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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 3 | North Qinling Paleozoic granite associations and their variation in space and time: Implications for orogenic processes in the orogens of central China显示文摘Integrated zircon U-Pb dating and whole rock geochemical analyses have been carried out for two typical S-and I-type granitoids in the north Qinling. Zircon dating by SIMS of the Piaochi S-type grani- toids yields an emplacement age of 495±6 Ma. The granitoids show whole-rock εNd(t)=-8.2--8.8, zircon εHf(t)=-6―-39. The Huichizi I-type granitoids have emplacement ages of 421±27 Ma and 434±7 Ma es- tablished by LA-ICP-MS and SIMS methods, respectively. Their whole-rock εNd(t)=-0.9-0.9 and zircon εHf(t)=-11-8.4. Combined with statistical analyses of 28 zircon ages of granitoid plutons collected from the literature, Paleozoic magmatism in the north Qinling can be divided into three stages. The first-stage magmatism (~505-470 Ma) mainly occurred in the east part of the north Qinling and has features of an I-type arc, associated with which are S-type granitoids such as Piaochi pluton. The early granitoids (~505-490 Ma) have close spatio-temporal relations to ultra-high-pressure (UHP) rocks, and thus are interpreted as an oceanic subduction system along a continental margin. The second-stage magmatism (~450-422 Ma) occured through the whole north Qinling, and is characterized by I-type granitoids represented by the Huichizi pluton. The magma is interpreted as partial melting of lower crust mixed by mantle-derived magma in a collisional setting with the uplift of terranes. The third-stage magmatism (~415-400 Ma) is dominated by I-type granitoids and only took place in the middle part of the north Qinling, and is regarded as a late-stage collision. The spatial and temporal variations of the Qinling Paleozoic magmatism reveal protracted subduction/collision. The subduction was initiated from the east part of the north Qinling, earlier than that in the Qilian-northern Qaidam, Kunlun, and northern Dabie regions. This demonstrates variations in time of subduction, accretion and collision of separate blocks or terranes in the orogenic systems in central China. | WANG Tao WANG XiaoXia TIAN Wei ZHANG ChengLi LI WuPing LI Shan | 2009 | Science China Earth Sciences2009，52，9： | 79 |
| 4 | Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial显示文摘 | CUI Li-ying ZHUYi-cheng GAO Shan WANG Jian-ming PENG Bing NI Jun ZHOU Li-xin HE Jia MA Xiu-qiang | 2013 | Chinese Medical Journal2013，，18： | 71 |
| 5 | Opportunities and challenges of the Sponge City construction related to urban water issues in China显示文摘Waterlogging is one of the major water issues in most cities of China and directly restricts their urbanization processes.The construction of Sponge City is an effective approach to solving the urban water issues,particularly for the waterlogging.In this study,both the urban issues emerged at the stage of rapid urbanization in China and the demands as well as problems of Sponge City construction related with the water issues were investigated,and the opportunities and challenges for the Sponge City construction in the future were also proposed.It was found that the current stormwater management focused on the construction of gray infrastructures(e.g.,drainage network and water tank) based on the fast discharge idea,which was costly and hard to catch up with the rapid expansion of city and its impervious surface,while green infrastructures(e.g.,river,lake and wetland)were ignored.Moreover,the current construction of Sponge City was still limited to low impacted development(LID) approach