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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Preparation of liposomes from stratum corneum lipids 显示文摘 | Wertz PW Abraham W Landmann L | 1986 | J Invest Dermatol1986，87，5： | 1 |
| 4 | Diversity of biphenyl degraders in a chlorobenzene polluted aquifeI显示文摘 | Abraham W Wenderoth D F Glaβer W | 2005 | Chemosphere2005，58，： | 1 |
| 5 | market structure and the holdup problem: investment incentives and coordination f 7 显示文摘 | ABRAHAM W INNOVATION L | 2004 | International Journal of Industrial Organization2004，22，71： | 1 |
| 6 | Processes in the Formation of Uhracold NaCs显示文摘 | ABRAHAM E R I RITCHIE N W M MCALEXANDER W I HULET R G | 1995 | J Chem Phys1995，103，： | 1 |
| 7 | ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines(Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure):developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation:endorsed by the Heart Rhythm Society显示文摘 | Hunt S A Abraham W T Chin M H | 2005 | Circulation2005，112，12： | 1 |
| 8 | Characteristics,treatments and outcomes of patients with preserved systolic function hospitalized for heart failure显示文摘 | Fonarow GC Gattis Stough W Abraham WT | | 0，，06： | 1 |
| 9 | Asphalt flow improvers as intelligent fillers' for hot asphalts-a new chapter in asphalt technology显示文摘 | DAMM K W ABRAHAM J BUTZ T | 2002 | Journal of Applied Asphalt Binder Technology2002，，4： | 1 |
| 10 | The safety and tolerability of darbepoetin alfa in patients with anaemia and symptomatic heart failure 显示文摘 | KLAPHOLZ M ABRAHAM W T GHALI J K | 2009 | Eur J Heart Fail2009，11，11： | 1 |
| 11 | Relocation and preferential elution of acidic solute through the snowpack of a small,remote,high -altitude Scottish catchment显示文摘 | Brimblecombe P Tranter M Abrahams P W | 1985 | Annals Glaciology1985，7，： | 1 |
| 12 | Isolation and culture of primaryequine tracheal epithelial cells显示文摘 | Shibeshi W Abraham G Kneuer C et at | 2008 | In Vitro Cell Dev Biol Anim2008，44，： | 1 |
| 13 | Cardiac re- synchronization therapy in asymptomatic or mildly symp- tomatic heart failure patients in relation to etiology: re- sults from the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction ) study显示文摘 | Linde C Abraham W T Gold M R | 2010 | J Am Coll Cardiol2010，56，22： | 1 |
| 14 | Symposium: Update on pre- diction and management of OHSS, A modern clas- sification of OHSS显示文摘 | Abraham G Ariel W | 2009 | Reprod Biomed Online2009，19，1： | 1 |
| 15 | Bioaetive sesquiterpenes produced by fungi: Are they useful for humans as well?显示文摘 | ABRAHAM W R | 2001 | Current Medicinal Chemistry2001，8，6： | 1 |
| 16 | Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials显示文摘 | METRA M EICHHORN E ABRAHAM W T | 2009 | Eur Heart J2009，30，24： | 1 |
| 17 | Sodium nitro Prusside for advaneed low-out Putheart failure显示文摘 | Mullens W Abrahams Z Franeis GS | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 18 | Microsystern technology: between research and industrial application显示文摘 | EHRFELD W HESSEL V | 1998 | Microelectronic Engineering1998，4142，： | 1 |
| 19 | Simultaneous radio immunoassay of plasma FSH, LH Progesterone, 17α-hydroxyprogesterone and oestradiol-17β during the menstrual cycle显示文摘 | ABRAHAM G E ODELL W D SWERDLOFF R S | 1972 | J Clin Endocrinol Metab1972，34，： | 1 |
| 20 | Soils : their implications to human health 显示文摘 | ABRAHAMS P W | 2002 | Sci Total Environ2002，291，13： | 1 |
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