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| 1 | XA23 Is an Executor R Protein and Confers Broad-Spectrum Disease Resistance in Rice显示文摘 | Chunlian Wang Xiaoping Zhang Yinglun Fan Ying Gao Qinlong Zhu Chongke Zheng Tengfei Qin Yanqiang Li Jinying Che Mingwei Zhang Bing Yang Yaoguang Liu Kaijun Zhao | 2015 | Molecular Plant2015，8，2： | 55 |
| 2 | Alkaline modification of ZSM-5 catalysts for methanol aromatization: The effect of the alkaline concentration显示文摘ZSM-5 催化剂的物理性质上并且在他们为到 aromatics 变换的甲醇的活动的碱的处理的效果被调查了。一个温和碱的处理(0.2 和 0.3 mol/L NaOH ) 在酸味上没有明显的效果在父母沸石创造了 mesopores。mesopores 的存在为 aromatics 给催化剂更长的一生和更高的选择。有 0.4 mol/L NaOH 的处理减少了 Br 的数字 ? nsted 酸地点由于 dealumination 和 desilication,它导致了更低的释放率。另外,更多的 mesopores 比与温和碱的处理被生产。作为结果,与 0.4 mol/L NaOH 对待的样品的一生是乘父母 ZSM-5 的的几乎五。有更高碱的集中(0.5 mol/L ) 的处理极大地减少了 Br 的数字 ? nsted 酸地点和导致不完全的甲醇变换的 micropores 的数字。当碱对待的催化剂与酸被洗时,一些孔被恢复,为 aromatics 的选择的细微增加被获得。 | Zhenhao Wei Tengfei Xia Minghui Liu Qingsheng Cao Yarong Xu Kake Zhu Xuedong Zhu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 18 |
| 3 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 4 | Effect of barium sulfate modification on the SO2 tolerance of V2O5/TiO2 catalyst for NH3-SCR reaction显示文摘Sulfur poisoning of V_2O_5/BaSO_4–TiO_2(VBT),V_2O_5/WO_3–TiO_2(VWT) and V_2O_5/BaSO_4–WO_3–TiO_2(VBWT) catalysts was performed in wet air at 350℃ for 3 hr,and activities for the selective catalytic reduction of NO_x with NH_3 were evaluated for 200–500℃.The VBT catalyst showed higher NO_x conversions after sulfur poisoning than the other two catalysts.The introduction of barium sulfate contributed to strong acid sites for the as-received catalyst,and eliminated the redox cycle of active vanadium oxide to some extent,which resulted in a certain loss of activity.Readily decomposable sulfate species formed on VBT-S instead of inactive sulfates on VWT-S.These decomposable sulfates increased the number of strong acid sites significantly.Some sulfate species escaped during catalyst preparation and barium sulfate was reproduced during sulfur poisoning,which protects vanadia from sulfur oxide attachment to a great extent.Consequently,the VBT catalyst exhibited the best resistance to sulfur poisoning. | Tengfei Xu Xiaodong Wu Xuesong Liu Li Cao Qiwei Lin Duan Weng | 2017 | Journal of Environmental Sciences2017，29，7： | 14 |
| 5 | Comparison of three evapotranspiration models with eddy covariance measurements for a Populus euphratica Oliv.forest in an arid region of northwestern China显示文摘The accurate estimation of evapotranspiration(ET) in arid regions is important for improving the water use efficiency of vegetation. Based on successive observations from May to October of 2014, we estimated the ET of a Populus euphratica Oliv. forest during the growing season in an extremely arid region using the PM(Penman-Monteith), SW(Shuttleworth-Wallace) and SSW(an improved canopy transpiration model) models. Estimated ET values were compared with those of the eddy covariance measurements. Results indicated that the actual ET of the P. euphratica forest was always overestimated by the PM model. The accuracy of the SW model was higher than that of the PM model. However, some data were not easily obtained because of the complicated structure of the SW model. The newly proposed SSW model gave the most accurate ET values, and its accuracy was higher at hourly than at daily time scale. In conclusion, the SSW model is more suitable for sparse vegetation system at large scales in extremely arid regions. | GAO Guanlong ZHANG Xiaoyou YU Tengfei LIU Bing | 2016 | Journal of Arid Land2016，8，1： | 12 |
| 6 | Raindrop Size Distribution Parameters Retrieved from Guangzhou S-band Polarimetric Radar Observations显示文摘According to the statistical shape–slope(μ–Λ) relationship observed for the first time by several 2 D-Video-Distrometers(2 DVD) in southern China, a constrained gamma(C-G) model was proposed for the retrieval of rain drop size distributions(DSDs) from Guangzhou S-band polarimetric radar observations. Two typical precipitation processes were selected to verify the accuracy of the retrieval scheme. The μ–Λ relationship: Λ = 0.0241μ2 + 0.867μ + 2.453 was obtained based on the 2 DVD observation results from at Huizhou Longmen station, which is a very representative location in the area. Relying on the Guangzhou polarimetric radar measurements of radar reflectivity(ZHH) and differential reflectivity(ZDR), the gamma(Γ) size distribution parameters(N0, μ, and Λ) can be retrieved by the C-G model retrieval scheme. The results show that the Guangzhou polarimetric radar retrievals of DSDs were close to the2 DVD observations at Guangzhou Maofengshan station. The rain rate, mass mean diameter, and normalized intercept parameter of radar retrievals were in good agreement with the 2 DVD observations, and the relative errors were less than 10%. The overall accuracy of the retrieval scheme was high. The retrieval scheme has established the relationship between the polarimetric radar measurements and gamma size distribution parameters. It will be helpful to in-depth research and application of the dual-polarization radar data in microphysical precipitation processes analysis,as well as convection-resolved numerical model data assimilation and prediction effect evaluation. | Xiantong LIU Qilin WAN Hong WANG Hui XIAO Yu ZHANG Tengfei ZHENG Lu FENG | 2018 | Journal of Meteorological Research2018，32，4： | 11 |
