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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | TDP-43 regulates cancer-associated microRNAs显示文摘 | Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu | 2018 | Protein & Cell2018，9，10： | 4 |
| 3 | Secondary donor-derived CD19 CAR-T therapy is safe and efficacious in acute lymphoblastic leukemia with extramedullary relapse after first autologous CAR-T therapy显示文摘Despite the advancement of treatments,adults with relapsed/refractory(R/R)B-lineage acute lymphoblastic leukemia(B-ALL)have poor prognosis,with an expected five-year overall survival(OS)rate of 10%‒20%(Nguyen et al.,2008;Oriol et al.,2010).Extramedullary relapse of B-ALL is regarded as a highrisk factor generally associated with poor survival,occurring in about 15%to 20%of all relapsed patients(Ding et al.,2017;Sun et al.,2018).The central nervous system(CNS)and the testes are the most common sites of extramedullary relapse of B-ALL.In addition,extramedullary leukemia can appear in the skin,eyes,breasts,bones,muscles,and abdominal organs.The prognosis of relapsed extramedullary B-ALL after allogeneic hematopoietic stem cell transplantation(allo-HSCT)is extremely poor(Spyridonidis et al.,2012;Dahlberg et al.,2019).Conventional chemotherapy or radiation is often ineffective in such patients.At present,there are no optimal treatment strategies for treating extramedullary leukemia after allo-HSCT. | Delin KONG Tingting YANG Jia GENG Ruirui JING Qiqi ZHANG GuoqingWEI He HUANG Yongxian HU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 2 |
| 4 | USP33, a new player in lung cancer, mediates Slit-Robo signaling显示文摘Ubiquitin 特定的朊酶(USP33 ) 33 是调整多样的细胞的过程的多功能的蛋白质。在肺癌症的 USP33 的表示和角色仍然保持未经勘探。在这研究,我们证明 USP33 在肺癌症病人的多重队是下面调整的, USP33 的那低表情与差的预后被联系。USP33 调停 Slit-Robo 在肺癌症房间移植发信号。USP33 的 Downregulation 在肺癌症房间减少 Robo1 的蛋白质稳定性,提供为在调停的 USP33 功能的以前未知的机制在肺癌症房间的裂缝活动。一起拿, USP33 是在调整 Slit-Robo 发信号的肺癌症的一个新播放器。我们的数据建议 USP33 可以作为一个预示的标记是为有潜力的肺癌症的候选人肿瘤 suppressor。 | Pushuai Wen Ruirui Kong Jianghong Liu Li Zhu Xiaoping Chen Xiaofei Li Yongzhan Nie Kaichun WU Jane Y. Wu | 2014 | Protein & Cell2014，5，9： | 2 |
| 5 | An accelerated simplex method显示文摘 | KONG Ruirui QIU Runchen ZHOU Kouhui | 2003 | Journal of Nanjing University of Science and Tec hnolagy2003，27，2： | 1 |
| 6 | Review on fiber morphology obtained by bubble electrospinning and blown bubble spinning显示文摘 | HE Jihuan KONG Haiyan YANG RuiRui | 2012 | Thermal Science2012，5，16： | 1 |
| 7 | The breakthrough in primary human hepatocytes in vitro expansion显示文摘Introduction As one of the most frequently diagnosed devastating diseases, liver failure is responsible for approximately two million deaths annually worldwide with poor prognosis1. Although liver transplantation has been developed for the most effective treatment for liver failure, it is far from demands for patients due to the shortage of high-quality donor livers and expensive treatment costs. Currently, with the development of cell therapy, cell transplantations including primary human hepatocytes (PHHs), human hepatocyte-like cells (HLCs) and liver organoids are emerging as great potential tools to alleviate this growing burden. | Mei Feng Ruirui Kong Yisheng Pan | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 8 | 1A6/DRIM, the human UTP20 functions in 28S and 5.8S rRNA processing显示文摘1A6/DRIM has been identified as UTP20, a small subunit processome component, functioning in 18S rRNA processing. In the present study, the maturation of 28S rRNA and 5.8S rRNA was inhibited when 1A6/DRIM was silenced in HeLa cells; and coincidently, an accumulation of 32S rRNA precursor was observed. Immunoprecipitation was