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| 1 | Epidemiology of opportunistic invasive fungal infections in China: review of literature显示文摘 | LIAO Yong CHEN Min Thomas Hartmann YANG Rong-ya LIAO Wan-qing | 2013 | Chinese Medical Journal2013，，2： | 35 |
| 2 | Helicity dependent directional surface plasmon polariton excitation using a metasurface with interfacial phase discontinuity显示文摘Surface plasmon polaritons(SPPs)have been widely exploited in various scientific communities,ranging from physics,chemistry to biology,due to the strong confinement of light to the metal surface.For many applications,it is important that the free space photon can be coupled to SPPs in a controllable manner.In this Letter,we apply the concept of interfacial phase discontinuity for circularly polarizations on a metasurface to the design of a novel type of polarization-dependent SPP unidirectional excitation at normal incidence.Selective unidirectional excitation of SPPs along opposite directions is experimentally demonstrated at optical frequencies by simply switching the helicity of the incident light.This approach,in conjunction with dynamic polarization modulation techniques,opens gateway towards integrated plasmonic circuits with electrically reconfigurable functionalities. | Lingling Huang Xianzhong Chen Benfeng Bai Qiaofeng Tan Guofan Jin Thomas Zentgraf Shuang Zhang | 2013 | Light(Science & Applications)2013，2，1： | 31 |
| 3 | 26mA cm^(-2) J_(sc) from organic solar cells with a low-bandgap nonfullerene acceptor显示文摘Nonfullerene-based organic solar cells(NFOSCs)have received great interest recently due to their higher performance and greater potential compared with fullerene-based solar cells[1].Power conversion efficiencies(PCEs)over 13% have been realized in single-junction NFOSCs[2].Compared with traditional fullerene acceptors,the greatest advantage of nonfullerene acceptors is their stronger light-harvesting capability in the visible and | Zuo Xiao Xue Jia Dan Li Shizhe Wang Xinjian Geng Feng Liu Junwu Chen Shangfeng Yang Thomas P.Russell Liming Ding | 2017 | Science Bulletin2017，62，22： | 28 |
| 4 | Video-assisted thoracoscopic surgery (VATS) for bilateral primary spontaneous pneumothorax显示文摘目的将由帮助录像的 thoracoscopic 外科(大桶) 考察我们双边的主要自发的气胸(PSP ) 的治疗的经验。回顾的图表评论被在诊所上或电话会见跟随的材料和方法。病人们被在乎为由在四个医学中心的一位胸的外科医生或在北、中央的台湾的社区医院。有双边的 PSP 的 13 个病人从 1994 年 7 月同时或顺序经历了双边的大桶到 2005 年 12 月。结果与从 15 ~ 36 年(平均数 23.1 年)的年龄, 12 男性和男性女性同时为双边的 PSP 与大桶被对待,在双边的 pneumothoracis 的指示下面(n=4 ) 或顺序(n=9 ) 。在为非同时的 PSP 病人的第一和第二个相反地侧面的大桶过程之间的间隔从 7 d 到 6 年。13 个病人(84.6%) 中的十一个有突出的肺的 bullae/blebs,并且与机械或化学的 pleurodesis 经历了 bullae 切除术。吝啬的起作用的时间是( 45.6 ±1 8.3 ) min (范围 25 ~9 6 min )并且( 120.6 ±2 8.7 ) min (范围 84 ~1 66 min )分别地为非同时(为在第一个大桶以后的相反地侧面的方面的复发的第二个大桶)并且同时(双边的大桶在里面一操作)过程。没有手术后的死亡。然而,延长了漏气(>7 d ) 在在保守治疗以后恢复了的一个病人(7.7%) 发生了。胸试管排水的吝啬的持续时间是 3.1 d 并且中部在时期上面列在后面是 3.4 年。结论大桶是在双边的 PSP 的治疗的一个安全、有效的过程。因为甚至与可见 bullae,复发的发生不在我的组并且在某以前的文学那么高,双边的大桶仅仅与同时双边的 PSP 为病人被推荐。在一个仰卧的位置的双边的大桶应该仅仅在选择情况中被使用,因为可能的肋膜的粘附或在以后的方面上隐藏 bullae。 | Yi-jen CHEN Shi-ping LUH Kun-yen HSU Cheng-ren CHEN Thomas Chang-yao TSAO Jia-yuh CHEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 20 |
| 5 | 冷水机利用变流量冷冻水的若干设计问题显示文摘目前变水量冷冻水系统的设计一般都采用一、二次双环路方式。但这种双环路配置方式会产生:使用两个水泵增加设备投资;冷冻水送水及回水的混合影响冷水机在部分负荷时的效率;实际的高负荷空调需求条件与最大设计工况条件不吻合时不能充分利用冷水机的全负荷容量等不良后果。设计单环路空调冷冻水系统可以避免上述问题。讨论了单环路变流量系统的长处以及可能产生的问题,并提供在整个运行范围内,能够实现安全、稳定和可靠的冷水机控制策略。 | Original by Thomas B. Hartman Translation by Liu Xuemin Reviewed by Steve Y. Chen | 1997 | 暖通空调1997，27，3： | 18 |
