|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Engineering exosomes as refined biologica nanoplatforms for drug delivery显示文摘 | Xin LUAN Kanokwan SANSANAPHONGPRICHA Ila MYERS Hongwei CHEN Hebao YUAN Duxin SUN | 2017 | Acta Pharmacologica Sinica2017，38，6： | 40 |
| 2 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 3 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Effect of Ginkgo biloba leaf extract on cerebral cortex amino acid levels in cerebral ischemia model rats显示文摘OBJECTIVE: To investigate the effect of Ginkgo biloba leaf extract on amino acid levels in the cerebral cortex of cerebral ischemia model rats induced by middle cerebral artery occlusion(MCAO).METHODS: A rat model of cerebral ischemia was established by MCAO. Male rats were divided into a negative control group(Control), a sham-operated group(Sham), an ischemic group(MCAO), and an ischemic group treated with Ginkgo biloba leaf extract(MCAO_D). All groups were divided into two subgroups with occlusion times of 12 and 24 h, respectively. The levels of 18 endogenous amino acids in the cerebral cortex were quantified by triple quadrupole-liquid chromatography-mass spectrometry.RESULTS: Compared with the MCAO group, behavioral performance, neurological deficit score, and cerebral infarct volume were significantly improved in the MCAO_D group(P < 0.05, P < 0.01). Compared with the sham group, the levels of 17 amino acids in the cerebral cortex were markedly changed in the MCAO group. The levels of Alanine(Ala), Isoleucine(Ile), Glutamic acid(Glu), Serine(Ser), Valine(Val), Phenylalanine(Phe), Proline(Pro),Threonine(Thr), Lysine(Lys), Tyrosine(Tyr), Hydroxyproline(Hyp), Arginine(Arg), Leucine(Leu),Tryptophan(Trp), and Glycine(Gly) were increased(P < 0.001, P < 0.05), while levels of Gln and Tau were decreased(P < 0.001, P < 0.05). Compared with the MCAO group, Ginkgo biloba extract treatment in the MCAO_D group significantly down-regulated the levels of 11 amino acids, especially those of Arg, Thr, and Ser in 12 or 24 h.CONCLUSION: Injection of Ginkgo biloba leaf extract has a therapeutic effect on model rats with MCAO-induced cerebral ischemia by acting on amino acids in the cerebral cortex. This effect might be associated with the regulation of amino acid metabolism in the cerebral cortex. | Cui Yiran Wu Hongwei Liu Mengting Qin Haijiao Liu Xin Yang Hongjun | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 8 |
| 6 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 7 | A Kinetic Spectrophotometric Method for the Determination of Iron (Ⅲ) in Water Samples显示文摘A new kinetic spectrophotometric method has been developed for the determination of iron (III). The method is based on the catalytic effect of iron (III) on the oxidation of weak acid brilliant blue dye (RAWL) by KIO4 in acid medium. The advantages of the proposed method are that it is sensitive, accurate, rapid, inexpensive, can be operated under room temperature and has a large determination concentration range compared to other techniques. The obtained optimum conditions are: pH 3.15, RAWL (200 mgL-1) 5.00 mL, Potassium periodate solution (0.01 molL-1) 0.30 mL, phenanthroline (0.02 molL-1) 1.00 mL, reaction temperature 25℃ and reaction time 7 min. With this method iron could quantitively be determined in the range 0.00?0.02 mgL-1, the detection limit being 4.10×10-10 g mL-1. The relative standard deviations (RSD) in five replicate determinations for 3 μgL-1and 5 μgL-1 iron (III) are 3.1% and 1.9%, respectively. The method has been applied to the determination of iron (III) in tap water samples and seawater samples (from the South China Sea), the recovery rates being 98.0% and 100.5%, respectively. | JI Hongwei XU Jian XIN Huizhen YANG Xiaoman | 2008 | Journal of Ocean University of China2008，7，2： | 7 |
