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| 1 | GL3.3, a Novel QTL Encoding a GSK3/SHAGGY- like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice显示文摘 | Duo Xia Nao Zhou Rongjia Liu Wenhan Dan Pingbo Li Bian Wu Junxiao Chen Lingqiang Wang Guanjun Gao Qinglu Zhang Yuqing He | 2018 | Molecular Plant2018，11，5： | 41 |
| 2 | Genome-wide Association Analyses Reveal the Genetic Basis of Stigma Exsertion in Rice显示文摘耻辱 exsertion,交配系统的米饭的一个关键决定因素,极大地在米饭贡献杂种优势的申请。尽管与耻辱 exsertion 联系的一些量的特点 loci 是印射或克隆的罚款,内在的基因建筑学仍然保持不清楚。我们用在 Oryza sativa 的 533 多样的就职描绘的 650 万 SNP 在耻辱 exsertion 和相关花的特点上执行了染色体宽的协会研究。我们识别了显著地与耻辱 exsertion 和相关特点,其三与三主要谷物尺寸基因 GS3, GW5,和 GW2 co 局部性被联系的 23 genomic loci。进一步的分析显示这三基因由控制小穗状花小穗和耻辱的尺寸和形状影响了耻辱 exsertion。GS3 和 GW5 的联合大部分定义耻辱 exsertion 和相关特点的层次。这二基因的选择在 O 的 subpopulations 之中导致了花的特点的特定的分布。sativa。低耻辱 exsertion 联合 gw5GS3 在栽培米饭变化的一半存在;因此,介绍 GW5gs3 联合进男无菌的线具有为改进混合米饭的种子生产的高潜力。 | Hao Zhou Pingbo Li WeiboXie Saddam Hussain Yibo Li Duo Xia Hu Zhao Shengyuan Sun Junxiao Chen Hong Ye Jun Hou Da Zhao Guanjun Gao Qinglu Zhang Gongwei Wang Xingming Lian Jinghua Xiao Sibin Yu Xianghua Li Yuqing He | 2017 | Molecular Plant2017，10，4： | 15 |
| 3 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 4 | The origin of Wx^(la) provides new insights into the improvement of grain quality in rice显示文摘Appearance and taste are important factors in rice(Oryza sativa) grain quality. Here, we investigated the taste scores and related eating-quality traits of533 diverse cultivars to assess the relationships between—and genetic basis of—rice taste and eating-quality. A genome-wide association study highlighted the Wx gene as the major factor underlying variation in taste and eating quality. Notably, a novel waxy(Wx) allele, Wx^(la), which combined two mutations from Wx^(b) and Wx^(in), exhibited a unique phenotype. Reduced GBSSI activity conferred Wx^(la) rice with both a transparent appearance and good eating quality. Haplotype analysis revealed that Wx^(la) was derived from intragenic recombination. In fact,the recombination rate at the Wx locus was estimated to be 3.34 kb/c M, which was about 75-fold higher than the genome-wide mean, indicating that intragenic recombination is a major force driving diversity at the Wx locus. Based on our results, we propose a new network for Wx evolution, noting that new Wx alleles could easily be generated by crossing genotypes with different Wx alleles. This study thus provides insights into the evolution of the Wx locus and facilitates molecular breeding for quality in rice. | Hao Zhou Duo Xia Da Zhao Yanhua Li Pingbo Li Bian Wu Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Journal of Integrative Plant Biology2021，63，5： | 8 |
| 5 | How rice organs are colored: The genetic basis of anthocyanin biosynthesis in rice显示文摘Anthocyanins are a major subclass of flavonoids that have diverse biological functions and benefit human health.In rice(Oryza sativa),the various colors shown by organs are due mainly to the accumulation of anthocyanins and are traits associated with domestication.Elucidating the genetic basis of anthocyanin biosynthesis in rice would support the engineering of anthocyanins as well as shedding light on the evolutionary history of O.sativa.We summarize recent progress in rice anthocyanin biosynthesis research,including gene cloning,biosynthetic pathway discovery,and study of the domestication process.We discuss the application of anthocyanin biosynthesis genes in rice breeding.Our object is to broaden knowledge of the genetic basis of anthocyanin biosynthesis in rice and support the breeding of novel rice cultivars. | Duo Xia Hao Zhou Yipei Wang Pingbo Li Pei Fu Bian Wu Yuqing He | 2021 | The Crop Journal2021，9，3： | 7 |
