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| 1 | Locking plate fixation combined with iliac crest bone autologous graft for proximal humerus comminuted fracture显示文摘 | Zhu Lian Liu Yueju Yang Zongyou Li Han Wang Juan Zhao Changping Chen Xiao Zhang Yingze | 2014 | Chinese Medical Journal2014，，9： | 40 |
| 2 | Analysis of the Fungal Community in Apple Replanted Soil Around Bohai Gulf显示文摘Apple replant disease(ARD) is a frequently occurring plant disease in replanted orchards around Bohai Gulf, which causes growth inhibition and even death of plants. The aim of this study was to investigate the etiology of ARD around Bohai Gulf. In this study, the primary growth inhibition of apple seedlings was evaluated in ten replanted soils, sampled around Bohai Gulf. A fungal clone library was used to identify changes in the structure and composition of the soil fungal community. The results revealed that the Simpson diversity indices of Laizhou and Pulandian orchards were higher than others, presenting severe ARD. Ascomycota dominated around Bohai Gulf at the phyla level. Fusarium and Saccharomyces were abundant in all replanted soils. In addition, correlations between the relative abundance of fungal genera in soils and the severity of ARD were analyzed. The results showed that Fusarium was correlated positively with the severity of ARD, but Mortierella was negatively correlated. Furthermore, the quantitative PCR of Fusarium oxysporum, which was regarded as a factor of ARD, was performed. Overall, this study demonstrated that ARD was strongly associated with an unbalanced microbial ecosystem with more pathogenic fungi, while Fusarium in the apple replanted soil was the key factor for ARD around Bohai Gulf. | WANG Gongshuai YIN Chengmiao PAN Fengbing WANG Xiaobao XIANG Li WANG Yanfang WANG Jinzheng TIAN Changping CHEN Jie MAO Zhiquan | 2018 | Horticultural Plant Journal2018，4，5： | 21 |
| 3 | Relationship between structure and function of JWA in the modulation of cell differentiation显示文摘To elucidate the structure characteristic, regulation of expression and the potential function of JWA——anovel rctinoic acid responsible and cytoskeleton associate gene, a rat JWA homologue gene and a 621-bp JWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR), JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter of JWA at -437 to -443 bp; rat JWA homologue gene showed that there are four nucleotides different from human JWA within coding region. After treatment with TPA, an uneven pattern of JWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in | XIA Wei ZHOU Jianwei CAO Haixia ZOU Changping WANG Chengya SHEN Qun LU Hua | 2001 | Chinese Science Bulletin2001，46，24： | 11 |
| 4 | High-voltage Ride Through Strategy for DFIG Considering Converter Blocking of HVDC System显示文摘This paper presents a P-Q coordination based highvoltage ride through(HVRT) control strategy for doubly fed induction generators(DFIGs) based on a combined Q-V control and P-V de-loading control. The active/reactive power injection effect of DFIG on transient overvoltage is firstly analyzed and the reactive power capacity evaluation of DFIG considering its de-loading operation is then conducted. In the proposed strategy, the reactive power limit of DFIG can be flexibly extended during the transient process in coordination with its active power adjustment. As a result, the transient overvoltage caused by DC bipolar block can be effectively suppressed. Moreover, key outer loop parameters such as Q-V control coefficient and deloading coefficient can be determined based on the voltage level of point of common coupling(PCC) and the available power capacity of DFIG. Finally, case studies based on MATLAB/Simulink simulation are used to verify the effectiveness of the proposed control strategy. | Changping Zhou Zhen Wang Ping Ju Deqiang Gan | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 