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| 1 | Role of MR-DWI and MR-PWI in the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbits显示文摘Objective: To detect the activity of tumor cells and tumor blood flow before and after the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbit models by using magnetic resonance diffusion-weighted imaging(MR-DWI) and magnetic resonance perfusion weighted imaging(MR-PWI), and to evaluate the effectiveness and safety of the radiotherapy based on the changes in the MR-DWI and MR-PWI parameters at different treatment stages.Methods: A total of 56 rabbit models with implanted pulmonary VX-2 carcinoma were established, and then equally divided into treatment group and control group. MR-DWI and MR-PWI were separately performed using a Philips Acheiva 1.5T MRI machine(Philips, Netherland). MRI image processing was performed using special perfusion software and the WORKSPACE advanced workstation for MRI. MRDWI was applied for the observation of tumor signals and the measurement of apparent diffusion coefficient(ADC) values; whereas MR-PWI was used for the measurement of wash in rate(WIR), wash out rate(WOR), and maximum enhancement rate(MER). The radiation treatment was performed using Siemens PRIMUS linear accelerator. In the treatment group, the radiotherapy was performed 21 days later on a once weekly dosage of 1,000 c Gy to yield a total dosage of 5,000 c Gy.Results: The ADC parameters in the region of interest on DWI were as follows: on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values at the center and the edge of the lesions were 1.352 and 1.461 in the treatment group and control group(P>0.05). During weeks 0-1 after treatment, the t values at the center and the edge of the lesions were 1.336 and 1.137(P>0.05). During weeks 1-2, the t values were 1.731 and 1.736(P<0.05). During weeks 2-3, the t values were 1.742 and 1.749(P<0.05). During weeks 3-4, the t values were 2.050 and 2.127(P<0.05). During weeks 4-5, the t values were 2.764 and 2.985(P<0.05). The ADC values in the treatment group were significantly higher than in the control group. After the radiotherapy(5,000 c Gy), the tumors remarkably shrank, along with low signal on DWI, decreased signal on ADC map, and remarkably increased ADC values. As shown on PWI, on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values of the WIR, WOR, and MER at the center of the lesions were 1.05, 1.31, and 1.33 in the treatment group and control group(P>0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.35, 1.07, and 1.51(P>0.05). During weeks 0-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 1.821, 1.856, and 1.931(P<0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.799, 2.016, and 2.137(P<0.05). During weeks 1-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.574, 2.156, and 2.059(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 1.869, 2.058, and 2.057(P<0.05). During weeks 2-3 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.461, 2.098, and 2.739(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.951, 2.625, and 2.154(P<0.05). During weeks 3-4 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.584, 2.107, and 2.869(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.057, 2.637, and 2.951(P<0.05). During weeks 4-5 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.894, 2.827, and 3.285(P<0.05) and the t values of the WIR, WOR, andMER at the edge of the lesions were 3.45, 3.246, and 3.614(P<0.05). After the radiotherapy(500 c Gy), the tumors shrank on the T1 WI, WIR, WOR, and MER; meanwhile, the PWI parameter gradually decreased and reached its minimum value.Conclusions: MR-DWI and MR-PWI can accurately and directly reflect the inactivation of tumor cells and the tumor hemodynamics in rabbit models with implanted pulmonary VX-2 carcinoma, and thus provide theoretical evidences for judging the clinical effectiveness of radiotherapy for the squamous cell carcinoma of the lung. | Qiang Zhang Mingmin Zhang Zhaoxin Liu Baoqi Shi Fuliang Qi Haijiang Wang Yuan Lv Haijiao Jin Weijing Zhang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 5 |
| 2 | Vehicle tracking by detection in UAV aerial video显示文摘With the maturity and popularity of UAV(un-manned aerial vehicle)technology [1-3],UAV video is becoming an effective supplement to the fixed monitoring video [4,5].In the aspect of traffic information acquisition,the advantages of UAV are obvious.UAV can fly not only between the buildings,but also on the freeway,and even into the tunnel,showing the unique flexibility and maneuverability. | Shaohua LIU Suqin WANG Wenhao SHI Haibo LIU Zhaoxin LI Tianlu MAO | 2019 | Science China(Information Sciences)2019，62，2： | 4 |
| 3 | Electro-Peroxone Treatment of Orange II Dye Wastewater显示文摘 | Bakheet B Yuan Shi Li Zhaoxin | 2013 | Water Res2013，47，16： | 1 |
| 4 | Blockchain Security Threats and Collaborative Defense:A Literature Review显示文摘As a distributed database,the system security of the blockchain is of great significance to prevent tampering,protect privacy,prevent double spending,and improve credibility.Due to the decentralized and trustless nature of blockchain,the security defense of the blockchain system has become one of the most important measures.This paper comprehensively reviews the research progress of blockchain security threats and collaborative defense,and we first introduce the overview,classification,and threat assessment process of blockchain security threats.Then,we investigate the research status of single-node defense technology and multi-node collaborative defense technology and summarize the blockchain security evaluation indicators and evaluation methods.Finally,we discuss the challenges of blockchain security and future research directions,such as parallel detection and federated learning.This paper aims to stimulate further research and discussion on blockchain security,providing more reliable security guarantees for the use and development of blockchain technology to face changing threats and challenges through continuous updating and improvement of defense technologies. | Xiulai Li Jieren Cheng Zhaoxin Shi Jingxin Liu Bin Zhang Xinbing Xu Xiangyan Tang Victor S.Sheng | 2023 | Computers, Materials & Continua2023，76，9： | 1 |
