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| 1 | UV/H2O2 oxidation of tri(2-chloroethyl) phosphate: Intermediate products, degradation pathway and toxicity evaluation显示文摘Tri(2-chloroethyl) phosphate(TCEP) with the initial concentration of 5 mg/L was degraded by UV/H2O2 oxidation process. The removal rate of TCEP in the UV/H2O2 system was 89.1% with the production of Cl-and PO4^3- of 0.23 and 0.64 mg/L. The removal rate of total organic carbon of the reaction was 48.8% and the pH reached 3.3 after the reaction. The oxidative degradation process of TCEP in the UV/H2O2 system obeyed the first order kinetic reaction with the apparent rate constant of 0.0025 min^-1( R^2 = 0.9788). The intermediate products were isolated and identified by gas chromatography-mass spectrometer. The addition reaction of HO · and H2O and the oxidation reaction with H2O2 were found during the degradation pathway of 5 mg/L TCEP in the UV/H2O2 system. For the first time, environment risk was estimated via the 'ecological structure activity relationships' program and acute and chronic toxicity changes of intermediate products were pointed out. The luminescence inhibition rate of photobacterium was used to evaluate the acute toxicity of intermediate products. The results showed that the toxicity of the intermediate products increased with the increase of reaction time, which may be due to the production of chlorine compounds. Some measures should be introduced to the UV/H2O2 system to remove the highly toxic Cl-containing compounds, such as a nanofiltration or reverse osmosis unit. | Qiuyi Ji Huan He Zhanqi Gao Xiaohan Wang Shaogui Yang Cheng Sun Shiyin Li Yong Wang Limin Zhang | 2020 | Journal of Environmental Sciences2020，32，12： | 4 |
| 2 | Effects of UV on the Corrosion Behavior of Pure Aluminum 1060 in Simulated Nansha Marine Atmosphere显示文摘The corrosion behavior of pure aluminum 1060 subjected to a wet-dry cyclic accelerated test in simulated Nansha marine atmosphere in the dark and under UV illumination has been investigated by means of scanning electron microscopy(SEM),electrochemical impedance spectroscopy(EIS),and Mott–Schottky measurements in this work.The results show that under the two conditions,the native oxide films are constantly destroyed and the thicknesses of the oxide films continuously decrease in the first 24 days of the corrosion test.In particular,UV illumination can diminish the pitting corrosion susceptibility of the native oxide films to an extent in terms of a photo-induced modifi cation of the native oxide film on the pure aluminum surfaces.Besides,UV illumination can also reduce the carrier concentration in the oxide films,thus reducing the conductivity and the corrosion rate. | Can Peng Mingxiao Guo Tianzhen Gu Xiaohan Li Chuan Wang Zhenyao Wang Cheng Sun | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，7： | 1 |
| 3 | 2 μm optical frequency comb generation via optical parametric oscillation from a lithium niobate optical superlattice box resonator显示文摘Optical parametric oscillators(OPOs) can downconvert the pump laser to longer wavelengths with octave separation via χ^((2)), which is widely used for laser wavelength extension including mid-infrared(MIR) generation.Such a process can be integrated in monolithic resonators, being compact and low in threshold. In this work, we show that the monolithic χ^((2))mini-OPO can also be used for optical frequency comb generation around 2096 nm and enters the boundary of MIR range. A new geometry called an optical superlattice box resonator is developed for this realization with near-material-limited quality factor of 4.0 × 10^(7). Only a continuous-wave near-infrared pump laser is required, with OPO threshold of 80 mW and output power up to 340 mW. Revival temporal profiles are measured at a detectable repetition frequency of 1.426 GHz, and narrow beat note linewidth of less than 10 Hz shows high comb coherence. These results are in good agreement with our simulation for a stable comb generation. Such an OPO-based comb source is useful for carbon dioxide sensing or the mine prospect applications and can be generalized to longer MIR wavelengths for general gas spectroscopy. | Xiaohan Wang Kunpeng Jia Mengwen Chen Shanshan Cheng Xin Ni Jian Guo Yihao Li Huaying Liu Liyun Hao Jian Ning Gang Zhao Xinjie Lv Shu-Wei Huang Zhenda Xie Shi-Ning Zhu | 2022 | Photonics Research2022，10，2： | 1 |
