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| 1 | Treating inflammatory bowel disease by adsorptive leucocytapheresis:A desire to treat without drugs显示文摘Ulcerative colitis and Crohn’s disease are the major phenotypes of the idiopathic inflammatory bowel disease(IBD),which afflicts millions of individuals throughout the world with debilitating symptoms,impairing function and quality of life.Current medications are aimed at reducing the symptoms or suppressing exacerbations.However,patients require life-long medications,and this can lead to drug dependency,loss of response together with adverse side effects.Indeed,drug side effects become additional morbidity factor in many patients on long-term medications.Nonetheless,the efficacy of anti-tumour necrosis factors(TNF)-αbiologics has validated the role of inflammatory cytokines notably TNF-αin the exacerbation of IBD.However,inflammatory cytokines are released by patients’own cellular elements including myeloid lineage leucocytes,which in patients with IBD are elevated with activation behaviour and prolonged survival.Accordingly,these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis(GMA)with an Adacolumn.Based on this background,recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries.Efficacy rates have been impressive as well as disappointing.In fact the clinical response to GMA seems to define the patients’disease course,response to medications,duration of active disease,and severity at entry.The best responders have been first episode cases(up to 100%)followed by steroid nave and patients with a short duration of active disease prior to GMA.Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA.It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD.Additionally,GMA is very much favoured by patients for its good safety profile.GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates.However,in patients with IBD,there is a scope for removing from the body the sources of proinflammatory cytokines and achieve disease remission.The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications,many patients should respond to GMA and avoid pharmacologics.This should fulfill the desire to treat without drugs. | Abbi R Saniabadi Tomotaka Tanaka Toshihide Ohmori Koji Sawada Takayuki Yamamoto Hiroyuki Hanai | 2014 | World Journal of Gastroenterology2014，20，29： | 11 |
| 2 | Trend in gastric cancer:35 years of surgical experience in Japan显示文摘AIM:To investigate the trend in gastric cancer surgery in the context of rapid therapeutic advancement in Japan and East Asia.METHODS:A retrospective analysis was performed on 4163 patients who underwent gastric resection for gastric cancer with histological confirmation between 1971 and 2007 at the surgical unit in Kitasato University Hospital,to determine the trend in gastric cancer requiring surgery.RESULTS:Gastric cancer requiring surgical resection increased in our hospital,but the incidence adjusted for population was constant during the observed pe-riod.Interestingly,the ratio of diffuse type/intestinal type gastric cancer was unexpectedly unchanged,and that of advanced/early gastric cancer(EGC)was,however,markedly reduced,while the actual incidence of potentially curative advanced gastric cancer tended to decrease.The incidence of EGC requiring surgery tended to increase as a whole,which is consistent with increased prevalence of endoscopic surveillance.As a result,overall survival and mortality of gastric cancer requiring gastric resection has recently markedly improved.CONCLUSION:In Japan,planned interventions may improve surgical gastric cancer mortality,but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention. | Keishi Yamashita Shinichi Sakuramoto Masayuki Nemoto Tomotaka Shibata Hiroaki Mieno Natsuya Katada Shiroh Kikuchi Masahiko Watanabe | 2011 | World Journal of Gastroenterology2011，17，29： | 11 |
| 3 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 4 | 回廊 laparoscopic 胆囊炎: 在在日本的一所社区医院的天大小写对一夜的外科的审计显示文摘 AIM: To evaluate the applicability and safety of ambulatory laparoscopic cholecystectomy (LC) and to compare day case and overnight stay LC. METHODS: Data were collected retrospectively and consecutively for day case and overnight stay LC patients from July 1, 2009 to April 30, 2011. Outcomes were analyzed for patient demographics, operation time, blood loss during operation and frequency and reasons for unexpected or prolonged hospitalization in each group. RESULTS: There was no hospital mortality and no patient was readmitted with serious morbidity after discharge. 