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| 1 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 2 | A Precise Sensor for SF_6 Based on Piezoelectric Ultrasound显示文摘Based on piezoelectric ultrasound technology,the paper theoretically analyses the determination of gas concentration and presents a norm-contrast method,which is realized by high-speed chip CPLD (Complex programmable logic device),to determine the concentration of SF_6 accurately with air as background.It is proved that this sensor can determine the concentration of SF_6 with the precision of 50μg/g.The sensor is in the process of producing. | Changping Zhu Minglei Shan Hongping Zhang Xiaohua Zhang Peng Zhen Yuanyun Tao | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 3 | Study on Enhancement Effect of Cavitation Caused by HIFU Piezoelectricity Transducer显示文摘An orthogonal ultrasonic irradiation system consisting of HIFU with frequency at 1.05 MHz combined with ultrasound with frequency at 28 kHz was applied in this paper.Effect of cavitation was detected by pH-value measurement and conductance measurement.The result shows that the effect of cavitation caused by ultrasound with frequency at 28 kHz is greatly enhanced by HIFU piezoelectricity transducer with frequency at 1.05 MHz. | Xinnan Fan Changping Zhu Shichuan He Minglei Shan Jiacai Chen | 2006 | 稀有金属材料与工程2006，35，A03： | 0 |
| 4 | Interface wave propagation characteristics of liquid-immersed porous cylinder显示文摘 | HAN Qingbang XU Zhouchen TONG Ziwei QI Lihua WANG Peng SHAN Minglei ZHU Changping | 2018 | Chinese Journal of Acoustics2018，37，2： | 0 |
| 5 | Parentage determination of black sea bream(Acanthopagrus schlegelii)for stock enhancement:effectiveness and loss of genetic variation显示文摘The stock enhancement programs for black sea bream Acanthopagrus schlegelii have been conducted in China for a fewyears.However,little information has been reported concerning the effectiveness and genetic effect of black sea bream stock enhancement.In order to detect the contribution of released individuals in Zhujiang River Estuary(ZRE)and Daya Bay(DB),six microsatellite markers were used to identify the hatchery-released individuals.In addition,this pedigree of hatchery populations(broodfish and hatchery-released offspring)was traced to detect the number of effective parents(N_(e)),the inbreeding coefficient and the decrease of genetic variability in the reproduction.The pedigree reconstruction showed that at least 69(out of 93)broodfish had offspring.The estimated N_(e) was 54.8,consequently the inbreeding coefficient was 0.91%.The genetic diversity of hatchery-released offspring was lower than that in that of broodfish(heterozygosity alleles,0.727-0.774),some alleles(number of alleles,61-69)and genetic variance were lost during reproduction.It was observed that wild samples had higher levels of genetic diversity compared with hatchery populations as well as recaptured samples in releasing area.A total of 128 hatchery-released black sea bream were identified among 487 recaptured samples in ZRE,while a total of 15 samples were identified among 96 samples in DB.In summary,there was a high survival of released fish.N_(e)vertheless,the results provided evidence to consider a loss of genetic variation in hatcheryreleased stock and a negative genetic effect of the stock enhancement. | Binbin Shan Yan Liu Na Song Changping Yang Shengnan Liu Tianxiang Gao Dianrong Sun | 2021 | Acta Oceanologica Sinica2021，40，6： | 0 |
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