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| 1 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 2 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 3 | Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain显示文摘The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single facial injection of BoNT/A induced a rapid and prolonged improvement of depression-like behaviors in naive and space-restriction-stressed(SRS)mice,reflected by a decreased duration of immobility in behavioral despair tests.BoNT/A significantly increased the 5-hydroxytryptamine(5-HT)levels in several brain regions,including the hippocampus and hypothalamus,in SRS mice.BoNT/A increased the expression of the N-methyl-Daspartate receptor subunits NR1 and NR2 B in the hippocampus,which were significantly decreased in SRS mice.Furthermore,BoNT/A significantly increased the expression of brain-derived neurotrophic factor(BDNF)in the hippocampus,hypothalamus,prefrontal cortex,and amygdala,which were decreased in SRS mice.Finally,BoNT/A transiently increased the levels of phosphorylated extracellular signal-regulated kinase(p-ERK)and cAMPresponse element binding protein(p-CREB),which were suppressed in the hippocampus of SRS mice.Collectively,these results demonstrated that BoNT/A treatment has antidepressant-like activity in mice,and this is associated with increased 5-HT levels and the activation of BDNF/ERK/CREB pathways in the hippocampus,supporting further investigation of BoNT/A therapy in depression. | Yang Li Jing Liu Xu Liu Cun-Jin Su Qi-Lin Zhang Zhi-Hong Wang Lei-Fang Cao Xue-Yan Guo Ya Huang Weifeng Luo Tong Liu | 2019 | Neuroscience Bulletin2019，35，4： | 10 |
| 4 | Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization显示文摘Background:Autologous platelet-rich plasma(PRP)has been suggested to be effective for wound healing.However,evidence for its use in patients with acute and chronic wounds remains insufficient.The aims of this study were to comprehensively examine the effectiveness,synergy and possible mechanism of PRP-mediated improvement of acute skin wound repair.Methods:Full-thickness wounds were made on the back of C57/BL6 mice.PRP or saline solution as a control was administered to the wound area.Wound healing rate,local inflammation,angiogenesis,re-epithelialization and collagen deposition were measured at days 3,5,7 and 14 after skin injury.The biological character of epidermal stem cells(ESCs),which reflect the potential for re-epithelialization,was further evaluated in vitro and in vivo.Results:PRP strongly improved skin wound healing,which was associated with regulation of local inflammation,enhancement of angiogenesis and re-epithelialization.PRP treatment significantly reduced the production of inflammatory cytokines interleukin-17A and interleukin-1β.An increase in the local vessel intensity and enhancement of re-epithelialization were also observed in animals with PRP administration and were associated with enhanced secretion of growth factors such as vascular endothelial growth factor and insulin-like growth factor-1.Moreover,PRP treatment ameliorated the survival and activated the migration and proliferation of primary cultured ESCs,and these effects were accompanied by the differentiation of ESCs into adult cells following the changes of CD49f and keratin 10 and keratin 14.Conclusion:PRP improved skin wound healing by modulating inflammation and increasing angiogenesis and re-epithelialization.However,the underlying regulatory mechanism needs to be investigated in the future.Our data provide a preliminary theoretical foundation for the clinical administration of PRP in wound healing and skin regeneration. | Pengcheng Xu Yaguang Wu Lina Zhou Zengjun Yang Xiaorong Zhang Xiaohong Hu Jiacai Yang Mingying Wang Binjie Wang Gaoxing Luo Weifeng He Biao Cheng | 2020 | Burns & Trauma2020，8，1： | 8 |
