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| 1 | The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval显示文摘A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease(AD) or mild cognitive impairment(MCI). The uncinate fasciculus(UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex(OFC)in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex(POR) and projecting to the ventrolateral orbitofrontal cortex(vlOFC)performs most of the functions of the UF in rodents.Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatialmemory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD. | Xinyang Qi Zhanhong Jeff Du Lin Zhu Xuemei Liu Hua Xu Zheng Zhou Cheng Zhong Shijiang Li Liping Wang Zhijun Zhang | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 2 | Synthesis and Characterization of Chiral Organogallium and Indium Complexes with Salen Ligands显示文摘Several new chiral organogallium and indium complexes with chiral Salen (1 and 2) as anxciliary ligands have been synthesized and characterized by elemental analysis, IR, 1H NMR and Mass spectroscopy. For the gallium, mono and bimetallic complexes were obtained, whereas ring closure complexes of indium were obtained. | Fu Xing GAO1,2, Cheng Jian ZHU1*, Fang YUAN1, Yu Hua ZHU1, Yi PAN1* 1Department of Chemistry, Nanjing University, Nanjing 210093 2Department of Chemistry, Xinyang Normal College, Xinyang 464000 | 2003 | Chinese Chemical Letters2003，14，2： | 3 |
| 3 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 4 | Changes of gut microbiome and metabolome in the AOM/DSS mouse model of colorectal cancer with FLASH radiation显示文摘Objective:To investigate the differences in small intestinal toxicity and taxonomic composition,diversity,and functional pathways of gut microbiome and metabolome after different radiotherapies in mouse colorectal cancer(CRC)model.Methods:Azoxymethane/dextran sodium sulfate(AOM/DSS)-induced mouse CRC model was treated with single pulse FLASH-RT(dose rate 100 Gy/s)or CONV-RT(dose rate 2 Gy/min)at whole abdomen.At 12 d after radiotherapy,sections of small intestinal tract tissue were dissected for hematoxylin and eosin(HE)staining and the fresh feces were collected for 16S ribosomal RNA(rRNA)microbiome sequencing and liquid chromatography and mass spectrometry(LC-MS)metabolomics sequencing to assess changes in the gut microbiota and metabolites.Microbial high-throughput 16S rRNA data was analyzed with QIIME2 and LEfSe softwares.ProteoWizard,XCMS and Ropls softwares were used for LC-MS analysis.Results:HE staining showed that FLASH-RT maintained small intestinal integrity and reduced the radiotherapyinduced injury.Sequencing analysis of gut fecal microbiome showed that phylum Bacteroidetes and genera Prevotella and Lactobacillus of microbial community were increased after FLASH-RT.Metabolomics sequencing analysis revealed that the metabolites after FLASH-RT were enriched in amino acid metabolism,while cholesterol metabolism was top enriched after CONV-RT.Conclusions:FLASH-RT significantly mitigates the small intestine tissue damage compared with CONV-RT.FLASHRT and CONV-RT have different impact on gut microbiota and its metabolites.Our results provide a theoretical basis for the early evaluation,prediction and individualized treatment of the irradiation effect after novel FLASHRT on tumors through the evaluation of intestinal microbiota and metabolites. | Mengmeng Xu Xinyu Qiu Qiu Chen Tianyu Yang Jingze Xu Liang Chen Lixiong Shuai Zhiming Xu Xinyang Cheng Yongsheng Zhang Zhifei Cao | 2023 | Radiation Medicine and Protection2023，4，1： | 2 |
| 5 | Synthesis and formation mechanism of HfB_(2) ultrafine powders with low oxygen via flocculating settling assisted process and carbo/borothermal reduction显示文摘In this study,ultrafine HfB_(2) powders with low oxygen were synthesized by a flocculating settling process which yielded ceramic precursors and subsequent carbo/borothermal reduction of the precursors.The liquid phase precursor method can achieve uniform mixing of components at the molecular level through multiple complexation reactions,and then realize the carbo/borothermal reduction reaction at a lower temperature to obtain ultrapure HfB2 powders.The as-resulted quasi-spherical HfB2 powders under the optimum conditions(atomic molar ratio M:B:C=1:2.8:10)calcined at 1500°C for 1 h have an average particle size of 205 nm and an oxygen content of 0.097 wt.