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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging显示文摘Hyperglycemia induces chronic low-grade inflammation(inflammaging),which is a newly identified contributor to diabetes-related tissue lesions,including the inflammatory bone loss in periodontitis.It is also a secondary senescent pattern mediated by an increased burden of senescent cells and senescence-associated secretory phenotype(SASP).Macrophage is a key SASPspreading cell and may contribute to the maintenance of SASP response in the periodontal microenvironment.Using a transgenic diabetic model(BLKS/J-Lepr^(db)/lepr^(db)mice)we identified striking senescence of the periodontium in young(18-wk)-diabetic mice accompanied by amassed p16^(+)-macrophages and enhanced early SASP response.Exposed to high glucose in vitro,bone marrow-derived macrophage(BMDM)revealed a strong GLUT1 m RNA response driving the elevated-glucose uptake.GLUT1 is a representative and facilitative glucose transporter in macrophages with potential roles in hyperglycemia-induced inflammation.In this study,both GLUT1 and the downstream GTPase Rheb expression upregulated in the gingiva of diabetic mice with impaired condition.Furthermore,SASP release and p16/p21 signaling were proven to be triggered by m TOR phosphorylation in BMDM and antagonized by restricting glucose uptake in GLUT1^(-/-)BMDM.Taken together,our findings suggest that elevated-GLUT1 sensor responded to high glucose is important for macrophage senescence and SASP response,generated as a result of hyperglycemia,and it is a potential molecular mechanism for the exacerbation of periodontitis in diabetes. | Qian Wang Lulingxiao Nie Pengfei Zhao Xinyi Zhou Yi Ding Qianming Chen Qi Wang | 2021 | International Journal of Oral Science2021，13，3： | 5 |
| 5 | Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?显示文摘癌症是高度好攻击、破坏的疾病,并且到痊愈的妨碍自己不仅仅从癌症产生。自从癌症的多数比平常是更复杂的,指向的治疗是困难的完成想象。作为平淡的临床的政体包括化疗和放射疗法的主流的方法论经常失败,最后导致倔强、医不好的病理。一个主要原因是对在多重剂量的管理的间隔期间熬过癌症房间的快速的人口渐渐。新奇压力应答的分子的小径逐渐地为瞄准 de novo 和获得的抵抗的先进策略作为新兴的目标被揭露并且出现诺言。我们加亮报导特别地,那些 genotoxic 能高度导致的治疗在肿瘤微型环境(TMEN ) 的非癌的成分保存了损坏回答的最近的数据。掌握管理者,包括,形成释放无数可溶的因素的激活的 TMEN 然而并非限于 NF-kB 和 C/EBP- ,被含有,他们的信号串联在一个柔韧、长期、染色体宽的能分泌的节目达到顶点。得到损坏但是实质上,离开目标和细胞,宿主基质的非自治的能分泌的显型引起不利后果,在哪个被获得之中癌症细胞的抵抗。利用从 TMEN 产生的信号,一个 pathophysiological 壁龛经常由医药干预损坏了,有潜力支持全面功效并且如果适当行动有才能地集成于当代的治疗,改进临床的结果。从而, anticancer 政体应该很好被调节建立一条创新临床的大街,并且如此的前进将允许未来 oncological 治疗更特定,精确,彻底、个性化。 | Fei Chen Xinyi Qi Min Qian Yue Dai Yu Sun | 2014 | Protein & Cell2014，5，11： | 4 |
| 6 | Rapid,visual,and equipment-free point-of-care testing for Staphylococcus aureus by direct recombinase polymerase amplification with SYBR GreenΙ显示文摘Food-borne diseases mainly caused by bacterial pathogens and the safety of genetically modified(GM)food have become global concerns[1].As a leading bacterial pathogen,Staphylococcus aureus can not only cause a variety of diseases[2]but also contaminate different kinds of animal food products[3].In addition,GM foods whose impact on human health and the natural environment is still a matter of controversy have gradually entered the commercial markets[4].Therefore,many countries have decided to implement labeling regulations for authorized genetically modified organisms(GMOs)to protect the consumers’right to know[5].Hence,it is critical to develop a rapid,simple,equipment-free,and on-site testing method to detect the GM contents in food samples and pathogen to ensure food safety. | Xiaorui Fan Fangti Han Binan Zhao Yan Xu Xiao Zhao Xinyi Pu Yanan Du Qi Zhang Xiaoxia Zhang Wanjing Zhang Wenjing Wu Zhiwei Chen Kai Zhao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 3 |
