments. The transverse non-dimensional elastic modulus of the cosine honeycomb increases (decreases) when the wavelength or the wall width increases (decreases), or when the amplitude decreases (increases). Compared with accordion honeycomb, the transverse non-dimensional elastic modulus of the cosine honeycomb is smaller, which means the driving force is smaller and the power consumption is less during deformation. In addition, the cosine honeycomb can satisfy the deform- ing requirements of the variable camber wing. | Liu Weidong Zhu Hua Zhou Shengqiang Bai Yalei Wang Yuan Zhao Chunsheng | 2013 | Chinese Journal of Aeronautics2013，26，4： | 10 |
| 19 | 采用Fisher判别法对GIS中局部放电类型的识别(英文)显示文摘To monitor the condition of online power apparatus accurately and provide appropriate guidance on their maintenance,a fundamental ultra-high frequency(UHF) database of partial discharges corresponding to different types of defects is presented for the observation of insulation state of gas insulated switchgear(GIS).In order to imitate the defects in a GIS online,five types of typical partial discharge(PD) sources(i.e.floating metal,protrusion,bouncing particles,void in spacer,and particle on the surface of solid insulation) were designed and fabricated.A wideband UHF sensor and an amplifier were applied to obtain UHF signals.Based on the characteristics of the five different defects,nine meaningful parameters which were independent of the phase of the applied voltage were extracted from the PD samples and then discussed.In this paper,Fisher discriminant analysis(FDA),a pattern recognition algorithm,was applied for the purpose of classifying the defects.In this way,there was no need to set complicated parameters and kernel function,and the total discrimination accuracy of test samples was 97.6%.It indicates that based on the nine especial parameters,the typical defects in GIS can be identified exactly by means of FDA.Hence the analysis method could be possibly regarded as a universal classification method. | DING Dengwei GAO Wensheng LIU Weidong | 2013 | 高电压技术2013，39，4： | 9 |
| 20 | Proactive Health: An Imperative to Achieve the Goal of Healthy China显示文摘Proactive Health has become a new service model to improve human health.Although the concept of Proactive Health has been proposed by the Outline of the Healthy China 2030 Plan and the Healthy China Initiative,the lack of a unified definition of Proactive Health in China’s academic community is still the most fundamental and critical deficiency.Therefore,based on the concepts of Proactive Health,this study analyzed and described the natural characteristics and implications of Proactive Health to establish an exact definition. | Jue Liu Weidong Li Hongyan Yao Jianjun Liu | 2022 | China CDC weekly2022，4，36： | 9 |
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