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| 1 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 2 | Biosynthesis of Triacylglycerol Molecules with a Tailored PUFA Profile in Industrial Microalgae显示文摘The composition of polyun saturated fatty acids (PUFAs) in triacylglycerols (TAGs) is key to health ben efits and for oil applications, yet the underlying genetic mechanism remains poorly understood. In this study, by in si Iico, ex vivo, and in vivo profili ng of type-2 diacylglycerol acyltransferases (DGAT2s) in Nannochloropsis oceanica we revealed two novel PUFA-preferring enzymes that discriminate individual PUFA species in TAG assembly, with NoDGAT2J for linoleic acid (LA) and NoDGAT2K for eicosapentaenoic acid (EPA). The LA and EPA composition of TAG molecules is mediated in vivo via the functional partitioning between NoDGAT2J and 2K, both of which are localized in the chloroplast envelope. By modulating transcript abundance of the DGAT2s, an N. oceanica strain bank was created, where proportions of LA and EPA in TAG vary by 18.7-fold (between 0.21% and 3.92% dry weight) and 34.7-fold (between 0.09% and 3.12% dry weight), respective!y. These findings lay the foundation for producing designer TAG molecules with tailored health benefits or for biofuel applications in industrial microalgae and higher-plant crops. | Yi Xin Chen Shen Yiting She Hong Chen Cong Wang Li Wei Kangsup Yoon Danxiang Han Qiang Hu Jian Xu | 2019 | Molecular Plant2019，12，4： | 10 |
| 3 | Adenomyosis-derived extracellular vesicles endow endometrial epithelial cells with an invasive phenotype through epithelial-mesenchymal transition显示文摘Extracellular vesicles from highly metastatic tumor cells have been shown to mediate epithelial-mesenchymal transition(EMT)-related events in recipient cells.In endometrial epithelial cells,EMT processes are known to be involved in the development of adenomyosis.We aimed to investigate whether adenomyosis-derived extracellular vesicles(AMEVs)are able to induce an EMT process in endometrial epithelial cells.In this study,AMEVs were isolated from patients with adenomyosis and characterized by transmission electron microscopy,Western blot,and nanoparticle tracking.Primary endometrial epithelial cells(EECs)were derived from normal endometrium tissues from patients with leiomyoma and co-cultured with AMEVs in vitro.AMEV uptake was examined by fluorescence confocal microscopy.The invasion of EECs was confirmed by Transwell assay.Immunohistochemistry,Western blot,and qRT-PCR were performed on EECs to illustrate the expression levels of cytokeratin 19,E-cadherin,vimentin,and zinc finger E-boxbinding homeobox 1(ZEB1).The results indicated that the cellular fluorescence intensity gradually increased after 48 h of co-culture,but decreased after 72 h.After co-culturing with AMEVs for 72 h,EECs expressed significantly lower levels of cytokeratin 19 and E-cadherin,and significantly higher levels of vimentin and ZEB1.Together these results demonstrated that AMEVs induce an EMT process and enhance the invasion of EECs.These changes may contribute to the pathogenesis and progression of adenomyosis. | Dayong Chen Hai Qiao Yiting Wang Ling Zhou Na Yin Liaoqiong Fang Zhibiao Wang | 2020 | Genes & Diseases2020，7，4： | 8 |
| 4 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 5 | Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys Iongispora FG216显示文摘 | Ruihua Guo Yiting Zhang Dong Duan Qiang Fu Xiangyu Zhang Xiaowei Yu Shujun Wang Bin Bao Wenhui Wu | 2016 | Chinese Journal of Chemistry2016，34，11： | 4 |
| 6 | Genetic architecture and key genes controlling the diversity of oil composition in rice grains显示文摘Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality. | Hao Zhou Duo Xia Pingbo Li Yiting Ao Xiaodong Xu Shanshan Wan Yanhua Li Bian Wu Huan Shi Kaiyue Wang Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Molecular Plant2021，14，3： | 4 |
| 7 | Effect of PCEs with Different Functional Groups on the Performance of Cement Paste显示文摘The adsorption behaviors and dispersing properties of polycarboxylate superplasticizer(PCE) with different functional groups were systematically analyzed to reveal the theory and methods of modifying PCE molecular structures and regulating PCE performances. By substituting carboxylic groups with sulfonic groups, ester groups or acylamino groups, respectively, modified PCEs with different functional groups were synthesized. Results show that introducing low amount of ester groups or sulfonic groups into the PCE molecules has no negative effects on the fluidity of cement paste, while introducing acylamino groups into PCE molecules significantly weakens the fluidity of cement paste. At low amount(when the molar ratio of sodium methallyl sulfonate to TPEG is lower than 0.4), the rapid adsorption of sulfonic groups onto the cement particles contributes to the high dispersing performance of the sulfonic group modified PCEs. When the substitution ratio of acrylic acid by sulfonic acid is higher than 