which was concentrated on source control measures without consideration of the critical functions of surrounding landscapes(i.e.,mountain,river,wetland,forest,farmland and lake),while application of the integrated urban water system approach and its supported technologies including municipal engineering,urban hydrology,environmental science,social science and ecoscape were relatively weak and needed to be improved.Besides,the lack of special Sponge City plan and demonstration area was also a considerable problem.In this paper,some perspectives on Good Sponge City Construction were proposed such as the point that idea of urban plan and construction should conform to the integral and systematic view of sustainable urban development.Therefore,both the basic theoretical research and the basic infrastructure construction such as monitoring system,drainage facility and demonstration area should be strengthened,meanwhile,the reformation and innovation in the urban water management system and the education system should also be urgently performed.The study was expected to provide a deeper thinking for the current Sponge City construction in China and to give some of suggestions for the future directions to urban plan and construction,as well as urban hydrology discipline. | XIA Jun ZHANG YongYong XIONG LiHua HE Shan WANG LongFeng YU ZhongBo | 2017 | Science China Earth Sciences2017，60，4： | 65 |
| 6 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 7 | Fecal microbiota transplantation broadening its application beyond intestinal disorders显示文摘Intestinal dysbiosis is now known to be a complication in a myriad of diseases.Fecal microbiota transplantation(FMT),as a microbiota-target therapy,is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases.New insights have raised an interest in FMT for the management of extra-intestinal disorders associated with gut microbiota.This review shows that it is an exciting time in the burgeoning science of FMT application in previously unexpected areas,including metabolic diseases,neuropsychiatric disorders,autoimmune diseases,allergic disorders,and tumors.A randomized controlled trial was conducted on FMT in metabolic syndrome by infusing microbiota from lean donors or from self-collected feces,with the resultant findings showing that the lean donor feces group displayed increased insulin sensitivity,along with increased levels of butyrate-producing intestinal microbiota.Case reports of FMT have also shown favorable outcomes in Parkinson's disease,multiple sclerosis,myoclonus dystonia,chronic fatigue syndrome,and idiopathic thrombocytopenic purpura.FMT is a promising approach in the manipulation of the intestinal microbiota and has potential applications in a variety of extra-intestinal conditions associated with intestinal dysbiosis. | Meng-Que Xu Hai-Long Cao Wei-Qiang Wang Shan Wang Xiao-Cang Cao Fang Yan Bang-Mao Wang | 2015 | World Journal of Gastroenterology2015，21，1： | 63 |
| 8 | Improved quality of life in patients with gastric cancer after esophagogastrostomy reconstruction显示文摘AIM:To compare postoperative quality of life (QOL) in patients with gastric cancer treated by esophagogastrostomy reconstruction after proximal gastrectomy.METHODS: QOL assessments that included functional outcomes (a 24-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) were performed in 149 patients with gastric cancer in the upper third of the stomach, who had received proximal gastrectomy with additional esophagogastrostomy.RESULTS: Fifty-four patients underwent reconstruction by esophagogastric anterior wall end-to-side anastomosis combined with pyloroplasty (EA group); 45 patients had