| 7 | 具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌临床病理学观察显示文摘目的:探讨具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌(ESC RCC)临床病理特征、免疫组织化学及分子遗传学特征和预后。方法:收集2017年至2018年2例ESC RCC临床资料,HE和免疫组织化学染色(EnVision)法进行形态学观察;荧光原位杂交检测TFE3、TFEB断裂重排基因;分子基因检测,PCR扩增,二代测序。结果:2例ESC RCC为男性,年龄分别9岁8个月和13岁,均发生在右肾。肿瘤大小5~7 cm,切面囊实性,灰红、灰白鱼肉样。显微镜下肿瘤具有纤维性包膜,肿瘤细胞突破胞膜。肿瘤细胞弥漫分布,圆形、多边性,胞质丰富,嗜伊红,可见大小不一的空泡,呈透明细胞样;部分区域类似乳头样结构,可见纤维轴心。细胞核圆形、泡状核,易见多核及巨核细胞,核分裂象未见;少量大小不一的囊样结构,囊壁可见单层瘤细胞被覆呈钉突样。间质见厚壁血管,灶状淋巴细胞浸润;较多嗜伊红坏死,可见钙化和胆固醇结晶。免疫组织化学阳性表达:PAX8(弥漫)、细胞角蛋白(CK)20、广谱细胞角蛋白(CKpan,局灶)、CD10(1例局灶/1例弥漫)、INI1、波形蛋白、CD68阳性,Ki-67阳性指数5%~10%。HMB45、S-100蛋白、Melan A、p53、结蛋白、TFE3、CK7、CK19、上皮细胞膜抗原(EMA)、CD56、嗜铬粒素A(CgA)、突触素、CD30、CD117、WT1、平滑肌肌动蛋白(SMA)阴性。分子遗传学检测:TFE3、TFEB断裂重排阴性。二代测序:例1,TSC2 p.Lys574Ter(0.198);例2,TSC2 p.Arg406Ter(0.355)。结论:ESC RCC儿童发病比较罕见,容易误诊,其具有独特的病理形态学特征、免疫表型和分子遗传学改变,预后较好。 | 杨文萍 Kenneth Tou En Chang 徐红艳 Chik Hong Kuick Eileen Hui Qi Ng 黄慧 熊枫 吴艳 曾松涛 樊金星 Xinyi Loh | 2020 | 中华病理学杂志2020，49，7： | 3 |
| 8 | Hydrodynamic studies on two wiggling hydrofoils in an oblique arrangement显示文摘The propulsive performance of an oblique school of fish is numerically studied using an immersed boundary technique. The effect of the spacing and wiggling phase on the hydrodynamics of the system is investigated. The hydrodynamics of the system is deeply affected by the spacing between each fish in the school. When the horizontal separation is smaller than the length of the fish body,the downstream fish exhibits a larger thrust coefficient and greater propulsive efficiency than the isolated fish. However,the corresponding values for the upstream fish are smaller.The opposite behavior occurs when the horizontal separation increases beyond the length of fish body. The propulsive performance of the entire oblique school of fish can be substantially enhanced when the separations are optimized. | Xingjian Lin Guoyi He Xinyi He Qi Wang Longsheng Chen | 2018 | Acta Mechanica Sinica2018，34，3： | 2 |
| 9 | Support Vector Regression for Bus Travel Time Prediction Using Wavelet Transform显示文摘In order to accurately predict bus travel time, a hybrid model based on combining wavelet transform technique with support vector regression(WT-SVR) model is employed. In this model, wavelet decomposition is used to extract important information of data at different levels and enhances the forecasting ability of the model. After wavelet transform different components are forecasted by their corresponding SVR predictors. The final prediction result is obtained by the summation of the predicted results for each component. The proposed hybrid model is examined by the data of bus route No.550 in Nanjing, China. The performance of WT-SVR model is evaluated by mean absolute error(MAE), mean absolute percent error(MAPE) and relative mean square error(RMSE), and also compared to regular SVR and ANN models. The results show that the prediction method based on wavelet transform and SVR has better tracking ability and dynamic behavior than regular SVR and ANN models. The forecasting performance is remarkably improved to obtain within 6% MAPE for testing section Ⅰ and 8% MAPE for testing section Ⅱ, which proves that the suggested approach is feasible and applicable in bus travel time prediction. | Yang Liu Yanjie Ji Keyu Chen Xinyi Qi | 2019 | Journal of Harbin Institute of Technology(New Series)2019，26，3： | 2 |
| 10 | Geothermal water at a coal mine: from risk to resource 显示文摘 | Qi Wang Xinyi Wang Quanlin Hou | 2015 | Mine Water and the Environ-ment2015，，7： | 1 |
| 11 | Evaluation of Hydraulic Characteristics of the Normal Fault Based on Key Data显示文摘 | Wang Qi Wang Xinyi Liu Xiaoman | 2015 | The Open Fuels & Energy Science Jourual2015，8，1： | 1 |
| 12 | Biological Characteristics of Aeromonas Strains in Nanchang Area显示文摘[Objectives]This study was conducted to find effective measures to prevent and control Pelteobagrus fulvidraco hemorrhage.[Methods]Typical disease materials were collected for bacterial isolation and culture and biological characteristics detection,and morphological characteristics were observed by pure culture method.Biochemical characteristics were identified by micro biochemical method.Molecular identification was performed by PCR amplification method.Drug resistance was detected by disk diffusion method.The agar diffusion method was used for the detection of in-vitro inhibitory effect.The immunogenicity of the isolates was detected by subcutaneous immunoassay.The virulence factor was detected by spot inoculation.The intraperitoneal injection was used for the detection of pathogenicity.