| 6 | Effectiveness of external Sanjierupi Gao on mastalgia caused by mammary gland hyperplasia: a placebo controlled trial显示文摘OBJECTIVE:To evaluate the curative effect of external application of the Chinese drug,Sanjierupi Gao,on mastalgia caused by mammary gland hyperplasia.METHODS:This randomized,double-blinded,and placebo controlled study enrolled 260 patients with mammary gland hyperplasia from five hospitals.Patients were randomly and equally divided in-to a Sanjierupi Gao treatment group and a placebo control group.An adhesive plaster was applied to the most painful area on either breast for 7 h a day.Treatment lasted for two menstrual cycles without application during menstruation.Mastalgia was used as the main index of curative effect.The change before and after treatment in days of mastalgia,the time to alleviate pain,pain extent,and severe pain scores were observed.RESULTS:Compared to the control group,the treatment group had significantly fewer days of mastalgia(P<0.01),a significantly lower severe pain score(P<0.01),and significantly less subjective pain and tenderness(P<0.05 and P<0.01,respectively).Three days before the follow-up visit,the pain score in the treatment group was significantly lower than that in the control group(P<0.05).A non-parametric test was used to compare the time to alleviate mastalgia between the two groups and found no statistical difference(Z=0.313,P=0.754).CONCLUSION:Application of Sanjierupi Gao can decrease mastalgia duration in patients with mammary gland hyperplasia during menstruation and alleviate the extent of mastalgia.The time to alleviate pain is psychologically influenced. | Yingyi Fan Xiaohua Pei Zhaolan Liu Zhongyuan Xia Dongxiao Zhang Afeng Song Duo Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 7 |
| 7 | Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells显示文摘动脉粥样硬化患者损害被丰富的类脂化合物和长期的发炎的累积描绘。以前的研究显示了导出巨噬细胞的脂蛋白脂肪分解酵素(LPL ) 由加速类脂化合物累积和支持 inflammatory cytokine 分泌物支持动脉粥样硬化前进。尽管 apelin-13 被认为是一个 atheroprotective 因素,它是否能调整 LPL 的表示,仍然保持不清楚。这研究的目的是在 THP-1 导出巨噬细胞的泡沫房间在 LPL 和内在的机制的表示上探索 apelin-13 的效果。Apelin-13 显著地减少了在 10 和 100 nM 的集中的全部的胆固醇,免费胆固醇,和胆固醇酉旨的细胞的层次。ELISA 分析证实有 apelin-13 的处理减少了支持 inflammatory cytokine 分泌物,例如 interleukin-6 (IL-6 ) , interleukin-1 (IL-1 ) 和肿瘤坏死 factor-alpha (TNF-) 。apelin-13 禁止了由西方的污点和即时 PCR 分析揭示了的 LPL 的表示,这也被发现。生物信息学分析和双酶的记者试金直接显示了那 miR-361-5p downregulated 由指向 LPL 的 3UTR 的 LPL 的表示。另外, apelin-13 + miR-361-5p 显著地模仿 downregulated 在房间的 LPL 的表示。最后,我们表明了那 apelin-13 downregulated 通过激活 PKC 的活动的 LPL 的表示。一起拿,我们的结果显示出那 apelin-13 downregulated 经由激活在 THP-1 导出巨噬细胞的泡沫房间表明小径的 APJ/PKC/miR-361-5p 的 LPL 的表示,导致类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制。因此,我们的研究由 apelin-13 提供重要新卓见进类脂化合物累积和支持 inflammatory cytokine 分泌物的抑制,并且在动脉粥样硬化作为一个有希望的治疗学的目标加亮 apelin-13。 | Xin Zhang Qiong Ye Duo Gong Yuan Lv Haipeng Cheng Chong Huang Lingyan Chen Zhenwang Zhao Liang Li Xie Wei Min Zhang Xiaodan Xia Xiaohua Yu Xilong Zheng Shuzhi Wang Zongbao Wang Chaoke Tang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 6 |
| 8 | Genetic architecture and key genes controlling the diversity of oil composition in rice grains显示文摘Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality. | Hao Zhou Duo Xia Pingbo Li Yiting Ao Xiaodong Xu Shanshan Wan Yanhua Li Bian Wu Huan Shi Kaiyue Wang Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Molecular Plant2021，14，3： | 4 |
| 9 | Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1/TGF-β1-dependent pathway显示文摘 | Hong-Tai Tang Da-Sheng Cheng Yi-Tao Jia Dao-Feng Ben Bing Ma Kai-Yang Lv Duo Wei Zhi-Yong Sheng Zhao-Fan Xia | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 1 |
| 10 | p38 mitogen-activated protein kinase inhibition attenuates burn-induced liver injury in rats显示文摘 | Xu-Lin Chen Zhao-Fan Xia You-Xin Yu Duo Wei Chang-Rong Wang Dao-Feng Ben | 2004 | Burns2004，，3： | 1 |
| 11 | Advances in the Application of Intestinal Flora in Anti-Tumor Therapy显示文摘The intestinal flora is the normal microecosystem of the gastrointestinal tract. The intestinal flora has great complexity, and plays crucial roles in nutrient intake, host metabolism, endocrine signaling, homeostasis and immune regulation. Disorders of the intestinal flora can lead to an out-of-balance in immune system, and even results in an increased risk of diseases, including the occurrence and development of malignant tumors. Accumulating evidence shows that intestinal microorganisms may assist in systemic therapy by increasing the “heterogeneity” of the tumor, thereby promoting anti-tumor therapy. Targeting intestinal flora during the treatment of cancer has shown good efficacy. This review focuses on recent advances in research about intestinal flora, the relationship with tumor development, and the potential anti-tumor effects. | Duo Wang Hong Wu Xia Yi Liang Jun Jie Liu Hang Li Chuan Xu | 2019 | Journal of Nutritional Oncology2019，4，2： | 1 |
