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| 1 | Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy显示文摘瞄准:介绍一个新方法:小内视镜的括约肌切开术(ES ) 与内视镜的乳突的大汽球膨胀(SES + EPLBD ) 结合了与大胆汁的石头对待病人。方法:大胆汁的石头的检索在 88 个病人被执行。吝啬的石头尺寸是 3 公里和石头的吝啬的数字是的 14 +/- 2.5 +/- 3.5。第一,有一个小切口的 ES 被执行。下次,内视镜的乳突的膨胀与一个大汽球被执行慢慢地匹配胆汁管的尺寸。石头然后与一个汽球和一个篮子从胆汁的管被检索。结果:没有需要,石头检索在除了一个膀胱的管石头盒子的所有情况中是成功的压碎大石头。吝啬的过程时间是 30 +/- 5 min。与一个大汽球扩大乳突的孔使没有压碎他们,顺利移开大石头可能。在有大汽球的膨胀以后,有流着,而是没有穿孔的一些例子。procedural 以后胰腺炎(1%) 的一个例子发生了。结论:没有机械碎石术的使用, SES + EPLBD 为大胆汁的石头的检索是有效的。 | Atsushi Minami Shinji Hirose Tomohiro Nomoto Shoichiro Hayakawa | 2007 | World Journal of Gastroenterology2007，13，15： | 24 |
| 2 | Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer显示文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study. | Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata | 2010 | World Journal of Gastroenterology2010，16，10： | 14 |
| 3 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 4 | Choroidal and cutaneous metastasis from gastric adenocarcinoma显示文摘Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions. | Shoichiro Kawai Tsutomu Nishida Yoshito Hayashi Hisao Ezaki Takuya Yamada Shinichiro Shinzaki Masanori Miyazaki Kei Nakai Takayuki Yakushijin Kenji Watabe Hideki Iijima Masahiko Tsujii Kohji Nishida Tetsuo Takehara | 2013 | World Journal of Gastroenterology2013，19，9： | 6 |
| 5 | 饮食、营养及癌症风险:已知与前景显示文摘几十年来科学家们就认为,营养在癌症发展中起着重要的作用。早在20世纪60年代就有流行病学研究显示,不同人群的癌症发病率差别非常大,而且从癌症低发国家移民到高发国家后,移民们的癌症发病率可能上升到与移民国家原住民的癌症发病率相当,甚至更高1-2。这些观察结果提示环境是导致癌症发生的重要因素。 | Timothy J Key Kathryn E Bradbury Aurora Perez-Comago Rashmi Sinha Konstantinos K Tsilidis Shoichiro Tsugane 徐欣悦(译) 严雪敏(校) | 2020 | 英国医学杂志中文版2020，23，7： | 5 |
| 6 | 包含的小岛移植: 过去,现在和未来显示文摘 Islet transplantation could become an ideal treatment for severe diabetes to prevent hypoglycemia shock and irreversible diabetic complications, once some of the major and unresolved obstacles are overcome, including limited donor supplies and side effects caused by permanent immunosuppressant use. Approximately 30 years ago, some groups succeeded in improving the blood glucose of diabetic animals by transplanting encapsulated islets with semi-permeable membranes consisting of polymer. A semi-permeable membrane protects both the inner islets from mechanical stress and the recipient’s immune system (both cellular and humoral immunities), while allowing bidirectional diffusion of nutrients, oxygen, glucose, hormones and wastes, i.e., immune-isolation. This device, which enables immune-isolation, is called encapsulated islets or bio-artificial pancreas. Encapsulation with a semipermeable membrane can provide some advantages: (1) this device protects transplanted cells from the recipient’s immunity even if the xenogeneic islets (from large animals such as pig) or insulin-producing cells are derived from cells that have the potential for differentiation (some kinds of stem cells). In other words, the encapsulation technique can resolve the problem of limited donor supplies; and (2) encapsulation can reduce or prevent chronic administration of immunosuppressants and, therefore, important side effects otherwise induced by immunosuppressants. And now, many novel encapsulated islet systems have been developed and are being prepared for testing in a clinical setting. | Naoaki Sakata Shoichiro Sumi Gumpei Yoshimatsu Masafumi Goto Shinichi Egawa Michiaki Unno | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，1： | 4 |