5 | Classification of hypersurfaces with constant Laguerre eigenvalues in R^n显示文摘Let x:M → Rn be an umbilical free hypersurface with non-zero principal curvatures.Then x is associated with a Laguerre metric g,a Laguerre tensor L,a Laguerre form C,and a Laguerre second fundamental form B,which are invariants of x under Laguerre transformation group.An eigenvalue of Laguerre tensor L of x is called a Laguerre eigenvalue of x.In this paper,we classify all oriented hypersurfaces with constant Laguerre eigenvalues and vanishing Laguerre form. | LI TongZhu LI HaiZhong WANG ChangPing | 2011 | Science China Mathematics2011，54，6： | 10 |
| 6 | Detrital Zircon Geochronology of the Radial Sand Ridge System of Jiangsu Coast, East China: Implication for Sediment Provenance显示文摘The radial sand ridge system(RSRS) located at Jiangsu coast of China attracts much attention on its origin and mechanic of formation for its special structure and potential land resource. Due to complicated hydrodynamic condition, the Jiangsu RSRS is a hot debated on its potential sources, Yangtze River or Yellow River? We collected ten sand samples from surface sediments along the west coast of Bohai Sea and Yellow Sea from the modern Yellow River estuary to Yangtze River estuary in summer, 2013. The samples are analyzed by method of detrital zircon age for source identification of the RSRS sediments. The U-Pb age spectra of detrital zircon grains of the samples show a wide range from Cenozoic to Late Archean with several age peaks. Comparing the age spectra between the Yangtze River and the Yellow River, the detrital zircons have younger age(<100 Ma) group in the Yangtze River. These age distribution of the Jiangsu coastal RSRS sediments are similar to that of the Yangtze River, but different from the Yellow River. The samples located adjacent to the old Yellow River Delta show more wide-range age distribution, implying a compounded origination from the both rivers. Based on these findings it is proposed that, contrary to common opinion, the main sediment source of the Jiangsu RSRS is the Yangtze River, rather than the Yellow River. By implication, there should be evidence of hydrodynamic mechanics of oceanic currents and tidal motion. This aspect awaits confirmation in future research. | Jinbao Su Wenbo Rao Yigang Wang Changping Mao | 2018 | Journal of Earth Science2018，29，1： | 6 |
| 7 | SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza显示文摘MYB transcription factors play vital roles in plant growth and metabolism.The phytohormone methyl jasmonate(MeJA)promotes phenolic acid accumulation in the medicinal herb Salvia miltiorrhiza,but the regulatory mechanism is poorly understood.Here,we identified the MeJA-responsive R2R3-MYB transcription factor gene 5mMYB2 from a transcriptome library produced from MeJAtreated S.mi'/horr/ifza hairy roots.Sm/VIYB2 expression was tightly correlated with the expression of key salvianolic acid biosynthetic genes including CYP^8Ai^.5mMYB2 was highly expressed in the periderm of S.miltiorrhiza and SmMYB2 localized to the nucleus.Overexpressing Sml\AYB2 in S.miltiorrhiza hairy roots significantly increased the levels of salvianolic acids(including rosmarinic acid and salvianolic acid B)by upregulating salvianolic acid biosynthetic genes such as CYP98A14.SmMYB2 binds to the MYB-binding motifs in the promoter of CYP98A14,as confirmed by a dual-luciferase assay and electrophoretic mobility shift assays.Anthocyanin contents were significantly higher in Sm/ViyB2-overexpressing hairy root lines than the control,primarily due to the increased expression of CHI,DFR,and ANS.These findings reveal the novel regulatory role of SmMYB2 in MeJA-mediated phenolic acid biosynthesis,providing a useful target gene for metabolic engineering and shedding light on the salvianolic acid regulatory network. | Changping Deng Yao Wang Fenfen Huang Sunjie Lu Limei Zhao Xingyuan Ma Guoyin Kai | 2020 | Journal of Integrative Plant Biology2020，62，11： | 6 |