| 4 | First Chinese ultraviolet-visible hyperspectral satellite instrument implicating global air quality during the COVID-19 pandemic in early 2020显示文摘In response to the COVID-19 pandemic,governments worldwide imposed lockdown measures in early 2020,resulting in notable reductions in air pollutant emissions.The changes in air quality during the pandemic have been investigated in numerous studies via satellite observations.Nevertheless,no relevant research has been gathered using Chinese satellite instruments,because the poor spectral quality makes it extremely difficult to retrieve data from the spectra of the Environmental Trace Gases Monitoring Instrument(EMI),the first Chinese satellite-based ultraviolet–visible spectrometer monitoring air pollutants.However,through a series of remote sensing algorithm optimizations from spectral calibration to retrieval,we successfully retrieved global gaseous pollutants,such as nitrogen dioxide(NO2),sulfur dioxide(SO2),and formaldehyde(HCHO),from EMI during the pandemic.The abrupt drop in NO2 successfully captured the time for each city when effective measures were implemented to prevent the spread of the pandemic,for example,in January 2020 in Chinese cities,February in Seoul,and March in Tokyo and various cities across Europe and America.Furthermore,significant decreases in HCHO in Wuhan,Shanghai,Guangzhou,and Seoul indicated that the majority of volatile organic compounds(VOCs)emissions were anthropogenic.Contrastingly,the lack of evident reduction in Beijing and New Delhi suggested dominant natural sources of VOCs.By comparing the relative variation of NO2 to gross domestic product(GDP),we found that the COVID-19 pandemic had more influence on the secondary industry in China,while on the primary and tertiary industries in Korea and the countries across Europe and America. | Cheng Liu Qihou Hu Chengxin Zhang Congzi Xia Hao Yin Wenjing Su Xiaohan Wang Yizhou Xu Zhiguo Zhang | 2022 | Light(Science & Applications)2022，11，2： | 1 |
| 5 | Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy显示文摘Oral tyrosine kinase inhibitors(TKIs) against epidermal growth factor receptor(EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery. | Xiaohan Zhou Kun Shi Ying Hao Chengli Yang Ruoyu Zha Cheng Yi Zhiyong Qian | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 1 |
| 6 | Agrobacterium–mediated Transformation of Kalanchoe laxiflora显示文摘Plants with crassulacean acid metabolism(CAM) generally utilize water 20%–80% more efficiently than non-CAM plants. The whole genomes of several CAM plants have been sequenced or are being sequenced. For effective genome characterization and genome editing of CAM plants,an efficient transformation system is essential. In this study, we developed an Agrobacterium-mediated transformation protocol for Kalanchoe laxiflora, an obligate CAM plant,by optimizing several factors affecting the transformation efficiency. Agrobacterium strains AGL1, C58, EHA105,and GV3101 were all suitable for K. laxiflora transformation. Fifty-nine percent of the leaf explants yielded kanamycin-resistant and GUS-positive shoots. Polymerase chain reaction and quantitative real-time PCR(qRT-PCR) using gus A-, gus Plus-, npt II-and hpt-specific primers confirmed that the transgenes were integrated into K. laxiflora genome and expressed. This efficient transformation system will allow effective functional characterization of genes through over-or down-expression, knockout, or genome editing. | Xiling Wang Xinlu Chen Qunkang Cheng Kaikai Zhu Xiaohan Yang Zongming Cheng | 2019 | Horticultural Plant Journal2019，5，5： | 1 |
