|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 3 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 4 | The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila显示文摘The limited bioavailability of plant-derived natural products with anticancer activity poses major challenges to the pharmaceutical industry.An example of this is camptothecin,a monoterpene indole alkaloid with potent anticancer activity that is extracted at very low concentrations from woody plants.Recently,camptothecin biosynthesis has been shown to become biotechnologically amenable in hairy-root systems of the natural producer Ophiorrhiza pumila.Here,time-course expression and metabolite analyses were performed to identify novel transcriptional regulators of camptothecin biosynthesis in O.pumila.It is shown here that camptothecin production increased over cultivation time and that the expression pattern of the WRKY transcription factor encoding gene OpWRKY2 is closely correlated with camptothecin accumulation.Overexpression of OpWRKY2 led to a more than three-fold increase in camptothecin levels.Accordingly,silencing of OpWRKY2 correlated with decreased camptothecin levels in the plant.Further detailed molecular characterization by electrophoretic mobility shift,yeast one-hybrid and dual-luciferase assays showed that OpWRKY2 directly binds and activates the central camptothecin pathway gene OpTDC.Taken together,the results of this study demonstrate that OpWRKY2 acts as a direct positive regulator of camptothecin biosynthesis.As such,a feasible strategy for the over-accumulation of camptothecin in a biotechnologically amenable system is presented. | Xiaolong Hao Chenhong Xie Qingyan Ruan Xichen Zhang Chao Wu Bing Han Jun Qian Wei Zhou Hans-Wilhelm Nutzmann Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 7 |
| 5 | dentification and characterization of GRA6/ SRA7 of Neospora caninum in MDBK cells显示文摘 | Jingquan Dong Jianhua Li Jinpeng Wang Fei Li Ju Yang Pengtao Gong He Li Xichen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 5 |
| 6 | Foraging strategies in the greater horseshoe bat(Rhinolophus ferrumequinum)on Lepidoptera in summer显示文摘The diet of the bat Rhinolophus ferrumequinum was studied at the Zhi’an Village of Ji’an City in China, from June to August 2004. The bats were trained in a laboratory (volume: 9×4×4 m3). Foraging strategies of the bat were ob- served at night and prey remains were collected and identi- fied. The results showed that the diet consisted mainly of Lepidoptera in summer, including 11 families, more than 30 species of moths, such as Noctuidae (36.6% by number), Sphingidae (24.1%), Geometridae (13.4%) and Limacodidae (9.5%). The length of culled wings ranged from 10―40 mm (97.7%). Pearson correlation analysis showed that the bat R. ferrumequinum foraged their prey selectively, but not op- portunistically. From field studies, two ways were observed in which the bats retrieved their prey including aerial hawk- ing during peak active period of the insects and flycatching during the insects’ non-peak activity period. The bats never gleaned prey from the ground, though they appeared to be well able to detect fluttering moths on the ground. | JIN Longru FENG Jiang SUN Keping LIU Ying WU Lei LI Zhenxin ZHANG Xichen | 2005 | Chinese Science Bulletin2005，50，14： | 5 |
| 7 | Experimental study of single-row chevron-jet impingement heat transfer on concave surfaces with different curvatures显示文摘To address the curvature effect on single-row chevron-nozzle jet impingement heat transfer on concave surface,a series of experiments are conducted in the present investigation.Four concave surfaces including one semi-cylindrical concave surface and three parabolic concave surfaces with different width-to-depth ratios are tested under three typical Reynolds numbers(Re=5000,10000 and 15000)and several dimensionless nozzle-to-surface distances ranging from 1 to 8.The results show that the concave curvature has a clear impact on chevron-nozzle jet impingement heat transfer,tightly dependent on jet Reynolds number and impinging distance.In general,the semicylindrical concave surface produces the highest longitudinally-averaged Nusselt number at the leading line of concave surface.Under a low jet Reynolds number,the parabolic concave surface with a highly curved curvature produces higher longitudinally-averaged Nusselt number at the leading line and more uniform longitudinally-averaged Nusselt number distribution along the curvilinear direction.However,the longitudinally-averaged Nusselt number at the leading line of concave surface is the lowest for the highly curved surface under a high jet Reynolds number and large impinging distance.In comparison with the round-nozzle,chevron nozzle plays a more significant role on improving jet impingement heat transfer at small impinging distances. | Yuanwei LYU Jingzhou ZHANG Xichen LIU Yong SHAN | 2019 | Chinese Journal of Aeronautics2019，32，10： | 3 |