| 8 | Conformal CMC-Surfaces in Lorentzian Space Forms显示文摘让 Q^3 是 Lorentzianspace 形式 R_1~3, S_1~3 和 H_1~3 的普通保角的 compactification 空间。我们在 Q^3.It 学习像空间的表面的保角的几何学被看在 Q^3 的保角的 CMC 表面必须是的那个任何东西正式等价于一个常数的反对在 R_1~3, S_1~3 或 H_1~3 的平均数弯曲表面。我们也看那是否 x: M → Q^3 是 g 其保角的度量标准有经常的弯曲 K 的 space-likeWillmore 表面,然后任何一个 K = -1 和 isconformally 等价于在 R_1~3 的最小的表面的 x ,或 K = 0 并且 x 正式是反对等价于表面 H^1 (1/( 2 ^( 1/2 )))在 H_1~3 的 x H^1 (1/( 2 ^( 1/2 )))。 | Changxiong NIE Xiang MA Changping WANG | 2007 | Chinese Annals of Mathematics,Series B2007，28，3： | 4 |
| 9 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 10 | N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA显示文摘Background:N-acetyltransferase 10(NAT10)is the only enzyme known tomediate the N4-acetylcytidine(ac4C)modification of mRNA and is crucial formRNA stability and translation efficiency.However,its role in cancer development and prognosis has not yet been explored.This study aimed to examine the possible role of NAT10 in colon cancer.Methods:The expression levels ofNAT10were evaluated by immunohistochemical analyses with a colon cancer tissue microarray,and its prognostic value in patients was further analyzed.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blotting were performed to analyze NAT10 expression in harvested colon cancer tissues and cell lines.Stable NAT10-knockdown and NAT10-overexpressing colon cancer cell lines were constructed using lentivirus.The biological functions of NAT10 in colon cancer cell lines were analyzed in vitro by Cell Counting Kit-8(CCK-8),wound healing,Transwell,cell cycle,and ferroptosis assays.Xenograft models were used to analyze the effect of NAT10 on the tumorigenesis and metastasis of colon cancer cells in vivo.Dot blotting,acetylated RNA immunoprecipitation-qPCR,and RNA stability analyses were performed to explore the mechanism by which NAT10 functions in colon cancer progression.Results:NAT10 was upregulated in colon cancer tissues and various colon cancer cell lines.This increased NAT10 expression was associated with shorter patient survival.Knockdown of NAT10 in two colon cancer cell lines(HT-29 and LoVo)impaired the proliferation,migration,invasion,tumor formation and metastasis of these cells,whereas overexpression of NAT10 promoted these abilities.Further analysis revealed that NAT10 exerted a strong effect on the mRNA stability and expression of ferroptosis suppressor protein 1(FSP1)in HT-29 and LoVo cells.In these cells,FSP1 mRNA was found to be modified by ac4C acetylation,and this epigenetic modification was associated with the inhibition of ferroptosis.Conclusions:Our study revealed that NAT10 plays a critical role in colon cancer development by affecting FSP1 mRNA stability and ferroptosis,suggesting that NAT10 could be a novel prognostic and therapeutic target in colon cancer. | Xiao Zheng Qi Wang You Zhou Dachuan Zhang Yiting Geng Wenwei Hu Changping Wu Yufang Shi Jingting Jiang | 2022 | Cancer Communications2022，42，12： | 3 |
| 11 | Water permeability in MXene membranes: Process matters显示文摘Recent studies have shown impressive transport behaviors of water and ions within lamellar MXene membranes,which endows great promise in developing advanced separation application based high performance MXene membranes.However,most of the researches focused on modification of MXene nanoflakes and optimizing interlayer distance,leaving the impact of membrane fabrication process marginal.In this work,we studied the water flux of membranes made by vacuum filtration using delaminated MXene nanoflakes as the building-blocks.Our results show that the water permeability is extremely sensitive to the process,especially at the drying process,loading and deposit rate of nanoflakes(the feeding concentration).We find that the voids from less ordered stack rather than in-plane defects and interlayer galleries contribute to the large water permeability.The voids can be effectively avoided via deposition of MXene nanoflakes at a slow rate.Manipulating the stack of MXene nanoflakes during vacuum filtration and drying are critical for development of MXene membranes with desired performance for water permeation. | Hang Zhou Yuwei Wang Fuqiang Wang Hao Deng Yongchen Song Changping Li Zheng Ling | 2020 | Chinese Chemical Letters2020，31，6： | 3 |