%.Detailed analysis of the phase evolution of precursors shows that the formation of HfB2 particles is a mass diffusion mode from the external to internal HfO_(2)cores.We reveal that below 1300°C,HfC is not an intermediate product of HfB2 powder during the transition of precursors.Instead,HfC was formed as a by-product at high temperatures in the carbo/borothermal reduction process.The proposed formation mechanism of HfB_(2) is completely different from the traditional two-step transformation method.After the sintering of the ultrafine powders,the HfB_(2) ceramics show a relative density of 96.1%and superior mechanical properties compared to other works.Furthermore,by simply replacing the initial metal source,chlorinated group IV and V transitional metals(Ti,Zr,Ta,Nb)can also convert into high-purity and ultrafine diborides.This work shows that flocculating settling assisted carbo/borothermal reduction has potential in lot size production of various high-purity and ultrafine boride powders. | Zhen Wang Yuan Cheng Kewei Li Tianxu Wang Mengen Hu Chunxue Zheng Xinyang Li Zhulin Huang Xiaoye Hu Yue Li Xinghong Zhang | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 6 | Spatiotemporal variation of dissolved oxygen in the Ediacaran surface ocean and its implication for oceanic carbon cycling显示文摘The Ediacaran Period(635–539 Ma)witnessed the largest negative excursion in inorganic carbon isotope(δ^(13)Ccarb)over the Earth’s geological history,also known as the Shuram Excursion(SE)event.The occurrence of the SE has been widely attributed to an increase in atmospheric-oceanic oxygen levels and the subsequent oxidation of organic matters in Earth’s surface system.However,the oxygen levels in the Ediacaran ocean during the SE remain poorly constrained,limiting our ability to better understand the cause and mechanisms behind the SE.Recently,the ratio of I/(Ca+Mg)in carbonate has emerged as an effective proxy for quantifying dissolved oxygen([O_(2)])in the local surface seawaters.In this study,we analyzed I/(Ca+Mg)ratios in the Shuiquan Formation at the Mochia-Khutuk(MK)section,which records the SE event in the Tarim continent.The I/(Ca+Mg)ratio shows synchronous variation withδ^(13)Ccarbin the MK section,with the average value decreasing from 2.2μmol/mol at the bottom of the section to 0.8μmol/mol in the middle and then increasing to 3.4μmol/mol at the very top along with the decline and recovery ofδ^(13)Ccarb.According to the relationship between I/(Ca+Mg)and oxygen content in minimum oxygen zones of the modern ocean,we infer that[O_(2)]of surface water in the MK section decreased from>20–70μmol/L to<20–70μmol/L during the SE,which may reflect the upwelling of the deep seawater enriched dissolved organic carbon(DOC)and reduced substance(such as Fe^(2+))together with its subsequent consumption of[O2]in the surface ocean.The I/(Ca+Mg)pattern in the MK section is significantly different from those of other contemporaneous SE records on other continents,indicating the surface[O_(2)]in the Ediacaran ocean could have been temporally and spatially heterogeneous.Local factors,such as latitude,temperature,productivity,and input of anoxic water masses could play important roles in regulating the surface ocean redox conditions.This observation further suggests that the atmospheric oxygen level during the Ediacaran was relatively low and insufficient to dominate the regulation of[O_(2)]in the surface ocean.The results of our study imply that the oxidation of the ocean and in turn the DOC reservoir therein during the SE could be spatially restricted to the continental shelf,rather than the whole ocean. | Zihu ZHANG Meng CHENG Haiyang WANG Xinyang CHEN Wei GUO Chao LI | 2023 | Science China Earth Sciences2023，66，8： | 0 |
| 7 | Understanding water conservation vs. prof ligation traits in vegetable legumes through a physio-transcriptomic-functional approach显示文摘Abstract Vegetable soybean and cowpea are related warm-season legumes showing contrasting leaf water use behaviors under similar root drought stresses,whose mechanisms are not well understood.Here we conducted an integrative phenomic-transcriptomic study on the two crops grown in a feedback irrigation system that enabled precise control of soil water contents.Continuous transpiration rate monitoring demonstrated that cowpea used water more conservatively under earlier soil drought stages,but tended to maintain higher transpiration under prolonged drought.Interestingly,we observed a soybean-specific transpiration rate increase accompanied by phase shift under moderate soil drought.Time-series transcriptomic analysis suggested a dehydration avoidance mechanism of cowpea at early soil drought stage,in which the VuHAI3 and VuTIP2;3 genes were suggested to be involved.Multifactorial gene clustering analysis revealed different responsiveness of genes to drought,time of day and their interactions between the two crops,which involved species-dependent regulation of the circadian clock genes.Gene network analysis identified two co-expression modules each associated with transpiration rate in cowpea and soybean,including a pair of negatively correlated modules between species.Module hub genes,including the ABA-degrading gene GmCYP707A4 and the trehalose-phosphatase/synthase gene VuTPS9 were identified.Intermodular network analysis revealed putative co-players of the hub genes.Transgenic analyses verified the role of VuTPS9 in regulating transpiration rate under osmotic stresses.These findings propose that species-specific transcriptomic reprograming in leaves of the two crops suffering similar soil drought was not only a result of the different drought resistance level,but a cause of it. | Pingping Fang Ting Sun Arun Kumar Pandey Libo Jiang Xinyang Wu Yannan Hu Shiping Cheng Mingxuan Li Pei Xu | 2023 | Horticulture Research2023，10，3： | 0 |
