|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of biofoulant of membrane hioreactors in soluble microbial products显示文摘 | Daisuke Okamura Yoshihiko Moil Tomotaka Hashimoto | 2009 | Water Research2009，43，17： | 1 |
| 2 | Identification of a Hashimoto Thyroiditis Susceptibility Locus Via a Genome-wide Comparison With Graves? Disease显示文摘 | Daisuke Oryoji Sho Ueda Ken Yamamoto Jaeduk Yoshimura Noh Ken Okamura Mitsuhiko Noda Natsuko Watanabe Ai Yoshihara Koichi Ito Takehiko Sasazuki | 2015 | The Journal of Clinical Endocrinology & Metabolism2015，，2： | 1 |
| 3 | Microencapsulation of l -menthol by spray drying and its release characteristics显示文摘 | Apinan Soottitantawat Kohei Takayama Kenji Okamura Daisuke Muranaka Hidefumi Yoshii Takeshi Furuta Masaaki Ohkawara Pekka Linko | 2005 | Innovative Food Science and Emerging Technologies2005，，2： | 1 |
| 4 | Repeat Pancreatectomy for Pancreatic Ductal Cancer Recurrence in the Remnant Pancreas after Initial Pancreatectomy -Is It Worthwhile?显示文摘 | Masaru Miyazaki Hideyuki Yoshitomi Hiroaki Shimizu Masayuki Otuka Hiroyuki Yoshidome Katsunori Furukawa Tsukasa Takayasiki Satoshi Kuboki Daiki Okamura Daisuke Suzuki Masayuki Nakajima | 2013 | Surgery2013，，： | 1 |
| 5 | Microencapsulation of l -menthol by spray drying and its release characteristics显示文摘 | Apinan Soottitantawat Kohei Takayama Kenji Okamura Daisuke Muranaka Hidefumi Yoshii Takeshi Furuta Masaaki Ohkawara Pekka Linko | 2005 | Innovative Food Science and Emerging Technologies2005，，2： | 1 |
| 6 | Inorganic arsenic exposure induces E 2 F ‐dependent G 0/ G 1 arrest via an increase in retinoblastoma family protein p130 in B ‐cell lymphoma A 20 cells显示文摘 | Kazuyuki Okamura Daisuke Miki Keiko Nohara | 2013 | Genes Cells2013，，10： | 1 |
| 7 | Atypical lipomatous tumor in the ligamentum teres of liver:A case report and review of the literature显示文摘A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Dynamic computed tomography revealed a highly enhanced effect from the portal-venous phase continuing to the equilibrium phase. T1-weighted gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced image revealed a high intensity effect at the early phase that continued to the next phase. On the other hand, it contained a low intensity area by a fat suppression of that image. In addition, a T2-weighted image did not show a high intensity effect. Laparotomy was performed on the second day of hospitalization. The tumor had arisen from the ligamentum teres of the liver, and no metastasis or invasion of other organs was noted. It consisted of a lipid component of mature adipocytes and a fibrous component of deep dyeing pleomorphic or multinuclear atypical stromal cells. Immunohistochemical study of the atypical stromal cells demonstrated that they were positive for MDM2 and CDK4. A pathological diagnosis of atypical lipomatous tumor(ALT) was made, and the patient was discharged on the eighth day following the procedure. At the 6-mo follow-up dynamic CT, the patient was free of recurrence or metastasis. We experienced a patient with ALT in the ligamentum teres of the liver. This case suggests the need for a careful and detailed examination when encountering patients presenting with a mass; when neoplastic lesion is confirmed by image inspection, we should thoroughly investigate, including further image investigations and pathologic examination. The latter is the most important. | Daisuke Usuda Kento Takeshima Ryusho Sangen Kisuke Nakamura Kei Hayashi Hideyuki Okamura Yasuhiro Kawai Yuji Kasamaki Yoshitsugu Iinuma Hitoshi Saito Tsugiyasu Kanda Sachio Urashima | 2018 | World Journal of Clinical Cases2018，6，12： | 0 |
| 8 | Recent updates of therapeutic strategy of esophagogastric junction adenocarcinoma显示文摘The incidence of esophagogastric junction(EGJ)adenocarcinoma has been increasing in Asian countries.Despite the recent advances in multidisciplinary treatments,EGJ adenocarcinoma remains aggressive with unfavorable outcomes.Regarding surgical strategy,EGJ adenocarcinoma arises between the esophagus and the stomach,and thus tumor cells spread through the lymphatic system both upward to the mediastinum and downward to the abdomen.Nevertheless,an optimal extent of lymphadenectomy remains controversial.Regarding drug therapy,the latest topic in gastric and EGJ adenocarcinoma is trastuzumab deruxtecan,which is an antibody-drug conjugate consisting of an anti-HER2 antibody.In addition,many clinical trials have recently demonstrated the efficacy of immune checkpoint inhibitors.Meanwhile,recent advances in sequencing technology have revealed that gastroesophageal adenocarcinoma could be categorized into four molecular subtypes:epstein-Barr virus-associated,high-level microsatellite instability,genomically stable,and chromosomal instability tumors.Furthermore,these subtypes show distinct clinical phenotypes and molecular alterations.We review the current surgical strategy and drug treatment such as molecular-targeted agents,immune checkpoint inhibitors,and molecular-subtype-based therapeutic strategies in EGJ adenocarcinoma.Clinical and molecular characteristics and response to immune checkpoint inhibitors differ among molecular subtypes.Treatment strategies based on molecular subtypes may be clinically beneficial for patients with EGJ adenocarcinoma. | Suguru Maruyama Yu Imamura Yasukazu Kanie Kei Sakamoto Daisuke Fujiwara Akihiko Okamura JunKanamori Masayuki Watanabe | 2021 | Journal of Cancer Metastasis and Treatment2021，7，1： | 0 |
| 9 | Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy显示文摘Aim:Definitive chemoradiotherapy(dCRT)is the standard treatment for locally advanced unresectable esophageal squamous cell carcinoma(LU-ESCC).This study aimed to describe the results of dCRT for T4 ESCC and evaluate the pretherapeutic predictive factors of the outcomes.Methods:A total of 133 patients with T4 ESCC who received dCRT were grouped into those who achieved a complete response(CR)or those who had residual disease(RD).The clinicopathologic variables were compared between the groups and the overall survival(OS)was evaluated.The predictive factor of RD was assessed and the prognostic factor for OS was identified.Results:Among the 133 patients,31(23%)achieved CR.The CR group had a significantly better OS than the RD group(89.9 months vs.10.7 months;hazard ratio=0.096;95%confidence interval:0.05-0.19;P<0.001).Multivariate analysis showed that a supracarinal tumor(OR=3.21;P=0.016),higher pretherapeutic serum SCC-Ag level(>1.6 ng/mL)(OR=2.86;P=0.018),and metastatic node invasion(OR=3.19;P=0.048)were independent predictors of RD.The increased level of pretherapeutic serum squamous cell carcinoma antigen(>1.6 ng/mL)(OR=1.61;P=0.022)was an independent predictor of poor survival.Conclusions:Among the patients who underwent dCRT for LU-ESCC,23%achieved CR,and the long-term outcome of these patients was favorable.Increased levels of pretherapeutic serum squamous cell carcinoma antigen were also found to be predictive of treatment failure. | Takeshi Suzuki Akihiko Okamura Masayuki Watanabe Takao Asari Izuma Nakayama Mariko Ogura Akira Ooki Daisuke Takahari Kensei Yamaguchi Keisho Chin | 2022 | Journal of Cancer Metastasis and Treatment2022，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员