| 8 | Corrosion behavior of Mg-Y alloy in NaCl aqueous solution | Xin Zhang a,b,c,Kui Zhang a,Xia Deng a,Hongwei Li b,c,Yongjun Li a,Minglong Ma a,Ning Li b,c,Yanlong Wang b,c a State Key Laboratory for Fabrication and Processing of Nonferrous Metals,Beijing General Research Institute for Nonferrous Metals,Beijing 100088,China b Beijing Engineering Research Center for Advanced Manufacturing and Evaluation of Special Vehicle Parts,Beijing 100072,China c Center of Technology,Beijing North Vehicle Group Corporation,Beijing 100072,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 9 | Integrated metabolo-transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum显示文摘Fusarium head blight(FHB) caused by Fusarium graminearum Schwabe(teleomorph Gibberella zeae(Schw.) Perch) results in large yield losses in annual global wheat production. Although studies have identified a number of wheat FHB resistance genes,a deeper understanding of the mechanisms underlying host plant resistance to F. graminearum is required for the control of FHB. Here, an integrated metabolomics and transcriptomics analysis of infected wheat plants(Triticum aestivum L.) enabled identification of 789 differentially accumulated metabolites, including flavonoids, phenolamides, tryptamine derivatives, and phytohormones, and revealed altered expression of more than 100 genes that function in the biosynthesis or regulation of these pathways. Our data regarding the effects of F. graminearum infection on flavonoids and auxin signaling led to follow-up experiments that showed that exogenous kaempferide and apigenin application on spikes increased wheat resistance to FHB,while exogenous auxin treatment increased FHB susceptibility. RNAi-mediated knockdown of the gene encoding the auxin receptor, Ta TIR1, increased FHB resistance. Our data supported the use of Ta TIR1 knockdown in controlling FHB. Our study provides insights on the wheat response to F.graminearum infection and its FHB resistance mechanisms while illustrating the potential of Ta TIR1 knockdown in increasing FHB resistance during crop improvement programs. | Peisen Su Lanfei Zhao Wen Li Jinxiao Zhao Jun Yan Xin Ma Anfei Li Hongwei Wang Lingrang Kong | 2021 | Journal of Integrative Plant Biology2021，63，2： | 6 |
| 10 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 11 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 12 | Synthetic apomixis with normal hybrid rice seed production显示文摘Heterosis has long been exploited in the hybrid seed industry,which contributes to high and stable yields of modern agriculture(Huang et al.,2016).However,heterosis phenotypes of hybrid plants are segregated in its offspring.Apomixis allows instant fixation and propagation though seeds with heterozygous genotypes,showing great potential in plant breeding and agricultural practice(Ye and Cui,2019).Apomixis naturally occurs in hundreds of plant species,but it is absent in major crop species(Underwood and Mercier,2022).Recently,synthetic apomixis has been engineered in rice by combining Mitosis instead of Meiosis(MiMe)with a mutation of MATRILINEAL or ectopic expression of BABY BOOM1(BBM1),enabling clonal reproduction of F1 hybrids through seeds and stable transmission of heterotic phenotypes over generations(Khanday et al.,2019;Wang et al.,2019;Liu et al.,2022).However,the fertility of both two strategies was significantly reduced compared with that of the wild type,which hinders the application of both strategies in agriculture.In this study,we established synthetic apomixis with a high fertility that is almost comparable to normal hybrid rice. | Xin Wei Chaolei Liu Xi Chen Hongwei Lu Jian Wang Shenlin Yang Kejian Wang | 2023 | Molecular Plant2023，16，3： | 5 |
| 13 | Significance and expression of Bax, Survivin and p53 in gastric carcinoma and precancerous lesions using tissue microarray显示文摘Objective: To explore the relationship between expressions of apoptosis-related protein Bax, Survivin and p53 and the molecular mechanisms of carcinogenesis and progression of gastric carcinoma. Methods: Tissue microarray and immunohistochemistry were used in this study. Results: The positive rate of Bax protein in gastric cancer (17.7%,17/96) was significantly lower than those in adjacent normal mucosa (51%), intestinal metaplasia (69.2%) and dysplasia (75%), P < 0.01. The positive rate of Survivin expression in gastric cancer (80.6%, 89/98) was significantly higher than that in adjacent normal mucosa (3.9%), P < 0.01. The positive rates of Survivin expression in tumors with different organ metastases (in lymph node metastasis 86.2%, liver 100% and ovarian 100%) were statistically higher than in tumors without metastasis (64.3%), P < 0.05. Bax expression was correlated with Survivin but not with mp53 that was closely related to Survivin expression (P < 0.05) in gastric cancer. Conclusion: The abnormal expressions of Bax, Survivin and mp53 were correlated with the tumorigenesis and progression of gastric carcinoma. P53 and Survivin genes may share the similar mechanism in regulating cell apoptosis, and because of the mutation, p53 gene may lower its down-regulation to Survivin expression. | Yuping Xiao Zhi Lin Lili Mao Dongying Wu Yujia Gao Hongwei Sun Yan Xin | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 5 |
