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| 1 | 医学领域一次研究和二次研究的方法学质量(偏倚风险)评价工具显示文摘方法学质量(偏倚风险)评估是医学研究开始前的重要步骤。因此,准确判断研究类型是前提,选择合适的评价工具也很重要。本综述介绍了用于随机对照试验(包括个体和整群)、动物实验、非随机干预性研究(包括随访研究、有对照组的前后对照研究、前后对照研究、非对照纵向研究、间断时间序列研究)、队列研究、病例-对照研究、横断面研究(包括分析和描述性研究)、观察性病例系列和病例报告、比较效果研究、诊断性研究、卫生经济学评价、预测研究(包括预测变量研究、预测模型影响研究、预后预测模型研究)、质性研究、结果测量工具(包括患者-报告的结果测量发展、内容真实性、结构真实性、内部一致性、跨文化真实性/测量不变性、信度、测量误差、校标真实性、结构真实性假设检验、反应度)、系统评价与Meta分析,以及临床实践指南的方法学质量评价工具。通过本综述,读者可以区分医学研究的类型并选择适当的工具。全面掌握相关知识并多加练习是正确评估方法学质量的基本要求。 | 李柄辉 訾豪 李路遥 王朝阳 任学群 郭毅(译) Ma LL Wang YY Yang ZH | 2021 | 医学新知2021，31，1： | 37 |
| 2 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 3 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 4 | Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro显示文摘INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional Chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent research.Salvianolic acid-A(SA-A)was an aqueous solublecomponent of Salvianolic radix.In our | Hu YY Liu CH Wang RP Liu C Liu P Zhu DY | 2000 | World Journal of Gastroenterology2000，6，3： | 15 |
| 5 | Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘 | Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 6 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 7 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 8 | Sequence variations of the S7 ribosomal protein gene in primitive cyprinid fishes: Implication on phylogenetic analysis显示文摘Cyprinidae is the largest fish family in the world and contains about 210 genera and 2010 species. Appropriate DNA markers must be selected for the phylogenetic analyses of Cyprinidae. In present study, the 1st intron of the S7 ribosomal protein (r-protein) gene is first used to examine the relationships among cyprinid fishes. The length of the 1st intron obtained by PCR amplification ranges from 655 to 859 bp in the 16 cyprinid species investigated, and is 602 bp in Myxocyprinus asiaticus. Out of the alignment of 925 nucleotide sites obtained, the parsimony informative sites are 499 and occupy 54% of the total sites. The results indicate that the 1st intron sequences of the S7 r-protein gene in cyprinids are rich in informative sites and vary remarkably in sequence divergence from 2.3% between close species to 66.6% between distant species. The bootstrap values of the interior nodes in the NJ (neighbor-joining) and MP (most-parsimony) trees based on the present S7 r-protein gene data are higher than | Wang, XZ He, SP Chen, YY | 2002 | Chinese Science Bulletin2002，47，19： | 5 |
| 9 | Powder Microstructure and Overlay Coating Property ofNiCrAlY Alloy显示文摘这被显示出更好(20-30 亩 m ) 粉末粒子经历快速的复辉和热抽取到导致微细胞的结构的环境,而更粗糙(40-50 亩 m ) 因为慢冷却跟随的复辉,粉末粒子展出粗糙的细胞、树枝状的混合结构。另外,这也被显示越好粉末粒子尺寸,越 higher 机械性质并且冶金热稳定性过分,涂层由把同样分裂成原子的粉末扔了,它大概为粉末的好尺寸部分被归因于稠密的好谷物结构和氧化物层的形成。(编辑作者摘要) 9 个裁判员。 | Chang, XC Wang, JQ Hao, YY Hou, WL Hu, ZQ | 1998 | Journal of Materials Science & Technology1998，14，4： | 3 |
| 10 | P53 codon 72 polymorphism contributes to breast cancer risk: a metaanalysis based on 39 case-control studies(摘要)显示文摘 | Zhang, ZZ Wang, ML Wu, DM Wang, MM Tong, N Tian, YY Zhang, ZD | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 3 |
| 11 | Computation of Design Load and Motion for Floating Structures Navigating in Waves显示文摘—Analytical and numerical investigation is made of the source potential for floating structurewith forward speed in waves.A particular form is selected for numerical applications,where the double in-tegral of the Green function is transformed into the single one and the oscillation characteristics forintegrands in the specific computation domain are treated numerically.A comparison of calculated exam-p1es with published data is given and it shows that the numerical simulation is satisfactory and the accura-cy is adequate to engineering application. | Wang, YY Zhu, RC Miao, J | 1999 | China Ocean Engineering1999，14，1： | 3 |
| 12 | Prediction of Extreme Sea-State Encountered by Oceangoing Vessels显示文摘In order to determine the extreme sea-state encountered by oceangoing vessels,a method forthe prediction of wave parameters based on the data of long-term distribution sample is developed by useof the fitting approach with the Weibull probability functions and the power functions.As an example aspecial calculation result is given including the analysis of wave parameters for the data of the NorthAtlantic Basin and the computation of motion and load encountered by two container ships CSLR andCSBV in different loading conditions.All computation results are satisfactory compared with corre-sponding design results. | Wang, YY Qian, K Zhu, RC | 1998 | China Ocean Engineering1998，13，4： | 2 |
| 13 | Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter显示文摘 | Gao DM Wang LF Liu J Kong YY Wang Y Xie YH | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 14 | Association between social support and health outcomes:a meta-analysis 显示文摘 | Wang HH Wu SZ Liu YY | 2003 | Kaohsiung J Med Sci2003，19，7： | 2 |
| 15 | Risk factors and mortality in patients with nosocomial Staphylococcus aureus bacteremia显示文摘 | Wang FD Chen YY Chen TL | 2008 | Am J Infect Control2008，36，2： | 1 |
| 16 | Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | WANG YY LIN SY | 2003 | Horm Res2003，60，4： | 1 |
| 17 | A reappeaial of cholangiocarcinoma in patient wuth hepatolithiasais显示文摘 | Jan yy Wang cs | 1993 | Cancer1993，71，： | 1 |
| 18 | The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer显示文摘 | Gao LB Rao L Wang YY | 2009 | Carcinogenesis2009，30，2： | 1 |
| 19 | Micro-and macrorheology of mucus显示文摘 | Lai SK Wang YY Wirtz D | 2009 | Adv DrugDeliv Rev2009，61，2： | 1 |
| 20 | Simultaneous determination and pharmacokinetic studies on (3,4-Dihydroxyphenyl)-lactic acid and protocatechuic aldehyde in rat serum after oral administration of Radix Salviae miltiorrhizae extract显示文摘 | Ye G Wang CS Li YY | 2003 | J Chromatogr Sci2003，41，6： | 1 |
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