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| 1 | 下肢浅静脉治疗术后的加压疗法:美国静脉论坛血管、外科学会、美国静脉学会、血管医学学会和国际静脉联盟的临床实践指南显示文摘一、指南的由来下肢浅静脉治疗术后应用压力治疗的方式是几代血管外科医师多年临床经验积累所得,现主要应用于大隐静脉剥脱术、下肢静脉点状剥脱术及静脉硬化治疗等。目前单就静脉硬化治疗而言,术后压力治疗的推荐也是基于相关文献及实验验证[1],但对于其他术式,尤其是对于大隐静脉的热消融术,目前还没有形成规范统一的建议,这也使得当前的压力治疗具有很大的临床差异性。 | Lurie F Lal BK Antignani PL Blebea J Bush R Caprini J Davies A Forrestal M Jacobowitz G Kalodiki E Killewich L Lohr J Ma H Mosti G Partsch H Rooke T Wakefield T 李丹(译) 陈程浩(译) 牛传强(译) 张靖(译) 黄建忠(译) | 2020 | 中华介入放射学电子杂志2020，8，4： | 16 |
| 2 | Early detection and prevention of pancreatic cancer:Is it really possible today?显示文摘Pancreatic cancer is the 4th leading cause of cancerrelated death in Western countries.Considering the low incidence of pancreatic cancer,population-based screening is not feasible.However,the existence of a group of individuals with an increased risk to develop pancreatic cancer has been well established.In particular,individuals suffering from a somatic or genetic condition associated with an increased relative risk of more than 5-to 10-fold seem to be suitable for enrollment in a surveillance program for prevention or early detection of pancreatic cancer.The aim of such a program is to reduce pancreatic cancer mortality through early or preemptive surgery.Considering the risk associated with pancreatic surgery,the concept of preemptive surgery cannot consist of a prophylactic removal of the pancreas in high-risk healthy individuals,but must instead aim at treating precancerous lesions such as intraductal papillary mucinous neoplasms or pancreatic intraepithelial neoplasms,or early cancer.Currently,results from clinical trials do not convincingly demonstrate the efficacy of this approach in terms of identification of precancerous lesions,nor do they define the outcome of the surgical treatment of these lesions.For this reason,surveillance programs for individuals at risk of pancreatic cancer are thus far generally limited to the setting of a clinical trial.However,the acquisition of a deeper understanding of this complex area,together with the increasing request for screening and treatment by individuals at risk,will usher pancreatologists into a new era of preemptive pancreatic surgery.Along with the growing demand to treat individuals with precancerous lesions,the need for low-risk investigation,lowmorbidity operation and a minimally invasive approach becomes increasingly pressing.All of these considerations are reasons for preemptive pancreatic surgery programs to be undertaken in specialized centers only. | Marco Del Chiaro Ralf Segersvrd Matthias Lohr Caroline Verbeke | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | Helicobacter pylori and pancreatic diseases显示文摘A possible role for Helicobacter pylori(H. pylori) infec-tion in pancreatic diseases remains controversial. H. pylori infection with antral predomination leading to an increase in pancreatic bicarbonate output and induc-ing ductal epithelial cell proliferation could contribute to the development of pancreatic cancer via complex interactions with the ABO genotype, dietary and smok-ing habits and N-nitrosamine exposure of the host. Although the individual study data available so far is inconsistent, several meta-analyses have reported an increased risk for pancreatic cancer among H. pylori seropositive individuals. It has been suggested that H. pylori causes autoimmune pancreatitis due to molecu-lar mimicry between H. pylori a-carbonic anhydrase(a-CA) and human CA type Ⅱ, and between H. pylori plasminogen-binding protein and human ubiquitin-protein ligase E3 component n-recognin 2, enzymes that are highly expressed in the pancreatic ductal andacinar cells, respectively. Future studies involving large numbers of cases are needed in order to examine the role of H. pylori in autoimmune pancreatitis more fully. Considering the worldwide pancreatic cancer burden, as well as the association between autoimmune pan-creatitis and other autoimmune conditions, a complete elucidation of the role played by H. pylori in the gen-esis of such conditions could have a substantial impact on healthcare. | Milutin Bulajic Nikola Panic Johannes Matthias Lohr | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 3 |
| 4 | Screening for gestational diabetes: a summary of the evidence for the U.S. Preventive Services Task Force显示文摘 | Seth C Brody Russell Harris Kathleen Lohr | 2003 | Obstetrics & Gynecology2003，，2： | 3 |