| 6 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 7 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 8 | Predicting the potential distribution of invasive exotic species using GIS and information-theoretic approaches:A case of ragweed(Ambrosia artemisiifolia L.)distribution in China显示文摘Invasive exotic species pose a growing threat to the economy,public health,and ecological integrity of nations worldwide. Explaining and predicting the spatial distribution of invasive exotic species is of great importance to prevention and early warning efforts. We are investigating the potential distribution of invasive exotic species,the environmental factors that influence these distributions,and the ability to predict them using statistical and information-theoretic approaches. For some species,detailed presence/absence occurrence data are available,allowing the use of a variety of standard statistical techniques. However,for most species,absence data are not available. Presented with the challenge of developing a model based on presence-only information,we developed an improved logistic regres-sion approach using Information Theory and Frequency Statistics to produce a relative suitability map. This paper generated a variety of distributions of ragweed(Ambrosia artemisiifolia L.) from logistic regression models applied to herbarium specimen location data and a suite of GIS layers including climatic,topographic,and land cover information. Our logistic regression model was based on Akaike's Information Criterion(AIC) from a suite of ecologically reasonable predictor variables. Based on the results we provided a new Frequency Statistical method to compartmentalize habitat-suitability in the native range. Finally,we used the model and the compartmentalized criterion developed in native ranges to “project” a potential distribution onto the exotic ranges to build habitat-suitability maps. | CHEN Hao CHEN LiJun Thomas P. ALBRIGHT | 2007 | Chinese Science Bulletin2007，52，9： | 12 |
| 9 | Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice显示文摘杂种优势比也是从二父母表演的后代改善了的生物现象和优异性能生来的父母线。混合米饭是在利用杂种优势的庄稼的最成功的 apotheoses 之一。由基因表示(半自动地面防空系统)的连续分析 F1 超级混血儿的米饭 Liangyou-2186 和它的父母介绍的 Transcriptional 表明 1183 差别表示了基因( DG ),在哪个之中 DG 被发现显著地在象光合作用和碳固定那样的小径充实,并且大多数涉及碳固定小径的关键基因在 F1 混合米饭展出了起来调整的表示。而且,相应的酶的增加的分解代谢的活动和光合的效率也被检测,它联合了显示那碳固定可能在 F1 混血儿,和力量被提高在超级混血儿的米饭与收益活力和杂种优势被联系。由有收益相关的量的特点 loci (QTL ) 的相关 DG,在微分基因表示和 phenotypic 变化之间的一种潜在的关系也被发现。另外,当以前在 Arabidopsis 报导了,包含生理节奏节奏、轻的发信号的小径的一个规章的网络也被发现,它建议如此的一个网络可能也与在混合米饭的杂种优势是相关的。总的来说,现在的学习为理解在米饭位于杂种优势下面的分子的机制提供另一个看法。 | Gui-Sheng Song Hong-Li Zhai Yong-Gang Peng Lei Zhang Gang Wei Xiao- Ying Chen Yu-Guo Xiao Lili Wang Yue-Jun Chen Bin Wu Bin Chen Yu Zhang Hua Chen Xiu-Jing Feng Wan-Kui Gong Yao Liu Zhi-Jie Yin Feng Wang Guo-Zhen Liu Hong-Lin Xu Xiao-Li Wei Xiao-Ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming Lu Mei Wang Jan van der Greef Zhen Zhu | 2010 | Molecular Plant2010，3，6： | 12 |
| 10 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 11 | Stem Cell Regulation by Arabidopsis WOX Genes显示文摘功能的多样化跟随的基因扩大是在进化的主要力量。这的一个典型例子在 WUSCHEL 相关的 HOMEOBOX (WOX ) 基因家庭被看见,依照 Arabidopsis 干细胞管理者 WUSCHEL 命名。这里,我们在 WOX 基因家庭分析功能的分叉。除了形成层干细胞管理者 WOX4, WUS clade 的成员能在射击和花的干细胞维护代替 WUS 功能到不同的度。WUS 的干细胞功能要求正规 WUS 盒子,为和 TPL/TPR 合作抑压者的相互作用必要,而压抑的耳朵领域是非必需的,酸的领域仅仅似乎为女富饶被要求。与 WUS clade 相对照,古老的 WOX13 和 WOX9 clades 的成员不能支持干细胞维护。尽管 homeodomains 在 WUS 和 WOX9 clade 成员之间是可互换的,和正规 WUS 盒子的 WUS 兼容的 homeodomain 不为干细胞维护是足够的。我们的结果建议在射击和 Arabidopsis 的花的分裂组织的那个 WOX 函数被限制为现代 WUS clade,建议干细胞控制是一个导出的函数。除了 homeodomain 和 WUS 盒子的然而未被发现的功能的领域为这功能是必要的。 | Alicja Dolzblasz Judith Nardmann Elena Clerici Barry Causier Eric van der Graaff Jinhui Chen Brendan Davies Wolfgang Werr Thomas Laux | 2016 | Molecular Plant2016，9，7： | 11 |