| 5 | Comparative study on local and global mechanical properties of bobbin tool and conventional friction stir welded 7085-T7452 aluminum thick plate显示文摘7085-T7452 plates with a thickness of 12 mm were welded by conventional single side and bobbin tool friction stir welding(SS-FSW and BB-FSW, respectively) at different welding parameters. The temperature distribution, microstructure evolution and mechanical properties of joints along the thickness direction were investigated, and digital image correlation(DIC) was utilized to evaluate quantitatively the deformation of different zones during tensile tests. The results indicated that heat-affected zone(HAZ), the local softening region, was responsible for the early plastic deformation and also the fracture location for SS-FSW samples, while a rapid fracture was observed in weld nugget zone(WNZ) before yield behavior for all BB-FSW specimens. The ultimate tensile strength(UTS) of SS-FSW joints presented the highest value of 410 MPa, 82% of the base material, at a rotational speed of 300 rpm and welding speed of 60 mm/min,much higher than that of BB-FSW joints, with a joint efficiency of only 47%. This should be attributed to the Lazy S defect produced by a larger extent of heat input during the BB-FSW process. The whole joint exhibited a much higher elongation than the slices. Scanning electron microscopic(SEM) analysis of the fracture morphologies showed that joints failed through ductile fracture for SS-FSW and brittle fracture for BB-FSW. | Weifeng Xu Yuxuan Luo Wei Zhang Mingwang Fu | 2018 | Journal of Materials Science & Technology2018，34，1： | 7 |
| 6 | “Wrapping the gastroduodenal artery stump” during pancreatoduodenectomy reduced the stump hemorrhage incidence after operation显示文摘Objective: After pancreaticoduodenectomy(PD), the postoperative gastroduodenal artery stump(GDAS) hemorrhage is one of the most serious complications. The purpose of this study is to determine whether wrapping the GDAS during PD could decrease the postoperative GDAS hemorrhage incidence.Methods: A retrospective review involving 280 patients who underwent PD from 2005 to 2012 was performed. Wrapping the GDAS during PD was defined as 'Wrapping the GDAS using the teres hepatis ligamentum during PD'. A total of 140 patients accepted the 'wrapping' procedure(wrapping group). The other 140 patients didn't apply the procedure(non-wrapping group). Age, sex, preoperative data, estimated intraoperative blood loss, postoperative complications, pathologic parameters and hospitalization time were compared between two groups.Results: There were no significant differences in patient characteristics between two groups. After wrapping, the incidence of postoperative GDAS bleeding decreased significantly(1/140 vs. 9/140, P=0.01). The rates of the other complications(such as intra-abdominal infection pancreatic fistula, billiary fistula, gastrointestinal bleeding, et al.) showed no significant differences. Conclusions: Wrapping the GDAS during PD significantly reduced the postoperative GDAS hemorrhage incidence. And the 'wrapping' had no obvious influence on other complications. | Chang Xu Xinwei Yang Xiangji Luo Feng Shen Mengchao Wu Weifeng Tan Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 7 |
| 7 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 8 | A novel technique for the optimal design of offshore wind farm electrical layout显示文摘The design of electrical layout is a key element in the offshore wind farm planning.We present a novel electrical layout design optimization method for offshore wind farms in this paper.The proposed method can be used to generate the network model based on fuzzy c-means(FCM)and binary integer programming(BIP)methods.It can automatically allocate wind turbines to the nearest substations and obtain the topology structure of cables utilized to connect wind turbines or turbine and substation.The objective of this optimization is to minimize the investment costs of cable connection and the transmission power losses.The results of case study clearly demonstrated the feasibility of the proposed method and showed that it can be used as a reliable tool for electrical layout design of offshore wind farms. | Yingying CHEN Zhaoyang DONG Ke MENG Fengji LUO Weifeng YAO Jing QIU | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 5 |
