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389篇 您的检索式：作者名="Wertz"

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	题名	作者	年代	出处	被引量
1	Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy显示文摘Protein kinases and phosphatases signal by phosphorylation and dephosphorylation to precisely control the activities of their individual and common substrates for a coordinated cellular outcome. In many situations, a kinase/phosphatase complex signals dynamically in time and space through their reciprocal regulations and their cooperative actions on a substrate. This complex may be essential for malignant transformation and progression and can therefore be considered as a target for therapeutic intervention. p38γ is a unique MAPK family member that contains a PDZ motif at its C-terminus and interacts with a PDZ domain-containing protein tyrosine phosphatase PTPH1. This PDZcoupled binding is required for both PTPH1 dephosphorylation and inactivation of p38γ and for p38γ phosphorylation and activation of PTPH1. Moreover, the p38γ/PTPH1 complex can further regulate their substrates phosphorylation and dephosphorylation, which impacts Ras transformation, malignant growth and progression, and therapeutic response. This review will use the p38γ/PTPH1 signaling network as an example to discuss the potential of targeting the kinase/phosphatase signaling complex for development of novel targeted cancer therapy.	Xiao-Mei Qi Fang Wang Matthew Mortensen Ryan Wertz Guan Chen	2018	Acta Pharmaceutica Sinica B2018，8，4：	2
2	Adjuvant IMRT/XELOX radiochemotherapy improves long-term overall- and disease-free survival in advanced gastric cancer显示文摘	J. Boda-Heggemann C. Weiss V. Schneider R.-D. Hofheinz S. Haneder H. Michaely H. Wertz U. Ronellenfitsch A. Hochhaus F. Wenz F. Lohr	2013	Strahlentherapie und Onkologie2013，，5：	2
3	Preparation of liposomes from stratum corneum lipids 显示文摘	Wertz PW Abraham W Landmann L	1986	J Invest Dermatol1986，87，5：	1
4	Regulation of death receptor signaling by the ubiquitin system显示文摘	Wertz IE Dixit VM	2010	Cell Death Differ2010，17，1：	1
5	New strategies for cultivation and detection of previously uncultured microbes显示文摘	Stevenson B S Eichorst S A Wertz J T	2004	Appl Environ Microbiol2004，70，：	1
6	The prouct of the respiratory syncytial virus M2 gene ORF1 enhance readingthrough of intergenic junctions during viral transcription 显示文摘	Dardy RW Wertz GW	1998	J Virol1998，72，：	1
7	The ubiquitin ligase COP1 is a critical negative regulator of p53 显示文摘	Dornan D Wertz I Shimizu H	2004	Nature2004，429，6987：	1
8	Alternative Algorithms for Generalized Predictive Control显示文摘	Zhu K Gorez R Wertz V	1990	Systems and Control Letters1990，15，2：	1
9	Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus 显示文摘	Wertz G W Perepelitsa V P Ball L A	1998	Proc Natl Acad Sci1998，95，：	1
10	Skeletal and dental changes accompanying rapid midpalatal suture opening显示文摘		1970	Am J Orthod1970，58，：	1
11	sCD44 phosphorylation in normal and primary open-angle glaucoma aqueous humor显示文摘	Nolan MJ Choi J wertz RD Knepper PA	2004	Invest ophthalmoi Vis Sci2004，45，：	1
12	Endovaseular abdominal aortic aneurysm repair:a community hospital's experience 显示文摘	Madden N Baril DT Wertz R	2009	Vase En- dovaseular Surg2009，43，1：	1
13	The ubiquitin ligase COP1 is a critical negative regulator of p53显示文摘	DORNAN D WERTZ I SHIMIZU H	2004	Nature2004，429，6987：	1
14	Signaling to NF-κ B:regulation by ubiquitination显示文摘	Wertz IE Dixit VM		0，，03：	1
15	Comparison of the expressed porcine VI3 and J repertoire of thymocytes and peripheral T cells 显示文摘	Butler JE Wertz N Sun J	2005	Immunology2005，114，2：	1
16	Characterization and quan- tification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls 显示文摘	Reiter LV Torres SM Wertz PW	2009	Vet Derma- tol2009，20，4：	1
17	Economic Factors Influencing Household Production of Refuse显示文摘	Kenneth Wertz	1976	The Journal of Environmental Economics and Management1976，，2：	1
18	The physical, chemical and tunc- tional properties of lipids in the skin and other biological barri- ers显示文摘	Wertz PW van den Bergh B	1998	Chem Phys Lipids1998，91，2：	1
19	Oxidative degradation of parylene C ( poly (monochloro-para-xylylene)) thin films on bulkmicromachined piezoresistive silicon pressure sensors显示文摘	Monk D J Toh H S Wertz J	1997	Sensors and Materials1997，9，5：	1
20	Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO显示文摘	Zhou H Wertz I O'Rourke K	2004	Nature2004，427，6970：	1

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