| 12 | Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity显示文摘 | Yu-cheng Wang Yuying Li Xin-yi Wang Duo Zhang Huihui Zhang Qi Wu Yu-qing He Jian-ying Wang Lian Zhang Hongfeng Xia Jun Yan Xihua Li Hao Ying | 2013 | Diabetologia2013，，10： | 1 |
| 13 | DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling显示文摘The outcome of pancreatic adenocarcinoma(PAAD)patients is poor,given resistance to gemcitabine.Long noncoding RNA(lncRNA)has been implicated in the carcinogenesis of pancreatic cancer;however,its function and mechanism in PAAD resistance to gemcitabine(GEM)are yet unknown.Herein,we demonstrate that lncRNA DSCR9 is significantly reduced in PAAD in vitro and in vivo.CCK-8,BrdU and flow cytometry assays show that overexpression of DSCR9 markedly suppresses pancreatic cancer cell proliferation and invasion,and promotes apoptosis under gemcitabine treatment.BTG2 acts as a tumor suppressor by reducing the proliferation and invasion of pancreatic cancer cells and increasing gemcitabine-induced apoptosis.Immunofluorescence(IF)staining combined with fluorescence in situ hybridization(FISH)of pancreatic cancer tissues shows that DSCR9 and BTG2 are both increased in pancreatic cancer tissues.Luciferase assay shows that miR-21-5p simultaneously binds to DSCR9 and 3′UTR of BTG2;DSCR9 relieves miR-21-5p-induced inhibition of BTG2 by competing with BTG2 for miR-21-5p binding.Overexpression of miR-21-5p enhances the invasiveness of pancreatic cancer cells by promoting cancer cell proliferation and invasion and attenuating gemcitabine-induced apoptosis.Overexpression of miR-21-5p attenuates the effect of DSCR9 overexpression on BTG2 expression and invasiveness of pancreatic cancer cells.Finally,miR-21-5p expression is increased,while BTG2 expression is decreased in pancreatic cancer tissues.miR-21-5p is negatively correlated with DSCR9 and BTG2.In conclusion,the DSCR9/miR-21-5p/BTG2 axis modulates pancreatic cancer proliferation,invasion,and gemcitabine resistance. | Hui Huang Xia Li Xianlin Zhang Zhiqiang Li Duo Han Wenzhe Gao Ling Liu Cheng Peng Hongwei Zhu Xiao Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 1 |
| 14 | A study of the construction times of the ancient cities in Ganjia Basin,Gansu Province,China显示文摘The Ganjia Basin in Xiahe County,Gansu Province,China,is located on the northeastern edge of the Tibetan Plateau.The area lies in the transitional zone between the Plateau ethnic groups dominated by ancestral Tibetans,and the Central Plains dynasties dominated by ancestral Han in history.The Ganjia Basin is therefore well suited to studying the history of the intermixing of the Han and Tibetan peoples.In this study,we collected samples of organic materials from two ancient cities,Bajiaocheng(BJC) and Sirougucheng(SRGC),in the Ganjia Basin,which were used for radiocarbon dating.Our aims were to determine the construction times and function of the cities,based on the radiocarbon ages,Bayesian age modeling,and the analysis of relevant historical records.The results are used to discuss the role of the Ganjia Basin in the conflicts between and the integration of the two ethnic groups during the historical period.We conclude that BJC was established during 663–732 CE(Common Era);its early occupation history can be divided into an initial establishment phase(670–780 CE) and a phase of regeneration(880–1030 CE).SRGC was probably built at the time of the transition between the Song and Yuan dynasties(~1271 CE).Combining the dating results with an analysis of the architectural styles and historical records,we conclude that BJC was originally built by the Tubo Kingdom as a military stronghold,and its major functions were military,economic and religious,and to support the major eastward expansion of the Tubo.SRGC was most likely a temple-focused city intended to promote Tibetan Buddhism which was a major political and religious leadership for the Tibetans at that time,reflecting changes in the status of different religions in the Ganjia Basin.In addition,the intermixing and blending of the Han and Tibetan groups,reflected by the human activities in the Ganjia Basin,was an important demographic and cultural foundation for the formation of the culturally-diverse but spiritually-united modern Chinese people. | XIA Huan ZHANG Dongju WANG Qiang WU Duo DUAN Yanwu CHEN Fahu | 2020 | Journal of Geographical Sciences2020，30，9： | 1 |