| 8 | A novel telomerase-interacting OTU protein of Eimeria tenella and its telomerase-regulating activity显示文摘 | Pu Wang Weirong Wang Ju Yang Yongxing Ai Pengtao Gong Xichen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 9 | Biomass-based aligned carbon networks with double-layer construction for tunable electromagnetic shielding with ultra-low reflectivity显示文摘Nowadays,carbon frameworks derived from natural biomaterials have attracted extensive attention for electromagnetic interference(EMI)shielding due to their renewability and affordability.However,it is critical and challenging to achieve effective regulation of shielding effectiveness(SE)as well as weaken the strong EM reflection of highly conductive biomass-based carbon materials.Herein,commercial cotton pads with oriented structure were selected as carbonaceous precursor to fabricate aligned carbon networks by pyrolysis,and the EMI SE of the samples with increased temperature of 800-1000℃ can be accurately controlled in the effective range of~21.7-29.1,~27.7-37.1 and~32.7-43.3 d B with high reflection coefficient of>0.8 by changing the cross-angle between the electric-field direction of incident EM waves and the fiber-orientation direction due to the occurrence of opposite internal electric field.Moreover,the further construction of Salisbury absorber-liked double-layer structure could result in an ultralow reflection coefficient of only~0.06 but enhanced SE variation range up to~38.7-49.3 d B during the adjustment of cross-angle,possibly due to the destructive interference of EM waves in the double-layer carbon networks.This work would provide a simple and effective way for constructing high-performance biomass carbon materials with adjustable EMI shielding and ultra-low reflectivity. | Jiali Chen Da Yi Xichen Jia Guoqing Wang Zhouping Sun Lihua Zhang Yinfeng Liu Bin Shen Wenge Zheng | 2022 | Journal of Materials Science & Technology2022，，8： | 2 |
| 10 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 11 | Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers(Panthera tigris altaica)in northeast China显示文摘INTRODUCTION Pentatrichomonas hominis,an anaerobic flagellated protozoan that inhabits the large intestines of mammals and belongs to the Trichomonadidae family(Wenrich 1944;Kim et al.2010;Li et al.2014b,2016,2018a,2020;Maritz et al.2014;Zhang et al.2019),is mainly transmitted through the fecal-oral route.It was originally presumed to be a commensal protozoan(Tolbert et al.2012)but was found to cause gastrointestinal symptoms. | Hongbo ZHANG Nan ZHANG Pengtao GONG Shuqin CHENG Xiaocen WANG Xin LI Zhijun HOU Chang LIU Tianqi BI Bobo WANG Yidan CHENG Jianhua LI Xichen ZHANG | 2022 | Integrative Zoology2022，17，4： | 1 |
| 12 | Host adaptation and host–parasite co-evolution in Cryptosporidium : implications for taxonomy and public health显示文摘 | Lihua Xiao Irshad M Sulaiman Una M Ryan Ling Zhou Edward R Atwill Monica L Tischler Xichen Zhang Ronald Fayer Altaf A Lal | 2002 | International Journal for Parasitology2002，，14： | 1 |
| 13 | Synthesis and application of starch-graft-poly (AM-co-AMPS) by using a complex initiation system of CS-APS显示文摘 | Song Hui Zhang Shufen Ma Xichen | 2007 | Carbohydrate Polymers2007，69，1： | 1 |
| 14 | Synthesis and application of starch-graft-poly(AM-co-AMPS)by using a complex initiation system of CS-APS显示文摘 | Song Hui Zhang Shufen Ma Xichen et a1 | 2006 | Carbohydrate Polymers2006，69，1： | 1 |
| 15 | ,Synthesis and applicaion of starch-graft-poly(AM-co-AMPS) by using a complex initiation system of CS-APS显示文摘 | Song Hui Zhang Shufen Ma Xichen et a1 | 2006 | Carbohydrate Polymers2006，69，1： | 1 |
| 16 | Synthesis and application of starch-graft-poly (AM-co-AMPS) by using a complex initiation system of CS-APS 显示文摘 | Song Hui Zhang Shufen Ma Xichen | 2007 | Carbohydrate Polymers2007，69，： | 1 |
| 17 | Synthesis and application of starch-graft-poly (AM-co-AMPS) by using a complex initiation system of CS-APS显示文摘 | Song Hui Zhang Shufen Ma Xichen | | 0，，： | 1 |
| 18 | An investigation of the synthesis and thermal stability of poly(dl-lactide)显示文摘 | Xichen Zhang Urs P. Wyss David Pichora Mattheus F. A. Goosen | 1992 | Polymer Bulletin1992，，6： | 1 |
| 19 | A recombinant pseudorabies virus expressing TgSAG1 protects against challenge with the virulent Toxoplasma gondii RH strain and pseudorabies in BALB/c mice显示文摘 | Quan Liu Shengyan Gao Li Jiang Limin Shang Jingtao Men Ze Wang Yujia Zhai Zhiping Xia Rongliang Hu Xichen Zhang Xing-Quan Zhu | 2008 | Microbes and Infection2008，，12： | 1 |
| 20 | A novel dense granule protein NcGRA23 in Neospora caninum显示文摘 | Weirong Wangt Pengtao Gongt Pu Wang Jingquan Dong Xiaocen Wang Zhengtao Yang Jianhua Li Xichen Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员