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| 1 | Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C显示文摘 | Laurent Castéra Julien Vergniol Juliette Foucher Brigitte Le Bail Elise Chanteloup Maud Haaser Monique Darriet Patrice Couzigou Victor de Lédinghen | 2005 | Gastroenterology2005，，2： | 8 |
| 2 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 3 | 骨关节病股骨头不同区域的骨密度测量显示文摘目的测量髋关节骨关节病患者股骨头不同区域骨密度,并探讨其与全髋关节置换后远期临床疗效之间的关系。方法将235个股骨头分为:骨关节炎组(OA组)、股骨头坏死组(ON组)、类风湿性关节炎组(RA组)、骨关节炎伴股骨颈骨折组(骨折组)和其他组。在股骨头顶中心部位,从冠状面切取两张骨片标本,其余部分沿矢状面依次切取骨片标本,厚度≤5mm,行X线检查。将骨片标本制成4μm厚的切片,采用骨形态计量学方法测量股骨头不同区域的骨密度和股骨距的骨密度。结果OA组和RA组的外上及内下非负重区、骨折组各区骨密度均低于正常,各组骨距区哈佛管的百分数均超过正常值。OA组与骨折组股骨头骨骺线以上的负重区和非负重区、ON组与骨折组的负重区和非负重区骨密度比较差异有显著性意义。OA组负重区与非负重区骨密度比较差异有非常显著性意义。骨折组负重区与非负重区骨密度比较差异有显著性意义。骨距区内哈佛管增多,骨密度下降,是造成假体松动,影响远期疗效的一个重要因素。结论获得的各种髋关节骨关节病股骨头骨密度数据,可为临床科研工作提供一个基本参考值;同时获得的骨距区骨密度值,既可以预测髋关节置换后远期临床疗效,又可为股骨假体的改进和设计提供骨形态计量学数据。 | 赵鉴非 Victor L Fornasier | 2003 | 中华骨科杂志2003，23，11： | 3 |
| 4 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 5 | Liver Fibrosis: Noninvasive Assessment with Acoustic Radiation Force Impulse Elastography—Comparison with FibroScan M and XL Probes and FibroTest in Patients with Chronic Liver Disease显示文摘 | Christophe Cassinotto Bruno Lapuyade Ania A?t-Ali Julien Vergniol Delphine Gaye Juliette Foucher Claire Bailacq-Auder Faiza Chermak Brigitte Le Bail Victor de Lédinghen | 2013 | Radiology2013，，1： | 3 |
| 6 | Controlled Attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5,323 examinations显示文摘 | Victor de Lédinghen Julien Vergniol Maylis Capdepont Faiza Chermak Jean-Baptiste Hiriart Christophe Cassinotto Wassil Merrouche Juliette Foucher Brigitte Le Bail | 2013 | Journal of Hepatology2013，，： | 3 |
| 7 | Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations显示文摘 | Juliette Foucher Laurent Castéra Pierre-Henri Bernard Xavier Adhoute David Laharie Julien Bertet Patrice Couzigou Victor de Lédinghen | 2006 | European Journal of Gastroenterology & Hepatology2006，，4： | 3 |
| 8 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 9 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 10 | Determination of ethyl carbamate in wine by high performance liquid chromatography显示文摘 | Zsolt Ajtony Norbert Szoboszlai László Bencs Erna Viszket Victor G. Mihucz | 2013 | Food Chemistry2013，，2： | 2 |
| 11 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 12 | Features associated with success rate and performance of fibroscan measurements for the diagnosis of cirrhosis in HCV patients: A prospective study of 935 patients显示文摘 | Adrien Kettaneh Patrick Marcellin Catherine Douvin Raoul Poupon Marianne Ziol Michel Beaugrand Victor de Lédinghen | 2006 | Journal of Hepatology2006，，4： | 2 |
| 13 | RANTES: a versatile and controversial chemokine显示文摘 | Victor Appay Sarah L Rowland-Jones | 2001 | Trends in Immunology2001，，2： | 2 |
| 14 | Diminished insulin receptors on erythrocyte ghosts in nonobese patients with essential hypertension independent of hyperinsulinemia显示文摘 | MIGUEL V JOSE A L | 1994 | J Cardiovasc Pharmacol1994，24，： | 1 |
| 15 | Flexible energy storage devices based on nanocomposite paper显示文摘 | Victor L Pushparaj Manikoth M Shaijumon Ashavani Kumar | 2007 | PNAS2007，104，13： | 1 |
| 16 | A Stable Motion Control System for Manipulator via Fuzzy Self-tuning显示文摘 | Miguel A L Rafael K Victor S | 2001 | Fuzzy Sets and System2001，124，2： | 1 |
| 17 | Real-time CORBA显示文摘 | Victor F W Dipippo L C Cooper G | 2000 | IEEE Transactions on Parallel and Distributed Systems2000，11，10： | 1 |
| 18 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 19 | Toxicological effects of dietary bio- genic amines显示文摘 | Victor L Marina C Maria F | 2010 | Current Nutrition & Food Science2010，6，2： | 1 |
| 20 | A Novel Cryptosystem Based on Grey Sys - tem Theory and Genetic Algorithm 显示文摘 | Victor R L | 2005 | Applied Mathe- matics and Computation2005，170，2： | 1 |
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