| 7 | Biodesign Research to Advance the Principles and Applications of Biosystems Design显示文摘Over the course of civilization,humans have increasingly expanded their freedom to live a better life.In comparison with the primitive society,our modern society has many more choices of life-supporting resources,such as yearround food supply,permanent shelters,diverse energy sources,and effective preventive and curing medicine.However,our society is currently still heavily relying on the resources provided by Mother Nature,which cannot meet the future global needs in terms of both quantity and quality under the pressure of population growth,natural resource reduction,and environmental deterioration.For example,the food sources originating from plants,animals,or microbes do not have the nutrition balance for optimal human health[1–3].Climate change and environmental deterioration threaten the food security[4–6].Increasingly,infectious diseases(e.g.,HIV/AIDS),genetic diseases(e.g.,cancer),and improper lifestyle-related disorders(e.g.,obesity)become more prevalent and remain challenging to be prevented,controlled,and cured.Conventional medical technologies and modern medicine development are also meeting the ceiling. | Xiaohan Yang Lei S.Qi Alfonso Jaramillo Zong-Ming(Max)Cheng | 2019 | BioDesign Research2019，，1： | 1 |
| 8 | Advances and perspectives in discovery and functional analysis of small secreted proteins in plants显示文摘Small secreted proteins(SSPs)are less than 250 amino acids in length and are actively transported out of cells through conventional protein secretion pathways or unconventional protein secretion pathways.In plants,SSPs have been found to play important roles in various processes,including plant growth and development,plant response to abiotic and biotic stresses,and beneficial plant–microbe interactions.Over the past 10 years,substantial progress has been made in the identification and functional characterization of SSPs in several plant species relevant to agriculture,bioenergy,and horticulture.Yet,there are potentially a lot of SSPs that have not been discovered in plant genomes,which is largely due to limitations of existing computational algorithms.Recent advances in genomics,transcriptomics,and proteomics research,as well as the development of new computational algorithms based on machine learning,provide unprecedented capabilities for genome-wide discovery of novel SSPs in plants.In this review,we summarize known SSPs and their functions in various plant species.Then we provide an update on the computational and experimental approaches that can be used to discover new SSPs.Finally,we discuss strategies for elucidating the biological functions of SSPs in plants. | Xiao-Li Hu Haiwei Lu Md Mahmudul Hassan Jin Zhang Guoliang Yuan Paul E.Abraham Him K.Shrestha Manuel I.Villalobos Solis Jin-Gui Chen Timothy J.Tschaplinski Mitchel J.Doktycz Gerald A.Tuskan Zong-Ming(Max)Cheng Xiaohan Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 9 | The Role of Surface Oxygen in the Growth of Large Single-Crystal Graphene on Copper显示文摘 | Yufeng Hao M. S. Bharathi Lei Wang Yuanyue Liu Hua Chen Shu Nie Xiaohan Wang Harry Chou Cheng Tan Babak Fallahazad H. Ramanarayan Carl W. Magnuson Emanuel Tutuc Boris I. Yakobson Kevin F. McCarty Yong-Wei Zhang Philip Kim James Hone Luigi Colombo Rodney S | 2013 | 2013 (6159)2013，，6159： | 1 |
| 10 | Diel dynamics of multi-omics in elkhorn fern provide new insights into weak CAM photosynthesis显示文摘Crassulacean acid metabolism(CAM)has high water-use efficiency(WUE)and is widely recognized to have evolved from C3 photosynthesis.Different plant lineages have convergently evolved CAM,but the molecular mechanism that underlies C3-to-CAM evolution remains to be clarified.Platycerium bifurcatum(elkhorn fern)provides an opportunity to study the molecular changes underlying the transition from C3 to CAM photosynthesis because both modes of photosynthesis occur in this species,with sporotrophophyll leaves(SLs)and cover leaves(CLs)performing C3 and weak CAM photosynthesis,respectively.Here,we report that the physiological and biochemical attributes of CAM in weak CAM-performing CLs differed from those in strong CAM species.We investigated the diel dynamics of the metabolome,proteome,and transcriptome in these dimorphic leaves within the same genetic background and under identical environmental conditions.We found that multi-omic diel dynamics in P.bifurcatum exhibit both tissue and diel effects.Our analysis revealed temporal rewiring of biochemistry relevant to the energy-producing pathway(TCA cycle),CAM pathway,and stomatal movement in CLs compared with SLs.We also confirmed that PHOSPHOENOLPYRUVATE CARBOXYLASE KINASE(PPCK)exhibits convergence in gene expression among highly divergent CAM lineages.Gene regulatory network analysis identified candidate transcription factors regulating the CAM pathway and stomatal movement.Taken together,our results provide new insights into weak CAM photosynthesis and new avenues for CAM bioengineering. | Cheng Li Wenjie Huang Xiaoxu Han Guohua Zhao Wenyang Zhang Weijun He Bao Nie Xufeng Chen Taijie Zhang Wenhui Bai Xiaopeng Zhang Jingjing He Cheng Zhao Alisdair RFernie Timothy JTschaplinski Xiaohan Yang Shijuan Yan Li Wang | 2023 | Plant Communications2023，4，5： | 0 |