[Results]The isolates were round,grayish white,and identified as Aeromonas.They fermented maltose,glucose,etc.,did not ferment lactose,and were negative for urea and H2S and positive for lysine and arginine.The target fragment appeared at 1 500,and the sequences shared the highest homology with Aeromonas.The isolates were highly susceptible to amikacin and gentamicin,and resistant to penicillin G and tetracycline.Eight lactic acid bacteria strains produced 1.1-1.9 cm of inhibition zone against the isolates.After the second vaccination,the titer reached 2^13;both hemolysin and protease were produced;and the test mice died within 24 h.[Conclusions]The isolates are Aeromonas,and have strong drug resistance,immunogenicity and pathogenicity.Inactivated emusion-oil vaccines of Aeromonas combined with the co-use of lactic acid bacteria and susceptible drugs can prevent the outbreak of diseases caused by Aeromonas. | Xinyi SHAN Dongxu WEN Xiaolan LIU Wangming TAO Mengjuan ZHANG Wei QI Fengwei ZHANG Zhixiu ZHU | 2019 | Agricultural Biotechnology2019，8，3： | 1 |
| 13 | Relationship analysis of the degree of fault complexity and the water irruption rate, based on fractal theory 显示文摘 | Li Renzheng Wang Qi Wang Xinyi | 2015 | Mine Water and the Environment2015，，5： | 1 |
| 14 | Distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China显示文摘Organic pollutants are widespread environmental pollutants with high toxicity,persistence,and bioaccumulation.Our aim was to investigate the distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China.Nineteen surface sediment samples were collected from the Dianchi Lake,and 40 types of organic pollutants were analyzed via gas chromatography-mass spectrometry.The total organic pollutant concentrations in the surface sediment of the Dianchi Lake varied from 27.4 to 1.62×10^3 ng/g.The concentrations of phenols were much higher than those in other water bodies but still within a controllable range,whereas the concentrations of the other organic pollutant classes were similar or even lower.The detection ratio of 3-or 4-methylphenol was the highest(100.00%)among the pollutants.The average total organic pollutant concentrations decreased in the following order:Caohai(540 ng/g)>the middle of Waihai(488 ng/g)>the edge of Waihai(351 ng/g)>Haigeng Dam(90.4 ng/g).Pearson analysis showed a strong correlation among 1-methylnaphthalene,2-methylnaphthalene,1,3-dinitronaphthalene,and 1,4-dinitronaphthalene(P<0.01).Caohai,the north lakeshore of Waihai and the south of Waihai showed higher risk because of high concentration;meanwhile,1,4-dichlorobenzene,3-or 4-methylphenol and 1,2,4-trichlorobenzene were mor e likely to cause risks. | Xinyi Hu Ting Yang Chen Liu Jun Jin Bingli Gao Xuejun Wang Min Qi Baokai Wei Yuyu Zhan Tan Chen Hongtao Wang Yanting Liu Dongrui Bai Zhu Rao Nan Zhan | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 1 |
| 15 | Publishing clinical prActice GuidelinEs(PAGE):Recommendations from Editors and Reviewers显示文摘Transparency Ecosystemfor Research and Journals inMedicine(TERM)Working Group summarized the essential recommendations that should be considered to review and publish a high-quality guideline.These recommendations fromeditors and reviewers included the 10 components of essential requirements:systematic review of existing relevant guidelines,guideline registration,guideline protocol,stakeholders,conflicts of interest,clinical questions,systematic reviews,recommendation consensus,guideline reporting,and external review.TERMWorking Group abbreviates them as PAGE(essential requirements for Publishing clinical prActice GuidelinEs),recommends guideline authors,editors,and peer reviewers use them for high-quality guidelines. | Nan Yang Wei Zhao Wenan Qi Chen Yao Chongya Dong Zhenguo Zhai Tong Chen Enmei Liu Guobao Li Youlin Long Xinyi Wang ZijunWang Ruobing Lei Qi Zhou Yaolong Chen Liang Du | 2022 | Infectious Diseases & Immunity2022，2，4： | 1 |