0.4, the viscosity and the yield stress of cement paste increases sharply. Redundant sulfonic groups lead to the excessive charge density of the PCE, which contributes to the inhomogeneous adsorption on the cement grains and hence results in the decline of the dispersing performance. Substitution of carboxylic group by acylamino group or ester group slightly changes the viscosity as well as the yield stress of cement paste. Introducing sulfonic group into PCE molecule improves the adsorption behavior of PCEs, while introducing ester group or acylamino group into PCE depresses the adsorption properties. | 何燕 ZHANG Xiong WANG Yiting KONG Yaning JI Tao SHUI Liangliang WANG Xiaofu WANG Haoren | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，5： | 3 |
| 8 | Isolation of Secondary Metabolites with Antimicrobial Activities from Bacillus amyloliquefaciens LWYZ003显示文摘The strain LWYZ003, which can restrain multiple pathogens, was screened from the sediment of the ocean and identified as Bacillus amyloliquefaciens. Large-scale fermentation and modern chromatographic separation technologies(macroporous resin column chromatography, silica gel column chromatography, thin-layer chromatography and high-performance liquid chromatography) were used to separate antimicrobial products from the fermentation broth of marine-derived Bacillus amyloliquefaciens LWYZ003. Bioactive-guided separation was used in the term of seeking antimicrobial products from the secondary metabolites of Bacillus amyloliquefaciens LWYZ003. As a result, two natural products cycloheximide( 1) and trehalose( 2) were obtained. Their structures were elucidated by Fourier transform infrared spectroscopy, high-resolution mass spectrometry, ~1 H and ^(13) C nuclear magnetic resonance analysis. In the cylinder plate method, compound 1 exhibited stronger antimicrobial activities than compound 2 against Micrococcus luteus, and also exhibited wider antimicrobial spectrum than compound 2. In conclusion, isolation of bioactive secondary metabolites from marine Bacillus sp. has enormous potentials in finding suitable antibiotics to inhibit multiple pathogens. | Zhen Liu Yiting Wang Xiaoqiang Jia Wenyu Lu | 2019 | Transactions of Tianjin University2019，25，1： | 3 |
| 9 | N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA显示文摘Background:N-acetyltransferase 10(NAT10)is the only enzyme known tomediate the N4-acetylcytidine(ac4C)modification of mRNA and is crucial formRNA stability and translation efficiency.However,its role in cancer development and prognosis has not yet been explored.This study aimed to examine the possible role of NAT10 in colon cancer.Methods:The expression levels ofNAT10were evaluated by immunohistochemical analyses with a colon cancer tissue microarray,and its prognostic value in patients was further analyzed.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blotting were performed to analyze NAT10 expression in harvested colon cancer tissues and cell lines.Stable NAT10-knockdown and NAT10-overexpressing colon cancer cell lines were constructed using lentivirus.The biological functions of NAT10 in colon cancer cell lines were analyzed in vitro by Cell Counting Kit-8(CCK-8),wound healing,Transwell,cell cycle,and ferroptosis assays.Xenograft models were used to analyze the effect of NAT10 on the tumorigenesis and metastasis of colon cancer cells in vivo.Dot blotting,acetylated RNA immunoprecipitation-qPCR,and RNA stability analyses were performed to explore the mechanism by which NAT10 functions in colon cancer progression.Results:NAT10 was upregulated in colon cancer tissues and various colon cancer cell lines.This increased NAT10 expression was associated with shorter patient survival.Knockdown of NAT10 in two colon cancer cell lines(HT-29 and LoVo)impaired the proliferation,migration,invasion,tumor formation and metastasis of these cells,whereas overexpression of NAT10 promoted these abilities.Further analysis revealed that NAT10 exerted a strong effect on the mRNA stability and expression of ferroptosis suppressor protein 1(FSP1)in HT-29 and LoVo cells.In these cells,FSP1 mRNA was found to be modified by ac4C acetylation,and this epigenetic modification was associated with the inhibition of ferroptosis.Conclusions:Our study revealed that NAT10 plays a critical role in colon cancer development by affecting FSP1 mRNA stability and ferroptosis,suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer. | Xiao Zheng Qi Wang You Zhou Dachuan Zhang Yiting Geng Wenwei Hu Changping Wu Yufang Shi Jingting Jiang | 2022 | Cancer Communications2022，42，12： | 3 |