reconstruction by esophagogastric posterior wall end-to-side anastomosis (EP group); and 50 patients had reconstruction by esophagogastric end-to-end anastomosis (EE group). The EA group showed the best postoperative QOL, such as recovery of body weight, less discomfort after meals, and less heart burn or belching at 6 and 24 mo postoperatively. However, the survival rates, surgical results and Spitzer QOL index were similar among the three groups.CONCLUSION: Postoperative QOL was better in the EA than EP or EE group. To improve QOL after proximal gastrectomy for upper third gastric cancer, the EA procedure using a stapler is safe and feasible for esophagogastrostomy. | Hao Zhang Zhe Sun Hui-Mian Xu Ji-Xian Shan Shu-Bao Wang Jun-Qing Chen | 2009 | World Journal of Gastroenterology2009，15，25： | 54 |
| 9 | Plant Terpenoids: Biosynthesis and Ecological Functions显示文摘在植物之中,第二等的代谢物 terpenoids 是在结构上很多样的组;他们直接在植物作为 phytoalex 在里面工作防卫,或作为在包含草食动物和他们的天敌的间接防卫回答的信号。在最近的年里,越来越多的注意对植物 terpenoids 的生态的角色的调查被给予了。单音的萜烯, sesquiterpenes ,和 diterpenes 的 Thebiosynthesis 小径包括 C5precursor isopentenyl diphosphate ( IPP )和它的 allylic 异构体 dimethylallyl diphosphate ( DMAPP )的合成,立即的 diphosphate 先锋的合成,并且多样的 terpenoids.Terpene synthases ( TPS )的形成在不稳定的萜烯合成起一个关键作用。由 TPSgenes 的表示,重要成就在新陈代谢的工程上被做了增加 terpenoidproduction。这评论主要在阐明总结最近的研究进步 terpenoids 的生态的角色和酶的描述在 terpenoid 生合成包含了。terpenoids 新陈代谢的空间、时间的规定也被讨论…… | Ai-Xia Cheng Yong-Gen Lou Ying-Bo Mao Shan Lu Ling-Jian Wang Xiao-Ya Chen | 2007 | Journal of Integrative Plant Biology2007，49，2： | 45 |
| 10 | A novel advanced oxidation process to degrade organic pollutants in wastewater:Microwave-activated persulfate oxidation显示文摘This article,for the first time,provides a novel advanced oxidation process based on sulfate radical(SO4. -) to degrade organic pollutants in wastewater:microwave(MW)-activated persulfate oxidation(APO)with or without active carbon(AC).Azo dye acid Orange 7(AO7)is used as a model compound to investigate the high reactivity of MW-APO.It is found that AO7(up to 1000 mg/L)is completely decolorized within 5-7 min under an 800 W MW furnace assisted-APO.In the presence of chloride ion(up to 0.50 mol/L),the decolorization is still 100%completed,though delayed for about 1-2 min.Experiments are made to examine the enhancement by AC.It is exciting to find that the 100%decolorization of AO7(500 mg/L)is achieved within 3 min by MW-APO using 1.0 g/L AC as catalyst,while the degradation effciency maintains at 50%by MW energy without persulfate after about 5 min.Besides the destruction of visible light chromophore band of AO7(484 nm),during MW-APO,two bands in the ultraviolet region(228 nm and 310 nm)are rapidly broken down.The removal of COD is about 83%-95%for 500 mg/L AO7.SO4. -is identified with quenching studies using specific alcohols.Both SO4. -and.OH could degrade AO7,but SO 4 .-plays the dominant role.In a word,MW-APO AC is a new catalytic combustion technology for destruction of organic contamination even for high concentration. | YANG Shiying WANG Ping YANG Xin WEI Guang ZHANG Wenyi SHAN Liang | 2009 | Journal of Environmental Sciences2009，21，9： | 41 |
| 11 | Characteristics of Obesity and Its Related Disorders in China显示文摘Obesity is a medical condition with excess body fat accumulation to the extent which leads to serious health consequences.Abdominal obesity,also known as central obesity,refers to the presence of excess fat in the abdominal area.Obesity,especially abdominal obesity,contributes to many metabolic disorders including metabolic syndrome (MetS),type 2 diabetes (T2DM) and cardiovascular diseases (CVD).The incidence of obesity has increased dramatically in recent years worldwide.In