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| 1 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 4 | Prevalence and control of dia-betes in Chinese adults 显示文摘 | Xu Y Wang LM He J | 2013 | J Am Med Assoc2013，310，9： | 1 |
| 5 | Prevalence and control of diabetes in Chinese adults显示文摘 | Xu Y Wang LM He J | 2013 | JAMA2013，310，9： | 1 |
| 6 | The ATM-Chk2 and ATR-Chk1Pathways in DNA damage signaling and cancer显示文摘 | Smith J Tho LM Xu N | 2010 | Adv Cancer Res2010，108，： | 1 |
| 7 | Prevalence and control of diabetes in Chinese adults显示文摘 | XU Y WANG LM HE J | 2013 | JAMA2013，310，9： | 1 |
| 8 | Tripterine inhibits the expression of adhesion molecules in activated endothelial cells显示文摘 | Zhang DH Marconi A Xu LM | 2006 | J Leukoc Biol2006，80，2： | 1 |
| 9 | Intensity modulated radiation therapy after doxorubicin-based chemotherapy for primary mediastinal large B-cell lymphoma显示文摘 | Xu LM Li YX Fang H | 2013 | Int J Radiation Oncol Biol Phys2013，85，： | 1 |
| 10 | Usefulness of diffusion-weighted magnetic resonance imaging in the diagnosis of prostate cancer显示文摘 | Wu LM Xu JR Gu HY | 2012 | Acad Radiol2012，19，： | 1 |
| 11 | Language lateralization and the role of the fusiform gyrus in semantic processing in young children显示文摘 | Balsamo LM Xu B Gaillard WD | | 0，，03： | 1 |
| 12 | Prevalence and control of diabetes in Chinese adults 显示文摘 | Xu Y Wang LM He J | 2013 | JAMA-Joumal of the American Medical Association2013，310，9： | 1 |
| 13 | Effects of MCI -154 on Vascular Reactivity and Its Mechanisms After Hemorrhagic Shock in Rats 显示文摘 | Yang GM Liu LM Xu J | 2006 | Journal of Cardiovascular2006，47，6： | 1 |
| 14 | Protective effects of HGF-MSP chimer(metron factor-1) on liver ischemia-reperfusion injury in rat model显示文摘 | Xue F Zhang JJ Xu LM | | 0，，： | 1 |
| 15 | Phenotypic correction of murine hemophilia A using an iPS cell-based therapy显示文摘 | Xu D Alipio Z Fink LM | 2009 | Proc Natl Acad Sci USA2009，106，3： | 1 |
| 16 | Role for alternative complement pathway in ischemia/reperfusion injury显示文摘 | Stahl GL XU YY HAO LM | 2003 | Am J Pathol2003，162，2： | 1 |
| 17 | Snail represses the splicing regulator epithelial splicing regulatory protein 1 to promote epithelial- mesenchymal transition 显示文摘 | Reinke LM Xu Y Chang C | 2012 | J Biol Chem2012，287，36： | 1 |
| 18 | Risk factors and prognosis of contrast induced nephropathy with renal dysfunction显示文摘 | Xu H Chen LM Li XW et aI | 2005 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao2005，27，2： | 1 |
| 19 | Clinical investigation of related factors of postoperative discitis following surgical treatment显示文摘 | Zhang LG Tong LM Xu YL | 2000 | Zhongguo Jizhu Jishui Zazhi (chin J spinal card)2000，10，1： | 1 |
| 20 | The ATM - Chk2 and ATR - Chkl pathways in DNA damage signaling and cancer显示文摘 | Smith J Tho LM Xu N | 2010 | Adv Cancer Res2010，108，： | 1 |
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