| 5 | 星形胶质细胞和嗅鞘细胞之间的Panglial缝隙连接介导Ca^(2+)瞬变的传递和神经血管耦合显示文摘星形胶质细胞排列在有高度组织性的缝隙连接耦合网络中,通过Ca^(2+)波的传播进行通信。星形胶质细胞不仅与邻近的星形胶质细胞结合,而且还与少突胶质细胞偶联,形成panglial合胞体。但panglial合胞体中的神经胶质细胞是否通过Ca^(2+)信号传递信息尚不清楚。我们使用共聚焦Ca^(2+)成像来研究小鼠嗅球中星形胶质细胞和嗅鞘神经胶质细胞(OECs)之间的细胞间通讯。研究结果表明,通过'笼状' ATP和'笼状' tACPD的局部光解可引起的肾小球旁星形胶质细胞中的Ca^(2+)瞬变,导致OEC中随之而来的Ca^(2+)反应。这种从星形胶质细胞到OEC的Ca^(2+)反应的传递在神经元抑制的情况下持续存在,但是当用甘珀酸抑制缝隙连接偶联时消失。当通过DHPG的抽吸在OEC中直接诱发Ca^(2+)瞬变时,它们导致肾小球星形胶质细胞中的Ca^(2+)反应延迟,表明Ca^(2+)信号的panglial传递以双向方式发生。此外,从星形胶质细胞到OEC的Ca^(2+)信号的panglial传递导致嗅觉神经层中OEC相关血管的收缩。本研究结果证明了在缝隙连接耦合的panglial网络中,不同类别的神经胶质细胞之间通过Ca^(2+)进行信号传递,并借此调节嗅球中血管的直径。 | Beiersdorfer A Scheller A Kirchhoff F Lohr C 聂昊 | 2019 | 神经损伤与功能重建2019，14，3： | 2 |
| 6 | Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals显示文摘Pancreatic ductal adenocarcinoma(PDAC) is a lethal neoplasia, for which secondary prevention(i.e., screening) is advisable for high-risk individuals with 'familiar pancreatic cancer' and with other specific genetic syndromes(Peutz-Jeghers, p16, BRCA2, PALB and mismatch repair gene mutation carriers). There is limited evidence regarding the accuracy of screening tests, their acceptability, costs and availability, and agreement on whom to treat. Successful target of screening are small resectable PDAC, intraductal papillary mucinous neoplasms with high-grade dysplasia and advanced pancreatic intraepithelial neoplasia. Both magnetic resonance imaging(MRI) and endoscopic ultrasound(EUS) are employed for screening, and the overall yield for pre-malignant or malignant pancreatic lesions is of about 20% with EUS and 14% with MRI/magnetic resonance colangiopancreatography. EUS performs better for solid and MRI for cystic lesions. However, only 2% of these detected lesions can be considered a successful target, and there are insufficient data demonstrating that resection of benign or low grade lesions improves survival. Many patients in the published studies therefore seemed to have received an overtreatment by undergoing surgery. It is crucial to better stratify the risk of malignancy individually, and to better define optimal screening intervals and methods either with computerized tools or molecular biomarkers, possibly in large multicentre studies. At the moment, screening should be carefully performed within research protocols at experienced centres, offering involved individuals medical and psychological advice. | Gabriele Capurso Marianna Signoretti Roberto Valente Urban Arnelo Matthias Lohr Jan-Werner Poley Gianfranco Delle Fave Marco Del Chiaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 7 | Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy显示文摘 | Jens G. Lohr Petar Stojanov Scott L. Carter Peter Cruz-Gordillo Michael S. Lawrence Daniel Auclair Carrie Sougnez Birgit Knoechel Joshua Gould Gordon Saksena Kristian Cibulskis Aaron McKenna Michael A. Chapman Ravid Straussman Joan Levy Louise M. Perkins | 2013 | Cancer Cell2013，，： | 2 |
| 8 | lnterventional endoscopic therapy of chronic pancreatitis 显示文摘 | Lohr M Schneider HT Farnbacher M | 1997 | J Gastroenterol1997，35，： | 2 |
| 9 | Adjuvant IMRT/XELOX radiochemotherapy improves long-term overall- and disease-free survival in advanced gastric cancer显示文摘 | J. Boda-Heggemann C. Weiss V. Schneider R.-D. Hofheinz S. Haneder H. Michaely H. Wertz U. Ronellenfitsch A. Hochhaus F. Wenz F. Lohr | 2013 | Strahlentherapie und Onkologie2013，，5： | 2 |
| 10 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019，25，44： | 2 |
| 11 | Extracranial stereotactic radiation therapy:set-up accuracy of patients treated for liver metastases显示文摘 | Herfarth K K Debus J Lohr F | 2000 | Int J Radiat Oncol Biol Phys2000，46，2： | 1 |
| 12 | Adjuvant treatment of brain metastases显示文摘 | Lohr F Pirzkall A Hof H | 2001 | Semin Surg Oncol2001，20，1： | 1 |
| 13 | Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B -restoration by exogenous interleution - 12 显示文摘 | Lohr HF Pingel S Bocher WO | 2002 | Clin Exp Immunol2002，130，： | 1 |
| 14 | Hippocampal pyramidal cells and aging in the human: a quantitative study of neu- ronal loss in sectors CAI to CA4显示文摘 | Mani RB Lohr JB Jeste DV | 1986 | Exp Neurol1986，94，1： | 1 |
| 15 | Perinatal depression: a systematic review of prevalence and incidence 显示文摘 | Gavin NI Gaynes BN Lohr KN | 2005 | Obstet Gynecol2005，106，5： | 1 |
| 16 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 17 | Oral mifepristone and buccalmisoprostol administered simultaneously for abortion:a pilot study显示文摘 | Lohr PA Reeves MF Hayes JL | 2007 | Contraception2007，76，3： | 1 |
| 18 | Inactivation of enveloped viruses by anthraquinones extracted from plants显示文摘 | Sydiskis RJ Owen DG Lohr JL | 1991 | Antiviral Agents Chemother1991，35，12： | 1 |
| 19 | Shoulder joint instability after primary arthroplasty显示文摘 | Lohr JF Floren M Schwyzer HK | 1998 | Orthopade1998，27，8： | 1 |
| 20 | Whipple disease confined to the central nervous system presenting as a solitary frontal tumor 显示文摘 | Lohr M Stenzel W Plum G | 2004 | J Neurosurg2004，101，： | 1 |
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