| 12 | The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza显示文摘Water-soluble phenolic acids are major bioactive compounds in the medicinal plant species Salvia miltiorrhiza.Phenolic acid biosynthesis is induced by methyl jasmonate(MeJA)in this important Chinese herb.Here,we investigated the mechanism underlying this induction by analyzing a transcriptome library of S.miltiorrhiza in response to MeJA.Global transcriptome analysis identified the MeJA-responsive R2R3-MYB transcription factor-encoding gene SmMYB1.Overexpressing SmMYB1 significantly promoted phenolic acid accumulation and upregulated the expression of genes encoding key enzymes in the phenolic acid biosynthesis pathway,including cytochrome P450-dependent monooxygenase(CYP98A14).Dual-luciferase(dual-LUC)assays and/or an electrophoretic mobility shift assays(EMSAs)indicated that SmMYB1 activated the expression of CYP98A14,as well as the expression of genes encoding anthocyanin biosynthesis pathway enzymes,including chalcone isomerase(CHI)and anthocyanidin synthase(ANS).In addition,SmMYB1 was shown to interact with SmMYC2 to additively promote CYP98A14 expression compared to the action of SmMYB1 alone.Taken together,these results demonstrate that SmMYB1 is an activator that improves the accumulation of phenolic acids and anthocyanins in S.miltiorrhiza.These findings lay the foundation for in-depth studies of the molecular mechanism underlying MeJA-mediated phenolic acid biosynthesis and for the metabolic engineering of bioactive ingredients in S.miltiorrhiza. | Wei Zhou Min Shi Changping Deng Sunjie Lu Fenfen Huang Yao Wang Guoyin Kai | 2021 | Horticulture Research2021，8，1： | 3 |
| 13 | Horizontal and vertical gene transfer drive sediment antibiotic resistome in an urban lagoon system显示文摘Rapid urbanization has resulted in pervasive occurrence of antibiotic resistance genes(ARGs)in urban aquatic ecosystems.However,limited information is available concerning the ARG profiles and the forces responsible for their assembly in urban landscape lagoon systems.Here,we employed high-throughput quantitative PCR(HT-q PCR)to characterize the spatial variations of ARGs in surface and core sediments of Yundang Lagoon,China.The results indicated that the average richness and absolute abundance of ARGs were 11 and 53 times higher in the lagoon sediments as compared to pristine reference Tibetan lake sediments,highlighting the role of anthropogenic activities in ARG pollution.Co-occurrence network analysis indicated that various anaerobic prokaryotic genera belonging to Alpha-,Deltaproteobacteria,Bacteroidetes,Euryarchaeota,Firmicutes and Synergistetes were the potential hosts of ARGs.The partial least squares-path modeling(PLS-PM)analysis revealed positive and negative indirect effects of physicochemical factors and heavy metals on the lagoon ARG profiles,via biotic factors,respectively.The horizontal(mediated by mobile genetic elements)and vertical(mediated by prokaryotic communities)gene transfer may directly contribute the most to drive the abundance and composition of ARGs,respectively.Furthermore,the neutral community model demonstrated that the assembly of sediment ARG communities was jointly governed by deterministic and stochastic processes.Overall,this study provides novel insights into the diversity and distribution of ARGs in the benthic habitat of urban lagoon systems and underlying mechanisms for the spread and proliferation of ARGs. | Hongjie Wang Liyuan Hou Yongqin Liu Keshao Liu Lanping Zhang Fuyi Huang Lin Wang Azhar Rashid Anyi Hu Changping Yu | 2021 | Journal of Environmental Sciences2021，33，4： | 2 |
