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| 1 | Recurrence or metastasis of HCC:predictors,early detection and experimental antiangiogenic therapy显示文摘AIM To investigate the predictors forrecurrence or metastasis of HCC,and toevaluate the effect of antiangiogenic therapy onthe growth of transplantable human HCC in nudemice.METHODS RT-PCR was used to measure theexpression of matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)in 56 pairs of nontumorous liver andtumor samples.Sixty blood samples from humanHCC were examined by nested RT-PCR to find outAFP mRNA.Recombinant human endostatin andpolyclonal antibody against VEGF wereadministered to treat human HCC transplanted innude mice.RESULTS Thirty of 56 HCC samples showedstronger expression of MMP-9 in tumoroustissues than in nontumorous tissues.Fifteen ofthe 26 patients with relative expression level ofMMP-9 more than 0.34 developed tumorrecurrence or metastasis,whereas only 7 of 30patients with relative expression level less than0.34 developed tumor recurrence(P<0.05).There was no significant difference in therelative expression level of VEGF betweenpatients with postoperative recurrence ormetastasis and those without recurrence.AFPmRNA was detectable in 53.3% of patients withHCC.The sensitivity and specificity of AFPmRNA as a marker to detect hematogenousdissemination of HCC cells was 81.8% and84.4%,respectively.Recombinant human endostatin and polyclonal antibody against VEGFinhibited the growth of transplantable HCC innude mice by 52.2% and 45.7%,respectively.CONCLUSION MMP-9 expression in HCCcorrelates with the postoperative recurrence ormetastasis of HCC.Patients with high level ofMMP-9 expression in HCC are susceptible tometastasis.AFP mRNA could serve as anindicator of hematogenous spreading of HCCcells in circulation and a predictor of recurrenceor metastasis of HCC.Antiangiogenesis may bean adjuvant therapy for HCC. | Jiang YF Yang ZH Hu JQ | 2000 | World Journal of Gastroenterology2000，6，1： | 57 |
| 2 | 医学领域一次研究和二次研究的方法学质量(偏倚风险)评价工具显示文摘方法学质量(偏倚风险)评估是医学研究开始前的重要步骤。因此,准确判断研究类型是前提,选择合适的评价工具也很重要。本综述介绍了用于随机对照试验(包括个体和整群)、动物实验、非随机干预性研究(包括随访研究、有对照组的前后对照研究、前后对照研究、非对照纵向研究、间断时间序列研究)、队列研究、病例-对照研究、横断面研究(包括分析和描述性研究)、观察性病例系列和病例报告、比较效果研究、诊断性研究、卫生经济学评价、预测研究(包括预测变量研究、预测模型影响研究、预后预测模型研究)、质性研究、结果测量工具(包括患者-报告的结果测量发展、内容真实性、结构真实性、内部一致性、跨文化真实性/测量不变性、信度、测量误差、校标真实性、结构真实性假设检验、反应度)、系统评价与Meta分析,以及临床实践指南的方法学质量评价工具。通过本综述,读者可以区分医学研究的类型并选择适当的工具。全面掌握相关知识并多加练习是正确评估方法学质量的基本要求。 | 李柄辉 訾豪 李路遥 王朝阳 任学群 郭毅(译) Ma LL Wang YY Yang ZH | 2021 | 医学新知2021，31，1： | 37 |
| 3 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 4 | Comparison of methods for total community DNA extraction and purification from compost显示文摘 | Yang ZH Xiao Y Zeng GM Xu ZY Liu YS | 2007 | 中国生物学文摘2007，21，8： | 18 |
| 5 | A FINITE-ELEMENT ANALYSIS OF ELECTROMAGNETIC SHEET METAL-EXPANSION PROCESS显示文摘1INTRODUCTIONElectromagneticforming,esentialybeingakindofapplicationofimpulseintensivecurenttechniqueinmetalworking,dealswith... | Huang, SY Chang, ZH Wang, ZR Wang, LF Yang, M | 1998 | 中国有色金属学会会刊:英文版1998，8，3： | 4 |