| 11 | Monolithic three-dimensional integration of aligned carbon nanotube transistors for high-performance integrated circuits显示文摘Carbon nanotube field-effect transistors(CNT FETs)have been demonstrated to exhibit high performance only through low-temperature fabrication process and require a low thermal budget to construct monolithic three-dimensional(M3D)integrated circuits(ICs),which have been considered a promising tech-nology to meet the demands of high-bandwidth computing and fully func-tional integration.However,the lack of high-quality CNT materials at the upper layer and a low-parasitic interlayer dielectric(ILD)makes the reported M3D CNT FETs and ICs unable to provide the predicted high performance.In this work,we demonstrate a multilayer stackable process for M3D integration of high-performance aligned carbon nanotube(A-CNT)transistors and ICs.A low-κ(-3)interlayer SiO_(2)layer is prepared from spin-on-glass(SOG)through processes with a highest temperature of 220℃,presenting low parasitic capaci-tance between two transistor layers and excellent planarization to offer an ideal surface for the A-CNT and device fabrication process.A high-quality A-CNT film with a carrier mobility of 650 cm 2 V^(-1)s^(-1)is prepared on the ILD layer through a clean transfer process,enabling the upper CNT FETs fabri-cated with a low-temperature process to exhibit high on-state current(1 mAμm^(-1))and peak transconductance(0.98 mSμm^(-1)).The bottom A-CNT FETs maintain pristine high performance after undergoing the ILD growth and upper FET fabrication.As a result,5-stage ring oscillators utilizing the M3D architecture show a gate propagation delay of 17 ps and an active region of approximately 100μm 2,representing the fastest and the most compact M3D ICs to date. | Chenwei Fan Xiaohan Cheng Lin Xu Maguang Zhu Sujuan Ding Chuanhong Jin Yunong Xie Lian-Mao Peng Zhiyong Zhang | 2023 | InfoMat2023，5，7： | 0 |
| 12 | HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins显示文摘The first HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones(27 examples,up to 98% yield) from readily available indoles and isatin derivatives are described.This protocol shows well tolerance of different functional groups and features mild reaction conditions such as short reaction time(~1 h),no usage of catalyst,easy operation and product isolation.Of particular intere st is the formation of two C-C bonds and one all-carbon quaternary center.This protocol could serve as an alternative strategy to synthesize biologically important 3,3-di(indolyl)indolin-2-ones for biological testing. | Xiaohan Yuan Shuai Wang Jialing Cheng Bin Yu Hong-Min Liu | 2020 | Chinese Chemical Letters2020，31，9： | 0 |
| 13 | miR-182通过调节骨骼肌的葡萄糖利用调控代谢稳态显示文摘阐明骨骼肌肌纤维分型以及代谢转换的调控机制将有助于深入了解生理和疾病条件下的能量代附。 | Duo Zhang Yan Li Xuan Yao Hui Wang Lei Zhao Haowen Jiang Xiaohan Yao Shengjie Zhang Cheng Ye Wei Liu Hongchao Cao Shuxian Yu Yucheng Wang Qiong Li Jingjing Jiang Yi Liu Ling Zhang Yun Liu Naoharu Iwai Hui Wang Jingya Li Jia Li Xihua Li 金子兵 应浩 | 2017 | 科学新闻2017，19，4： | 0 |
