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| 1 | 3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare显示文摘In the last fewyears,3D printing has emerged as a promising alternative for the fabrication ofmicrofluidic devices,overcoming some of the limitations associated with conventional soft-lithography.Stereolithography(SLA),extrusion-based technology,and inkjet 3D printing are three of the widely used 3D printing technologies owing to their accessibility and affordability.Microfluidic devices can be 3D printed by employing a manufacturing approach from four fundamental manufacturing approaches classified as(1)direct printing approach,(2)mold-based approach,(3)modular approach,and(4)hybrid approach.To evaluate the feasibility of 3D printing technologies for fabricating microfluidic devices,a review focused on 3D printing fundamental manufacturing approaches has been presented.Using a broad spectrum of additive manufacturing materials,3D printed microfluidic devices have been implemented in various fields,including biological,chemical,and material synthesis.However,some crucial challenges are associated with the same,including low resolution,low optical transparency,cytotoxicity,high surface roughness,autofluorescence,non-compatibility with conventional sterilization methods,and low gas permeability.The recent research progress in materials related to additive manufacturing has aided in overcoming some of these challenges.Lastly,we outline possible implications of 3D printed microfluidics on the various fields of healthcare such as in vitro disease modeling and organ modeling,novel drug development,personalized treatment for cancer,and cancer drug screening by discussing the current state and future outlook of 3D printed‘organs-on-chips,’and 3D printed‘tumor-on-chips.’We conclude the review by highlighting future research directions in this field. | Viraj Mehta Subha N.Rath | 2021 | Bio-Design and Manufacturing2021，4，2： | 6 |
| 2 | Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B显示文摘AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed.Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection criteria.Range of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 fibrosis.In total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow up.Predictors of CVS included lower baseline DNA level(P=0.001),hepatitis B virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting.Resistance and rebound rates are very low.This is similar to data from controlled and uncontrolled trials around the world. | Farzan Fahrtash-Bahin Viraj C Kariyawasam Timothy Gray Karen Byth Jacob George Mark W Douglas | 2013 | World Journal of Gastroenterology2013，19，5： | 5 |
| 3 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 4 | Minimally Invasive Endovascular Techniques to Treat Acute Renal Hemorrhage显示文摘 | Benjamin N. Breyer Jack W. McAninch Sean P. Elliott Viraj A. Master | 2008 | The Journal of Urology2008，，6： | 2 |
| 5 | A novel preoperative inflammatory marker prognostic score in patients with localized and metastatic renal cell carcinoma显示文摘Objective:Several inflammatory markers have been studied as potential biomarkers in renal cell carcinoma(RCC),however few reports have analyzed their prognostic value in aggregate and in non-clear cell histologies.We hypothesize that a combination of specific inflammatory markers into an RCC Inflammatory Score(RISK)could serve as a rigorous prognostic indicator of overall survival(OS)in patients with clear cell and non-clear cell RCC.Methods:Combination of preoperative C-reactive protein(CRP),albumin,erythrocyte sedimentation rate(ESR),corrected calcium,and aspartate transaminase to alanine transaminase(AST/ALT)ratio was used to develop RISK.RISK was developed using grid-search methodology,receiver-operating-characteristic(ROC)analysis,and sensitivity-specificity trade-off analysis.Prognostic value of RISK was analyzed using the KaplaneMeier method and Cox proportional regression models.Predictive accuracy was compared with RISK to Size,Size,Grade,and Necrosis(SSIGN)score,University of California-LOS Angeles(UCLA)Integrated Staging System(UISS),and Leibovich Prognosis Score(LPS). | Rishi R.Sekar Dattatraya Patil Yoram Baum Jeffrey Pearl Anna Bausum Mehmet A.Bilen Omer Kucuk Wayne B.Harris Bradley C.Carthon Mehrdad Alemozaffar Christopher P.Filson John G.Pattaras Peter T.Nieh Kenneth Ogan Viraj A.Master | 2017 | Asian Journal of Urology2017，4，4： | 2 |