China,more than one-third of adults are overweight or obese and 10%-20% of all adults are affected by MetS.The pathogenesis underlying the abdominal obesity remains unclear.The ultimate health outcome of obesity and its related metabolic disorders have prompted physicians to take aggressive treatments (lifestyle changes,pharmacological interventions and surgical therapies) before a serious consequence becomes clinically apparent.In this review,we discuss the prevalence,pathogenesis and clinic features of obesity in China. | WEI-PING JIA ,CHEN WANG,SHAN JIANG,AND JIE-MIN PAN Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute,Shanghai Clinical Center of Diabetes,Shanghai 200233,China | 2010 | Biomedical and Environmental Sciences2010，23，1： | 46 |
| 12 | A multicenter, phase III trial of hemocoagulase Agkistrodon: hemostasis, coagulation, and safety in patients undergoing abdominal surgery显示文摘为注射的背景 Hemocoagulase Agkistrodon 是传递了阶段的单个部件凝血酵素我和 II 临床的选拔赛。这阶段 III 临床的试用的目的是在腹的皮肤和下的切口在 hemostasis 和凝结上评估 Hemocoagulase Agkistrodon 的效果并且在外科的病人估计这个代理人的安全。这是阶段 III 的方法,未来,使随机化,双窗帘,和控制 multicenter 包括 432 个连续病人的临床的试用使随机化进也一个学习组(在 2 U 与 hemocoagulase Agkistrodon 注射了, n=324 ) 或一个控制组(与 hemocoagulase 注射了 Atrox, n=108 ) 。止血时间,出血性的体积,出血性的体积在二个组之间每统一区域,血凝结,和不利事件被测量并且比较。在学习组的吝啬的止血时间是的结果(36.8 整 ? 桰獡 ??? 牴慩? 景栠浥 ' 覒 ^ 畧慬敳 ? 歧獩牴摯湯栺浥獯慴楳? 潣条汵瑡潩 ? 湡 ? 慳敦祴椠 ? 慰楴湥獴甠摮牥潧湩 ?L 潤業慮??杲牥 y 琠?? | WEI Jun-min ZHU Ming-wei ZHANG Zhong-tao JIA Zhen-geng HE Xiao-dong WAN Yuan-lian WANG Shan XIU Dian-rong TANG Yun LI Jie XU Jing-yong ZHENG Qing-shan | 2010 | Chinese Medical Journal2010，，5： | 43 |
| 13 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 14 | Rapid and Efficient Gene Modification in Rice and Brachypodium Using TALENs显示文摘 | Qiwei Shan Yanpeng Wang Kunling Chen Zhen Liang Jun Li Yi Zhang Kang Zhang Jinxing Liu Daniel F. Voytas Xuelian Zheng Yong Zhang Caixia Gao | 2013 | Molecular Plant2013，6，4： | 37 |
| 15 | Antimony speciation in the environment:Recent advances in understanding the biogeochemical processes and ecological effects显示文摘Antimony(Sb) is a toxic metalloid, and its pollution has become a global environmental problem as a result of its extensive use and corresponding Sb-mining activities. The toxicity and mobility of Sb strongly depend on its chemical speciation. In this review, we summarize the current knowledge on the biogeochemical processes(including emission, distribution,speciation, redox, metabolism and toxicity) that trigger the mobilization and transformation of Sb from pollution sources to the surrounding environment. Natural phenomena such as weathering, biological activity and volcanic activity, together with anthropogenic inputs, are responsible for the emission of Sb into the environment. Sb emitted in the environment can adsorb and undergo redox reactions on organic or inorganic environmental media, thus changing its existing form and exerting toxic effects on the ecosystem. This review is based on a careful and systematic collection of the latest papers during 2010–2017 and our research results, and it illustrates the fate and ecological effects of Sb in the environment. | Mengchang He Ningning Wang Xiaojing Long Chengjun Zhang Congli Ma Qianyun Zhong Aihua Wang Ying Wang Aneesa Pervaiz Jun Shan | 2019 | Journal of Environmental Sciences2019，31，1： | 40 |