| 7 | Simeprevir with Peginterferon/Ribavirin for Treatment-Na?ve Hepatitis C Genotype 1 Patients in Japan: CONCERTO-1, a Phase III Trial显示文摘 | Norio Hayashi Namiki Izumi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Hepatology2014，，： | 3 |
| 8 | New scoring system in assessment of Hoffa's fat pad synovitis: A comparative study with established scoring systems显示文摘AIM To investigate the reliability of the established and new scoring methods for Hoffa's fat pad synovitis using magnetic resonance imaging(MRI).METHODS A total of 139 knees of 115 patients who underwent MRI of the knee with and without gadolinium contrast were enrolled in this study. Proton density(PD)-weighted, PD-weighted fat-suppressed(PD-FS), and postcontrast T1-weighted fat-suppressed(T1CE) images were used for evaluation. Using contrast and noncontrast images, our grading method for synovitis was performed to measure synovial thickness and signal intensity changes of the fat pad [Synovial membrane(SM) score], which was compared with the established methods,including MRI Osteoarthritis Knee Score(MOAKS), parapatellar synovitis score,Whole-Organ Magnetic Resonance Imaging Score(WORMS), and suprapatellar effusion diameter. Intraclass correlation coefficients(ICC) for intra and interobserver reproducibility and Spearman correlation coefficients(r) were calculated for the parapatellar synovitis score and each scoring method.RESULTS All of the scores presented substantial to almost perfect intrareliability. Among three readers, effusion diameter had substantial to almost perfect interreliability(ICC = 0.68-0.81) and WORMS had substantial interreliability(ICC = 0.61-0.70).For two out of three readers, there was substantial interreliability for the thickness score in T1CE(ICC = 0.55-0.69), SM scores in T1CE(ICC = 0.56-0.78)and PD-FS(ICC = 0.51-0.79), and parapatellar synovitis score in T1CE(ICC =0.53-0.72). The parapatellar synovitis score was significantly correlated with the thickness score in T1CE(r = 0.70) and the SM score in T1CE(r = 0.81) and PD-FS(r = 0.65).CONCLUSION The newly proposed quantitative thickness score on T1CE and the semiquantitative SM score on T1CE and PD-FS can be useful for Hoffa's fat pad synovitis. | Shigeo Hagiwara Albert Yang Shoichiro Takao Yasuhito Kaneko Taiki Nozaki Hiroshi Yoshioka | 2018 | World Journal of Radiology2018，10，11： | 3 |
| 9 | 南美白对虾壳中虾青蛋白性质的研究显示文摘采用远紫外圆二色光谱法对提取自南美白对虾Litopenaeus vannamei壳中的β虾青蛋白的理化性质进行了研究。结果表明:该蛋白是一种以α螺旋(含量为69%)为主要二级结构存在的二聚物,相对分子质量约为75 000,最大吸收波长为580 nm;在40℃以下加热以及外加盐未加热时,该蛋白会出现可逆变性,升温至40℃以上、改变溶液pH均会对二级结构造成破坏,引起蛋白不可逆变性;加热30 min时,α螺旋损失率最大,约为50%;外加盐在升温时会加速蛋白的不可逆变性,其加速能力与盐浓度成反比;从南美白对虾壳与美国龙虾壳中提取的虾青蛋白在吸收光谱、离子柱亲合力等上有明显区别。研究表明,南美白对虾壳中的虾青蛋白具有水溶性、热不稳定性和遇热显色等性质,可作为食品着色剂或温度敏感指示剂。 | 潘创 Shoichiro Ishizaki 吉宏武 潘广坤 | 2014 | 大连海洋大学学报2014，29，3： | 2 |
| 10 | pH调节法分离凡纳滨对虾壳中β虾青蛋白的研究显示文摘采用pH调节法对凡纳滨对虾(Litopenaeus vannamei)虾壳中影响虾壳红变的β虾青蛋白进行分离回收,以蛋白质回收率、纯度和二级结构含量为分离特性参数,以1.0为pH变化梯度,研究pH调节法从虾壳中提取β虾青蛋白的规律。结果显示,pH调节法的回收率为47.5%,所得蛋白质纯度为78.23%、分子量为45 000 Da。该蛋白质在pH3.0和11.0时有最大溶解度,分别为60.5%和55.7%;在pH5.0时溶解度最低为15.4%;等电点为5.6。通过圆二色光谱图分析得知β虾青蛋白是一种以α螺旋为主要二级结构存在的物质,pH调节法所得α螺旋含量为70.1%。 | 潘创 SHOICHIRO Ishizaki 吉宏武 | 2014 | 南方水产科学2014，10，4： | 2 |