| 16 | Immediate and long-term outcomes after treat-all among people living with HIV in China:an interrupted time series analysis显示文摘Background In 2003,China implemented free antiretroviral therapy(ART)for people living with HIV(PLHIV),establishing an eligibility threshold of CD4<200 cells/μl.Subsequently,the entry criteria were revised in 2012(eligibility threshold:CD4≤350 cells/μl),2014(CD4≤500 cells/μl),and 2016(treat-all).However,the impact of treat-all policy on HIV care and treatment indicators in China is unknown.We aimed to elucidate the immediate and long-term impact of the implementation of treat-all policy in China.Methods Anonymized programmatic data on ART initiation and collection in PLHIV who newly started ART were retrieved between 1 January 2015 and 31 December 2019,from two provincial and municipal Centers for Disease Control and Prevention and ten major infectious disease hospitals specialized in HIV care in China.We used Poisson and quasi-Poisson segmented regression models to estimate the immediate and long-term impact of treat-all on three key indicators:monthly proportion of 30-day ART initiation,mean CD4 counts(cells/μl)at ART initiation,and mean estimated time from infection to diagnosis(year).We built separate models according to gender,age,route of transmission and region.Results Monthly data on ART initiation and collection were available for 75,516 individuals[gender:83.8%males;age:median 39 years,interquartile range(IQR):28-53;region:18.5%Northern China,10.9%Northeastern China,17.5%Southern China,49.2%Southwestern China].In the first month of treat-all,compared with the contemporaneous counterfactual,there was a significant increase in proportion of 30-day ART initiation[+12.6%,incidence rate ratio(IRR)=1.126,95%CI:1.033-1.229;P=0.007]and mean estimated time from infection to diagnosis(+7.0%,IRR=1.070,95%CI:1.021-1.120;P=0.004),while there was no significant change in mean CD4 at ART initiation(IRR=0.990,95%CI:0.956-1.026;P=0.585).By December 2019,the three outcomes were not significantly different from expected levels.In the stratified analysis,compared with the contemporaneous counterfactual,mean CD4 at ART initiation showed significant increases in Northern China(+3.3%,IRR=1.033,95%CI:1.001-1.065;P=0.041)and Northeastern China(+8.0%,IRR=1.080,95%CI:1.003-1.164;P=0.042)in the first month of treat-all;mean estimated time from infection to diagnosis showed significant increases in male(+5.6%,IRR=1.056,95%CI:1.010-1.104;P=0.016),female(+14.8%,IRR=1.148,95%CI:1.062-1.240;P<0.001),aged 26-35(+5.3%,IRR=1.053,95%CI:1.001-1.109;P=0.048)and>50(+7.8%,IRR=1.078,95%CI:1.000-1.161;P=0.046),heterosexual transmission(+12.4%,IRR=1.124,95%CI:1.042-1.213;P=0.002)and Southwestern China(+12.9%,IRR=1.129,95%CI:1.055-1.208;P<0.001)in the first month of treat-all.Conclusions The implementation of treat-all policy in China was associated with a positive effect on HIV care and treatment outcomes.To advance the work of rapid ART,efforts should be made to streamline the testing and ART initiation process,provide comprehensive support services,and address the issue of uneven distribution of medical resources. | Xinsheng Wu Guohui Wu Ping Ma Rugang Wang Linghua Li Yinghui Sun Junjie Xu Yuwei Li Tong Zhang Quanmin Li Yuecheng Yang Lijing Wang Xiaoli Xin Ying Qiao Bingxue Fang Zhen Lu Xinyi Zhou Yuanyi Chen Qi Liu Gengfeng Fu Hongxia Wei Xiaojie Huang Bin Su Hui Wang Huachun Zou | 2023 | Infectious Diseases of Poverty2023，12，4： | 0 |
| 17 | Surface charge property governing co-transport of illite colloids and Eu(Ⅲ) in saturated porous media显示文摘The transport of colloids and radionuclides is sophisticated because of the variety of charge properties between colloidal particles and host subsurface media, which causes great difficulty in establishing a reliable model of radionuclides migration by taking the colloid phase into consideration. In this work,the co-transport of illite colloids(IC) and Eu(Ⅲ) in the quartz sand and iron-coated sand porous media was investigated by column experiments to address the predominant mechanism of charge properties on co-transport. Results showed that Eu(Ⅲ) transport was driven by the illite colloids and electrostatic interaction was critical in governing the co-transport patterns. The promotion of Eu(Ⅲ) transport by IC was attenuated in the iron-coated sand systems;more