| 7 | Influence of Nitrogen Flow Ratio on the Microstructure, Composition, and Mechanical Properties of DC Magnetron Sputtered Zr-B-O-N Films显示文摘Nanocrystalline ZrB 2 film and nanocomposite Zr-B-O-N films were prepared by non-reactive as well as reactive magnetron sputtering techniques, respectively. By means of X-ray diffraction analysis, electron probe microanalysis, X-ray photoelectron spectroscopy, and scanning electron microscopy, the influence of nitrogen flow ratio on the film microstructure and characteristics were investigated systematically, including the deposition rate, chemical compositions, phase constituents, grain size, chemical bonding, as well as cross-sectional morphologies. Meanwhile, the hardness and adhesion of above films were also evaluated by micro-indentation method and a scratch tester. With increasing the nitrogen flow ratio, the deposition rate of above films decreased approximately linearly, whereas the contents of N and O in the films increased gradually and tended to saturation. Moreover, the film microstructure was also altered gradually from a fine columnar microstructure to a featureless glass-structure. As the nitrogen flow ratio was 11.7%, the Zr-B-O-N film possessed an typical nanocomposite structure and presented good mechanical properties. During the process of reactive sputtering of metal borides, the introduction of nitrogen can show a pronounced suppression of columnar grain growth and strong nanocomposite structure forming ability. | Tie-Gang Wang Yanmei Liu Tengfei Zhang Doo-In Kim KwanKHo Kim | 2012 | Journal of Materials Science & Technology2012，28，11： | 10 |
| 8 | Generation of ready to use (RTU) products over China based on Landsat series data显示文摘Earth observation community has entered into the era of big data.Family of Landsat sensors have collected massive medium resolution satellite images,which are valuable for long-term land surface monitoring.In order to significantly reduce the magnitude of data processing for remote sensing data users,Landsat-based Ready to Use(RTU)products have been produced.Main RTU products,including orthorectified products,land surface reflectance,land surface temperature,large-area mosaic image,and standard image map products,are described.The resulting Landsat RTU products are hosted on the RSGS earth observation data sharing web site for free download(http://gffzz959b1a8e74bf485dhuu6kvpckqcqx6b6k.ffgz.tsg.suse.edu.cn/rtu/).These new products will provide consistent,standardized,multi-decadal image data for robust land cover change detection and monitoring across the Earth sciences.In the coming years,CASEarth DataBank system will be constructed,which is an intelligent data service platform for providing not only the RTU products from multi-source satellite data,but also big earth data analysis methods. | Guojin He Zhaoming Zhang Weili Jiao Tengfei Long Yan Peng Guizhou Wang Ranyu Yin Wei Wang Xiaomei Zhang Huichan Liu Bo Cheng Bo Xiang | 2018 | Big Earth Data2018，2，1： | 8 |
| 9 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 10 | State of the Art and Prospects in Metal-Organic Framework-Derived Microwave Absorption Materials显示文摘Microwave has been widely used in many fields,including communication,medical treatment and military industry;however,the corresponding generated radiations have been novel hazardous sources of pollution threating human’s daily life.Therefore,designing high-performance microwave absorption materials(MAMs)has become an indispensable requirement.Recently,metal-organic frameworks(MOFs)have been considered as one of the most ideal precursor candidates of MAMs because of their tunable structure,high porosity and large specific surface area.Usually,MOF-derived MAMs exhibit excellent electrical conductivity,good magnetism and sufficient defects and interfaces,providing obvious merits in both impedance matching and microwave loss.In this review,the recent research progresses on MOF-derived MAMs were profoundly reviewed,including the categories of MOFs and MOF composites precursors,design principles,preparation methods and the relationship between mechanisms of microwave absorption and microstructures of MAMs.Finally,the current challenges and prospects for future opportunities of MOF-derived MAMs are also discussed. | Shuning Ren Haojie Yu Li Wang Zhikun Huang Tengfei Lin Yudi Huang Jian Yang Yichuan Hong Jinyi Liu | 2022 | Nano-Micro Letters2022，14，4： | 6 |
