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| 1 | Sensor design and implementation for a downhole NMR fluid analysis laboratory显示文摘This paper tries to build a multi-functional downhole nuclear magnetic resonance (NMR) fluid analysis laboratory that can evaluate fluid information in real time at reservoir conditions at a depth of several thousand meters. The aim is to monitor the pollution of the formation fluids and quantitatively evaluate NMR characteristics of the fluids. It focuses on the design of the structure and parameters of a sensor with zero stray fields. Two separate coils are designed to measure NMR characteristics of flowing or static fluids. A method is proposed to use the Bloch equation, to guide the optimization of the NMR sensor. Finally, the measured results confirm that the design is reasonable. There is a homogeneous static field (perpendicular to the axial direction) in the center of the sensor, and there are no stray external fields. The novel design of pre-polarization magnet improves the signal to noise ratio, while shortening the sensor length. | Wu Baosong Xiao Lizhi Li Xin Yu Huijun An Tianlin | 2012 | Petroleum Science2012，9，1： | 10 |
| 2 | Prion protein and cancers显示文摘正常细胞的 prion 蛋白质, PrP C 是一高度在所有哺乳动物保存了并且广泛地表示了房间表面 glycoprotein。PrP 的表示是 prion 疾病的枢轴的 inthe 致病;然而, PrP C 遗体不完全地理解。在房间模型,基于研究功能的过多被归因于 PrP C 。在这份报纸,我们考察了潜在的角色那 PrP 在房间生理学的 C 戏并且集中了于它对 tumorigenesis 的贡献。 | Xiaowen Yang Yan Zhang Lihua Zhang Tianlin He Jie Zhang Chaoyang Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 3 | SbMYB3 transcription factor promotes root-specific f lavone biosynthesis in Scutellaria baicalensis显示文摘Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the transcriptional regulation of f lavone biosynthesis in S.baicalensis remains unclear.We show that the SbMYB3 transcription factor functions as a transcriptional activator involved in the biosynthesis of RSFs in S.baicalensis.Yeast one-hybrid and transcriptional activation assays showed that SbMYB3 binds to the promoter of flavone synthase II-2(SbFNSII-2)and enhances its transcription.In S.baicalensis hairy roots,RNAi of SbMYB3 reduced the accumulation of baicalin and wogonoside,and SbMYB3 knockout decreased the biosynthesis of baicalein,baicalin,wogonin,and wogonoside,whereas SbMYB3 overexpression enhanced the contents of baicalein,baicalin,wogonin,and wogonoside.Transcript profiling by qRT–PCR demonstrated that SbMYB3 activates SbFNSII-2 expression directly,thus leading to more abundant accumulation of RSFs.This study provides a potential target for metabolic engineering of RSFs. | Yumin Fang Jie Liu Minmin Zheng Sanming Zhu Tianlin Pei Mengying Cui Lijing Chang Hanwen Xiao Jun Yang Cathie Martin Qing Zhao | 2023 | Horticulture Research2023，10，2： | 2 |
| 4 | Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype显示文摘Whether direct manipulation of Parkinson’s disease(PD)risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue.Here,we used an adeno-associated virus serotype 9(AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras(SNs)of two monkey groups:an old group and a middle-aged group.After the operation,the old group exhibited all the classic PD symptoms,including bradykinesia,tremor,and postural instability,accompanied by key pathological hallmarks of PD,such as severe nigral dopaminergic neuron loss(>64%)and evidentα-synuclein pathology in the gene-edited SN.In contrast,the phenotype of their middle-aged counterparts,which also showed clear PD symptoms and pathological hallmarks,were less severe.In addition to the higher final total PD scores and more severe pathological changes,the old group were also more susceptible to gene editing by showing a faster process of PD progression.These results suggested that both genetic and aging factors played important roles in the development of PD in the monkeys.Taken together,this system can effectively develop a large number of genetically-edited PD monkeys in a short time(6–10 months),and thus provides a practical transgenic monkey model for future PD studies. | Hao Li Shihao Wu Xia Ma Xiao Li Tianlin Cheng Zhifang Chen Jing Wu Longbao Lv Ling Li Liqi Xu Wenchao Wang Yingzhou Hu Haisong Jiang Yong Yin Zilong Qiu Xintian Hu | 2021 | Neuroscience Bulletin2021，37，9： | 2 |
| 5 | The research onremote control robot snake driving by servo 显示文摘 | Song Tianlin Zao IJng Shen Xuanxuan | 2011 | Prot ediaEngineering2011，15，： | 1 |
| 6 | Study on the volatile profile characteristics of oyster Crassostrea gigas during storage by a combination sampling method coupled with GC/MS显示文摘 | ZHANG Zhuomin LI Tianlin WANG Dan | 2009 | Food Chemistry2009，115，3： | 1 |
| 7 | Structural and optical properties of zinc nitride films prepared by rf magnetron sputtering显示文摘 | Yang Tianlin Zhang Zhisheng Li Yanhui | 2009 | Appl Surf Sci2009，255，2： | 1 |