IC-Eu(Ⅲ) complexes were retained uniformly in the column. The pore throat shrinkage caused by electrostatic attachment between aggregated IC and iron oxides exacerbated the physical straining and size exclusion effect of IC-Eu(Ⅲ) complexes. An aggravated irreversible retention of IC-Eu(Ⅲ) was detected in iron-coated sand column due to the electrostatic attraction of IC-Eu(Ⅲ) to host media. The findings are essential for improving the understanding on the potential transport, retention and release risk of colloids associated radionuclides, and imply that the positively charged permeable reactive barrier is an effective strategy to reduce the transport risk of colloid associated radionuclides. | Xiaoyan Wei Duoqiang Pan Qi Tan Xinyi Shi Junjun Hou Qingfeng Tang Zhen Xu Wangsuo Wu Bin Ma | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 18 | Supercontinuum fiber laser-based coherent anti-Stokes Raman scattering microscopy for label-free chemical imaging显示文摘Coherent anti-Stokes Raman scattering(CA RS)microscopy can resolve the chemical compo-nents and distribution of living biological systems in a label-firee manner and is favored in several disciplines.Current CA RS microscopes typically use bulky,high-performance solid-state lasers,which are expensive and sensitive to environmental changes.With their relatively low cost and environmental sensitivity,supercontinum fiber(SF)lasers with a small footprint have found increasing use in biomedical applications.Upon these features,in this paper,we homebuilt a low-cost CARS microscope based on a SF laser module(scCA RS microscope).This SF laser module is specially customized by adding a time synchronized seed source channel to the SF laser to form a dual-channel output laser.The performance of the scCARS microscope is evaluated with dimethyl sulfoxide,whose results confirm a spatial resolution of better than 500nm and a detection sensitivity of millimolar concentrations.The dual-color imaging capability is further demonstrated by imaging different species of mixed microspheres.We finally explore the potential of our scCARS microscope by mapping lipid droplets in different cancer cells and corneal stromal lenses. | Nan Wang Jiaojiao Zhang Wangting Zhou Siting Liu Jing Li Xinyi Xu Qi Zeng Yong Li Shouping Zhu Xueli Chen | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 0 |
| 19 | Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments显示文摘Fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological variation.However,it is difficult to transfer classical genetic mapping to most non-model species.In this study,we performed a comparative sequence analysis of Fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale phenotypes.While considerable amino acid(AA)substitutions were observed,molecular evolution analysis indicates that the overall coding regions were subject to functional constraint.We also identified extra copies of Fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one AA substitution specific to these duplicates.We speculate that Fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events,which was further followed by the diversification of species.In silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was detected.Collectively,our results highlight the important role of Fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the Qinghai-Tibetan Plateau. | Xinyi GUO Ling XIE Xuze ZHANG Yinfa JI Juan CHEN Bo PANG Yongtao XU Delin QI Songchang GUO | 2016 | Integrative Zoology2016，11，2： | 0 |
| 20 | Study on Method of Measuring 128I(n,γ)Reaction Cross Section by Accelerator Mass Spectrometry显示文摘The thermal neutron cross section of 128I(n,γ)129I is an important parameter in the research of nuclear physics.For the national application data,stellar evolution model,reactor design,waste disposal and other research has important applications.At present,this reaction cross section has no experimental data in the world. | ZHANG Yuxuan YIN Xinyi HE Ming ZHAO Qingzhang WANG Fangfang WU Shaoyong PANG Yijun MENG Qi YU Bo | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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