| 12 | Personalized targeted therapy for esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial. | Xiaozheng Kang Keneng Chen Yicheng Li Jianying Li Thomas A D'Amico Xiaoxin Chen | 2015 | World Journal of Gastroenterology2015，21，25： | 10 |
| 13 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 14 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 15 | IGCT——更高功率处理能力的正确选择显示文摘IGCT被视为大功率应用的理想开关器件,其主要优势不仅体现在高可靠性上,同时,其低损耗使得系统损耗较低。在三电平拓扑中,IGCT与目前最高水平的IGBT在器件损耗方面的对比结果为IGCT的较低。由于IGCT器件是基于晶闸管特性,系统中独立的箝位电路设计是必须的,以实现其与续流二极管配合工作时的高可靠性。文中不仅提到了对故障现象的特别考虑,重点介绍了外围电路设计和故障电流保护策略,而且介绍了IGCT目前最新的研发成果。在朝更大功率容量方向发展方面,IGCT器件具有很大的潜力。 | Thomas Stiasny Vasileios Kappatos Thomas Setz Sven Klaka Makan Chen Madhan Mohan | 2015 | 大功率变流技术2015，0，6： | 8 |
| 16 | Variations in carbon isotopic composition in the subcontinental lithospheric mantle beneath the Yangtze and North China Cratons:Evidence from in-situ analysis of diamonds using SIMS显示文摘The components and evolution of subcontinental lithospheric mantle beneath the North China Craton and the Yangtze Craton is a current topic in the geological study of China and the carbon isotopic composition of diamond is one of the most direct probes into cratonic lithospheric mantle processes.In this paper,in-situ SIMS(Secondary Ion Mass Spectrometry) techniques were used to analyze the carbon isotope compositions at different internal growth zones of diamonds from Shandong and Liaoning in the North China Craton and Hunan in the Yangtze Craton.It was found that the carbon isotopic range of diamonds from the North China Craton are rather distinct from those of the Yangtze Craton;the former has a range of 6.0‰ to 2.0‰(relative to VPDB) with an average value of 3.0‰ in their core areas,which is consistent with global peridotitic diamonds;the diamonds from the Yangtze Craton,however,have a carbon isotopic range from 8.6‰ to 3.0‰ with an average value of 7.4‰ in their core areas,being more consistent with global eclogitic diamonds.The variations of carbon isotope ratios between different internal growth zones in individual diamonds were different in the three diamond localities studied.There was a clear correlation between changes in carbon isotopic composition and phases of diamond dissolution and new growth,while no correlation was observed between δ13C and internal inclusions.The variations suggest that the carbon isotopic compositions of mantle fluids were changing during the process of diamond crystallization,and that the heterogeneity of the carbon isotopic composition in mantle carbon reservoirs was a more important factor than carbon isotope fractionation in controlling the carbon isotopic compositions and their variation in diamonds.In addition,the preliminary results of in-situ nitrogen analyses demonstrated that the variation of carbon isotopic compositions between the core and outer growth zones does not correlate with nitrogen abundances,implying either that diamonds crystallized in an open environment or that the carbon isotopic composition and nitrogen contents in mantle fluids were controlled by other,not yet understood factors.The experimental results provide hints that the isotopic composition of carbon and its original sources were different in metasomatic fluids controlling diamond formation in the mantle beneath the North China Craton and the Yangtze Craton. | CHEN Hua QIU ZhiLi LU TaiJin STERN Richard STACHEL Thomas SUN Yuan ZHANG Jian KE Jie PENG ShuYi QIN SheCai | 2013 | Chinese Science Bulletin2013，58，1： | 7 |