performed with the anti-1A6/DRIM antibody, followed by Northern blot with the ITS2 probe. The results showed that 1A6/DRIM was associated with both 32S and 12S rRNA precursors in vivo. The expression profile of 1A6/DRIM during rRNA processing was investigated by sucrose density gradient fractionation in combination with Western blot analysis. The results demonstrated that 1A6/DRIM was involved in the pre-60S particles in addition to the pre-40S particles and co-sediment with the 32S and 12S rRNA precursors in the nucleolus. Furthermore, the interaction of U8 snoRNA with 1A6/DRIM was revealed by immunoprecipitation. These results demonstrated that 1A6/DRIM interacted with both 32S rRNA and U8 snoRNA, being involved in 28S rRNA and 5.8S rRNA processing. | KONG RuiRui HAN Wei ULRICH H. Weidle NING Tao DU XiaoJuan KE Yang | 2010 | Chinese Science Bulletin2010，55，17： | 0 |
| 9 | Therapy of Primary Liver Cancer显示文摘Primary liver cancer(PLC)is a fatal disease that affects millions of lives worldwide.PLC is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming decades.PLC can be categorized into three major histological subtypes:hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC),and combined HCC-ICC.These subtypes are distinct with respect to epidemiology,clinicopathological features,genetic alterations,and clinical managements,which are thoroughly summarized in this review.The state of treatment strategies for each subtype,including the currently approved drugs and the potential novel therapies,are also discussed. | Mei Feng Yisheng Pan Ruirui Kong Shaokun Shu | 2020 | The Innovation2020，1，2： | 0 |
| 10 | Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer显示文摘Objective:Liver cancer is a deadly malignancy associated with high mortality and morbidity.Less than 20%of patients with advanced liver cancer respond to a single anti-PD-1 treatment.The high heterogeneity of neutrophils in the tumor immune microenvironment in liver cancer may contribute to resistance to immune checkpoint blockade(ICB).However,the underlying mechanism remains largely unknown.Methods:We established an orthotopic liver cancer model by using transposable elements to integrate the oncogenes Myc and KrasG12Dinto the genome in liver cells from conditional Trp53 null/null mice(pTMK/Trp53^(-/-)).Flow cytometry and immunohistochemistry were used to assess the changes in immune cells in the tumor microenvironment.An ex vivo coculture assay was performed to test the inhibitory effects of tumor-associated neutrophils(TANs)on CD8^(+)T cells.The roles of neutrophils,T cells,and NK cells were validated through antibody-mediated depletion.The efficacy of the combination of neutrophil depletion and ICB was evaluated.Results:Orthotropic pTMK/Trp53^(-/-)mouse liver tumors displayed a moderate response to anti-Ly6G treatment but not PD-1 blockade.Depletion of neutrophils increased the infiltration of CD8^(+)T cells and decreased the number of exhausted T cells in the tumor microenvironment.Furthermore,depletion of either CD8^(+)T or NK cells abrogated the antitumor efficacy of anti-Ly6G treatment.Moreover,the combination of anti-Ly6G with anti-PD-L1 enhanced the infiltration of cytotoxic CD8^(+)T cells and thereafter resulted in a significantly greater decrease in tumor burden.Conclusions:Our data suggest that TANs may contribute to the resistance of liver cancer to ICB,and combining TAN depletion with T cell immunotherapy synergistically increases antitumor efficacy. | Mei Feng Fangyanni Wang Xinyu Liu Tingting Hao Ning Zhang Mi Deng Yisheng Pan Ruirui Kong | 2023 | Cancer Biology & Medicine2023，20，6： | 0 |
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