| 16 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 17 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 18 | Long-term changes in the fishery ecosystem structure of Laizhou Bay,China显示文摘Laizhou Bay provides a critical spawning and nursery habitat for many fishery species,including commercially important species,such as Fenneropenaeus chinensis and Larimichthys polyactis.The bay is severely stressed due to high fishing pressure and environmental changes.Based on the long-term ecosystem surveys in Laizhou Bay during the main spawning period(May) of most fishery species from 1959 to 2008,the responses of the Laizhou Bay fishery ecosystem were analyzed here,including regime shifts in species composition,biomass,species diversity,zooplankton,phytoplankton,and environmental variables.The dominant species of large-size and high economic value(e.g.Trichiurus haumela,L.polyactis) have been replaced by the short-lived,low-trophic-level planktivorous pelagic species(e.g.Setipinna taty,Engraulis japonicus) since the 1980s,and it is probable that the small-sized pelagic fishes have been recently replaced by invertebrates(e.g.Oratosquilla oratoria,Crangon affinis).The biomass of fishery resources declined continuously from 423.6 kg haul?1 h?1 in 1959 to 164.6 kg haul?1 h?1 in 1982,37.7 kg haul?1 h?1 in 1993,and less than 8 kg haul?1 h?1 in 1998-2008.Moreover,the biomass of zooplankton showed an increasing trend during 1959-2006,but showed a slight decline in 2008.The abundance of phytoplankton increased from 1959 through 1982,decreased substantially in 1993,and increased again until 2004.More recently,however,the phytoplankton abundance was very low.The sea surface temperature(SST) and sea bottom temperature(SBT) in May increased by 0.23°C a?1 and 0.16°C a?1,respectively,during 1982-2008.The salinity in May showed large fluctuations and reached its lowest values in 2004 and 2006.The ratio of dissolved inorganic nitrogen(DIN) to dissolved inorganic phosphate(DIP) increased.However,the dissolved silicon(DSi):DIP and DSi:DIN ratios decreased to a low level during 1959-2008.These changes seriously impacted primary production,and cascade effects then changed the structure and function of the fishery ecosystem.Further analysis indicated that multiple stresses caused the alterations in the structure of the Laizhou Bay fishery ecosystem.The top-down effect was identified as the main influence on the fishery species(at the top of the food chain) over the past five decades due to the increasing fishing pressure,whereas the bottom-up effect increased over the past three decades due to the strong variations in the environment. | JIN XianShi SHAN XiuJuan LI XianSen WANG Jun CUI Yi ZUO Tao | 2013 | Science China Earth Sciences2013，56，3： | 31 |
| 19 | Non-canonical regulation of SPL transcription factors by a human OTUBl-like deubiquitinase defines a new plant type rice associated with higher grain yield显示文摘完成增加的谷物生产率长是引起节目的谷物的制服的焦点。ideotype 途径被用来在国际瑞斯研究院并且在中国改进米饭收益潜力。然而,在米饭的收益相关的特点的基因基础仍然保持不清楚。这里,我们显示出那一个主要量的特点地点, qNPT1,通过建筑学由更少 tillers 描绘了的一种新植物类型(NPT ) 的决心的行为,更坚定的灰煤杆和更大的圆锥花序,并且它与相同编码 deubiquitinating 酶到人的 OTUB1。OsOTUB1 的 Downregulation 提高 meristematic 活动,导致在谷物产量的减少的 tiller 数字,增加的谷物数字,提高的谷物重量和米饭的作为结果的增加。不同于人的 OTUB1, OsOTUB1 能劈开连接 K48 、连接 K63 的 polyubiquitin。OsOTUB1 与 E2 结合 ubiquitin 蛋白质 OsUBC13 和 squamosa 倡导者绑定交往像蛋白质的抄写因素 OsSPL14。OsOTUB1 和 OsSPL14 分享普通目标基因,和他们的物理相互作用限制 OsSPL14 的连接 K63 的 ubiquitination (K63Ub ) ,它接着支持 OsSPL14 的 K48Ub 依赖的 proteasomal 降级。相反地, OsOTUB1 的 loss-of-function 与 OsSPL14 的高水平的累积被相关,导致 NPT 建筑学。我们也证明 high-yielding npt1 和 dep1-1 等位基因节节上升为增加在当前是可完成的的上面的米饭收益潜力提供新策略。 | Shuansuo Wang Kun Wu Qian Qian Qian Liu Qi Li Yajun Pan Yafeng Ye Xueying Liu Jing Wang Jianqing Zhang Shan Li Yuejin Wu Xiangdong Fu | 2017 | Cell Research2017，27，9： | 33 |
| 20 | Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China显示文摘 | Cao Hailong Qu Rui Zhang Zhihua Kong Xinyue Wang Shan Jiang Kui Wang Bangmao | 2014 | Chinese Medical Journal2014，，7： | 29 |
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