| 9 | Optimization of control parameters of droplet density in citrus trees using UAVs and the Taguchi method显示文摘The control parameters of the unmanned aerial vehicle(UAV)should be carefully designed to improve UAV spraying performance on citrus trees.The present study investigated the optimal droplet distribution control parameters in citrus trees using a UAV and the Taguchi method,of which optimal results were observed with an inverted triangle citrus tree canopy shape,a spraying height of 1.40 m,and a flight speed of 1.0 m/s.Among the discussed control parameters,the flight speed presented the most significant effect with a contribution percentage of 74.0%.The established multiple regression model predicted an optimal spraying height of 1.27 m and a maximum droplet density of 35.39 droplets/cm2.In addition,the effects of individual control parameter on the droplet density of the lower layer of citrus trees were systematically analyzed,of which inverted triangle shape more significantly affected the droplet density of the lower layer and presented an 82.0%increase in droplet density as compared to the triangle shape.An improvement of 59.6%in the lower layer droplet density was observed at a spraying height of 1.40 m.In addition,the other spraying heights did not present significant differences in their coefficient of variation(CV)values. | Chaojun Hou Yu Tang Shaoming Luo Jintian Lin Yong He Jiajun Zhuang Weifeng Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 10 | Temperature-dependent evolution of surface charge screening and polarization at ferroelectric surfaces显示文摘The polarization and domain behavior on the surface of a ferroelectric material are significantly affected by the screening processes [1-12].Recently,there has been a notable increase in the theoretical calculations and experiments investigating the dynamics of polarization and domain behaviors coexisting in phase transitions of ferroelectric materials. | LongFei Wang Yi Luo JieSu Wang XiuShi Huang ZhaoMeng Gao TieYing Yang XiaoLong Li Pei Li KuiJuan Jin WeiFeng Zhang HaiZhong Guo | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，8： | 3 |
| 11 | Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization显示文摘Background:Epidermal stem cells(EpSCs)that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin homeostasis.Little is known about the effects of photochemical activation on EpSC differentiation,proliferation and migration during wound healing.The present study aimed to determine the effects of photodynamic therapy(PDT)on wound healing in vivo and in vitro.Methods:We created mouse full-thickness skin resection models and applied 5-aminolevulinic acid(ALA)for PDT to the wound beds.Wound healing was analysed by gross evaluation and haematoxylin–eosin staining in vivo.In cultured EpSCs,protein expression was measured using flow cytometry and immunohistochemistry.Cell migration was examined using a scratch model;apoptosis and differentiation were measured using flow cytometry.Results:PDT accelerated wound closure by enhancing EpSC differentiation,proliferation and migration,thereby promoting re-epithelialization and angiogenesis.PDT inhibited inflammatory infiltration and expression of proinflammatory cytokines,whereas the secretion of growth factors was greater than in other groups.The proportion of transient amplifying cells was significantly greater in vivo and in vitro in the PDT groups.EpSC migration was markedly enhanced after ALAinduced PDT.Conclusions:Topical ALA-induced PDT stimulates wound healing by enhancing re-epithelialization,promoting angiogenesis as well as modulating skin homeostasis.This work provides a preliminary theoretical foundation for the clinical administration of topical ALA-induced PDT in skin wound healing. | Zengjun Yang Xiaohong Hu Lina Zhou Yaxiong He Xiaorong Zhang Jiacai Yang Zhenyu Ju Yih-Cherng Liou Han-Ming Shen Gaoxing Luo Michael R.Hamblin Weifeng He Rui Yin | 2021 | Burns & Trauma2021，9，1： | 3 |
| 12 | Investigations on femtosecond laser-induced surface modification and periodic micropatterning with anti-friction properties on Ti6Al4V titanium alloy显示文摘Titanium alloys have a wide application in aerospace industries as it has greater strength and low density, but it has poor tribological properties. To improve its friction and wear performance, in present work, a femtosecond laser is used to directly irradiate the Ti6Al4V titanium alloy surface in air conditioning, which results in localized ablation and the formation of periodic microstructures but also a strong pressure wave, propagating the material inside. Through the optimization of processing parameters, surface modification and periodic micropatterning with effective anti-friction properties were successfully induced on the surface. After a treatment of femtosecond laser-induced surface modification(FsLSM), the surface microhardness was improved by 16.6% and compressive residual stress reached-746 MPa. Besides, laser-induced periodic surface structures(LIPSS) with a