| 14 | The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry显示文摘The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the nucleus.We report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the nucleus.We showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in cyanobacteria.We propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy production.We demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription regulation.Together,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation. | Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 15 | Genetic segregation analysis of unsaturated fatty acids content in the filial generations of high-linolenic-acid rapeseed(Brassica napus)显示文摘Alpha linolenic acid(ALA)is an essential polyunsaturated fatty acids that can improve human health.Rapeseed is the second largest oil crop in the world but the ALA content in its seed fatty acids is only about 10%.Two rapeseed germplasms YH25005 and R8Q10 with high content(up to 21%)ALA were developed by intervarietal crossing.They were used as the maternal parent(P_(1))when crossed with a low ALA parent SW(P2)to produce the seeds of the F1 hybrid,F2,and backcrosses to P1(BCP1)and P2(BCP2).A multigeneration joint segregation analysis was conducted to determine major gene t polygene effects of the content of three major unsaturated fatty acids including oleic(OA),linoleic(LA)and ALA.The results showed that,although some genes favorable to ALA accumulation were not allelic in R8Q10 and YH25005,all the inheritances of OA,LA and ALA in YH25005×SW and R8Q10×SW followed a genetic model of‘two pairs of additive major genes t additive-dominant polygenes’.It is suggested that the contents of OA,LA and ALA are closely related and the major genes in the parent SW containing loss-of-function mutations in FAD2 and FAD3 loci had strong effect to reduce ALA and elevate OA.However,total genetic effect of the polygenes was greater than that of the two major genes,especial on ALA content.It indicated that it is necessary to employ a larger F2 population to find the plant that accumulate enough minor-effect polygenes for high ALA content.The results are useful for high ALA rapeseed breeding and future work of gene mapping. | Xiaohan Zhang Jinglong Lian Chunyan Dai Xiaoli Wang Mingzheng Zhang Xing Su Yaohua Cheng Chengyu Yu | 2021 | Oil Crop Science2021，6，4： | 0 |
| 16 | On High-Resolution Entropy-Consistent Flux with Slope Limiter for Hyperbolic Conservation Laws显示文摘This paper proposes a new version of the high-resolution entropy-consistent(EC-Limited)flux for hyperbolic conservation laws based on a new minmod-type slope limiter.Firstly,we identify the numerical entropy production,a third-order differential term deduced from the previous work of Ismail and Roe[11].The corresponding dissipation term is added to the original Roe flux to achieve entropy consistency.The new,resultant entropy-consistent(EC)flux has a general and explicit analytical form without any corrective factor,making it easy to compute and a less-expensive method.The inequality constraints are imposed on the standard piece-wise quadratic reconstruction to enforce the pointwise values of bounded-type numerical solutions.We design the new minmod slope limiter as combining two separate limiters for left and right states.We propose the EC-Limited flux by adding this reconstruction data method to the primitive variables rather than to the conservative variables of the EC flux to preserve the equilibrium of the primitive variables.These resulting fluxes are easily applied to general hyperbolic conservation laws while having attractive features:entropy-stable,robust,and non-oscillatory.To illustrate the potential of these proposed fluxes,we show the applications to the Burgers equation and the Euler equations. | Xuan Ren Jianhu Feng Supei Zheng Xiaohan Cheng Yang Li | 2023 | Communications on Applied Mathematics and Computation2023，5，4： | 0 |
| 17 | Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4(BRD4) inhibitors显示文摘Targeting bromodomain-containing protein 4(BRD4) has been proved to be an effective strategy for cancer therapy.To date,numerous BRD4 inhibitors and degraders have been identified,some of which have advanced into clinical trials.In this work,a focused library of new [1,2,4]triazolo [1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4.WS-722 inactivated BRD4(BD1/BD2),BRD2(BD1/BD2) and BRD3(BD1/BD2) broadly with the IC_(50) values less than 5 μmol/L.Besides,WS-722 inhibited growth of THP-1 cells with an IC_(50) value of 3.86 μmol/L.Like(+)-JQ1,WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability.Docking studies showed that WS-722 occupied the central acetyl-lysine(Kac) binding cavity and formed a hydrogen bond with Asn140.In THP-1 cells,WS-722 showed target engagement to BRD4.Cellular effects of WS-722 on THP-1 cells were also examined,showing that WS-722 could block c-MYC expression,induce G0/G1 phase arrest and p21 up-regulation,and promote differentiation of THP-1 cells.BRD4 inhibition by WS-722 resulted in cell apoptosis and upregulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines.The [1,2,4]triazolo[1,5-a]pyrimidine is a new template for the development of new BRD4 inhibitors. | Shuai Wang Dandan Shen Lijie Zhao Xiaohan Yuan Jialing Cheng Bin Yu Yichao Zheng Hongmin Liu | 2020 | Chinese Chemical Letters2020，31，2： | 0 |