| 8 | Characteristics of compensatory mutations in the rpoC gene and their association with compensated transmission of Mycobacterium tuberculosis显示文摘The aim of this study was to characterize rpoC gene mutations in Mycobacterium tuberculosis(MTB)and investigate the factors associated with rpoC mutations and the relation between rpoC mutations and tuberculosis(TB)transmission.A total of 245 MTB clinical isolates from patients with TB in six provinces and two municipalities in China were characterized based on gene mutations through DNA sequencing of rpoC and rpoB genes,phenotyping via standard drug susceptibility testing,and genotypic profiling by mycobacterial interspersed repetitive unit-variable number tandem repeat(MIRU-VNTR)typing.Approximately 36.4%of the rifampinresistant isolates harbored nonsynonymous mutations in the rpoC gene.Twenty-nine nonsynonymous single mutations and three double mutations were identified.The rpoC mutations at locus 483(11.3%)were predominant,and the mutations at V483G,W484G,I491V,L516P,L566R,N698K,and A788E accounted for 54.5%of the total detected mutations.Fifteen new mutations in the rpoC gene were identified.Rifampin resistance and rpoB mutations at locus 531 were significantly associated with rpoC mutations.MIRU-VNTR genotype results indicated that 18.4%of the studied isolates were clustered,and the rpoC mutations were not significantly associated with MIRU-VNTR clusters.A large proportion of rpoC mutation was observed in the rifampicin-resistant MTB isolates.However,the findings of this study do not support the association of rpoC mutation with compensated transmissibility. | Shengfen Wang Yang Zhou Bing Zhao Xichao Ou Hui Xia Yang Zheng Yuanyuan Song Qian Cheng Xinyang Wang Yanlin Zhao | 2020 | Frontiers of Medicine2020，14，1： | 0 |
| 9 | A transient production prediction method for tight condensate gas wells with multiphase flow显示文摘Considering the phase behaviors in condensate gas reservoirs and the oil-gas two-phase linear flow and boundary-dominated flow in the reservoir,a method for predicting the relationship between oil saturation and pressure in the full-path of tight condensate gas well is proposed,and a model for predicting the transient production from tight condensate gas wells with multiphase flow is established.The research indicates that the relationship curve between condensate oil saturation and pressure is crucial for calculating the pseudo-pressure.In the early stage of production or in areas far from the wellbore with high reservoir pressure,the condensate oil saturation can be calculated using early-stage production dynamic data through material balance models.In the late stage of production or in areas close to the wellbore with low reservoir pressure,the condensate oil saturation can be calculated using the data of constant composition expansion test.In the middle stages of production or when reservoir pressure is at an intermediate level,the data obtained from the previous two stages can be interpolated to form a complete full-path relationship curve between oil saturation and pressure.Through simulation and field application,the new method is verified to be reliable and practical.It can be applied for prediction of middle-stage and late-stage production of tight condensate gas wells and assessment of single-well recoverable reserves. | BAI Wenpeng CHENG Shiqing WANG Yang CAI Dingning GUO Xinyang GUO Qiao | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 10 | Flotation separation of wolframite from calcite using a new trisiloxane surfactant as collector显示文摘Since wolframite is usually associated with calcite,the separation and enrichment of wolframite by froth flotation remains a great challenge.Herein,a novel trisiloxane surfactant N-(2-aminoethyl)-3-ami nopropyltrisiloxane(AATS)was successful synthesized,which was used for the separation of wolframite from calcite for the first time.The flotation separation performance of AATS was studied by flotation test,and its adsorption mechanism was explored based on contact angle,infrared spectrum analysis(FTIR),zeta potential and density functional theory(DFT)calculation.The results of microflotation test and binary mixed ore flotation test pointed that AATS had excellent selectivity and more prominent