| 10 | Effects of Exogenous 5-Aminolevulinic Acid and 24-Epibrassinolide on Cd Accumulation in Rice from Cd-Contaminated Soil显示文摘High grain-Cd-accumulating rice variety Yongyou 9 was planted in Cd-contaminated farmland in Taizhou City, Zhejiang Province, China to study the effects of 5-aminolevulinic acid(ALA) and24-epibrassinolide(EBR) on Cd accumulation in brown rice. Results showed that the exogenous ALA and EBR had no significant effects on agronomic traits, soil pH and total Cd content in soil, but had some effects on the available Cd content in soil, and significantly influenced the Cd accumulation in the different parts of rice. Results also showed that 100 mg/L exogenous ALA significantly reduced the Cd accumulation in brown rice to blow the food safety standard(0.2 mg/kg), and also significantly reduced the Cd contents in the roots and culm of rice. However, 200 mg/L exogenous ALA treatment increased the Cd content in brown rice remarkably. In addition, 0.15 mg/L EBR treatment increased Cd accumulation in roots, culm, leaves and brown rice notably, whereas 0.30 mg/L exogenous EBR treatment reduced the Cd accumulation in brown rice properly, but it was not significant. Therefore,proper concentration of ALA can effectively reduce the Cd accumulation in brown rice, which can be used as an effective technical method for the safe production of rice in Cd polluted farmland. | WANG Feijuan ZHANG Yiting GUO Qinxin TAN Haifeng HAN Jiahui LIN Haoran WEI Hewen XU Guangwei ZHU Cheng | 2018 | Rice science2018，25，6： | 3 |
| 11 | Recent progress in perovskite solar cells:material science显示文摘Perovskite solar cells represent a promising third-generation photovoltaic technology with low fabrication cost and high power conversion efficiency.In light of the rapid development of perovskite materials and devices,a systematic survey on the latest advancements covering a broad range of related work is urgently needed.This review summarizes the recent major advances in the research of perovskite solar cells from a material science perspective.The discussed topics include the devices based on different type of perovskites(organic-inorganic hybrid,all-inorganic,and lead-free perovskite and perovskite quantum dots),the properties of perovskite defects,different type of charge transport materials(organic,polymeric,and inorganic hole transport materials and inorganic and organic electron transport materials),counter electrodes,and interfacial materials used to improve the efficiency and stability of devices.Most discussions focus on the key progresses reported within the recent five years.Meanwhile,the major issues limiting the production of perovskite solar cells and the prospects for the future development of related materials are discussed. | Jiang-Yang Shao Dongmei Li Jiangjian Shi Chuang Ma Yousheng Wang Xiaomin Liu Xianyuan Jiang Mengmeng Hao Luozheng Zhang Chang Liu Yiting Jiang Zhenhan Wang Yu-Wu Zhong Shengzhong(Frank)Liu Yaohua Mai Yongsheng Liu Yixin Zhao Zhijun Ning Lianzhou Wang Baomin Xu Lei Meng Zuqiang Bian Ziyi Ge Xiaowei Zhan Jingbi You Yongfang Li Qingbo Meng | 2023 | Science China Chemistry2023，66，1： | 3 |
| 12 | Distinguishing Between Natural and GAN-Generated Face Images by Combining Global and Local Features显示文摘With the development of face image synthesis and generation technology based on generative adversarial networks(GANs), it has become a research hotspot to determine whether a given face image is natural or generated. However, the generalization capability of the existing algorithms is still to be improved. Therefore,this paper proposes a general algorithm. To do so, firstly,the learning on important local areas, containing many face key-points, is strengthened by combining the global and local features. Secondly, metric learning based on the Arc Face loss is applied to extract common and discriminative features. Finally, the extracted features are fed into the classification module to detect GAN-generated faces.The experiments are conducted on two publicly available natural datasets(Celeb A and FFHQ) and seven GANgenerated datasets. Experimental results demonstrate that the proposed algorithm achieves a better generalization performance with an average detection accuracy over 0.99 than the state-of-the-art algorithms. Moreover, the proposed algorithm is robust against additional attacks, such as Gaussian blur, and Gaussian noise addition. | CHEN Beijing TAN Weijin WANG Yiting ZHAO Guoying | 2022 | Chinese Journal of Electronics2022，31，1： | 2 |
| 13 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 14 | Prevention and treatment for radiation-induced skin injury during radiotherapy显示文摘The skin tissue has the largest area in the human body and functions as both a barrier and a defender.As such,it tends to be the first tissue to be damaged.Advances in medical technology provide prospects as well as side effects,for example,radiation therapy for cancer.With increasing cancer morbidity and radiation widely applied for cancer therapy,radiation-induced skin injury(RSI)has become a serious concern.In recent decades,research efforts have focused on the mechanisms underlying RSI.This review summarizes the mainstream opinions on these mechanisms,including the pathological,molecular biological,and cytobiological alterations.Radiationinduced reactive oxygen species(ROS),cytokines and involved signaling pathways are evaluated.Other relevant aspects include radiation-induced skin fibrosis(RSF)and radiation-related skin cell senescence.Moreover,we review strategies for the prevention and treatment in clinical and pre-clinical studies to support the treatment of RSI during radiotherapy.The prevention strategies include dose control,pre-irradiation instructions,and RSI assessments,while the main treatments include physical therapy,external-use dressings or creams,biological therapy and surgical reconstruction. | Yimin Wang Wenling Tu Yiting Tanga Shuyu Zhang | 2020 | Radiation Medicine and Protection2020，1，2： | 2 |
