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| 1 | Vitamin D,calcium homeostasis and aging显示文摘Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented. In addition, mechanisms involved in age-related dysregulation of 1,25(OH)_2D_3action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis(which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance. | Vaishali Veldurthy Ran Wei Leyla Oz Puneet Dhawan Yong Heui Jeon Sylvia Christakos | 2016 | Bone Research2016，4，3： | 5 |
| 2 | Recent advances in elucidating the genetics of common variable immunodeficiency显示文摘Common variable immunodeficiency disorders(CVID),a heterogeneous group of inborn errors of immunity,is the most common symptomatic primary immunodeficiency disorder.Patients with CVID have highly variable clinical presentation.With the advent of whole genome sequencing and genome wide association studies(GWAS),there has been a remarkable improvement in understanding the genetics of CVID.This has also helped in understanding the pathogenesis of CVID and has drastically improved the management of these patients.A multiomics approach integrating the DNA sequencing along with RNA sequencing,proteomics,epigenetic and metabolomics profile is the need of the hour to unravel specific CVID associated disease pathways and novel therapeutic targets.In this review,we elaborate various techniques that have helped in understanding the genetics of CVID. | Vaishali Aggarwal Aaqib Zaffar Banday Ankur Kumar Jindal Jhumki Das Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 4 |
| 3 | Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific显示文摘94 氨基酸(PSP94 ) 的能分泌的蛋白质被显示出与充满半胱氨酸的能分泌的蛋白质交往的前列腺 3 (CRISP-3 ) 在里面人的精液的血浆。有趣地, PSP94 表示被减少或在前列腺瘤的多数输了,而 CRISP-3 表示与正常前列腺织物相比是在前列腺癌症的 upregulated。为了获得单个角色的更好的理解,这些蛋白质在前列腺 tumourigenesis 和他们的相互作用的功能的关联有,我们宫外地在三根前列腺细胞线(PC3, WPE1-NB26 和 LNCaP ) 与 CRISP-3 一起表示了 PSP94 或 PSP94 并且执行了生长抑制试金。反向的抄写聚合酶链反应和西方的污点分析被用来为 PSP94 和 CRISP-3 表示屏蔽前列腺房间线。为人的 PSP94 和 CRISP-3 的哺乳动物的表示构造也被产生, recombinant 蛋白质的表示,本地化和分泌物是由西方的污点分析和 immunofluorescence 试金跟随的 transfection 的 assayed。PSP94 或 CRISP-3 的宫外的表示在房间生长上有的效果被 clonogenic 幸存试金追随者 transfection 学习。评估二蛋白质的合作表示的效果,表示了 PSP94 的 PC3 的稳定的克隆被产生。他们是随后有 CRISP-3 表示构造的 transfected 并且使遭到了到 clonogenic 幸存试金。我们的结果证明 PSP94 和 CRISP-3 能各在一根细胞线导致生长抑制特定的举止。尽管 CRISP-3-positive 房间线的生长被 PSP94 禁止,生长抑制由 CRISP-3 调停了没被 PSP94 的存在或缺席影响。这建议 CRISP-3 可以在前列腺 tumourigenesis 期间参予 PSP94 独立的活动。 | Bhakti R. Pathak Ananya A. Breed Vaishali H. Nakhawa Dhanashree D. Jagtap Smita D. Mahale | 2010 | Asian Journal of Andrology2010，12，5： | 3 |
| 4 | Leukocyte adhesion defect:Where do we stand circa 2019?显示文摘Migration of polymorphonuclear leukocytes from bloodstream to the site of inflammation is an important event required for surveillance of foreign antigens.This trafficking of leukocytes from bloodstream to the tissue occurs in several distinct steps and involves several adhesion molecules.Defect in adhesion of leukocytes to vascular endothelium affecting their subsequent migration to extravascular space gives rise to a group of rare primary immunodeficiency diseases(PIDs)known as Leukocyte Adhesion Defects(LAD).Till date,four classes of LAD are discovered with LAD I being the most common form.LAD I is caused by loss of function of common chain,cluster of differentiation(CD)18 of β2 integrin family.These patients suffer from life-threatening bacterial infections and in its severe form death usually occurs in childhood without bone marrow transplantation.LAD II results from a general defect in fucose metabolism.These patients suffer from less severe bacterial infections and have growth and mental retardation.Bombay blood group phenotype is also observed in these