| 17 | A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation Pathways in Soybean显示文摘Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to ammonia.The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AON).However,how these pathways are integrated and their underlying mechanisms are unclear.Here,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AON pathway.NNC1 interacts with GmNINa,the soybean ortholog of Lotus NODULE INCEPTION(NIN),and hampers its transcriptional activation o i G m RICI and GmRIC2.Importantly,GmNINa acts as a transcriptional activator of miR172c.Intriguingly,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory network.Moreover,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription.Thus,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling,supporting the balance between nodulation and AON in soybean. | Lixiang Wang Zhengxi Sun Chao Su Yongliang Wang Qiqi Yan Jiahuan Chen Thomas Ott Xia Li | 2019 | Molecular Plant2019，12，9： | 7 |
| 18 | Qidong: a crucible for studies on liver cancer etiology and prevention显示文摘Qidong(Jiangsu, China) has been of interest to cancer epidemiologists and biologists because, until recently, it was an endemic area for liver cancer, having amongst the highest incidence rates in the world. The establishment of the Qidong Cancer Registry together with the Qidong Liver Cancer Institute in 1972 has charted the patterns of liver cancer incidence and mortality in a stable population throughout a period of enormous economic, social, and environmental changes as well as of improvements in health care delivery. Updated incidence trends in Qidong are described. Notably, the China age-standardized incidence rate for liver cancer has dropped by over 50% in the past several decades. Molecular epidemiologic and genomic deep sequencing studies have affirmed that infection with hepatitis B virus as well as dietary exposure to aflatoxins through contamination of dietary staples such as corn, and to microcystins–blue-green algal toxins found in ditch and pond water – were likely important etiologic factors that account for the high incidence of liver cancer in this region. Public health initiatives to facilitate universal vaccination of newborns against HBV and to improve drinking water sources in this rural area, as well as economic and social mandates serendipitously facilitating dietary diversity, have led to precipitous declines in exposures to these etiologic factors, concomitantly driving substantive declines in the liver cancer incidence seen now in Qidong. In this regard, Qidong serves as a template for the global impact that a package of intervention strategies may exert on cancer burden. | Jianguo Chen Jian Zhu Gaoren Wang John D.Groopman Thomas W.Kensler | 2019 | Cancer Biology & Medicine2019，16，1： | 6 |
| 19 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 20 | Experimental Investigation of Forced Convective Boiling Flow Instabilities in Horizontal Helically Coiled Tubes显示文摘ExperimentalInvestigationofForcedConvectiveBoilingFlowInstabilitiesinHorizontalHelicallyCoiledTubesL.J.Guo;Z.P.Feng;X.J.Chen(... | L. J. Guo Z. P. Feng X. J. Chen N. H. Thomas | 1996 | Journal of Thermal Science1996，5，3： | 5 |
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