| 15 | An improved HAdV-41 E1 B55 K-expressing 293 cell line for packaging fastidious adenovirus显示文摘 | Xiao HZ Xia X Duo LC | | 0，，02： | 1 |
| 16 | Primary Malignant Melanoma of the Vagina A Retrospective Clinicopathologic Study of 44 Cases显示文摘 | Lingfang Xia Duo Han Wentao Yang | 2014 | Int J Gynecol Cancer2014，24，1： | 1 |
| 17 | Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins显示文摘保护(2S,4R )-2-amino-4-methyldecanoic 酸, culicinins 的一个建议部件用 Wittig 反应和 Sch 在 10 个步骤上并且在总数 28% 收益被综合了 ? 是的 llkopf 氨基酸合成关键步骤。 | Wei Zhang Tian Tian Sun Duo Mei Jun Fei Wang Ying Xia Li | 2008 | Chinese Chemical Letters2008，19，9： | 0 |
| 18 | Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS显示文摘The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully. | Lin Zhu Jian‑Rong Zhou Yuan‑Guang Xia Liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen Jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng Li‑Xin Zeng Jia‑Jie Li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑Xun Shen Jun Xu Li‑Jiang Liao Xiao‑Zhuang Wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu Zhi‑Duo Li Song‑Lin Wang Jian Zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo Chen | 2023 | Nuclear Science and Techniques2023，34，1： | 0 |
| 19 | Synthesis and characterization ofα-butyl-ω-{3-[(2,2-dihydroxymethyl)-propionyloxy]}propylpolydimethylsiloxanes显示文摘A series of polydimethylsiloxanes containing two primary hydroxyl groups at one single chain end were synthesized by five-step reactions which included esterification,hydroxyl protection,anionic ring-opening polymerization,hydrosilylation and deprotection. The prepared compounds in each step were characterized.The results showed that each step synthesis was successfully carried out and objective products could be achieved. | Meng Zhang Jun Ying Li GUO Wei Zhou Yuan Juan Wu Yong Mei Xia Tian Duo Li | 2009 | Chinese Chemical Letters2009，20，12： | 0 |
| 20 | Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation显示文摘Gene therapy has drawn great attention in the treatments of many diseases,especially for cardiovascular diseases.However,the development of gene carriers with low cytotoxicity and multitargeting function is still a challenge.Herein,the multitargeting REDV-G-TATG-NLS peptide was conjugated to amphiphilic cationic copolymer poly(e-caprolactone-co-3(S)-methyl-morpho-line-2,5-dione)-g-polyethyleneimine(PCLMD-g-PEI)via a heterobifunctional orthopyridyl disulfde-poly(ethylene glycol)-N-hydroxysuccinimide(OPSS-PEG-NHS)linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop the gene carriers with low cytotoxicity and high transfection efficiency.The multitargeting micelles were prepared from PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers by self-assembly method and used to load pEGFP-ZNF580 plasmids(pDNA)to form gene complexes for enhancing the proliferation and migration of endothelial cells(ECs).The loading pDNA capacity was proved by agarose gel electrophoresis assay.These multitargeting gene com-plexes exhibited low cytotoxicity by 3-(4,-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide assay.The high internalization efficiency of these gene complexes was confirmed by flow cytometry.The results of in vitro transfection demonstrated that these multitargeting gene complexes possessed relatively high transfection effi-ciency.The rapid migration of ECs transfected by these gene complexes was verified by wound healing assay.Owing to ECs-targeting ability,cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS pep-tide,the multitargeting polycationic gene carrier with low cytotoxicity and high transfection efficiency has great potential in gene therapy. | Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb Yakai Feng | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 0 |
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