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| 1 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 2 | Application of synchrotron source based DEI method in guinea pig cochleae imaging显示文摘难 X 光检查衍射提高的成像(DEI ) 基于同步加速器来源和 monochromator-analyzer-crystal 系统,是为成像的一个有效方法 X 光检查阶段移动。与高尖的敏感利用分析器晶体微弧度, DEI 罐头措施播送,测定并且当投射到一件样品上时,散布了 X 光。它戏剧性地改进对比和结果的图象的空间分辨率。在北京同步加速器放射设备(BSRF ) 的地形学车站,我们在畿尼猪 cochleae 成像实现了 DEI 方法并且获得了一系列 DEI 图象。把图象,明显的吸收和折射基于这些图象被计算。DEI 图象清楚地揭示了整体的螺线结构和畿尼猪 cochleae 的内部细节,甚至包括在细胞的水平的结构,例如毛乎乎的房间的静态的睫和汉森房间的异色边缘。由于高对比,高空间的分辨率和不同提高边的效果的优点, DEI 方法在不久的将来在生物学,药和诊所答应广泛的应用程序。 | YIN Hongxia LIU Bo GAO Xin GAO Xiulai LUO Shuqian | 2007 | Progress in Natural Science:Materials International2007，17，1： | 3 |
| 3 | Enhancement of α-ketoisovalerate production by relieving the product inhibition of L-amino acid deaminase from Proteus mirabilis显示文摘L-Amino acid deaminase(LAAD) is a key enzyme in the deamination of L-valine(L-val) to produce α-ketoisovalerate(KIV). However, the product inhibition of LAAD is a major hindrance to industrial KIV production.In the present study, a combination strategy of modification of flexible loop regions around the product binding site and the avoidance of dramatic change of main-chain dynamics was reported to reduce the product inhibition.The four mutant PM-LAAD^(M4)(PM-LAAD^(S98A/T105A/S106A/L341A)) achieved a 6.2-fold higher catalytic efficiency and an almost 6.7-fold reduction in product inhibition than the wild-type enzyme. Docking experiments suggested that weakened interactions between the product and enzyme, and the flexibility of the 'lid' structure relieved LAAD product inhibition. Finally, the whole-cell biocatalyst PM-LAAD^(M4) has been applied to KIV production,the titer and conversion rate of KIV from L-val were 98.5 g·L^-1 and 99.2% at a 3-L scale, respectively. These results demonstrate that the newly engineered catalyst can significantly reduce the product inhibition, that making KIV a prospective product by bioconversion method, and also provide the understanding of the mechanism of the relieved product inhibition of PM-LAAD. | Shanshan Pei Xiaobo Ruan Jia Liu Wei Song Xiulai Chen Qiuling Luo Liming Liu Jing Wu | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 2 |
| 4 | Diabolical points in coupled active cavities with quantum emitters显示文摘In single microdisks,embedded active emitters intrinsically affect the cavity modes of the microdisks,resulting in trivial symmetric backscattering and low controllability.Here we demonstrate macroscopic control of the backscattering direction by optimizing the cavity size.The signature of the positive and negative backscattering directions in each single microdisk is confirmed with two strongly coupled microdisks.Furthermore,diabolical points are achieved at the resonance of the two microdisks,which agrees well with theoretical calculations considering the backscattering directions.Diabolical points in active optical structures pave the way for an implementation of quantum information processing with geometric phase in quantum photonic networks. | Jingnan Yang Chenjiang Qian Xin Xie Kai Peng Shiyao Wu Feilong Song Sibai Sun Jianchen Dang Yang Yu Shushu Shi Jiongji He Matthew JSteer Iain GThayne Bei-Bei Li Fang Bo Yun-Feng Xiao Zhanchun Zuo Kuijuan Jin Changzhi Gu Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 5 | Observation of coupling between zero- and two- dimensional semiconductor systems based on anomalous diamagnetic effects显示文摘我们报导在一个单个自我装配的 InAs 量点和弄湿的层之间联合的直接观察,基于用磁电机光致发光光谱学的许多身体激子状态的强壮的抗磁的移动。当在弄湿的层的一个电子在量点与一个洞结合时,一个极其大的积极抗磁的系数被观察;系数比在量点限制的激子状态的大将近一个数量级。有在联合系统的一个量点的洞的电子的再结合导致不平常的否定抗磁的效果,它在一个纯量点系统是比那强壮五倍的。这效果能被归因于在再结合以后处于量点的激动的状态在弄湿的层或电子的传播仍然是电子到弄湿的层的 wavefunction 的扩大。在这种情况中,因为洞的缺席,在量点飞机的最后的状态的 wavefunction 程度比起始的状态的大得多吸引电子。在弄湿的层取决于大电子 wavefunction 程度的射出的光子的性质显示联合发生在不同维数的系统之间,它也从在不同配置使用一个磁场获得的结果被验证。这研究铺平一条新道路与零维、二维的结构观察混合状态,它能为调查 Kondo 物理并且实现是有用的基于纺纱固态量信息处理。 | Shuo Cao Jing Tang Yue Sun Kai Peng Yunan Gao Yanhui Zhao Chenjiang Qian Sibai Sun Hassan Ali Yuting Shao Shiyao Wu Feilong Song David A. Williams Weidong Sheng Kuijuan Jin Xiulai Xu | 2016 | Nano Research2016，9，2： | 2 |
| 6 | Short-term, Mild Hypothermia Can Increase the Beneficial Effect of Permissive Hypotension on Uncontrolled Hemorrhagic Shock in Rats显示文摘 | Tao Li Xiulai Lin Yu Zhu Lijie Li Liangming Liu | 2012 | Anesthesiology2012，，6： | 1 |
