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1篇 您的检索式:作者名="Edith Cheng"
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1LSD1 is required for euchromatic origin firing and replication timing显示文摘The chromatin-based rule governing the selection and activation of replication origins remains to be elucidated.It is believed that DNA replication initiates from open chromatin domains;thus,replication origins reside in open and active chromatin.However,we report here that lysine-specific demethylase 1(LSD1),which biochemically catalyzes H3K4me1/2 demethylation favoring chromatin condensation,interacts with the DNA replication machinery in human cells.We find that LSD1 level peaks in early S phase.Yue Wang Yunchao Huang Edith Cheng Xinhua Liu Yu Zhang Jianguo Yang Jordan T.F.Young Grant W.Brown Xiaohan Yang Yongfeng Shang 2022Signal Transduction and Targeted Therapy2022,7,5:0
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