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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Formal semantics and analysis of control flow in WS-BPEL显示文摘 | OUYANG C VERBEEK E AALST van der W | 2007 | Science of Computer Programming2007，67，23： | 1 |
| 3 | Formal semantics and analysis of control flow in WSBPEL显示文摘 | OUYANG C VERBEEK E VAN DER AALST W M P | 2007 | Science of Computer Programming2007，67，23： | 1 |
| 4 | The role of the mars and van krevelen mechanism in the selcetinve oxidation of nitrosobenzene and the deoxygenation of nitrobenzene of oxidic catalysts 显示文摘 | Grootendorst E J Verbeek Y Ponce V | 1995 | Journal off Catalysis1995，157，2： | 1 |
| 5 | Neovascular age-related maeular degeneration and its relationship to antioxidant intake 显示文摘 | SNELLEN E L VERBEEK A L van den HOOGEN G W | 2002 | Acta Ophthalmol Scand2002，80，： | 1 |
| 6 | Formal se- mantics and analysis of control flow in WS-BPEL显示文摘 | Ouyang C Verbeek E Van Der Aalst W M P | 2007 | Science of Computer Programming2007，67，2： | 1 |
| 7 | Selecting copulas for risk management 显示文摘 | KOLE E KOEDIJK K VERBEEK M | 2007 | Journal of Banking & Finance2007，31，8： | 1 |
| 8 | Selecting Copulas for risk management显示文摘 | KOLE E KOEDIJK K VERBEEK M | | 0，，8： | 1 |
| 9 | Formal semantics and analysis of control flow in WS-BPEL显示文摘 | CHUN OUYANG VERBEEK E van der AALST M P | 2007 | Science of Computer Programming2007，67，23： | 1 |
| 10 | Murine igGl complexes trigger immune effector functions predominantly via Fc gamma RⅢ(CD16显示文摘 | Hazenbos W L Heijnen I A Meyer D Hofhuis F M Renardel de Lavalette C R Schmidt R E Capel P J van de Winkel J G Gessner J E van den Berg T K Verbeek J S | | 0，，06： | 1 |
| 11 | The double explosive layer cylindrical compaction method 显示文摘 | Stuivinga M Verbeek H J Carton E P | 1999 | Journal of Materials Processing Technology1999，85，： | 1 |
| 12 | Selecting copulas for risk management显示文摘 | Kole E Koedijk K Verbeek M | 2007 | Journal of Banking and Finance2007，，31： | 1 |
| 13 | Development and evaluation of a quality assessment instrument for occupational physicians显示文摘 | Van der Weide W E Verbeek J Van Dijk F J H | 1998 | Occupational and Environmental Medicine1998，55，6： | 1 |
| 14 | Selecting Copulas for risk management显示文摘 | Kole E Koedijk K Verbeek M | 2007 | Journal of Banking & Finance2007，31，8： | 1 |
| 15 | A new gene,encoding an anion transporter,is mutated in sialic acid storage diseases显示文摘 | Verheijen FW Verbeek E Aula N | 1999 | Nature genetics1999，23，4： | 1 |
| 16 | Selecting copulas for risk management显示文摘 | Kole E Koedijk K Verbeek M | 2007 | Journal of Banking : Finance2007，31，8： | 1 |
| 17 | Do science-technology interactions pay off when developing technology 显示文摘 | Van Looly B Zimerman R Veu~:elers R Verbeek E Mello J Debackere K | 2003 | Scientometrics2003，57，3： | 1 |
| 18 | Selecting copulas for risk markagement显示文摘 | Kole E Koedijk K Verbeek M | 2007 | Journal of Banking & Finance2007，31，： | 1 |
| 19 | Selecting Copulas for Risk Manage- ment显示文摘 | Kole E Koedijk K Verbeek M | 2007 | Journal of Banking & Finance2007，31，8： | 1 |
| 20 | Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection显示文摘 | Meijer A H Verbeek F J Salas-Vidal E | 2005 | Molecular Immunology2005，42，10： | 1 |
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