| 7 | Ship Detection and Recognition Based on Improved YOLOv7显示文摘In this paper,an advanced YOLOv7 model is proposed to tackle the challenges associated with ship detection and recognition tasks,such as the irregular shapes and varying sizes of ships.The improved model replaces the fixed anchor boxes utilized in conventional YOLOv7 models with a set of more suitable anchor boxes specifically designed based on the size distribution of ships in the dataset.This paper also introduces a novel multi-scale feature fusion module,which comprises Path Aggregation Network(PAN)modules,enabling the efficient capture of ship features across different scales.Furthermore,data preprocessing is enhanced through the application of data augmentation techniques,including random rotation,scaling,and cropping,which serve to bolster data diversity and robustness.The distribution of positive and negative samples in the dataset is balanced using random sampling,ensuring a more accurate representation of real-world scenarios.Comprehensive experimental results demonstrate that the proposed method significantly outperforms existing state-of-the-art approaches in terms of both detection accuracy and robustness,highlighting the potential of the improved YOLOv7 model for practical applications in the maritime domain. | Wei Wu Xiulai Li Zhuhua Hu Xiaozhang Liu | 2023 | Computers, Materials & Continua2023，，7： | 1 |
| 8 | Blockchain Security Threats and Collaborative Defense:A Literature Review显示文摘As a distributed database,the system security of the blockchain is of great significance to prevent tampering,protect privacy,prevent double spending,and improve credibility.Due to the decentralized and trustless nature of blockchain,the security defense of the blockchain system has become one of the most important measures.This paper comprehensively reviews the research progress of blockchain security threats and collaborative defense,and we first introduce the overview,classification,and threat assessment process of blockchain security threats.Then,we investigate the research status of single-node defense technology and multi-node collaborative defense technology and summarize the blockchain security evaluation indicators and evaluation methods.Finally,we discuss the challenges of blockchain security and future research directions,such as parallel detection and federated learning.This paper aims to stimulate further research and discussion on blockchain security,providing more reliable security guarantees for the use and development of blockchain technology to face changing threats and challenges through continuous updating and improvement of defense technologies. | Xiulai Li Jieren Cheng Zhaoxin Shi Jingxin Liu Bin Zhang Xinbing Xu Xiangyan Tang Victor S.Sheng | 2023 | Computers, Materials & Continua2023，76，9： | 1 |
| 9 | Improving succinate production by engineering oxygen‑dependent dynamic pathway regulation in Escherichia coli显示文摘Succinate is an important building block for chemical synthesis.However,during the fermentation process,excessive osmotic stress and byproduct accumulation substantively impair the performance of the microbial cell factory.To this end,two strategies were proposed.First,an osmo-tolerant mutant,Escherichia coli FMME-N-2,was screened by combined mutagenesis(ARTP and^(60)Co-γirradiation)to produce 51.8 g L^(−1)succinate with a productivity of 0.81 g L^(−1)h^(−1).Second,an oxygen-dependent bifunctional switch(OBS)was developed with promoter PfnrF8-based activation and tobacco etch virus protease-based inhibition functions.With ribosomal binding site(RBS)and degron optimization of OBS,the optimal strain E.coli FMME-N-30 achieved a succinate titer and productivity of 119 g L^(−1)and 1.65 g L^(−1) h^(−1),respectively,in a 30-L fermentor,while only 7.1 g L^(−1)acetate and no formate or lactate were detected.Compared to the wild-type strain E.coli FMME-N,the succinate titer was increased by 3.3-fold.These results highlight the applicability of OBS for the large-scale production of value-added chemicals. | Cong Gao Wenxiu Tang Liang Guo Guipeng Hu Jia Liu Liming Liu Xiulai Chen | 2022 | Systems Microbiology and Biomanufacturing2022，2，2： | 1 |
