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| 1 | Potential role of strike-slip faults in opening up the South China Sea显示文摘Radiometric dates of key rock units indicate that a remnant Late Mesozoic ocean of the Huatung Basin is still preserved today east of the South China Sea(SCS).We integrate regional geology with a Cretaceous oceanic basement in the vicinity of the Huatung Basin to reconstruct the Huatung Plate east of the Eurasian continent.Results of geophysical investigations,four expeditions of deep-sea drilling and a renaissance of regional geology allow us to propose a hypothesis that the mechanism responsible for the SCS opening was raised from strike-slip fault on the east.The hypothesis suggests that the SCS opening could highly relate to the strike-slip faults inherited from Late Mesozoic structures onshore–offshore the SE Cathaysia Block to develop rhombic-shaped extensional basins en echelon on the thinned Eurasian continental crust in the Early Cenozoic.It was followed by sinistral strike-slip movements along the boundary between the Eurasian Plate and the Huatung Plate driven by oblique subduction of the Huatung Plate to the northwest coupled with slab-pull force by southward subduction of the Proto-SCS to open up the triangle-shaped oceanic East Sub-basin in the Early Oligocene(33/34 Ma).The spreading ridge then propagated southwestward in the step-over segment between the Zhongnan-Lile and the Red River strike-slip fault systems to open the triangle-shaped oceanic Southwest Sub-basin by 23 Ma.The plate boundary fault was subsequently converted into the Manila Trench when the Eocene Sierra Madre arc of the Huatung Plate had moved from the south to its present latitude by the Middle Miocene. | Chi-Yue Huang Pinxian Wang Mengming Yu Chen-Feng You Char-Shine Liu Xixi Zhao Lei Shao Guangfa Zhong Graciano P.Yumul Jr | 2019 | National Science Review2019，6，5： | 16 |
| 2 | Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats显示文摘 | Zhang Jing Guo Xu Shi Yanwei Ma Jing Wang Guangfa | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 3 | Morphology, sedimentary characteristics, and origin of the Dongsha submarine canyon in the northeastern continental slope of the South China Sea显示文摘The Dongsha submarine canyon is a large canyon belonging to a group of canyons on the northeastern South China Sea margin. Investigation of the Dongsha canyon is important for understanding the origin of this canyon group as well as the transport mechanism of sediments on the margin, and the evolution of the Taixinan foreland basin and the associated Taiwan orogenic belt. In this study, the morphology, sedimentary characteristics, and origin of the Dongsha canyon were investigated by integrating high-resolution multi-channel seismic reflection profiles and high-precision multibeam bathymetric data. This is a slope-confined canyon that originates in the upper slope east of the Dongsha Islands, extends downslope in the SEE direction, and finally merges with the South Taiwan Shoal canyon at a water depth of 3000 m. The total length and average width of the canyon are around 190 and 10 km, respectively. Eleven seismic sequence boundaries within the canyon fills were identified and interpreted as incision surfaces of the canyon. In the canyon fills, four types of seismic facies were defined: parallel onlap fill, chaotic fill, mounded divergent facies, and migrated wavy facies. The parallel onlap fill facies is interpreted as alternating coarser turbidites or other gravity-flow deposits and fine hemipelagic sediments filling the canyon valley. The chaotic fill facies is presumed to be debrites and/or basal lag deposits filling the thalwegs. The mounded divergent and migrated wavy seismic facies can be explained as canyon levees consisting mainly of overspilled fine turbidites and sediment waves on the levees or on the canyon-mouth submarine fans. Age correlation between the sequence boundaries and the ODP Site 1144 data suggests that the Dongsha canyon was initiated at approximately 0.9 Ma in the middle Pleistocene. Mapping of the canyon indicates that the canyon originated at the upstream portion of the middle reach of the modern canyon, and has been continuously expanding both upstream and downstream by retrogressive erosion, incision, and deposition of turbidity currents and other gravity transport processes. The ages of the sequence boundaries representing major canyon incision events are in good agreement with those of global sea-level lowstands, indicating that sea-level changes may have played an important role in the canyon's development. The Dongsha canyon developed in a region with an active tectonic background characterized by the Taiwan uplifting and the development of the Taixinan foreland basin. However, no evidence suggests that the canyon formation is directly associated with local or regional faulting and magmatic activities. Turbidity currents and other gravity transport processes(including submarine slides and slumps) may have had an important influence on the formation and evolution of the canyon. | YIN ShaoRu WANG LiaoLiang GUO YiQun ZHONG GuangFa | 2015 | Science China Earth Sciences2015，58，6： | 6 |