| 18 | Photonic-dispersion neural networks for inverse scattering problems显示文摘Inferring the properties of a scattering objective by analyzing the optical far-field responses within the framework of inverse problems is of great practical significance.However,it still faces major challenges when the parameter range is growing and involves inevitable experimental noises.Here,we propose a solving strategy containing robust neuralnetworks-based algorithms and informative photonic dispersions to overcome such challenges for a sort of inverse scattering problem—reconstructing grating profiles.Using two typical neural networks,forward-mapping type and inverse-mapping type,we reconstruct grating profiles whose geometric features span hundreds of nanometers with nanometric sensitivity and several seconds of time consumption.A forward-mapping neural network with a parameters-to-point architecture especially stands out in generating analytical photonic dispersions accurately,featured by sharp Fano-shaped spectra.Meanwhile,to implement the strategy experimentally,a Fourier-optics-based angle-resolved imaging spectroscopy with an all-fixed light path is developed to measure the dispersions by a single shot,acquiring adequate information.Our forward-mapping algorithm can enable real-time comparisons between robust predictions and experimental data with actual noises,showing an excellent linear correlation(R2>0.982)with the measurements of atomic force microscopy.Our work provides a new strategy for reconstructing grating profiles in inverse scattering problems. | Tongyu Li Ang Chen Lingjie Fan Minjia Zheng Jiajun Wang Guopeng Lu Maoxiong Zhao Xinbin Cheng Wei Li Xiaohan Liu Haiwei Yin Lei Shi Jian Zi | 2021 | Light(Science & Applications)2021，10，10： | 0 |
| 19 | LSD1 is required for euchromatic origin firing and replication timing显示文摘The chromatin-based rule governing the selection and activation of replication origins remains to be elucidated.It is believed that DNA replication initiates from open chromatin domains;thus,replication origins reside in open and active chromatin.However,we report here that lysine-specific demethylase 1(LSD1),which biochemically catalyzes H3K4me1/2 demethylation favoring chromatin condensation,interacts with the DNA replication machinery in human cells.We find that LSD1 level peaks in early S phase. | Yue Wang Yunchao Huang Edith Cheng Xinhua Liu Yu Zhang Jianguo Yang Jordan T.F.Young Grant W.Brown Xiaohan Yang Yongfeng Shang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
| 20 | Microparticle Effect of Carbon Dioxide Hydrate Crystal Nucleus in Reaction Kettle显示文摘This study analyzed the partial effect of carbon dioxide hydrate in reaction kettle experiments.The particle and bubble characteristics of the crystal nucleus during carbon dioxide hydrate decomposition were observed under the microscope.The results showed that in the temperature range of 0.5℃–3.5℃,the pressure range of 3 MPa–5.5 MPa,phase characteristics in the reaction kettle changed in a complex fashion during carbon dioxide hydrate formation.During hydrate decomposition,numerous carbon dioxide bubbles were produced,mainly by precipitation at high temperatures or in the hydrate cage structure.The hydrate crystal nucleus initially exhibited fluidity in the reaction.However,as the reaction progressed,the hydrate crystal nucleus migrated upward under the influence of gravity and carbon dioxide diffused into the aqueous phase.Next,the hydrate was formed and accumulated,finally forming a solid carbon dioxide hydrate layer. | Yujie Bai Youquan Huang Guangsheng Cao Xiaohan Nan Qingchao Cheng Lei Wang Tong Du | 2021 | Journal of Renewable Materials2021，9，4： | 0 |
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