| 10 | A Modified PointNet-Based DDoS Attack Classification and Segmentation in Blockchain显示文摘With the rapid development of blockchain technology,the number of distributed applications continues to increase,so ensuring the security of the network has become particularly important.However,due to its decentralized,decentralized nature,blockchain networks are vulnerable to distributed denial-of-service(DDoS)attacks,which can lead to service stops,causing serious economic losses and social impacts.The research questions in this paper mainly include two aspects:first,the classification of DDoS,which refers to detecting whether blockchain nodes are suffering DDoS attacks,that is,detecting the data of nodes in parallel;The second is the problem of DDoS segmentation,that is,multiple pieces of data that appear at the same time are determined which type of DDoS attack they belong to.In order to solve these problems,this paper proposes a modified PointNet(MPointNet)for the classification and type segmentation of DDoS attacks.A dataset containing multiple DDoS attack types was constructed using the CIC-DDoS2019 dataset,and trained,validated,and tested accordingly.The results show that the proposed DDoS attack classification method has high performance and can be used for the actual blockchain security maintenance process.The accuracy rate of classification tasks reached 99.65%,and the accuracy of type segmentation tasks reached 85.47%.Therefore,the method proposed in this paper has high application value in detecting the classification and segmentation of DDoS attacks. | Jieren Cheng Xiulai Li Xinbing Xu Xiangyan Tang Victor S.Sheng | 2023 | Computer Systems Science & Engineering2023，47，10： | 1 |
| 11 | Efficient synthesis of tyrosol from L-tyrosine via heterologous Ehrlich pathway in Escherichia coli显示文摘For the efficient conversion of L-tyrosine(L-Tyr)to tyrosol,which is an aromatic compound widely used in the pharmaceutical and chemical industries,a novel four-enzyme cascade pathway based on the Ehrlich pathway of Saccharomyces cerevisiae was designed and reconstructed in Escherichia coli.Then,the expression levels of the relevant enzymes were coordinated using a modular approach and gene duplication after the identification of the pyruvate decarboxylase from Candida tropicalis(CtPDC)as the rate-limiting enzymatic step.In situ product removal(ISPR)strategy with XAD4 resins was explored to avoid product inhibition and further improve tyrosol yield.As a result,the titer and conversion rate of tyrosol obtained were 35.7 g·L^(-1) and 93.6%,respectively,in a 3-L bioreactor.Results presented here provide a potential enzymatic process for industrial production of tyrosol from cheap amino acids. | Xiaobo Ruan Sheng Zhang Wei Song Jia Liu Xiulai Chen Liming Liu Jing Wu | 2022 | Chinese Journal of Chemical Engineering2022，35，7： | 1 |
| 12 | Anisotropies of the g-factor tensor and diamagnetic coefficient in crystal-phase quantum dots in InP nanowires显示文摘Crystal-phase low-dimensional structures offer great potential for the implementation of photonic devices of interest for quantum information processing.In this context,unveiling the fundamental parameters of the crystal phase structure is of much relevance for several applications.Here,we report on the anisotropy of the g-factor tensor and diamagnetic coefficient in wurtzite/zincblende(WZ/ZB)crystal-phase quantum dots(QDs)realized in single InP nanowires.The WZ and ZB alternating axial sections in the NWs are identified by high-angle annular dark-field scanning transmission electron microscopy.The electron(hole)g-factor tensor and the exciton diamagnetic coefficients in WZ/ZB crystal-phase QDs are determined through micro-photoluminescence measurements at low temperature(4.2 K)with different magnetic field configurations,and rationalized by invoking the spin-correlated orbital current model.Our work provides key parameters for band gap engineering and spin states control in crystal-phase low-dimensional structures in nanowires. | Shiyao Wu Kai Peng Sergio Battiato Valentina Zannier Andrea Bertoni Guido Goldoni Xin Xie Jingnan Yang Shan Xiao Chenjiang Qian Feilong Song Sibai Sun Jianchen Dang Yang Yu Fabio Beltram Lucia Sorba Ang Li Bei-bei Li Francesco Rossella Xiulai Xu | 2019 | Nano Research2019，12，11： | 1 |
| 13 | Metabolic engineering of Streptomyces to enhance the synthesis of valuable natural products显示文摘The mycelial bacterium Streptomyces is a workhorse for producing natural products,serving as a key source of drugs and other valuable chemicals.However,its complicated life cycle,silent biosynthetic gene clusters(BGCs),and poorly characterized metabolic mechanisms limit efficient production of natural products.There-fore,a metabolic engineering strategy,including traditional and emerging tools from different disciplines,was developed to further enhance natural product synthesis by Streptomyces.Here,current trends in systems metabolic engineering,including tools and strategies,are reviewed.Particularly,this review focuses on recent developments in the selection of methods for regulating the Streptomyces life cycle,strategies for the activation of silent gene clusters,and the exploration of regulatory mechanisms governing antibiotic production.Finally,future challenges and prospects are discussed. | Zuwei Xu Lihao Ji Wenxiu Tang Liang Guo Cong Gao Xiulai Chen Jia Liu Guipeng Hu Liming Liu | 2022 | Engineering Microbiology2022，2，2： | 0 |