| 11 | Dominant Gene cplsr1 Corresponding to Premature Leaf Senescence Resistance in Cotton (Gossypium hirsutum L.)显示文摘Cotton (Gossypium hirsutum L.) premature leaf senescence-resistant inbred XLZ33 and senescence-susceptible inbred lines XLZ13 were selected and crossed to produce F1, F1-reciprocal, F2 and BC1 generations for evaluation of leaf senescence process and inheritance. The results showed that leaf senescence processes for XLZ13 and XLZ33 were obviously different and leaf senescence traits could be distinguished between the two parents at particular periods of cotton growth. Inheritance anlysis for the cotton premature leaf senescence resistant trait further showed that the segregation in the F2 fit a 3:1 ratio inheritance pattern, with resistance being dominant. The backcross of F1 to the susceptible parent produced a 1:1 ratio, confirming that cotton premature leaf senescence resistant trait was from a single gene. The single dominant gene controlling cotton premature leaf senescence resistance in XLZ33 was named as cotton premature leaf senescence resistance 1, with the symbol cplsr1. | Jingqing Zhao Tengfei Jiang Zhi Liu Wenwei Zhang Guiliang Jian Fanfljun Qi | 2012 | Journal of Integrative Plant Biology2012，54，8： | 6 |
| 12 | Metal chalcogenides for potassium storage显示文摘Potassium-based energy storage technologies,especially potassium ion batteries(PIBs),have received great interest over the past decade.A pivotal challenge facing high-performance PIBs is to identify advanced electrode materials that can store the large-radius K+ions,as well as to tailor the various thermodynamic parameters.Metal chalcogenides are one of the most promising anode materials,having a high theoretical specific capacity,high in-plane electrical conductivity,and relatively small volume change on charge/discharge.However,the development of metal chalcogenides for PIBs is still in its infancy because of the limited choice of high-performance electrode materials.However,numerous efforts have been made to conquer this challenge.In this article,we overview potassium storage mechanisms,the technical hurdles,and the optimization strategies for metal chalcogenides and highlight how the adjustment of the crystalline structure and choice of the electrolyte affect the electrochemical performance of metal-chalcogenide-based electrode materials.Other potential potassium-based energy storage systems to which metal chalcogenides can be applied are also discussed.Finally,future research directions focusing on metal chalcogenides for potassium storage are proposed. | Jingwen Zhou Ye Liu Shilin Zhang Tengfei Zhou Zaiping Guo | 2020 | InfoMat2020，2，3： | 6 |
| 13 | Development and validation of an analytical method for detecting chlorantraniliprole residues in fresh tea leaves显示文摘An efficient method using multiwalled carbon nanotubes(MWCNTs)as dispersive solid-phase extraction sorbent was established for determining chlorantraniliprole residues in fresh tea leaves,which are known to be a troublesome matrix containing abundant pigments,via gas chromatography with an electron capture detector.Acetonitrile was used as the extraction solvent,with sodium chloride enhancing the analyte partition in the organic phase.The optimal mixture of MWCNTs and primary secondary amine(PSA)was based on the distribution of the target analyte recovery and on the clean-up efficiency;while matrix-matched calibration was recommended to combat the matrix effect.Mean recoveries of 95.2%–108.8%were obtained with intraday and interday precisions of less than 7.9%and 10.3%,respectively.Good linearity was observed for concentrations of 0.02–1.0 mg/kg with a correlation coefficient of 0.9984.The limits of detection and quantification were 0.005 mg/kg and 0.02 mg/kg,respectively.The method was employed to investigate the dissipation dynamics of chlorantraniliprole in fresh tea leaves with real field samples.Consequently,the dissipation rates of chlorantraniliprole in fresh tea leaves followed pseudo-first-order kinetics with a half-life of 1.9 d,and the average chlorantraniliprole residue content was below 0.02 mg/kg with a harvest withholding period of 14 d. | Tengfei Liu Minghui Dong Fengjie Zhou Daifeng Yang Xueming Zhang | 2019 | Food Science and Human Wellness2019，8，4： | 5 |