| 6 | Potential of biochar and organic amendments for reclamation of coastal acidic-salt affected soil显示文摘Salinity and acidity have affected several hundred million hectares of land throughout the globe which poses a major threat to global food security and biodiversity.Application of organic amendments for salt-affected soils has been identified as one of the most effective ways to mitigate salinity-induced problems and considered as a green technique offering twin benefits of waste load reduction and land reclamation.However,studies on reclaiming acidic-salt affected soils are limited.Therefore,this study aimed to determine the reclamation potential of biochars and organic amendments involving Gliricidia sepium biochar produced at 300℃,500℃,and 700℃,green waste compost,and municipal sewage sludge at three different amend-ment ratios,1.0%,2.5%and 5.0%.The incubation experiment was conducted for a 4-month period with different amendment ratios applied to the coastal acidic-salt affected soil.Subsamples were extracted from incubation pots after 1 and 4 months and analyzed for soil chemical parameters(pH,EC,NO_(3)^(−),PO_(4)^(3−,total organic carbon,cation exchange capacity,sodium adsorption ratio,exchangeable sodium percentage)and microbial enzyme activity(catalase activity,and acid-and alkaline phosphatase activity).All organic amendments demonstrated enhancement of the soil properties in a significant manner.However,increasing incubation time and amendment ratio increase the changes of soil parameters by a great percentage.Therefore,the maximum amendment ratio of 5.0%and 4 months of incubation period rendered a significant improvement in the reclamation of acidic-salt affected soil.However,the biochar produced at 500℃ contributed the maximum towards the improved physicochemical and biochemical profile of acidic-salt affected soil,making it the most promising organic amend-ment for the reclamation of acidic-salt affected soil.The overall reclamation efficiency of organic amendments registered the following order of variation:700 BC | Viraj Gunarathne Athula Senadeera Udaya Gunarathne Jayanta Kumar Biswas Yaser A.Almaroai Meththika Vithanage | 2020 | Biochar2020，2，1： | 2 |
| 7 | Soft thermal nanoimprint lithography using a nanocomposite mold显示文摘 | Viraj Bhingardive Liran Menahem Mark Schvartzman | 2018 | Nano Research2018，11，5： | 2 |
| 8 | Comparison of posterior capsule opacification with hydrophobic acrylic and hydrophilic acrylic intraocular lenses显示文摘 | Abhay R. Vasavada Shetal M. Raj Alpesh Shah Gauri Shah Viraj Vasavada Vaishali Vasavada | 2011 | Journal of Cataract & Refractive Surgery2011，，6： | 2 |
| 9 | Influence of substrate C/N ratio on the structure of multi-species biofilms consisting of nitrifiers and heterotrophs 显示文摘 | Ohashi A Viraj de Silva D G Mobarry B | 1995 | Water Science and Technology1995，32，8： | 1 |
| 10 | Treatment and outcome of invasive bladder cancer in patients after renal transplantation 显示文摘 | Viraj AM Maxwell VM Gary DG | 2004 | J Urol2004，171，3： | 1 |
| 11 | Dis- covery of the poly (ADP-ribose) polymerase (PARP) inhibitor 2--1H-benz- imidazole-4-carboxamide(ABT-888) for the treatment of cancer显示文摘 | PENNING T D GUI-DONG Z VIRAJ B | 2009 | J Med Chem2009，52，2： | 1 |
| 12 | Intracranial pressure monitor in patients with traumatic brain injury 显示文摘 | ANDREW T VIRAJ P VERNARD F | 2015 | J Surg Res2015，194，2： | 1 |
| 13 | Ultrasonic pulse attenuation as a measure of damage growth during cyclic loading of concrete显示文摘 | Viraj Fernando | 1987 | ACI Materials Journal1987，84，3： | 1 |
| 14 | Inhibition of CD44 expression in hepatocellular carcinoma cells enhances apoptosis, chemosensitivity, and reduces tumorigenesis and invasion显示文摘 | Zhigang Xie Pei Feng Choong Lai Fong Poon Jianbiao Zhou Jiaying Khng Viraj Janakakumara Jasinghe Senthilnathan Palaniyandi Chien-Shing Chen | 2008 | Cancer Chemotherapy and Pharmacology2008，，6： | 1 |
| 15 | Health realated quality of life significance of single pad urinary incontinence following RP显示文摘 | Matthew R Cooperberg Viraj A | 2003 | J Urol2003，170，： | 1 |
| 16 | The association between C-reactive protein(CRP)level and biochemical failure-free survival in patients after radiation therapy for nonmetastatic adenocarcinoma of the prostate显示文摘 | William A Hall Dana C Nickleach Viraj A Master | 2013 | Cancer2013，30，19： | 1 |
| 17 | Concurrent hyperm- ethylation of multipleregulatory genes in chewing to bacco associated oral squamous cell carcinomas and adjacent normal tissues 显示文摘 | VIRAJ K DHANANJAYA S | 2004 | Oral Oncol2004，40，： | 1 |
| 18 | Transcriptional networks in a rat model for nonalcoholic fatty liver disease: A microarray analysis显示文摘 | Meena R. Sharma Rathnagiri Polavarapu Daniel Roseman Viraj Patel Eric Eaton P.B. Kavi Kishor Amin A. Nanji | 2006 | Experimental and Molecular Pathology2006，，： | 1 |
| 19 | Renal cell carcinoma in patients with end‐stage renal disease has favorable overall prognosis显示文摘 | Adam B. Shrewsberry Adeboye O. Osunkoya Kun Jiang Ruth Westby Daniel Canter John Pattaras Nicole Turgeon Viraj A. Master Kenneth Ogan | 2014 | Clin Transplant2014，，： | 1 |
| 20 | Efficient method for demethylation of aryl methyl ether using aliquat-336 显示文摘 | Suresh B Waghmode Ganesh Mahale Viraj P Patil | 2013 | Synthetic Communications2013，43，： | 1 |
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