| 14 | Micropascal-sensitivity ultrasound sensors based on optical microcavities显示文摘Whispering gallery mode(WGM)microcavities have been widely used for high-sensitivity ultrasound detection,owing to their optical and mechanical dual-resonance enhanced sensitivity.The ultrasound sensitivity of the cavity optomechanical system is fundamentally limited by thermal noise.In this work,we theoretically and experimentally investigate the thermal-noise-limited sensitivity of a WGM microdisk ultrasound sensor and optimize the sensitivity by varying the radius and a thickness of the microdisk,as well as using a trench structure around the disk.Utilizing a microdisk with a radius of 300μm and thickness of 2μm,we achieve a peak sensitivity of 1.18μPa Hz^(-1/2)at 82.6 k Hz.To the best of our knowledge,this represents the record sensitivity among cavity optomechanical ultrasound sensors.Such high sensitivity has the potential to improve the detection range of air-coupled ultrasound sensing technology. | HAO YANG XUENING CAO ZHI-GANG HU YIMENG GAO YUECHEN LEI MIN WANG ZHANCHUN ZUO XIULAI XU BEI-BEI LI | 2023 | Photonics Research2023，11，7： | 0 |
| 15 | Advances in microbial engineering for the production of value‑added products in a biorefinery显示文摘Microbial biorefineries to produce chemicals from renewable feedstock provides attractive advantages,including mild reaction conditions and sustainable manufacturing.However,low-efficiency biorefineries always result in an uncompetitive biological process compared to the current petrochemical process.Thus,improving microbial capacity to maximize product yield,productivity,and titer has been recognized as a central goal for bioengineers and biochemists.The knowledge of cellular biochemistry has enabled the regulation of microbial physiology to couple with chemical production.The rapid development in metabolic engineering provides diverse strategies to enhance the efficiency of chemical biosynthesis pathways.New synthetic biology tools as well as novel regulatory targets also offer the opportunity to improve biorefinery environmental adaptivity.In this review,the recent advances in building efficient biorefineries were showcased.In addition,the challenges and future perspectives of microbial host engineering for increased microbial capacity of a biorefinery were discussed. | Cong Gao Liang Guo Wei Song Jing Wu Xiulai Chen Liming Liu | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 16 | An Adaptive DDoS Detection and Classification Method in Blockchain Using an Integrated Multi-Models显示文摘With the rising adoption of blockchain technology due to its decentralized,secure,and transparent features,ensuring its resilience against network threats,especially Distributed Denial of Service(DDoS)attacks,is crucial.This research addresses the vulnerability of blockchain systems to DDoS assaults,which undermine their core decentralized characteristics,posing threats to their security and reliability.We have devised a novel adaptive integration technique for the detection and identification of varied DDoS attacks.To ensure the robustness and validity of our approach,a dataset amalgamating multiple DDoS attacks was derived from the CIC-DDoS2019 dataset.Using this,our methodology was applied to detect DDoS threats and further classify them into seven unique attack subcategories.To cope with the broad spectrum of DDoS attack variations,a holistic framework has been pro-posed that seamlessly integrates five machine learning models:Gate Recurrent Unit(GRU),Convolutional Neural Networks(CNN),Long-Short Term Memory(LSTM),Deep Neural Networks(DNN),and Support Vector Machine(SVM).The innovative aspect of our framework is the introduction of a dynamic weight adjustment mechanism,enhancing the system’s adaptability.Experimental results substantiate the superiority of our ensemble method in comparison to singular models across various evaluation metrics.The framework displayed remarkable accuracy,with rates reaching 99.71%for detection and 87.62%for classification tasks.By developing a comprehensive and adaptive methodology,this study paves the way for strengthening the defense mechanisms of blockchain systems against DDoS attacks.The ensemble approach,combined with the dynamic weight adjustment,offers promise in ensuring blockchain’s enduring security and trustworthiness. | Xiulai Li Jieren Cheng Chengchun Ruan Bin Zhang Xiangyan Tang Mengzhe Sun | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 17 | Preface to the Special Issue on Quantum Light Source from Semiconductors显示文摘The invention of laser has tremendously changed the world. Great efforts have been made to increase the laser power, in which each pulse contains many photons. On the other hand, researchers also play a lot of interests on the generation of a single photon in a single pulse, i.e., the single photon sources. Single photons and their strongly correlated components (e.g. entangled photons) have played critical roles in the development of quantum mechanics. Nowadays, these quantum light sources have also found important applications in modern quantum information processing, such as quantum communication, quantum metrology and quantum computation. Many different kinds of methods have been developed to generate these quantum light sources. Semiconductors are of particular appealing materials. | Xiulai Xu Jinshi Xu | 2019 | Journal of Semiconductors2019，40，7： | 0 |
| 18 | Gain-Scheduling H_∞ Autopilot Design for Tactical Missiles with Variable-Swept Wings显示文摘A new approach to gain-scheduling of H∞controllers is proposed for a cruise missile with variableswept wings( VSW) in bank-to-turn( BTT) mode. A nonlinear dynamic model is established and anticipant performance criterions are given at first. For the selected operating points,feedback robust controllers of threechannels are designed independently to restrain cross-channel couple disturbances and aerodynamic perturbations. Then,the sweepback and Ma number are selected to schedule controller gains iteratively to ensure all closed-loop poles locating inside the desired region. The proposed method here attempts to extend the performance of initial design obtained for a single arbitrary point to the whole linearized domain while maintaining the expected stability over the entire range of sweepback and full flight envelope. Some time-domain analysis procedures based on the proposed method are carried out and assessed,while the performance of tracking and robustness to aerodynamic perturbations in different situations are contrasted by some nonlinear simulations. Finally,the numerical simulations demonstrate that the proposed autopilot design method has better tracking performance and is robust,effective and feasible. | Hongyang Bai Ruisheng Sun Weiming Li Xiulai Wang | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，1： | 0 |
| 19 | Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation显示文摘Cytochrome P450 enzymes(CYPs)catalyze a series of C-H and C=C oxygenation reactions,including hydroxylation,epoxidation,and ketonization.They are attractive biocatalysts because of their ability to selectively introduce oxygen into inert molecules under mild conditions.This review provides a comprehensive overview of the C-H and C=C oxygenation reactions catalyzed by CYPs and the various strategies for achieving higher selectivity and enzymatic activity.Furthermore,we discuss the application of C-H and C=C oxygenation catalyzed by CYPs to obtain the desired chemicals or pharmaceutical intermediates in practical production.The rapid development of protein engineering for CYPs provides excellent biocatalysts for selective C-H and C=C oxygenation reactions,thereby promoting the development of environmentally friendly and sustainable production processes. | Yu Yan Jing Wu Guipeng Hu Cong Gao Liang Guo Xiulai Chen Liming Liu Wei Song | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 0 |
| 20 | Transport of a topologically protected photonic waveguide on-chip显示文摘We propose a design on integrated optical devices on-chip with an extra width degree of freedom by using a photonic crystal waveguide with Dirac points between two photonic crystals with opposite valley Chern numbers.With such an extra waveguide,we demonstrate numerically that the topologically protected photonic waveguide retains properties of valley-locking and immunity to defects.Due to the design flexibility of the width-tunable topologically protected photonic waveguide,many unique on-chip integrated devices have been proposed,such as energy concentrators with a concentration efficiency improvement of more than one order of magnitude,and a topological photonic power splitter with an arbitrary power splitting ratio.The topologically protected photonic waveguide with the width degree of freedom could be beneficial for scaling up photonic devices,and provides a flexible platform to implement integrated photonic networks on-chip. | SAI YAN JINGNAN YANG SHUSHU SHI ZHANCHUN ZUO CAN WANG XIULAI XU | 2023 | Photonics Research2023，11，6： | 0 |
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