| 14 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 15 | Observation of parity-time symmetry in microwave photonics显示文摘Symmetry plays a crucial role in explorations of the laws of nature.Parity-time(PT)symmetry phenomena can lead to entirely real spectra in non-Hermitian systems,which attracts considerable attention in the fields of optics and electronics because these phenomena provide a new tool for the manipulation of oscillation modes and nonreciprocal signal transmission.A potential new field of application is microwave photonics,an interdisciplinary field in which the interaction between microwaves and optical signals is exploited.In this article,we report the experimental use of PT symmetry in an optoelectronic oscillator(OEO),a key microwave photonics system that can generate singlefrequency sinusoidal signals with high spectral purity.PT symmetry is theoretically analyzed and experimentally observed in an OEO with two mutually coupled active oscillation cavities via a precise manipulation of the interplay between gain and loss in the two oscillation cavities.Stable single-frequency microwave oscillation is achieved without using any optical/electrical filters for oscillation mode selection,which is an indispensable requirement in traditional OEOs.This observation opens new avenues for signal generation and processing based on the PT symmetry principle in microwave photonics. | Yanzhong Liu Tengfei Hao Wei Li Jose Capmany Ninghua Zhu Ming Li | 2018 | Light(Science & Applications)2018，7，1： | 5 |
| 16 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 17 | Numerical Investigation on Porous Media Quenching Behaviors of Premixed Deflagrating Flame using RANS/LES Model显示文摘To understand the mechanism of premixed flame quenching by porous media,a zonal hybrid RANS/LES model was employed,in which the LES flow solver was used to resolve the large turbulent structures within the non-porous region,while RANS was applied to porous media zone.The predicted results were compared with previous experimental data.And it was evident that the premixed flame propagation rates and structure as well as quenching behaviors were reproduced by this numerical approach with a better accuracy.Due to the inherently higher heat transfer coefficients between the solid and gas phases in porous media,the gas phase temperature has been decreased rapidly.However,upstream obstacles can cause the flame propagating faster and thus reduce the axial gas temperature gradients,resulting in the invalidity of the operation of premixed flame quenching.By comparison with the case without upstream obstacle,the values of reaction rate attained in the case with three pairs of obstacles are higher,which makes a positive impact on the flame passing through the porous medium.In addition,the porous media with greater pore density has an excellent flame quenching property mainly owing to both the larger volumetric heat transfer and higher quenching temperature. | WEN Xiaoping SU Tengfei LIU Zhigang XIE Maozhao WANG Fahui LIU Zhichao | 2019 | Journal of Thermal Science2019，28，4： | 4 |
| 18 | TDP-43 regulates cancer-associated microRNAs显示文摘 | Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu | 2018 | Protein & Cell2018，9，10： | 4 |
| 19 | Deep feature extraction and motion representation for satellite video scene classification显示文摘Satellite video scene classification(SVSC)is an advanced topic in the remote sensing field,which refers to determine the video scene categories from satellite videos.SVSC is an important and fundamental step for satellite video analysis and understanding,which provides priors for the presence of objects and dynamic events.In this paper,a two-stage framework is proposed to extract spatial features and motion features for SVSC.More specifically,the first stage is designed to extract spatial features for satellite videos.Representative frames are firstly selected based on the blur detection and spatial activity of satellite videos.Then the fine-tuned visual geometry group network(VGG-Net)is transferred to extract spatial features based on spatial content.The second stage is designed to build motion representation for satellite videos.The motion representation of moving targets in satellite videos is first built by the second temporal principal component of principal component analysis(PCA).Second,features from the first fully connected layer of VGG-Net are used as high-level spatial representation for moving targets.Third,a small network of long and short term memory(LSTM)is further designed for encoding temporal information.Two-stage features respectively characterize spatial and temporal patterns of satellite scenes,which are finally fused for SVSC.A satellite video dataset is built for video scene classification,including 7209 video segments and covering 8 scene categories.These satellite videos are from Jilin-1 satellites and Urthecast.The experimental results show the efficiency of our proposed framework for SVSC. | Yanfeng GU Huan LIU Tengfei WANG Shengyang LI Guoming GAO | 2020 | Science China(Information Sciences)2020，63，4： | 4 |
| 20 | m6A RNA methylation-mediated HNF3γreduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
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