| 6 | A Facile Procedure for the oxidative Coupling of 2-Naphthol and 2-Naphthalenethiol in Solid State显示文摘The oxidation of 2-naphthol and 2-naphthalenethiol to 1,1’ -bi-2-naphthol and bis-2naphthyl disulfide respectively has been carried out in excellent yields in solid state in the presence of Fe3+-montmorillonite or alumina-supported FeCl3. | Li, TS Zhang, ZH Yang, F Duan, HY Li, BZ Tewari, BB | 1998 | Chinese Chemical Letters1998，9，7： | 2 |
| 7 | A shared antigen among Vibrio species: outer membrane protein-OmpK as a versatile Vibriosis vaccine candidate in Orange-spotted grouper 显示文摘 | Li NQ Yang ZH Bai JJ | 2010 | Fish Shellfish Immunol2010，28，56： | 1 |
| 8 | Phenylbutyric acid protects against spatial memory deficits in a model of repeated electroconvulsive therapy显示文摘 | Yao ZH Kang X Yang L ct al | 2014 | Curr Neurovasc Res2014，11，2： | 1 |
| 9 | Synthesis and structure analysis of kinematic structures of 6-dof parallel robotic mechanisms显示文摘 | Shen H P Yang T L Ma L ZH | 2005 | Mechanism and Machine Theory2005，40，： | 1 |
| 10 | Rapid multimodality registration based on MM-SURF 显示文摘 | ZHAO D YANG Y JI ZH H | 2014 | Neurocomputing2014，131，5： | 1 |
| 11 | Apical tooth germ cellconditioned medium enhances the differentiation of pe- riodontal ligament stem cells into cementum/periodontal lig- ament-like tissues显示文摘 | Yang ZH Zhang X J Dang NN | 2009 | J Periodont Res2009，44，2： | 1 |
| 12 | Homeochronous usage fratruc- tural bone allog rafts with vascularized fibular autografts for biologi- cal repair of massive bone defects in the lower extremities after bone tumor excision显示文摘 | Yang YF Zhang GM Xu ZH | 2010 | Reconstr Microsurg2010，26，： | 1 |
| 13 | 显示文摘 | Li DX Zhang Zh J | 2000 | J Photochem Photobiol A2000，137，23： | 1 |
| 14 | Effect of KAI1 gene on growth and invasion of human hepatocetlular carcinoma MHCC97-H cells显示文摘 | SI SH YANG JM PENG ZH | 2004 | World J Gastroenterol2004，10，14： | 1 |
| 15 | Texture image segmentation based on improve wavelet neural network显示文摘 | FENG D CH YANG ZH X QIAO X J | 2007 | Lecture Notes in computer science2007，，4493： | 1 |
| 16 | Low-dose adaptive sequentialscanfor dual-source CT coronary angiography in patients withhigh heartrate:comparison with retrospective ECG gating显示文摘 | Xu L Yang L Zhaoqi ZH | 2010 | Eur J Radiol2010，76，2： | 1 |
| 17 | Composition and structure of bacterial communities in waste water of aquatic products processing factories显示文摘 | Wang ZH Yang JQ Zhang D J | 2014 | Research Journal of Biotechnology2014，9，2： | 1 |
| 18 | Identification of α-gliadin genes in Dasypyrum in relation to evolution and breeding显示文摘 | LI G R LIU CH ZENG Z X JIA J Q ZHANG T ZHOU J P REN ZH L YANG Z J | 2009 | Euphytica2009，165，： | 1 |
| 19 | BEPAS-a life cycle building Environmental Perofrmance assessment model 显示文摘 | Zhang ZH Wu X Yang XM | 2006 | Building and Environment2006，41，： | 1 |
| 20 | Alkaloids from Cynanchum komarovii with Inhibitory activity against the tobacco masaic virus显示文摘 | An T Y Huang R Q Yang Zh | 2001 | Phytochemistry2001，58，： | 1 |
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