collection capacity for the flotation of wolframite when compared with industrial reagent sodium oleate(NaOL).The measurement results of contact angle proved that AATS improved the hydrophobicity of the wolframite surface.The highly selective adsorption mechanism of AATS surfactant on mineral surfaces were further researched and analyzed by FTIR and zeta potential.The results revealed that AATS surfactant had significant adsorption effect on wolframite,yet almost no adsorption on calcite.DFT calculation indicated that AATS produced electrostatic adsorption with wolframite surface through—N+H3 group. | Shuyi Shuai Zhiqiang Huang Vladimir E.Burov Vladimir Z.Poilov Fangxu Li Hongling Wang Rukuan Liu Shiyong Zhang Chen Cheng Wenyuan Li Xinyang Yu Guichun He Weng Fu | 2023 | International Journal of Mining Science and Technology2023，33，3： | 0 |
| 11 | Electro-catazone treatment of an ozone-resistant drug:Effect of sintering temperature on TiO_(2) nanoflower catalyst on porous Ti gas diffuser anodes显示文摘Electrochemical heterogeneous catalytic ozonation(E-catazone) is a promising and advanced oxidation technology that uses a titanium dioxide nanoflower(TiO_(2-NF))-coated porous Ti gas diffuser as an anode material.Our previous study has highlighted that the importance of the TiO_(2-NF)coating layer in enhancing*OH production and rapidly degrading O_(3)-resistant drugs.It is well known that the properties of TiO_(2-NF)are closely related to its sintering temperature.However,to date,related research has not been conducted in E-catazone systems.Thus,this study evaluated the effect of the sintering temperature on the degradation of the O_(3)-resistant drug para-chlorobenzoic acid(p-CBA) using both experimental and kinetic modeling and revealed its influence mechanism.The results indicated that the TiO_(2-NF)sintering temperature could influence p-CBA degradation and*OH production.TiO_(2-NF)prepared at 450 C showcased the highest p-CBA removal efficiency(98.5% in 5 min) at a rate of 0.82 min^(-1),and an*OH exposure of 8.41 x 10^(-10) mol L^(-1) s.Kinetic modeling results and interface characterization data revealed that the sintering temperature could alter the TiO_(2) crystallized phase and the content of surfaceadsorbed oxygen,thus affecting the two key limiting reactions in the E-catazone process.That is,≡TiO_(2) surface reacted with H_(2) O to form TiO_(2)-(OH)_(2),which then heterogeneously catalyzed O_(3) to form *OH.Consequently,E-catazone with a TiO_(2-NF)anode prepared at 450°C generated the highest surface reaction rate(5.00 x 10^(-1) s^(-1) and 4.00 x 10^(-3) L mol^(-1) s^(-1),respectively),owing to its higher anatase content and adsorbed oxygen.Thus,a rapid O_(3)-TiO_(2) reaction was achieved,resulting in an enhanced*OH formation and a highly effective p-CBA degradation.Overall,this study provides novel baseline data to improve the application of E-catazone technology. | Xinyang Li Yannan Li Hao Zhang Zhen Shen Shuang Cheng Guicheng Liu Hong Yao | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 12 | Surface modification of hollow capsule by Dawson-type polyoxometalate as sulfur hosts for ultralong-life lithium-sulfur batteries显示文摘Reasonable construction of sulfur host with high conductivity,large sulfur storage gap,strong chemical adsorption,and fast oxidation–reduction kinetics of polysulfide is very significant for its practical use in lithium-sulfur batteries(LSBs).In this paper,the surface modification of MIL-88A(Fe)is carried out by Dawson-type polyoxometalate(POM),and a hollow capsule shell material with P_(2)W_(18),Fe_(3)O_(4),and C components is synthesized by the subsequent carbonization process.When applied as the sulfur host,the hollow capsule shell material can efficiently improve the conductivity of sulfur electrode and restrain the volumetric change of active sulfur while charging and discharging.On this foundation,electrochemical analysis and density functional theory(DFT)calculation show that the P_(2)W_(18)on the outer layer of the capsule shell have effective electrocatalytic activity and potent chemical bond on the lithium polysulfides(LiPSs),which is helpful to block the shuttle effect.Therefore,the as-assembled LSBs display the outstanding specific capacity and prominent cycle stability.Specifically,it delivers an excellent reversible capacity of 1063 mAh/g after 100 cycles of charge–discharge at a rate of 0.5 C,accounting for a preservation by 96%in comparison to that of the initial cycle.Moreover,even after 2000 cycles at 1 C,the reversible specific capacity of 585 mAh/g can still be maintained with an average decay rate of only 0.021%. | Mingliang Wang Di Yin Yundong Cao Xinyang Dong Guanggang Gao Xun Hu Cheng Jin Linlin Fan Jian Yu Hong Liu | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
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