patients.LAD III is caused by abnormal integrin activation.LAD III patients suffer from severe bacterial and fungal infections.Patients frequently show delayed detachment of umbilical cord,impaired wound healing and increased tendency to bleed.LAD IV is the most recently described class.It is caused by defects in β2 and α4β1 integrins which impairs lymphocyte adhesion.LAD IV patients have monogenic defect in cystic-fibrosis-transmembraneconductance-regulator(CFTR)gene,resulting in cystic fibrosis.Pathophysiology and genetic etiology of all LAD syndromes are discussed in detail in this paper. | Jhumki Das Avinash Sharma Ankur Jindal Vaishali Aggarwal Amit Rawat | 2020 | Genes & Diseases2020，7，1： | 2 |
| 5 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 6 | Comparison of posterior capsule opacification with hydrophobic acrylic and hydrophilic acrylic intraocular lenses显示文摘 | Abhay R. Vasavada Shetal M. Raj Alpesh Shah Gauri Shah Viraj Vasavada Vaishali Vasavada | 2011 | Journal of Cataract & Refractive Surgery2011，，6： | 2 |
| 7 | Issue and challenges facing rechargeable thin film lithium batteries显示文摘 | Arun Patil Vaishali Patil Dong Wook Shin | | 0，，8： | 1 |
| 8 | Magnetic resonance cholangiopancreatography in obstructive jaundice显示文摘 | Vaishali MD Agarwal AK Upadhyaya DN | 2004 | J Clin Gastroenterol2004，38，10： | 1 |
| 9 | Tricaprylin microemulsion for oral delivery of low molecular weight heparin conjugates 显示文摘 | Kim SK Lee EH Vaishali B | 2005 | J Control Release2005，105，12： | 1 |
| 10 | Efficient Solvent System Containing Malonamides in Room Temperature IonicLiquids : Actinide Extraction, Fluorescence and Radiolytic Degradation Studies 显示文摘 | Patil A B Pathak P Vaishali S | 2013 | Dalton Trans2013，5，： | 1 |
| 11 | Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis显示文摘 | Harikesh Maurya Vaishali Mangal Sanjay Gandhi | 2014 | International Journal of Inflammation2014，，： | 1 |
| 12 | Magnetic resonance cholangiopancreatography in obstructive jaundice显示文摘 | Vaishali MD Agarwal AK Upadhyaya DN | 2004 | J Clin Gastroenterol2004，38，10： | 1 |
| 13 | Effect of cardiopulmonary physiotherapy on lung parameters in mechanically ventilated neonates显示文摘 | Singh VP Vaishali Kamath N | 2012 | Int J Med Sci2012，4，10： | 1 |
| 14 | Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians显示文摘 | Manasi Mittal Vaishali Kapoor Bidhu Kalyan Mohanti Satya Narayan Das | 2010 | Oral Oncology2010，，8： | 1 |
| 15 | Papillary glioneuronal tumor—a rare entity: report of four cases and brief review of literature显示文摘 | Shipra Agarwal Mehar Chand Sharma Geetika Singh Vaishali Suri Chitra Sarkar Ajay Garg Rajinder Kumar P. Sharat Chandra | 2012 | Child’s Nervous System2012，，11： | 1 |
| 16 | Tricaprylin microemulsion for oral delivery of low molecular weight heparin conjugates显示文摘 | KIM SK LEE EH VAISHALI B | 2005 | J Control Release2005，105，12： | 1 |
| 17 | Issue and challenges facing rechargeable thin film lithium batteries 显示文摘 | Arun Patil Vaishali Patil Dong Wook Shin etc | 2008 | Materials Research Bulletin2008，，202： | 1 |
| 18 | Aspiring Teachers Take Up Residence显示文摘 | Vaishali Honawar | 2008 | Education Week2008，，8： | 1 |
| 19 | Au/TiO2 catalysts encapsulated in the mesopores of siliceous MCM-48-reproducible synthesis, structural characterization and activity for CO oxidation 显示文摘 | Vijay S Narkhede Andrea De Toni Vaishali V Narkhede | 2009 | Microporous and Mesoporous Materials2009，118，13： | 1 |
| 20 | Clinical management practices adopted by physiotherapists in India for chronic obstructive pulmonary disease: A national survey 显示文摘 | Jingar A Alaparthi GK Vaishali K | 2013 | Lung India2013，30，2： | 1 |
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