| 4 | Recombinant osteopontin attenuates hyperoxia-induced acute lung injury through inhibiting nuclear factor kappa B and matrix metalloproteinases 2 and 9显示文摘 | Zhang Xiangfeng Liu Fen Zhu Guangfa Wang Zengzhi | 2014 | Chinese Medical Journal2014，，23： | 4 |
| 5 | Hydrothermal synthesis of blue-emitting YPO4:Yb3+ nanophosphor显示文摘 | Guangfa WANG Linhui GAO Hongliang ZHU Weijie ZHOU | 2016 | Frontiers of Materials Science2016，10，2： | 1 |
| 6 | Characteristics and occurrence of submarine canyon- associated landslides in the middle of the northern continental slope, South China Sea显示文摘 | He Ye Zhong Guangfa Wang Liaoliang | 2014 | Marine and Petroleum Geology2014，57，： | 1 |
| 7 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 8 | Convenient synthesis of an N-glycan octasaccharide of the bisecting type显示文摘 | WANG Guangfa ZHANG Wei LU Zhichao | | 0，，： | 1 |
| 9 | HHT based cardiopulmonary coupling analysis for sleep apnea detection显示文摘 | Dongdong Liu Xiaochen Yang Guangfa Wang Jing Ma Yanhui Liu Chung-Kang Peng Jue Zhang Jing Fang | 2012 | Sleep Medicine2012，，5： | 1 |
| 10 | Optimization of microwave-assisted extraction of active components from Yuanhu Zhitong prescription 显示文摘 | Liao Zhenggen Wang Guangfa Liang Xinli | 2008 | Separation and Purification Technology2008，63，2： | 1 |
| 11 | A family of oligo(p-phenylenevinylene)derivative aggregation-induced emission probes:Ultrasensitive,rapid,and anti-interfering fluorescent sensing of perchlorate via precise alkyl chain length modulation显示文摘The precise regulation of interactions provided by aggregation-induced emission(AIE)probes is of considerable significance for improving the sensing performance in the field of on-site detection.Here,a highly sensitive perchlorate detection probe was designed by precisely modulating the van der Waals interactions by adjusting the length of the alkyl chain.The optimized AIE probe demonstrated superior perchlorate detection performance owing to its strong van der Waals interactions with perchlorate,including a low detection limit(53.81 nM),rapid response(<5 s),and excellent specificity even in the presence of 16 interfering anions.In addition,a hydrogel-based device loaded with the probe was constructed to achieve ultrasensitive recognition of perchlorate particles with a detection limit as low as 15 fg under a fluorescence microscope.Moreover,the practicality of the probe was further verified by employing a sensing chip in a portable detector,and thus the probe has been proven to be highly promising for trace perchlorate monitoring in real scenarios.We expect the present study to be of great value for the efficient design of high-performance fluorescent probes. | Fangfang Xiao Yushu Li Jiguang Li Da Lei Guangfa Wang Tianshi Zhang Xiaoyun Hu Xincun Dou | 2023 | Aggregate2023，4，2： | 0 |
| 12 | Study on Seawater Intrusion in Kiaochow Bay Region显示文摘General situation of the seawater intrusion in Kiaochow Bay region was analyzed.Current status of the seawater intrusion and its formation mechanism,influence factor and hazard in Kiaochow Bay region were summarized.Finally,against seawater intrusion situation in the region,a series of practical prevention and control countermeasures were proposed. | Xin Guo Jianwei Zhang Ying Xu Hao Xu Guangfa Ding Zijian Wang Xueying Ma | 2013 | Meteorological and Environmental Research2013，4，1： | 0 |
| 13 | THE STRATEGY OF RESOURCE MANAGEMENT BASED ON GRID COMPUTING显示文摘This paper analyzes the defaults of traditional method according to the resource management method of grid computing based on virtual organization. It supports the concept to ameliorate the resource management with mobile agent and gives the ameliorated resource management model. Also pointed out is the methodology of ameliorating resource management and the way to realize in reality. | Wang Ruchuan Han Guangfa Wang Haiyan | 2006 | Journal of Electronics(China)2006，23，4： | 0 |
| 14 | Inhibition of central Na+/H+ exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats显示文摘 | Wang Qimin Zhou Rong Zhang Cheng Dong Hui Ma Jing Wang Guangfa | 2014 | Chinese Medical Journal2014，，1： | 0 |
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