| 5 | Microbiome analysis reveals soil microbial community alteration with the effect of animal excretion contamination and altitude in Tibetan Plateau of China显示文摘The fertile forages in the Tibetan Plateau provide natural conditions for animal husbandry,whereas it is still unclear that whether animal excretion can result in the alteration of soil microbial community.Therefore,this study was performed to investigate the impact of animal excretion contamination and land altitude on the soil microbial community in different grazing areas of Tibetan Plateau.A total of 1160,190 high-quality valid sequences and 25,478 operational taxonomic units were achieved from 18 samples at three different altitude sites(Linzhi,Rikaze and Shannan).Here,we found excremental contamination did not alter the richness and diversity of soil microbial community,but it resulted in a significant alteration in the proportion of some bacteria.Specifically,the proportion of Proteobacteria in the LZa was obviously increased,whereas Gemmatimonadetes was significantly decreased as compared to LZe.Moreover,significant difference can also be observed in Verrucomicrobia between RKZe and RKZa.Remarkably,we also found that excremental contamination significantly decreased the abundance of some bacterial genera,such as Sphingopyxis,Polycyclovorans,Singulisphaera Cohnella,Polycyclovorans,Defluviicoccus,and Arthrobacter,which were closely related to soil health,pollutant degradation,and nutrient metabolism.Importantly,excremental contamination increased the proportion of harmful and beneficial bacteria in soil,such as the percentage of Acidibacter,Gemmatimonadaceae and Pajaroellobacter increased,while the ratio of Pontibacter,Flavisolibacter,Parasegetibacter,and Niastella decreased.Remarkably,soil samples collected from different altitude sites also displayed different soil microbial community structures.Our results demonstrated that excremental contamination could alter the soil microbial community structure and affect the normal function of the soil by affecting the proportion of harmful bacteria to beneficial bacteria.Moreover,this study can also provide a theoretical basis for the establishment of a supervision system for soil quality in Tibet. | Aoyun Li Yaping Wang Yajing Wang Hailong Dong Qingxia Wu Khalid Mehmood Zhenyu Chang Ying Li Yung-Fu Chang Lijun Shi Zhaoxin Tang Hui Zhang | 2021 | International Soil and Water Conservation Research2021，9，4： | 1 |
| 6 | Effective degradation of refractory organic pollutants in landfill leachate by electro-peroxone treatment 显示文摘 | Li Zhaoxin Yuan Shi Qiu Cuicui | 2013 | Electrochimica Acta2013，102，： | 1 |
| 7 | Evaluation and prospect of scientific research capacity ranking for community healthcare centres in China显示文摘The National Health and Family Planning Commission of the People's Republic of China has proposed to improve the medical capacity of general practitioners and the establishment of general practice in recent health reform.For the first time,the ability to conduct scientific research was included in this reform,which demands community healthcare centres(CHCs)to strengthen their research capacity.The evaluation of community scientific research capacity has become an important endeavour to promote the implementation of research in CHCs.Since 2016,our research team has been working on an evaluation system and has published the scientific research capacity ranking for the top 100 CHCs in China.The latest released ranking of scientific research capacities of China CHCs has aroused great attention in the country. | Qian Liu Jianwei Shi Dehua Yu Hua Jin Xuhua Ge Hanzhi Zhang Zhaoxin Wang | 2020 | Family Medicine and Community Health2020，8，1： | 0 |
| 8 | Sleep deprivation reorganizes the dynamic configurations of default mode network activity during recovery sleep显示文摘Sleep deprivation causes disturbances of the neural activity, leading to the impairment of brain functions. However, the exact mechanism of sleep deprivation and how it affects the dynamics of brain activity during the recovery sleep remains unclear. In the current study, we performed sleep deprivation experiments on ten adult rats, and recorded the local field potentials from default mode network(DMN) regions during sleep before and after sleep deprivation. The DMN dynamics was assessed with the configurations of coactive micropatterns(CAMPs) using our previously proposed CAMP method. Our analysis revealed that the effects of sleep deprivation on DMN dynamics in the slow-wave sleep(SWS) state and the rapid eye-movement sleep(REM)state were disparate. Dynamic configurations of DMN activity in the SWS state were significantly impaired after sleep deprivation, with increased occurrence of low-activity CAMP and reorganized transition structure across three CAMPs. Moreover,enhanced functional connectivity and improved efficiencies in all CAMP networks were observed during the SWS state in the recovery sleep. However, there were no significant alterations in either DMN dynamics or CAMP network structures in the REM sleep state after sleep deprivation. Our results described the alterations of DMN dynamics in different sleep states after sleep deprivation, and illustrated the differential effects of sleep deprivation on two sleep states. These findings demonstrated the underlying neural mechanisms of the effects of sleep deprivation on DMN activity during sleep and increased our understanding of the physiological roles of the DMN in maintain sleep homeostasis after sleep deprivation. | CUI Yan WU ShengDun ZHAO Shi LONG TianYao JIAN ZhaoXin YU Shuang ZHANG Ge BISWAL Bharat GUO DaQing XIA Yang YAO DeZhong | 2022 | Science China(Technological Sciences)2022，65，7： | 0 |
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