| 15 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 16 | Gas Occurrence and Accumulation Characteristics of Cambrian–Ordovician Shales in the Tarim Basin, Northwest China显示文摘The Tarim Basin is located in northwestern China and is the biggest basin in China with huge oil and gas resources. Especially the Lower to Middle Cambrian and Middle to Upper Ordovician possess the major marine source rocks in the Tarim Basin and have large shale gas resource potential. The Cambrian–Ordovician shales were mainly deposited in basin–slope facies with thicknesses between 30–180 m. For shales buried shallower than 4500 m, there is high organic matter abundance with TOC(total organic carbon) mainly between 1.0% and 6.0%, favorable organic matter of Type I and Type II, and high thermal maturity with RoE as 1.3%–2.75%. The mineral composition of these Cambrian–Ordovician shale samples is mainly quartz and carbonate minerals while the clay minerals content is mostly lower than 30%, because these samples include siliceous and calcareous shale and marlstone. The Cambrian and Ordovician shales are compacted with mean porosity of 4% and 3%, permeability of 0.0003×10^(-3)–0.09×10^(-3) μm^2 and 0.0002×10^(-3)–0.11×10^(-3) μm^2, and density of 2.30 g/m^3 and 2.55 g/m^3, respectively. The pores in the shale samples show good connectivity and are mainly mesopore in size. Different genetic types of pores can be observed such as intercrystal, intergranular, dissolved, organic matter and shrinkage joint. The reservoir bed properties are controlled by mineral composition and diagenesis. The maximum adsorption amount to methane of these shales is 1.15–7.36 cm^3/g, with main affecting factors being organic matter abundance, porosity and thermal maturity. The accumulation characteristics of natural gas within these shales are jointly controlled by sedimentation, diagenesis, hydrocarbon generation conditions, reservoir bed properties and the occurrence process of natural gas. The natural gas underwent short-distance migration and accumulation, in-place accumulation in the early stage, and adjustment and modification in the later stage. Finally, the Yulin(well Y1) and Tazhong(well T1) areas are identified as the targets for shale gas exploration in the Tarim Basin. | LIU Luofu WANG Ying CHEN Yiting SHEN Baojian GAO Xiaoyue | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 17 | Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift显示文摘Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin. | TIAN Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 2 |
| 18 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 19 | A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer显示文摘Drug resistance,accounting for therapeutic failure in the clinic,remains a major challenge to effectively manage cancer.Cyclosporin A(CsA)can reverse multidrug resistance(MDR),especially resistance to epidermal growth factor receptor tyrosine kinase inhibitors.However,the application of both drugs in cancer therapies is hampered by their poor aqueous solubility and low bioavailability due to oral administration.CsA augments the potency of gefitinib(Gef)in both Gef-sensitive and Gef-resistant cell lines.Here,we show that the simultaneous encapsulation of CsA and Gef within polyethylene glycol-block-poly(D,L-lactic acid)(PEG-PLA)produced a stable and systemically injectable nanomedicine,which exhibited a sub-50-nm diameter and spherical structures.Impressively,the co-delivery of therapeutics via single nanoparticles(NPs)outperformed the oral administration of the free drug combination at suppressing tumor growth.Furthermore,in vivo results indicated that CsA formulated in NPs sensitized Gef-resistant cells and Gefresistant tumors to Gef treatment by inactivating the STAT3/Bcl-2 signaling pathway.Collectively,our nanomedicine approach not only provides an alternative administration route for the drugs of choice but also effectively reverses MDR,facilitating the development of effective therapeutic modalities for cancer. | Weidong Han Linlin Shi Lulu Ren Liqian Zhou Tongyu Li Yiting Qiao Hangxiang Wang | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 2 |
| 20 | PACAP in hibit the release and cytokine activity of HMGB1 and im prove the survival during lethal endotoxemia显示文摘 | YITING TANG BEN LV HAICHAO WANG | 2008 | Interna tional Immunopharmacology2008，8，： | 1 |
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