50 patients received a day case LC and 19 had an overnight stay LC. There was a significant difference in age between both groups (P<0.02). There were no significant differences between the day case LC performed (n=41) and failed (n=9) groups and between the day case LC performed and the one night stay LC (n=12) groups. There was a significant difference in age between the one night stay and more nights stay LC groups (P<0.05). Thus, elderly patients showed a tendency to like to stay in hospital rather than being a day case. The proportion of unexpected or prolonged hospitalization was not significantly different between the day case and overnight stay LC groups, when the patient’s request was excluded. CONCLUSION: Day case LC can be performed with a low rate of complications. In overnight stay patients, there are many who could be performed safely as a day case. Moreover, we need to take special care to treat elderly patients. | Atsushi Sato Yukio Terashita Yoichiro Mori Tomotaka Okubo | 2012 | World Journal of Gastrointestinal Surgery2012，4，12： | 7 |
| 5 | Hepatic artery pseudoaneurysm associated with cholecystitis that ruptured into the gallbladder显示文摘 | Tomotaka Akatsu Shinobu Hayashi Tomohisa Egawa Masakazu Doi Atsushi Nagashima Mitsuhide Kitano Takashi Yamane Hiroshi Yoshii Masaki Kitajima | 2004 | Journal of Gastroenterology2004，，9： | 2 |
| 6 | Characterization of denitrifying phosphate accumulating organisms cultivated under different electron aeeeptor conditions using polymerase chain reaction-denaturing gradient gel electrophoresis assay显示文摘 | JOHONWAN A TOMOTAKA D SATOSHI T | 2002 | Water Res2002，36，： | 1 |
| 7 | Frequency characteristics of leakage current waveforms of a string of suspension insulators显示文摘 | Suda Tomotaka | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
| 8 | Identification of biofoulant of membrane hioreactors in soluble microbial products显示文摘 | Daisuke Okamura Yoshihiko Moil Tomotaka Hashimoto | 2009 | Water Research2009，43，17： | 1 |
| 9 | Green Tea Consumption and Subsequent Risk of Gastric Cancer by Subsite: The JPHC Study显示文摘 | Shizuka Sasazuki Manami Inoue Tomoyuki Hanaoka Seiichiro Yamamoto Tomotaka Sobue Shoichiro Tsugane | 2004 | Cancer Causes and Control2004，，5： | 1 |
| 10 | High plasma brain na- triuretic peptide levels in stable COPD without pulmonary hyper- tension or cor pulmonale 显示文摘 | Yuzuru Inoue Tomotaka Kawayama | 2009 | Inter Med2009，48，11： | 1 |
| 11 | Pathophysiology of disseminated intravascular coagulation (DIC) progresses at a different rate in tissue factor-induced and lipopolysaccharide-induced DIC models in rats显示文摘 | Hidesaku Asakura Yukio Suga Tomotaka Yoshida | 2003 | Blood Coagulation and Fibrinolysis2003，14，3： | 1 |
| 12 | Frequency characteristics of leakage current waveforms of a string of suspension insulators显示文摘 | TOMOTAKA Suda | 2005 | IEEE Transaction on Power Delivery2005，20，1： | 1 |
| 13 | Calculation of large ion densities under HVDC transmission lines by the finite difference method显示文摘 | Tomotaka Suda Yoshitaka Sunaga | 1995 | IEEE Transactions on Power Delivery1995，10，4： | 1 |
| 14 | Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder ( Kinako ) 显示文摘 | Shaw Watanabe Momoko Yamaguchi Tomotaka Sobue | 1998 | Nutrition1998，128，10： | 1 |
| 15 | Metabolic behavior of denitrifying phosphate-accumulating organisms under nitrate and nitrite electron acceptor conditions显示文摘 | JOHWAN A TOMOTAKA D SATOSHI T | 2001 | Journal of Bioscience and Bioengineering2001，92，5： | 1 |
| 16 | Characterizaion of denitrifying phosphate accumulating organisms cultivat- ed under different electron aeceptor conditions using polymerase chain re- action-denaturing gradient gel electrophoresis assay显示文摘 | JOHONWAN AHN TOMOTAKA DAIDOU SATOSHI TSUNEDA | 2002 | Water Res2002，36，： | 1 |
| 17 | Influence of coffee drinking on subsequent risk of hepatocellular carcinoma:A prospective study in japan显示文摘 | Manami Inoue Itsuro Yoshimi Tomotaka Sobue | 2005 | Journal d the National Cancer Institute2005，97，4： | 1 |
| 18 | Frequency characteristics of leakage current waveforms of a string of suspension insulators显示文摘 | Tomotaka Suda | 2005 | IEEE Transactions on Power Delivery2005，20，1： | 1 |
| 19 | Characterization of denitrifying phosphate-accumulation organisms cultivated under different electron acceptor conditions using polymerase chain reaction -denaturing gradient gel electrophoresis assay显示文摘 | AHN J Tomotaka Daidou Satoshi Tsuneda | 2002 | Wat Res2002，36，： | 1 |
| 20 | Pilot study of a submerged membrane bioreactor for water reclamation显示文摘 | Jianjun Q Maung-Hmn O Guihe T Kiran-A K Tomotaka H | 2009 | Water Science2009，60，2009： | 1 |
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