titanium oxide outer coating were fabricated uniformly on the titanium alloy surface. Rotary ball-on-disk wear experiments revealed that the average coefficient of friction(COF) and wear mass loss of the specimen with Fs LSM treatment were largely reduced by 68.9% and 90% as compared to that of untreated specimens, respectively. It was analyzed that the reason for the remarkable wear resistance was attributed to the comprehensive action of the generation of LIPSS, the titanium oxide outer coating, high amplitude compressive residual stress and gradient grain size distribution on the subsurface during the laser surface treatment. Since the findings here are broadly applicable to a wide spectrum of engineering metals and alloys, the present results offer unique pathways to enhancing the tribological performance of materials. | Xinlei PAN Weifeng HE Zhenbing CAI Xuede WANG Ping LIU Sihai LUO Liucheng ZHOU | 2022 | Chinese Journal of Aeronautics2022，35，4： | 2 |
| 13 | Mixed lymphocyte reaction induced by multiple alloantigens and the role for IL-10 in proliferation inhibition显示文摘The frequency of T cells that can respond to alloantigens is unusually high.It remains unclear how T cells would respond when stimulated by multiple major histocompatibility complex(MHC)disparate alloantigens in the same cultures.In this report,we examined potential interactions of T cell clones that were stimulated simultaneously by two sets of complete MHC disparate alloantigens using mixed lymphocyte reaction(MLR).In this assay,we observed that proliferation of B6 lymphocytes(H-2b)stimulated by both BALB/c(H-2d)and C_(3)H(H-2k)allogeneic cells was not increased but rather reduced as compared to B6 cells stimulated with either BALB/c or C_(3)H allogeneic cells.Interestingly,interleukin(IL)-10 expressions at both protein level and mRNA level was signifi cantly increased in cultures stimulated with the two MHC alloantigens,while IL-2,tumor necrosis factor(TNF)-α,transforming growth factor(TGF)-β1 production did not show any differences.In addition,Foxp_(3) mRNA expression was comparable amongst all groups.In conclusion,we observed an inhibitory effect in T cell proliferation in response to multiple MHC mismatched alloantigens in MLR,and this effect might be associated with the upregulation of IL-10 expression. | Junyi Zhou Weifeng He Gaoxing Luo Jun Wu | 2014 | Burns & Trauma2014，2，1： | 2 |
| 14 | Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases显示文摘The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound. | Haowen Xu Jiahao Chen Pan Chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng Chen Wu Luo Guang Liang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 2 |
| 15 | CC chemokine ligand 2 (CCL2)enhances TTX-sensitive sodium channel activity of primary afferent neurons in the complete Freud adjuvant-induced inflammatory pain model显示文摘CC chemokine ligand 2 (CCL2)has been implicated in pathological pain,but the mechanism underlying the pronociceptive effect of CCL2 is not fully understood.Voltage-gated sodium (Nav)channels are important determinants of the excitability of sensory neurons.Hence we tested the hypothesis that CCL2 contributes to inflammatory pain via modulating Nay channel activity of primary afferent neurons. Chronic inflammatory pain was induced in rats by intraplantar injection of the complete Freud adjuvant (CFA)to one of the hind paws.Control rats received intraplantar injection of equal volume of saline.A significant increase of CCL2 mRNA and CCL2 receptor (CCR2)protein expression was detected in the ipsilateral dorsal root ganglion (DRG)in CFA-treated rats.lntrapiantar injection of CCL2 protein in the control rats had minimal effect on the paw withdrawal threshold (PWT)in response to mechanical stimulation.However,in CFA-treated rats,intraplantar CCL2 led to an increase in pain responses.Patchclamp recording of acutely dissociated DRG neurons revealed that CCL2 had minimum effect on the excitability of sensory neurons from control rats.However,CCL2 directly depolarized a large proportion of small to medium-sized sensory neurons from CFA-treated rats.In addition,CCL2 was found to enhance whole-cell TTX-sensitive sodium currents without significantly affecting the TTX-resistant sodium currents and the potassium currents.These results are in agreement with previous reports concerning the involvement of CCL2-CCR2 signaling in inflammatory hyperalgesia and further indicate that enhanced TTX-sensitive channel activity may partly underlie the pronociceptive effects of CCL2. | Ping Luo Jiayun Shao Yingfu Jiao Weifeng Yu Weifang Rong | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 2 |
