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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Long-term fertilizer effects on organic carbon and total nitrogen and coupling relationships of C and N in paddy soils in subtropical China显示文摘 | Tong CL Xiao HA Tang GY Wang HQ Huang TP Xia HA Keith S J Li Y Liu SL Wu JS | 2009 | Soil and Tillage Research2009，106，1： | 1 |
| 3 | A bronchofiberoscopy-asso- ciated outbreak of multidrug-resistant Acinetobacter bau- mannii in an intensive care unit in Beijing,China显示文摘 | Xia YK Lu CL Zhao JY | 2012 | BMC Infectious Diseases2012，12，： | 1 |
| 4 | Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degen2 eration in Chinese Han population显示文摘 | Zhu GB Jiang XR Xia CL | 2011 | Biomarkers2011，16，6： | 1 |
| 5 | Preliminary report on hand searching results of 15 Chinese dental journals from the earliest first volume of 1953 to the volumes of 2000显示文摘 | Shi ZD Guo CL Chen E Zhang WL Xia F Chen L | 2003 | Chin J Evidence-based medicine2003，3，1： | 1 |
| 6 | Effect of low-frequency rT- MS on aphasia in stroke patients: a meta-analysis of random- ized controlled trials 显示文摘 | Ren CL Zhang GF Xia N | 2014 | PLoS One2014，9，10： | 1 |
| 7 | Factors associated with dental behaviour management problems in children aged 2-8 years in Beijing,China显示文摘 | Xia B Wang CL Ge LH | 2011 | Int J Paediatr Dent2011，21，3： | 1 |
| 8 | Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembranecleaving aspartyl protease显示文摘 | Wolfe MS Xia W Moore CL | 1999 | Biochemistry1999，38，15： | 1 |
| 9 | Factors associated with dental behaviour management problems in children aged 2-8 years in Beijing,China显示文摘 | Xia B Wang CL Ge LH | | 0，，03： | 1 |
| 10 | Factors associated with dental behavior management problems in children aged 2 - 8 year in Beijing, China 显示文摘 | Xia B Wang CL Ge LH | 2011 | Int J Paediatr Dent2011，21，3： | 1 |
| 11 | Differential expression of S100 proteins in the developing human hippocampus and temporal cortex显示文摘 | Chan WY Xia CL Dong DL | 2003 | Microsc Res Tech2003，60，6： | 1 |
| 12 | Musca domestica larva lectin induces apoptosis in BEL-7402 cells through a Ca2+/JNK- mediated mitochondrial pathway显示文摘 | Wang CL Xia Y Nie Z | 2012 | Cell Biochem Biophys2012，22，4： | 1 |
| 13 | Phosphorus fractions and alkaline phosphataseactivity in sediments of a large eutrophic Chinese lake(Lake Taihu) 显示文摘 | Zhou YY Song CL Cao XY Li JQ Chen GY Xia ZY Jiang PH | 2008 | Hydrobiologia2008，599，： | 1 |
| 14 | Factors associated with dental behaviour management problems in children aged 2 -8 years in Beijing, China 显示文摘 | Xia B Wang CL Ge LH | 2011 | Int J Paediatr Dent2011，21，3： | 1 |
| 15 | A2B5 lineages of human astrocylic tumors and their recurrence显示文摘 | Xia CL Du ZW Liu ZY | 2003 | Int J Oncol2003，23，： | 1 |
| 16 | Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults, a large-scale, randomised, double-blind placebo- controlled, phase 3 trial 显示文摘 | Zhu FC Zhang J Zhang XF Zhou C Wang ZZ Huang SJ Wang H Yang CL Jiang HM Cai JP Wang YJ Ai X Hu YM Tang Q Yao X Yan Q Xian YL Wu T Li YM Miao J Ng MH Shih JW Xia NS | 2010 | Lancet2010，376，： | 1 |
| 17 | A NEW PATHWAY OF GAS-TO-LIQUID CONVERSION USING CATALYTIC DIELECTRIC-BARRIER DISCHARGE显示文摘A new pathway of gas-to-liquid conversion, directly from methane and carbon dioxide, was established recently using a catalytic dielectric-barrier discharge (DBD) with zeolite. Direct fuel synthesis becomes possible at reaction conditions close to ambient ones. The products from such direct fuel synthesis include alkanes, alkenes, oxygenates and Syngas (CO + H2). The product distribution is similar to that from Fischer-Tropsch(F-T) synthesis but it does not follow the Flory-Schulz kinetics. The presence of zealots within discharge plasmas improves the selectivity of lighter hydrocarbons. | Liu Changjun, Li Yang, Zhang Yueping, Jiang Tao, Xia Qing and Xu Genhui Eliasson Baldur and Xue Bingzhang (State Key Lab. of Cl Chem. Tech. and Dept. of Chemistry Tianjin University Tianjin 300072, China) (Energy and Global Change, ABB Corporate | 2000 | 化工学报2000，51，S1： | 1 |
| 18 | Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice显示文摘 | Jin L Xiao CL Xia M | 2009 | Leukemia2009，583，12： | 1 |
| 19 | Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of a- dult rats with ventricular fibrillation after cardiopulmonary re- suscitation显示文摘 | Hu CL Xia JM Cai J | 2013 | Clinics ( Sao Paulo)2013，68，： | 1 |
| 20 | Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo 显示文摘 | Xia Q Sung J Chowdhury W Chen CL Hoti N Shabbeer S | 2006 | Cancer Res2006，66，14： | 1 |
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