| 14 | Time-like Willmore surfaces in Lorentzian 3-space显示文摘Let R13 be the Lorentzian 3-space with inner product (,). Let Q3 be the conformal compactification of R13, obtained by attaching a light-cone C∞ to R13 in infinity.Then Q3 has a standard conformal Lorentzian structure with the conformal transformation group O(3, 2)/{±1}. In this paper, we study local conformal invariants of time-like surfaces in Q3 and dual theorem for Willmore surfaces in Q3. Let M ( ) R13 be a time-like surface.Let n be the unit normal andHthe mean curvature of the surface M. For any p ∈ M we define S12(p) = {X ∈ R13 | (X - c(p),X - c(p)) = 1/H(p)2} with c(p) = p + 1/H(p)n(p) ∈ R13.Then S12(p) is a one-sheet-hyperboloid in R13, which has the same tangent plane and mean curvature as M at the point p. We show that the family {S12(p),p ∈ M} of hyperboloid in R13defines in general two different enveloping surfaces, one is M itself, another is denoted by (M) (may be degenerate), and called the associated surface of M. We show that (i) if (M) is a time-like Willmore surface in Q3 with non-degenerate associated surface (M), then (M) is also a time-like Willmore surface in Q3 satisfying (M)= M; (ii) if M is a single point, then M is conformally equivalent to a minimal surface in R13. | DENG Yanjuan WANG Changping | 2006 | Science China Mathematics2006，49，1： | 2 |
| 15 | Time-Like Conformal Homogeneous Hypersurfaces with Three Distinct Principal Curvatures显示文摘A hypersurface x(M)in Lorentzian space R41 is called conformal homogeneous,if for any two points p,q on M,there exists,a conformal transformation of R41,such that(x(M))=x(M),(x(p))=x(q).In this paper,the authors give a complete classifica-tion for regular time-like conformal homogeneous hypersurfaces in R41 with three distinct principal curvatures. | Yanbin LIN Ying LU Changping WANG | 2020 | Chinese Annals of Mathematics,Series B2020，41，5： | 2 |
| 16 | Moebius geometry of submanifolds in ? n显示文摘 | Changping Wang | 1998 | manuscripta mathematica1998，，4： | 1 |
| 17 | (g,f)-Factors in Graphs显示文摘 | | 1998 | J of Math (PRC)1998，18，： | 1 |
| 18 | Totally real minimal 2-spheres in quaternionic projective space显示文摘Let HPn be the quaternionic projective space with constant quaternionic sectional curvature 4. Then locally there exists a tripe {I, J,K} of complex structures on HPn satisfying IJ = -JI = K, JK = -KJ = I, KI = -IK = J. A surface M HPn is called totally real, if at each point p ∈ M the tangent plane TpM is perpendicular to I(TpM),J(TpM) and K(TpM). It is known that any surface M RPn HPn is totally real, where RPn HPn is the standard embedding of real projective space in HPn induced by the inclusion R in H, and that there are totally real surfaces in HPn which don't come from this way. In this paper we show that any totally real minimal 2-sphere in HPn is isometric to a full minimal 2-sphere in RP2m RPn HPn with 2m ≤ n. As a consequence we show that the Veronese sequences in RP2m (m ≥ 1) are the only totally real minimal 2-spheres with constant curvature in the quaternionic projective space. | HE Yijun WANG Changping | 2005 | Science China Mathematics2005，48，3： | 1 |
| 19 | Geochemical constraints on the provenance of surfacesediments of radial sand ridges off the Jiangsu CoastalZone,East China显示文摘 | RAO Wenbo MAO Changping WANG Yigang | 2015 | Marine Geology2015，359，： | 1 |
| 20 | Positive solution of fourth order ordinary differential equation with four point boundary value problem显示文摘 | Chen Shihua Ni Wei Wang Changping | 2006 | Appl Math Lett2006，19，： | 1 |
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