| 11 | Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma显示文摘 | Norie Sawada Manami Inoue Motoki Iwasaki Shizuka Sasazuki Taichi Shimazu Taiki Yamaji Ribeka Takachi Yasuhito Tanaka Masashi Mizokami Shoichiro Tsugane | 2012 | Gastroenterology2012，，7： | 2 |
| 12 | Critical exponents of the dielectric constants in diffused-phase-transition crystals显示文摘 | Kenji Uchino Shoichiro Nomura | 1982 | Ferroelectrics1982，，1： | 2 |
| 13 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 14 | Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study显示文摘瞄准:进行一个双窗帘,控制安慰剂使随机化并且评估 Ganoderma 的摘录的安全和功效的变化剂量的学习易懂嗯(G。易懂嗯) 在有更低的泌尿道症状(LUTS ) 的人。方法:我们注册了男志愿者(≥ 50 年) 与一个国际前列腺症状分数(IPSS;问题 1-7 ) ≥ 5 并且前列腺特定的抗原(PSA ) 价值 <
4 ng/mL。志愿者被使随机化进一些安慰剂(n = 12 ) , G。易懂 0.6 mg 的 um (n = 12 ) , 6 mg (n = 12 ) 或 60 mg (n = 14 ) ,管理从前每日。功效在 IPSS 和山峰尿流动率(Q_( 最大)) 从基线作为一个变化被测量。前列腺体积和残余尿被 ultrasonography 估计,并且包括 PSA 层次,验血在基线并且在处理的结束被测量。结果:全面管理很好被容忍,没有主要不利效果。在在试验性的组之间的变化的大小的统计意义在星期被观察 4 和 8。没有变化被观察关于 Q_( 最大) ,残余尿,前列腺体积或 PSA 铺平。结论:G 的摘录。易懂嗯很好被容忍,在 IPSS 的改进被观察。G 的摘录的推荐剂量。易懂嗯是在有 LUTS 的人的 6 mg。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 15 | 亚洲人群需要降低重组组织型纤溶酶原激活剂的剂量治疗急性缺血性卒中吗?显示文摘在欧美国家,急性缺血性卒中(acute ischaemic stroke,AIS)患者在4.5 h时间窗内给予静脉应用重组组织型纤溶酶原激活剂(recombinant tissue plasminogen activator,rt-PA)治疗的标准剂量为0.9 mg/kg,然而在亚洲国家由于对患者颅内出血风险的担忧以及患者经济承受能力的差异,部分国家或地区在临床实践中选择应用低剂量rt-PA,日本甚至将0.6 mg/kg的剂量纳入其指南。 | XIA WANG SHOUJIANG YOU SHOICHIRO SATO 李淑娟 | 2018 | 中国卒中杂志2018，13，5： | 2 |
| 16 | Pulse pressure is an independent risk factor for stroke among middle-aged Japanese with normal systolic blood pressure: the JPHC study显示文摘 | Katsutoshi Okada Hiroyasu Iso Renzhe Cui Manami Inoue Shoichiro Tsugane | 2011 | Journal of Hypertension2011，，2： | 2 |
| 17 | Diet and the risk of gastric cancer: review of epidemiological evidence显示文摘 | Shoichiro Tsugane Shizuka Sasazuki | 2007 | Gastric Cancer2007，，2： | 2 |
| 18 | Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms显示文摘瞄准:评估 Ganoderma 的一篇摘录的安全和功效易懂嗯那出现最强壮 5 α-reductase 在由一个双窗帘的 19 朵可食、药用的蘑菇的摘录之中的禁止的活动,控制安慰剂,使随机化并且在有更低的尿道症状(LUTS ) 的人的变化剂量的学习。方法:在这试用,我们随机分配了与 G 有 slight-to-moderate LUTS 到 12 星期处理的超过 49 年岁的 88 个人。易懂嗯摘录(6 mg 一次一天) 或安慰剂。主要结果措施是在国际前列腺症状分数(IPSS ) 和 uroflowmetry 的变量的变化。第二等的结果措施在前列腺尺寸包括了变化,剩余在 voiding,实验室价值和报导不利效果以后的尿体积。结果: G。易懂嗯对为改进全部的 IPSS, 2.1 个点在处理的目的减少的安慰剂有效、显著地优异(吝啬的差别, −1.18 点;95% 信心间隔, −1.74 到 −0.62;P <
0.0001 ) 。没有变化关于生活分数的质量被观察,山峰尿流动,吝啬的尿流动,剩余尿,前列腺体积,浆液前列腺特定的抗原或睾丸激素层次。全面处理很好没有严重不利效果被容忍。结论:G 的摘录。易懂嗯很好被容忍并且改进了 IPSS 分数。这些结果用 G 的摘录为长持续时间鼓励了植物治疗法的进一步的、大规模评估。易懂嗯在有 LUTS 的人上。 | Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu Ryuichiro Kondo Kei Matsuoka | 2008 | Asian Journal of Andrology2008，10，5： | 2 |
| 19 | Improving emulsifying activity ofε-poly-lysine by conjugation with dextran through the Maillard reaction显示文摘 | Yu-Ting H Shoichiro M unehiko T | 2000 | Food Chemistry2000，68，4： | 1 |
| 20 | Advancement in Stereo chemical Aspects of Schiff Base Metal Complexes显示文摘 | Shoichiro Y | 1999 | Coordination Chemistry Reviews1999，，： | 1 |
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