| 14 | Role of the inter-pass cooling rate in recrystallization behaviors of Ni-based superalloy during interrupted hot compression显示文摘The microstructural evolution of a Ni-based superalloy under interrupted hot compressive deformation with different cooling rates in the inter-pass stage is investigated. It is found that metadynamic recrystallization(MDRX) in the inter-pass stage is more sensitive to the accumulated strain than the deformation temperature which is above the recrystallization temperature. The variations of both the grain distribution and the texture intensity caused by MDRX during the interpass stage result in variations of the yield stress(YS) and the work hardening(WH) rate in each stage. Results also show that the MDRX process in the inter-pass stage has a considerable influence on the final microstructure of three-pass compression. The final grain distribution is more uniform,and the compression texture gradually transforms into recrystallization texture with an increasing degree of MDRX. In order to predict the MDRX fraction in the inter-pass cooling stage, a modified kinetic equation is established, which can reasonably predict the MDRX behavior under multi-pass compression with different conditions in the inter-pass stage. Meanwhile, the influence of the interpass cooling stage on the mechanism of dynamic recrystallization(DRX) is studied. It is universally acknowledged that the discontinuous dynamic recrystallization(DDRX) process is the major deformation mechanism for the Ni-based superalloy. However, the continuous dynamic recrystallization(CDRX) process is promoted in the compression stage with a decrease of the cooling rate in each inter-pass stage. | Xin ZHANG Hongwei LI Mei ZHAN Siliang YAN Ning ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 5 |
| 15 | Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to hypoxia.Bruceine D(BD)is an isolated natural quassinoid with multiple anti-cancer effects.Here,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell metabolism.Using biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of BD.By targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α expression.Furthermore,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in vitro.Our data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism. | Rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao Lv Dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 16 | Simultaneous Determination of Iron and Manganese in Water Using Artificial Neural Network Catalytic Spectrophotometric Method显示文摘A new analytical method using Back-Propagation (BP) artificial neural network and kinetic spectrophotometry for simultaneous determination of iron and magnesium in tap water, the Yellow River water and seawater is established. By conditional experiments, the optimum analytical conditions and parameters are obtained. Levenberg-Marquart (L-M) algorithm is used for calculation in BP neural network. The topological structure of three-layer BP ANN network architecture is chosen as 15-16-2 (nodes). The initial value of gradient coefficient μ is fixed at 0.001 and the increase factor and reduction factor of μ take the default values of the system. The data are processed by computers with our own programs written in MATLAB 7.0. The relative standard deviation of the calculated results for iron and manganese is 2.30% and 2.67% respectively. The results of standard addition method show that for the tap water, the recoveries of iron and manganese are in the ranges of 98.0%-104.3% and 96.5%-104.5%, and the RSD is in the range of 0.23%-0.98%; for the Yellow River water (Lijin