| 8 | Study on the volatile profile characteristics of oyster Crassostrea gigas during storage by a combination sampling method coupled with GC/MS显示文摘 | ZHANG Zhuomin LI Tianlin WANG Dan | 2009 | Food Chem2009，115，： | 1 |
| 9 | Sensitive determination of trace- metal elements in tea with capillary electrophoresis by using chelating agent 4 - (2 - pyridylazo) resorcinol (PAR) 显示文摘 | Huatao Feng Tianlin Wang Sam Fong | 2003 | Food Chemistry2003，81，： | 1 |
| 10 | The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure显示文摘In recent years,Non-Hodgkin lymphoma(NHL)has been one of the most fast-growing malignant tumor diseases.NHL poses severe damages to physical health and a heavy burden to patients.Traditional therapies(chemotherapy or radiotherapy)bring some benefit to patients,but have severe adverse effects and do not prevent relapse.The relevance of emerging immunotherapy options(immune-checkpoint blockers or adoptive cellular methods)for NHL remains uncertain,and more intensive evaluations are needed.In this work,inspired by the idea of vaccination to promote an immune response to destroy tumors,we used a biomaterial-based strategy to improve a tumor cell-based vaccine and constructed a novel vaccine named Man-EG7/CH@CpG with antitumor properties.In this vaccine,natural tumor cells are used as a vector to load CpG-ODN,and following lethal irradiation,the formulations were decorated with mannose.The study of the characterization of the doubleimproved vaccine evidenced the enhanced ability of DCs targeting and improved immunocompetence,which displayed an antitumor function.In the lymphoma prevention model,the Man-EG7/CH@CpG vaccine restrained tumor formation with high efficiency.Furthermore,unlike the non-improved vaccine,the double-improved vaccine elicited an enhanced antitumor effect in the lymphoma treatment model.Next,to improve the moderate therapeutic effect of the mono-treatment method,we incorporated a chemotherapeutic drug(doxorubicin,DOX)into the process of vaccination and devised a combination regimen.Fortunately,a tumor inhibition rate of~85%was achieved via the combination therapy,which could not be achieved by mono-chemotherapy or mono-immunotherapy.In summary,the strategy presented here may provide a novel direction in the establishment of a tumor vaccine and is the basis for a prioritization scheme of immuno-chemotherapy in enhancing the therapeutic effect on NHL. | Tianlin Zhou Jinrong Penga Ying Hao Kun Shi Kai Zhou Yun Yang Chengli Yang Xinlong He Xinmian Chen Zhiyong Qian | 2021 | Bioactive Materials2021，6，3： | 1 |
| 11 | Cyclotron cavity analysis based on field circuit model显示文摘 | Dong Tianlin Zhan Lamin Hong Yueming | 2003 | Nuclear Instruments and Methods in Physics Research A2003，513，11： | 1 |
| 12 | Topical Metal Chelation Therapy Ameliorates Oxidation-Induced Toxicity in Diabetic Cataract显示文摘 | Min Zhang Mohammad Shoeb Ping Liu Tianlin Xiao Dale Hogan IraG. Wong GeraldA. Campbell NaseemH. Ansari | 2011 | Journal of Toxicology and Environmental Health Part A2011，，6： | 1 |
| 13 | Study on the new fluorescence enhance- mentsystem of Zn-bis-(trimethylolaminomethane)-4-tert-but yl-disalicylicimine in the presence of β-cyclodextrin and its analytical application显示文摘 | Yang Tianlin Qin Wenwu Liu Weisheng | 2004 | Science Direct Talanta2004，62，： | 1 |
| 14 | Sintering pa- rameters and wear performances of vitrified bond diamond grinding wheels 显示文摘 | Kuan Honglin Shih Fengpeng Shun Tianlin | 2007 | International Journal of Refractory Met- als & Hard Materials2007，25，2007： | 1 |
| 15 | Effects of brazing route and brazing alloy on the interfacial structure between diamond and bonding matrix显示文摘 | Sheng Fanghuang Hsien Lungtsai Shun Tianlin | 2004 | Materials Chemistry and Physics2004，84，： | 1 |
| 16 | Cell cycle-regulated phosphorylation of p220NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription显示文摘 | Ma Tianlin van Tine B A Harper J W et ol | 2000 | Genes Dev2000，14，： | 1 |
| 17 | Effect of GZO thickness and annealing temperature on the structural,electrical and optical properties of GZO/Ag/GZO sandwich films显示文摘 | SONG Shumei YANG Tianlin XIN Yanqing | 2010 | Current Appl Phys2010，10，2： | 1 |
| 18 | The red cell immune system显示文摘 | Siegel I Liu Tianlin Gleicher N | 1981 | Lancet1981，2，8246： | 1 |
| 19 | Primary Treatment of Acute Dacryocystitis by Endoscopic Dacryocystorhinostomy with Silicone Intubation Guided by a Soft Probe显示文摘 | Wencan Wu Wentao Yan Julia K. MacCallum Yunhai Tu Alice C. Jiang Yuan Yang Tianlin Xiao Jin Li Qinmei Wang Jia Qu | 2009 | Ophthalmology2009，，1： | 1 |
| 20 | The study on infrared scattering of red tide显示文摘 | Lin Hong Dong Tianlin Ma Yong | 2007 | International Journal of Infrared and Millimeter Waves2007，28，4： | 1 |
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