| 16 | Real-time remote monitoring system for aquaculture water quality显示文摘A multi-parameters monitoring system based on wireless network was set up to achieve remote real-time monitoring of aquaculture water quality,in order to improve the quality of aquaculture products and solve such problems as being difficult in wiring and high costs in current monitoring system.In the system solar cells and lithium cells were used for power supply.The YCS-2000 dissolved oxygen sensor,pH electrode,Pt1000 temperature sensor and ammonia nitrogen sensor were used to monitor the parameters of aquaculture water quality;STM32F103 chip was used for data processing;Zigbee and GPRS modules were used for data transmission to the remote monitoring center,where the data were stored and displayed.The system was connected with aerator to realize automatic control of dissolved oxygen concentration.The test results showed high confidence level of data transmission with a packet loss rate of 0.43%.Therefore,the system could fulfill the real-time remote monitoring of aquaculture water quality and had great practical significance in reduction of labor intensity,improvement of quality of aquatic products and protection of water environment. | Luo Hongpin Li Guanglin Peng Weifeng Song Jie Bai Qiuwei | 2015 | International Journal of Agricultural and Biological Engineering2015，8，6： | 2 |
| 17 | Propofol pretreatment attenuates remote kidney injury induced by orthotopicliver autotransplantation, which is correlated with the activation of Nrf2 inrats显示文摘 | Mian Ge Gangjian Luo Weifeng Yao Chenfang Luo Shaoli Zhou Dongdong Yuan Xinjin Chi Ziqing Hei | 2015 | Molecular Medicine Reports2015，，5： | 1 |
| 18 | Experimental study on the separation of CO2 from flue gas using hollow fiber membrane contactors without wetting显示文摘 | Yan Shuiping Fang Mengxiang Zhang Weifeng Wang Shuyuan Xu Zhikang Luo Zhongyang Cen Kefa | | 0，，： | 1 |
| 19 | Characteristics and Mechanism of Upper Permian Reef Reservoirs in the Eastern Longgang Area, Northeastern Sichuan Basin, China显示文摘As a typical kind of lithologic reservoirs,reef reservoirs are generally featured by their large single-well reservoir thickness,good reservoir physical properties,and high gas well productivity.The Upper Permian Changxing Formation is an important natural gas exploration target in the Sichuan Basin,which hosts a large reef gas reservoir and is mainly distributed along the Kaijiang-Liangping Trough.Comprehensive analyses are implemented to investigate reservoir characteristics and identify controlling factors of reef reservoirs in Changxing Formation in the Eastern Longgang Area,Northeastern Sichuan Basin,including core,logging,and seismic data analyses.Changxing Formation reservoirs in the study area mainly occur in the reef-shoal complex,which are featured by wide distribution,large thickness and generally good physical properties.Reservoir rocks are dominantly composed of bioclastic dolomite and silty-fine dolomite(with grain phantom structure),while the main reservoir space consists of residual intergranular pores,intergranular dissolution pores,and karst vugs.In the seismic profiles,typical mound-shaped chaotic reflections can be clearly seen.It is suggested by the main reservoir development controlling factor analysis that the distributions of reef reservoirs are typically controlled by sedimentary facies belts,while the scale of the reef-shoal complex is determined by the pene-sedimentary micro-paleo-geomorphology.Dolomitization can not only significantly preserve the primary pores but also enhance the permeability of rocks.Moreover,karstification is the key to high-quality reef-shoal reservoirs. | Lei Tan Hong Liu Yuzhe Tang Bing Luo Ya Zhang Yuran Yang Yisha Liao Weifeng Du Xiran Yang | 2020 | Petroleum2020，6，2： | 1 |
| 20 | Intensification of β-poly( l -malic acid) production by Aureobasidium pullulans ipe-1 in the late exponential growth phase显示文摘 | Weifeng Cao Jianquan Luo Juan Zhao Changsheng Qiao Luhui Ding Benkun Qi Yi Su Yinhua Wan | 2012 | Journal of Industrial Microbiology & Biotechnology2012，，7： | 1 |
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