district of Shandong Province), the recoveries of iron and manganese are in the ranges of 96.0%-101.0% and 98.7%-104.2%, and the RSD is in the range of 0.13%-2.52%; for the seawater in Qingdao offshore, the recoveries of iron and manganese are in the ranges of 95.3%-104.8% and 95.3%-104.7%, and the RSD is in the range of 0.14%-2.66%. It is found that 21 common cations and anions do not interfere with the determination of iron and manganese under the optimum experimental conditions. This method exhibits good reproducibility and high accuracy in the determination of iron and manganese and can be used for the simultaneous determination of iron and manganese in tap water and natural water. By using the established ANN- catalytic spectrophotometric method, the iron and manganese concentrations of the surface seawater at 11 sites in Qingdao offshore are determined and the level distribution maps of iron and manganese are drawn. | JI Hongwei XU Yan LI Shuang XIN Huizhen CAO Hengxia | 2012 | Journal of Ocean University of China2012，11，3： | 4 |
| 17 | Nest-like multilevel structured graphene oxide-on-polyacrylonitrile membranes for highly efficient filtration of ultrafine particles显示文摘Developing filtration media for particulate matter(PM)removal has been proven to be extremely challenging.Here,we report a facile and scalable strategy to fabricate a multi-level structured polyacrylonitrile/graphene oxide(PAN/GO)air filtration membrane to remove ultrafine particles in air by combining multi-jet electrospinning and physical bonding.Our approach allows the thin PAN nanofibers and two-dimensional GO nanosheets to form interpenetrating bonding structures on non-woven fabric and to assemble into stable filtration media.The resultant composite membranes can filtrate 300 nm particles with a high removal efficiency of 98.8%,a low pressure drop of 55 Pa,and a desirable quality factor of 0.34 Pa^(-1).This multi-level PAN/GO filter is expected to have wider applications not only for the ultrafine particle filtration and separation but also for the design of three-dimensional functional structures in the future. | Jing Li Danzhen Zhang Xin Jiang Xuanliang Zhao Ruirui Hu Yujia Zhong Hongwei Zhu | 2019 | Journal of Materiomics2019，5，3： | 4 |
| 18 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 19 | A New Spectrophotometric Method for Measuring COD of Seawater显示文摘这研究为测量海水的化学需氧量(货到付款) 学习了一个新 Spectrophotometric 方法。在这个方法, COD 用一个分光光度计被测量而不是与钠 thiosulphate 滴定。测量波长被选择是三个标准葡萄糖答案的 470 nm,和 COD (货到付款 = 0.5, 1.5 和 2.5 mgL^(-1), 分别地) 并且二件海水样品(从南方黄海和 Jiaozhou 海湾) 我们分别地使用 Spectrophotometric 方法和 titrimetric 方法的 remeasured。结果证明 Spectrophotometric 方法比 titrimetric 方法有点好。Spectrophotometric 方法的相对标准差(RSD ) 是不到 2.7% ,并且海水样品的恢复从 96.3% ~ 103.8%。另外, Spectrophotometric 方法有象快速那样的另外的优点,操作简洁,分析 automatization,等等。Thereforethe Spectrophotometric 方法能被用来与令人满意的结果测量海水的 COD。 | LIU Ying JI Hongwei XIN Huizhen LIU Li | 2006 | Journal of Ocean University of China2006，5，2： | 3 |
| 20 | Distribution of Dissolved Inorganic Carbon (DIC) and Its Related Parameters in Seawater of the North Yellow Sea and off the Qingdao Coast in October, 2007显示文摘Data on the distribution of dissolved inorganic carbon (DIC) were obtained from two cruises in the North Yellow Sea (NYS) and off the Qingdao Coast (QC) in October, 2007. Carbonate parameters were calculated. The concentrations of DIC are from 1.896-2.229 mmolL-1 in the NYS and from 1.939-2.032 mmolL-1 off the QC. In the southwest of the NYS, DIC in the upper layers decreases from the north of the SP (Shandong Peninsula) shelf to the center of the NYS; whereas in the lower layers DIC increases from the north of the SP shelf to the center of the NYS and South Yellow Sea. In the northeast of the NYS, DIC in all layers in- creases from the YR (Yalu River) estuary to the centre of the NYS. The distribution of DIC in NYS can be used as an indicator of Yellow Sea Cold Water Mass (YSCWM). Air-sea CO2 fluxes were calculated using three models and the results suggest that both the NYS and the QC waters are potential sources of atmospheric CO2 in October. | JI Hongwei SHENG Guiyun XIN Huizhen SHA Yuanyuan | 2009 | Journal of Ocean University of China2009，8，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员